The data on SSRI’s seems to be mixed with a significant amount of studies showing they’re no better than placebo. The takeaway for me is that depression is not just about Serotonin. I think we’ll be much better off when we can accurately understand what is going on in the brain for each individual.
I think you’re ultimately right, but my view is that serotonin and the other monoamines are very often involved with depression. So while low serotonin is certainly not the only cause, it is often (not always!) part of the equation for a given individual.
Did you know that they also cause akathisia and some other extrapyramidal symptoms? Did you know that antidepressants also damage serotonin and dopaminergic pathways in the brain? Where did you get that they help with neuroplasticity? 😮
Gave me permanent anhedonia that I haven’t been able to shake off even heard after discontinuation. Darn! Was a completely different person before starting SSRIs. I could actually feel human emotions, good and bad. Not anymore
Look up Branchi I. The double edged sword of neural plasticity: increasing serotonin levels leads to both greater vulnerability to depression and improved capacity to recover. Psychoneuroendocrinology. 2011 Apr;36(3):339-51. doi: 10.1016/j.psyneuen.2010.08.011. Epub 2010 Sep 26. PMID: 20875703.
I don't think it increases plasticity rather treats an underline lack of. I was fully convinced I got smarter, I think it just makes the neurons fire more effectively.
Not at all! I currently have no sponsorships. More importantly, there is empirical evidence that SSRIs can enhance neuroplasticity. For example, here's a quote from a 2022 study: "In animal models, selective serotonin reuptake inhibitors (SSRIs) have been shown to facilitate neuroplasticity. This is especially prominent during emotional relearning, such as fear extinction, which may translate to clinical improvements in patients." Reference: Klöbl, M., Seiger, R., Vanicek, T., Handschuh, P., Reed, M. B., Spurny-Dworak, B., ... & Lanzenberger, R. (2022). Escitalopram modulates learning content-specific neuroplasticity of functional brain networks. NeuroImage, 247, 118829. doi.org/10.1016/j.neuroimage.2021.118829
The data on SSRI’s seems to be mixed with a significant amount of studies showing they’re no better than placebo. The takeaway for me is that depression is not just about Serotonin. I think we’ll be much better off when we can accurately understand what is going on in the brain for each individual.
I think you’re ultimately right, but my view is that serotonin and the other monoamines are very often involved with depression. So while low serotonin is certainly not the only cause, it is often (not always!) part of the equation for a given individual.
Did you know that they also cause akathisia and some other extrapyramidal symptoms? Did you know that antidepressants also damage serotonin and dopaminergic pathways in the brain? Where did you get that they help with neuroplasticity? 😮
So I’m fucked from taking Prozac? Should I kill myself and get it over with?
Gave me permanent anhedonia that I haven’t been able to shake off even heard after discontinuation. Darn! Was a completely different person before starting SSRIs. I could actually feel human emotions, good and bad. Not anymore
Antidepressants cause neurotoxicity.
My QEEG and Spect scan show brain damage.
How are you now
Huh? Would LOVE to see how they're measuring neuroplasticity. . .my guess is psuedoscientific measurement equating to nothing tangible
Look up Branchi I. The double edged sword of neural plasticity: increasing serotonin levels leads to both greater vulnerability to depression and improved capacity to recover. Psychoneuroendocrinology. 2011 Apr;36(3):339-51. doi: 10.1016/j.psyneuen.2010.08.011. Epub 2010 Sep 26. PMID: 20875703.
I don't think it increases plasticity rather treats an underline lack of. I was fully convinced I got smarter, I think it just makes the neurons fire more effectively.
Sounds like sponsored content. 😂
They help my sinuses
Even stroke increase neuroplasticity, so do you think ssri are neurotoxic and brain increases neuroplaticity to combat this neurotoxicity
ghis video is sponsored by pfizer 🤡
Not at all! I currently have no sponsorships. More importantly, there is empirical evidence that SSRIs can enhance neuroplasticity. For example, here's a quote from a 2022 study: "In animal models, selective serotonin reuptake inhibitors (SSRIs) have been shown to facilitate neuroplasticity. This is especially prominent during emotional relearning, such as fear extinction, which may translate to clinical improvements in patients." Reference: Klöbl, M., Seiger, R., Vanicek, T., Handschuh, P., Reed, M. B., Spurny-Dworak, B., ... & Lanzenberger, R. (2022). Escitalopram modulates learning content-specific neuroplasticity of functional brain networks. NeuroImage, 247, 118829. doi.org/10.1016/j.neuroimage.2021.118829
Love your work. Thank you so much 🙏
Thank you!
Interesting
bs!