Dear Jeff, Thank you for investing your time to communicate your research work. The reported findings are very interesting and the online app Is an awesome tool that I Will share with my students. It would be interesting to perform further modeling analysis evaluating the Association of AMPK modifications induced by Exercise training with the increment of biomarkers of muscle oxidative capacity and fatty acids utilization. Moreover, further research analyzing the Association of AMPKa2 polymorphisms with AMPKa2 activation induced by Exercise training would also be interesting. Hopefuly, we could collaborate in a future project. Best Wishes, Isaac
Dear Jeff, Thank you for sharing this great and interesting study. I have a question about it. Although, the statistical analysis from your study has shown that no significant correlation between AMPK activation and CHO ingestion before or during exercise. However, when we consume CHO, the use of muscle glycogen is decreased. Thus, higher glycogen levels remain at the end of the exercise, which has a significant correlation with AMPK activity, according to your study. I would be grateful if you let me know your opinion about this matter. The best Mohammad
Hi Mohammad, good question. Contrary to what you might expect, most studies show no difference in muscle glycogen reduction in the fed vs fasted state... Here are a few…. academic.oup.com/jcem/article/105/3/660/5599745 pubmed.ncbi.nlm.nih.gov/3514573/ pubmed.ncbi.nlm.nih.gov/3571097/ pubmed.ncbi.nlm.nih.gov/8889742/ Sometimes you may see a difference if someone has eaten a big meal really far in advance of exercise, but in most cases it shouldn’t make a difference. And carb ingestion during exercise seems to save liver but not muscle glycogen journals.physiology.org/doi/full/10.1152/ajpendo.00376.2015
Dear Jeff,
Thank you for investing your time to communicate your research work. The reported findings are very interesting and the online app Is an awesome tool that I Will share with my students. It would be interesting to perform further modeling analysis evaluating the Association of AMPK modifications induced by Exercise training with the increment of biomarkers of muscle oxidative capacity and fatty acids utilization. Moreover, further research analyzing the Association of AMPKa2 polymorphisms with AMPKa2 activation induced by Exercise training would also be interesting.
Hopefuly, we could collaborate in a future project.
Best Wishes,
Isaac
such informative video!
Awesome !!
Dear Jeff,
Thank you for sharing this great and interesting study. I have a question about it. Although, the statistical analysis from your study has shown that no significant correlation between AMPK activation and CHO ingestion before or during exercise. However, when we consume CHO, the use of muscle glycogen is decreased. Thus, higher glycogen levels remain at the end of the exercise, which has a significant correlation with AMPK activity, according to your study. I would be grateful if you let me know your opinion about this matter.
The best
Mohammad
Hi Mohammad, good question. Contrary to what you might expect, most studies show no difference in muscle glycogen reduction in the fed vs fasted state... Here are a few….
academic.oup.com/jcem/article/105/3/660/5599745
pubmed.ncbi.nlm.nih.gov/3514573/
pubmed.ncbi.nlm.nih.gov/3571097/
pubmed.ncbi.nlm.nih.gov/8889742/
Sometimes you may see a difference if someone has eaten a big meal really far in advance of exercise, but in most cases it shouldn’t make a difference. And carb ingestion during exercise seems to save liver but not muscle glycogen journals.physiology.org/doi/full/10.1152/ajpendo.00376.2015
@@jeffrothschildmsrd5633
Thanks Jeff for your reply and sharing the articles.
This is very interesting.