Roger: H5N1 is a genuinely scary prospect, and you are truly an outstanding teacher in this [and your other] presentations. I say this not casually, being a former Chair of one of the Biology Depts at the Univ of Colo [Frank Stahl was head of my grad student unit long ago] and as a former NIH panel member. Especially I note your presentation of the molecular difference between the 2,6 and 2,3 linkages. I think it is immensely important to not shy away from the molecular chemistry, but to give a visualization of what many people feel is incomprehensible if they just hear the words. People will learn it. Kudos to you! Please keep it up. Cheers r [prof biophysics retired]
@@Katiebelly123 A moment of silence for those that were duped into taking the mystery juice from the pharmakeia industry that is causing myocarditis, pericarditis, mitral regurgitation, tachycardia, atrial fibrillation, arrhythmia, cardiac arrest, micro blood clotting, severe tinnitus, neurological disease, loss of hearing, vestibular neuritis, aortic stenosis, extreme fatigue & exhaustion, anaphylaxis, guillain barre syndrome, bell’s palsy, cranial nerve palsy, loss of vision, dysgeusia, paralysis, hemiparesis, transverse myelitis, strokes, pulmonary embolism, stillbirth & miscarriage, hyperprogressive disease, aneurysms, etc,. etc,.
Expanding on my comment on the last video, it's just amazing that you can make such a complex topic understandable (for the most part) to a layperson. You are an incredibly valuable resource to the public at large. Thank you immensely. Regards.
I don't like that I'm getting flashbacks to your earliest COVID videos as we're starting to learn more about H5N1. Thank you for your clear and concise videos once again.
Thank you for providing a clear explanation of what’s known about this case and the mutation of this virus so far. I’ve learned a lot from MedCram these past 4-5 yrs and appreciate your thoughtful and easy to digest updates. You guys rock!
I’m in Aotearoa/NZ and am watching this case closely, because not only is NZ no longer under the government that did so well during the COVID pandemic, our primary fauna are birds. We only have one indigenous mammal family (bats), and outside of reptiles and insects almost all our land-based critters are birds.
Our public health infrastructure is about to be decimated, but I guess it doesn’t much matter because nobody really trust them anyway. Of course, this means getting good information is going to be extremely difficult. Thanks for your channel.
FYI, that area of Canada has biggest concentration of chicken meat and egg ranchers in the nation. The youth did not work in industry, so human to human transmission seems likely, though bird to human can not be ruled out yet.
Likely? Based on what? You forgetting there is a record breaking outbreak occurring in wild birds? Especially in waterfowl in that area in North America. Canada tested the soil in an area where waterfowl live and it had pretty high levels of H5…you all are underestimating how much of this stuff is in the environment now due to the outbreak in wild birds.
From Bloom lab and credited to BC CDC and Canadian Public Health: Ambiguous codons are "ga[gt]" and "ca[at]" The possible amino under these codes are E or D at 190, and G or H at 226
I really appreciate your explaining this so that a common person can understand it. When Covid started, I relied on your videos to get thru the pandemic Covid free. I live in the US and i have a backyard poultry flock of geese, turkeys, and chickens that I rely on for food. Do you have any recommendations to help keep me and my flock safe?
Thank you! I don’t have evidence specifically but if they have are outside and have assess to sunlight and fresh air I think they will have the best chance of survival.
From Global News Canada Nov 25, 2024: "Provincial health officer Dr. Bonnie Henry will provide an update Tuesday morning on the status of a B.C. teenager infected with H5N1 avian influenza and the investigation into the case. The press conference will take place at 11 a.m. PT."
@@Medcram B.C., at least the lower mainland (most dense population of the Province) is just entering it's longest period of clouds, rain and fog, ie low sun values until at least April 2025.
Thank you for graphically showing what the 2,3 and 2,6 linkage actually means. This was just noise to me until I watched this video. I was also a bit confused by your statement "actually should be a 6 up here" for the galactose molecule in birds (4:18). Did you mean the diagram was drawn wrong, and there should be another corner before the oxygen indicating a 6th carbon atom, as in the human diagram above in (A)? I also noticed the carbon corners show 3 linkages coming out of them (except for number 6 with two). I'm guessing the other carbon linkages not shown are to hydrogen atoms? I don't know if Dr. Seheult will see this question, but if not, maybe someone else could clarify?
@@majo3423 Assuming that was not just a cute remark for humor value, the influenza virus attaches to the surface of the host cell through its HA (hemagglutinin) protein. This happens at the sialic acid binding site of host cells, where a sialic acid molecule connects to a galactose molecule in a particular way. This connection is between an oxygen attached to a carbon atom in the sialic acid and a carbon in the galactose molecule. The carbons in these subunits are numbered in a specific, consistent way. 2,3 linkage means number 2 carbon of the sialic acid bonds through the oxygen with number 3 carbon of the galactose. 2,6 linkage means that same oxygen in the sialic acid bonds to the number 6 carbon in the galactose. This means the binding sites in birds are shaped differently than those in humans, and a virus with HA receptors shaped to bind with the human sialic acid - galactose structure can infect human hosts. (I invite any actual biochemists out there to correct me if I scrambled that explanation at all.)
Thanks for the clear explanation of the genetic change that could cause this pathogen to become widespread in people. Glad the investigators are doing a good job. 😉👍🕊❤️
@@Patrick_Ross No human to human transmission. All healthcare workers tested negative. Household contacts blood had some response to H5N1 but not enough for a conclusive positive test and the symptoms of the household contact began the same day as the original patient so it would seem unlikely they got it from each other instead from a common source.
Astounding. Eight different amino acids represented at position 226 and 3 at 190. Truly astounding. Do we know which amino acid substitutions are most likely to lead to binding in humans? Perhaps more importantly, do we know what sequence changes are most likely to lead to binding in both humans and birds (ducks and geese - most importantly). Two other important factors. 1) Flu used to be dominantly transferred by birds (especially ducks and geese) defecting and urinating in air as they flew south from the arctic breeding grounds. Airborne transmission and cycling through birds and swine, with global oscillation driving mutation shifts. This allowed us some warning in some cases. With massive air travel by humans, that route was largely supplanted. It never went away. Hence the importance of the flyways, and also of staying away from dead birds. 2) Flu is easily transmitted on surfaces, unlike SARS-CoV-2. This is a huge difference. It may also be easily transmitted through the eyes. Do you know whether that is a major route? Also, do we have data on contact times of various sterilants to kill the virus?
I’ve been a fan since Covid. I’m a very healthy, active 80 year old, using no Rx meds. If I had the magical opportunity to be young again and choose a different career path it would be science and medicine.
Thank you for the clarification, building on your previous video about the Canadian teenager. Sadly we get little information about these infections and which species they affect here in the UK.
The U.S. Food and Drug Administration (FDA) has approved H5N1 vaccines made by Sanofi, GSK subsidiary ID Biomedical Corporation of Quebec (IDB), and CSL Seqirus
Considering the paper that was published in the early noughties, I assume there's hopefully work done on vaccines or work that could once more lead to developing one quickly?
America might just be the worst country in the world to deal with another pandemic, especially when some states made it a crime to administer mRNA vaccines. Regardless, I plan to get the H5N1 mRNA vaccine when it becomes available, even if I have to travel out of state.
No state has made it illegal to administer an mRNA vaccine. There have been laws passed against vaccine mandates and vaccine passports but no state has outright band vaccinations. You'll be able to get a vaccination wherever you live as soon as one is available.
@@Joe-mz6dc This channel once had numerous comments from scientific and HC professions. Thankfully, many within these professions figured out none of these injections have ever halted transm...
Yup, but thankfully his symptoms were mild and they initiated anti-viral treatment quick enough, so he seems to be recovering from the latest reports and nobody in the immediate household has tested positive for it yet. They're still trying to investigate the origin of the transmission.
Thank you for your presentation and bringing this to light doctor. I’ve been following you for years and you always inspire me to continue to educate myself and pursue education whether it’s formal or informal Can you please let me know what software or video editing program you use? I would love to make videos to educate others. Thank you.
There was another case in California of a minor that came down with H5N1, but thankfully their symptoms were mild and they treated it aggressively with anti-virals and nobody in the immediate family has been infected that we know of. Again, they're also investigating the origins of the transmission, which isn't clear.
Dr. Roger Seheult explains H5N1 mutations in a recent Canadian case that may favor human transmission. He discusses sialic acid receptors, the difference between avian and human binding preferences, and concerning mutations detected in the hospitalized teen's virus.
Thank you for explaining this. Although my wife and I get our adjuvanted UK flu jab in a couple of days, we also take a daily does of NIR as an additional preventative measure.
Lets guess... the mutation includes how it now binds to human receptor. Lets guess how that happened... Which insane agency funded this gain of function experiment?
Not every gain of function that exists needs to be funded. Binding to receptor biochemically is not a real giant leap forward. It might have consequences but these things are happening all the time in the environment.
@@Medcram since youtube deletes posts including urls, search for "EXCLUSIVE: Controversial experiments that could make bird flu more risky poised to resume"
Would this be similar in effect to the historic Pneumonic Plagues . I think they caused widespread population decline, didn't they?I am interested in the 450 outbreaks
Would avian influenza in nature naturally vane if we didn't have poultry to pick it up? Does the infection go both ways so that poultry infect wild birds as well?
@@LoisoPondohva Ok, interesting. But it just shows up in nature periodically, right? Otherwise there would soon be no birds left. Unless many have become immune.
@carinaekstrom1 antibiotics don't work against viruses. It's common in nature mainly because it has much lower mortality in birds than in humans. So basically, if it was as bad in birds, infected birds would just die and not infect a lot of others. But instead they are relatively healthy so it just spreads and then reduces. It is possible that it will go extinct in time if enough birds will get immunity and it doesn't mutate fast enough. But that's not expected to happen soon. Edit: in captivity, we destroy the sick birds, so it doesn't spread.
The following information has been presented to the Priminister of Australia. The very latest research into covid vaccines. Very worrying. Uploaded to Utube 26th Nov 2024 Kevin McKernan on DNA contamination .
Based on a paper from 2024 (and 2004 and previous) for the shift at position 226 (and 228), it seems that to confer human transmissibility a change from glutamine to leucine at residue 226 and from glycine to serine at residue 228 is sufficient. One of the changes in the virus in the young Canadian was Q226H which is a glutamine to histidine shift. That increases transmissibility, but isn't optimal. His virus also apparently had E190D and E627K. That there are 7 226 changes and 2 190 changes that increase human transmission potential, it just emphasizes how important it is to be vigilant about human cases, and monitoring the changes changes in cows, birds (many species) and swine, and also in animals that come into contact with dairy cattle or milk (rodents, birds and cats). The surmise that the ambiguity in the sequence may mean it mutated in the patient seems reasonable, though not certain. If it did, the risk is less as he did not seem to transmit it to anyone (or anything) else. That's the good news. I would hope that the mRNA (and other) vaccine developers are developing new H5N1 vaccines based on this information, just in case. I also have read that the two current vaccines seem to be very much less effective against the variants, which greatly increases the concern. The current vaccines might provide some protection, but still be far from optimal. The bad news is that the proposed "leaders" for HHS, NIH, CDC and FDA are antivaxxers, and are particularly hostile to mRNA. We may need to look to Europe or Asia to develop the new vaccines. Getting those approved here may face significant hurdles and delays or roadblocks.
@@Medcram Thank you so much for keeping all of us informed along the spectrum from the concerned citizens, to the scientists, to the fellow healthcare professionals. I'm sorry you have to deal with sooooo many friggin' idiots who can barely read at a 3rd grade level. Please keep doing what you're doing; we'll need your insight and information esp come January and beyond.
I have studied much science over my lifetime. Excellent discussion here. But…… I do question mRNA vax now. I had a bad reaction in my arm to it, which then flared my lymphnodes on that side that had to be monitored for over a year with CT and THEN….. I got breast cancer on that same side. Have now had a double mastectomy and going through all that. Is it independent of the mRNA? Due to the lymphnode reaction, I do not think so, but we will never know. Will I take another mRNA? NO!!! Just in case!!! I will have to be an extreme hermit next time. Thanks for your detailed analysis and I thank MedCram for all these wonderful videos❤
The cool thing about disregarding this one, like the last one, and refusing the mystery juice is not getting myocarditis, pericarditis, mitral regurgitation, tachycardia, atrial fibrillation, arrhythmia, cardiac arrest, micro blood clotting, severe tinnitus, neurological disease, loss of hearing, vestibular neuritis, aortic stenosis, extreme fatigue & exhaustion, anaphylaxis, guillain barre syndrome, bell’s palsy, cranial nerve palsy, loss of vision, dysgeusia, paralysis, hemiparesis, transverse myelitis, strokes, pulmonary embolism, stillbirth & miscarriage, hyperprogressive disease, aneurysms, etc,. etc,.
I'm going through a raunchy flu (my COVID test swabs looked negative) right now, despite having gotten a flu shot about 2 weeks ago, (Nov 6, day after election I was in a bad mood and instead of moving in bed decided to get my covered yearly shots [influenza and moderna COVID booster, and a possibly missed or outdated hepatitis C shot because I was born in 1990] before trump destroys the ACA.) how would I even bother going through getting a PCR to find out what gene sequence my flu is from? Or if that would even be worthwhile at this point?
Prior to 1850, there was no influenza. There was also no diabetes, heart disease, and no cancer. These were only discovered from rare cases. Once causes were identified, chronic illness coincided with for-profit healthcare. Think about that.
It's a little bit disconcerting here, in Arizona, this time of year due to all of the yearly seasonal Canadian visitors, aka Snowbirds. They overwinter for months at a time in our much more pleasant Arizona winter climate. We may be in for some ridiculously predictable H5N1 human transmission. A question I have regarding the infected Canadian teen... Is the "teen" a family member of a Latino poultry facility worker? The news media is silent regarding this possibility.
@chrisu.5097 Whether the patient is of Latino descent is immaterial. If he had been from a family of poultry workers would be however. I don't think there are Latino- and - non-Latino poultry processing plants in BC. If I were you I would take advantage ofvthe edit feature here. Whether you intended to or not, sounds as if you're vilifying Latinos for some reason here. Perhaps you speak like this all the time, so you're completely unaware of how racist your remark sounds.
Roger: H5N1 is a genuinely scary prospect, and you are truly an outstanding teacher in this [and your other] presentations. I say this not casually, being a former Chair of one of the Biology Depts at the Univ of Colo [Frank Stahl was head of my grad student unit long ago] and as a former NIH panel member. Especially I note your presentation of the molecular difference between the 2,6 and 2,3 linkages. I think it is immensely important to not shy away from the molecular chemistry, but to give a visualization of what many people feel is incomprehensible if they just hear the words. People will learn it. Kudos to you! Please keep it up. Cheers r [prof biophysics retired]
Thank you very much. It means a lot.
@@Katiebelly123 A moment of silence for those that were duped into taking the mystery juice from the pharmakeia industry that is causing myocarditis, pericarditis, mitral regurgitation, tachycardia, atrial fibrillation, arrhythmia, cardiac arrest, micro blood clotting, severe tinnitus, neurological disease, loss of hearing, vestibular neuritis, aortic stenosis, extreme fatigue & exhaustion, anaphylaxis, guillain barre syndrome, bell’s palsy, cranial nerve palsy, loss of vision, dysgeusia, paralysis, hemiparesis, transverse myelitis, strokes, pulmonary embolism, stillbirth & miscarriage, hyperprogressive disease, aneurysms, etc,. etc,.
Expanding on my comment on the last video, it's just amazing that you can make such a complex topic understandable (for the most part) to a layperson. You are an incredibly valuable resource to the public at large. Thank you immensely. Regards.
Thank you very much!
I'd like to second that.
Ai, nice try
Brevity is the essence of wit as they say.
Yeah…in the USA there is a wave of anti science so…?
I don't like that I'm getting flashbacks to your earliest COVID videos as we're starting to learn more about H5N1. Thank you for your clear and concise videos once again.
Yeah, I know what you mean. Let’s hope this is only informational.
I get no flashbacks of COVID. COVID was being found all over the place and was highly transmissible not the case at least rn
Well Trump was elected and they didn’t kill enough humans to “save” the planet last time.
@@C_ALEBit was first reported in china if you follow from late 2019 this is scary similar story
Thank you for providing a clear explanation of what’s known about this case and the mutation of this virus so far. I’ve learned a lot from MedCram these past 4-5 yrs and appreciate your thoughtful and easy to digest updates. You guys rock!
I’m in Aotearoa/NZ and am watching this case closely, because not only is NZ no longer under the government that did so well during the COVID pandemic, our primary fauna are birds. We only have one indigenous mammal family (bats), and outside of reptiles and insects almost all our land-based critters are birds.
Our public health infrastructure is about to be decimated, but I guess it doesn’t much matter because nobody really trust them anyway. Of course, this means getting good information is going to be extremely difficult. Thanks for your channel.
No "Fauci Ouchie" for this one. The next POTUS will probably name someone whose name rhymes with placebo or prayer.
Maybe an wwe superstar will head it
FYI, that area of Canada has biggest concentration of chicken meat and egg ranchers in the nation. The youth did not work in industry, so human to human transmission seems likely, though bird to human can not be ruled out yet.
Do they know if this kid was a hunter or avid outdoors person? That would make sense.
Don't play with the geese this winter or spring...
Likely? Based on what? You forgetting there is a record breaking outbreak occurring in wild birds? Especially in waterfowl in that area in North America. Canada tested the soil in an area where waterfowl live and it had pretty high levels of H5…you all are underestimating how much of this stuff is in the environment now due to the outbreak in wild birds.
Seems unlikely. Just another animal to human
But who is the other human?
From Bloom lab and credited to BC CDC and Canadian Public Health: Ambiguous codons are "ga[gt]" and "ca[at]"
The possible amino under these codes are E or D at 190, and G or H at 226
Thank you!
This thing will surely stop the wars 😅
Ying and Yang
😮
Excellent presentation
"Wake up babe ... " it's that time again ;_;
I really appreciate your explaining this so that a common person can understand it. When Covid started, I relied on your videos to get thru the pandemic Covid free. I live in the US and i have a backyard poultry flock of geese, turkeys, and chickens that I rely on for food. Do you have any recommendations to help keep me and my flock safe?
Thank you! I don’t have evidence specifically but if they have are outside and have assess to sunlight and fresh air I think they will have the best chance of survival.
From Global News Canada Nov 25, 2024: "Provincial health officer Dr. Bonnie Henry will provide an update Tuesday morning on the status of a B.C. teenager infected with H5N1 avian influenza and the investigation into the case. The press conference will take place at 11 a.m. PT."
She belongs in jail.
@@Joe-mz6dcshe’s just the lackey messenger, doubtful she makes any big decisions
I'd I never see her face again it will be too soon. I agree with the other comment that she belongs in jail.
Lmao 😂 Clown 🤡
Oh, glowball news? They are totally legit.
Thank you so much!
You're welcome!
Thank you for keeping us informed 👍
I haven't seen more effort devoted to making bird flu transmissible . Maybe they should stop overcrowding humans and animals.
Bogus.
This is far more worrying than Covid. The fatality rate is downright scary. Would NIR light therapy help with this also?
Pretty sure sunlight was used successfully in 1918 so yes.
@@Medcram B.C., at least the lower mainland (most dense population of the Province) is just entering it's longest period of clouds, rain and fog, ie low sun values until at least April 2025.
Photobiomodulation, Vitamin C and D, etc.....naw just trust the shot there’s nothing we can do we are helpless....
Our next public health emergency, ladies and germs.
Milton Berle?
We'll see if it's a real emergency this time. 🙄
Thank you for graphically showing what the 2,3 and 2,6 linkage actually means. This was just noise to me until I watched this video.
I was also a bit confused by your statement "actually should be a 6 up here" for the galactose molecule in birds (4:18). Did you mean the diagram was drawn wrong, and there should be another corner before the oxygen indicating a 6th carbon atom, as in the human diagram above in (A)? I also noticed the carbon corners show 3 linkages coming out of them (except for number 6 with two). I'm guessing the other carbon linkages not shown are to hydrogen atoms? I don't know if Dr. Seheult will see this question, but if not, maybe someone else could clarify?
Yes. I think they were missing a carbon on that Gal. Each bend is a carbon. The sialic acid sugars should all have 9 carbons.
@@Medcram Thanks for explaining!
@@jimrodarmel8512 Now can you please explain it to us?
@@majo3423 Assuming that was not just a cute remark for humor value, the influenza virus attaches to the surface of the host cell through its HA (hemagglutinin) protein. This happens at the sialic acid binding site of host cells, where a sialic acid molecule connects to a galactose molecule in a particular way. This connection is between an oxygen attached to a carbon atom in the sialic acid and a carbon in the galactose molecule. The carbons in these subunits are numbered in a specific, consistent way. 2,3 linkage means number 2 carbon of the sialic acid bonds through the oxygen with number 3 carbon of the galactose. 2,6 linkage means that same oxygen in the sialic acid bonds to the number 6 carbon in the galactose. This means the binding sites in birds are shaped differently than those in humans, and a virus with HA receptors shaped to bind with the human sialic acid - galactose structure can infect human hosts. (I invite any actual biochemists out there to correct me if I scrambled that explanation at all.)
@@jimrodarmel8512 will continue to see where this takes us. Thank you
Oh no! Not so soon. Thanks for the info doc, plz keep us updated. Thanks.
Hoping that the new California case does not also have these two mutations!
Thanks Dr S🇨🇦
We still haven't had a serious pandemic in like 100 years. It's about due.
Thanks. I am not in the medical field and I appreciate your clear explanations.
Thanks for the clear explanation of the genetic change that could cause this pathogen to become widespread in people. Glad the investigators are doing a good job. 😉👍🕊❤️
Damn! If I had a television I would know all about H5N2, H5N3, H5N4, so as to arrive at a cohesive understanding of H5N...where was I?
Thank you !
You're welcome!
CDC investigators in Missouri were looking into a case of possible human to human transmission. Any word on what became of that?
@@Patrick_Ross No human to human transmission. All healthcare workers tested negative. Household contacts blood had some response to H5N1 but not enough for a conclusive positive test and the symptoms of the household contact began the same day as the original patient so it would seem unlikely they got it from each other instead from a common source.
Astounding. Eight different amino acids represented at position 226 and 3 at 190. Truly astounding. Do we know which amino acid substitutions are most likely to lead to binding in humans? Perhaps more importantly, do we know what sequence changes are most likely to lead to binding in both humans and birds (ducks and geese - most importantly).
Two other important factors.
1) Flu used to be dominantly transferred by birds (especially ducks and geese) defecting and urinating in air as they flew south from the arctic breeding grounds. Airborne transmission and cycling through birds and swine, with global oscillation driving mutation shifts. This allowed us some warning in some cases. With massive air travel by humans, that route was largely supplanted. It never went away. Hence the importance of the flyways, and also of staying away from dead birds.
2) Flu is easily transmitted on surfaces, unlike SARS-CoV-2. This is a huge difference. It may also be easily transmitted through the eyes. Do you know whether that is a major route? Also, do we have data on contact times of various sterilants to kill the virus?
It is known. But I need to understand it better myself. More videos to come.
The only way to fight ignorance is by educating... we need this, thank you
Ok, this is terrifying.
I'm surprised the patient isn't in quarantine.
The person is hospitalized and likely in quarantine.
Thanks for updating us
Thank you for this and all the work you’re doing!
Our pleasure!
Thank you for the information
Is this new version of the virus transmitted through the air or is it ingested?
Droplet. Let rest of the flu.
I’ve been a fan since Covid. I’m a very healthy, active 80 year old, using no Rx meds. If I had the magical opportunity to be young again and choose a different career path it would be science and medicine.
Do you get boosted? I’m 67 and vegan.
Oh yes the magic sauce everyone desires 😂
@@100pyatt I hear its going to come in tangy cajun flavor next time
Hmm must keep an eye on this. Thank you.
I recently went back to Medcram #59. Is it safe to think this would also help with influenza's?
Yes. Probably more so. Especially sunlight and hydrotherapy.
All my biochem lectures coming back for the win! Thanks so much Dr.
Glad you like them!
Concerning! Do we start planning? Thank you for the update.
@@annae9639 always plan but also no need to panic right now. Still no evidence of sustained human spread
CHECK OUT THE OUTSIDE AIR QUALITY
IT IS IN THE AIR QUALITY FOR SURE
Thanks for the updates.
Thank you for the clarification, building on your previous video about the Canadian teenager. Sadly we get little information about these infections and which species they affect here in the UK.
Good ty
Almost like it was intentionally DESIGNED
We are all going to die. Everyone. Buy a sailboat and run.
The U.S. Food and Drug Administration (FDA) has approved H5N1 vaccines made by Sanofi, GSK subsidiary ID Biomedical Corporation of Quebec (IDB), and CSL Seqirus
Considering the paper that was published in the early noughties, I assume there's hopefully work done on vaccines or work that could once more lead to developing one quickly?
America might just be the worst country in the world to deal with another pandemic, especially when some states made it a crime to administer mRNA vaccines. Regardless, I plan to get the H5N1 mRNA vaccine when it becomes available, even if I have to travel out of state.
No state has made it illegal to administer an mRNA vaccine. There have been laws passed against vaccine mandates and vaccine passports but no state has outright band vaccinations. You'll be able to get a vaccination wherever you live as soon as one is available.
Yikes. Some people never learn apparently.
@@Joe-mz6dc This channel once had numerous comments from scientific and HC professions. Thankfully, many within these professions figured out none of these injections have ever halted transm...
@@Joe-mz6dc ...and at best, they're suboptimal. Unfortunately, it appears we may get gaslit again.
@@celticsunise4ever You got a point. If you let people die of the virus, it might be harder for them to transm...
This is the one they'll get us with next?
Idk if this is true but I heard there was a case of a kid in California.
Yup, but thankfully his symptoms were mild and they initiated anti-viral treatment quick enough, so he seems to be recovering from the latest reports and nobody in the immediate household has tested positive for it yet. They're still trying to investigate the origin of the transmission.
@ I also saw they found some in milk in Cali.
I haven’t been keeping up with it or what it is I just saw headlines.
@@rager4able Yup, raw milk....the stuff that tapeworm guy says will make our kids big and strong -rolls eyes-
Whoopie, RFK Jr. (The F stands for effing.)
Maybe the authorities should shut down these farms and compensate the farmers for the losses. That's probably cheaper than dealing with a pandemic.
90M chickens have ben culled in the US due to H5N1, last time I checked.
If this evolved in that poor guy, well, don't let it escape !!!
Thank you for your presentation and bringing this to light doctor.
I’ve been following you for years and you always inspire me to continue to educate myself and pursue education whether it’s formal or informal
Can you please let me know what software or video editing program you use? I would love to make videos to educate others. Thank you.
I use smoothdraw 4 which is free and a Huion screen as a tablet. Capture with snagit.
And are there any further known cases?
Thanks for the update Doc! Yet another important video to send off to my cousin (M.D.) for viewing. Hope that all is well!
I still have PTSD from the start of Covid. I hope our government is taking this one seriously. I am not ready for refrigerated trucks again
Question
What is/was the event that percipitated this sudden ability for the virus to cross over to humans.
That’s the question. Obviously random mutations load the gun. But often human contact pulls the trigger.
There was another case in California of a minor that came down with H5N1, but thankfully their symptoms were mild and they treated it aggressively with anti-virals and nobody in the immediate family has been infected that we know of. Again, they're also investigating the origins of the transmission, which isn't clear.
Great.
So what's going on in southeast Asia where the teen was asked about recent travel?
Thank you.
And how many birds have died from this virus? .....vs how many have been killed because a sketchy PCR test?
Pcr has nothing to do with this.
How will they test for this virus in the population?
So let's see them allow for the vaccined vs non...
As long as there is a safe n eff ective treatment that works 100% of the time than I am not worried 😅😮....
I
Know
Right
🧐
Dr. Roger Seheult explains H5N1 mutations in a recent Canadian case that may favor human transmission. He discusses sialic acid receptors, the difference between avian and human binding preferences, and concerning mutations detected in the hospitalized teen's virus.
I love priming. Will look a bit poor on the health officials once they look to what happened in 2020 labs are great! cheers to a new variant.
Excellent. Thank you!
Sure
Covid 24 reported perfected.last January?
Time for everyone to repent and get right with The Lord Jesus Christ! The dice are loaded. H5N1 would be a pandemic of biblical proportions.
Thank you for explaining this. Although my wife and I get our adjuvanted UK flu jab in a couple of days, we also take a daily does of NIR as an additional preventative measure.
Favor = Targets?
Hard to say. But it looks as though the mutations would make that more likely.
Lets guess... the mutation includes how it now binds to human receptor. Lets guess how that happened... Which insane agency funded this gain of function experiment?
Not every gain of function that exists needs to be funded. Binding to receptor biochemically is not a real giant leap forward. It might have consequences but these things are happening all the time in the environment.
@@Medcram since youtube deletes posts including urls, search for "EXCLUSIVE: Controversial experiments that could make bird flu more risky poised to resume"
Seems like a good time to mask back up
Id never been so healthy and non miserable than when we masked up...Im going back to it, worth it to me.
❤❤❤
I don't LOVE my chickens!
Would this be similar in effect to the historic Pneumonic Plagues . I think they caused widespread population decline, didn't they?I am interested in the 450 outbreaks
Those plagues were caused by Yersinia pestis bacteria which is a totally different disease organism.
Would avian influenza in nature naturally vane if we didn't have poultry to pick it up? Does the infection go both ways so that poultry infect wild birds as well?
Yes, infection goes both ways. But it is more common in nature at this time. It won't vane naturally, it's endemic.
@@LoisoPondohva Ok, interesting. But it just shows up in nature periodically, right? Otherwise there would soon be no birds left. Unless many have become immune.
@@LoisoPondohva And if it's more common in nature, is that because wild birds get no antibiotics?
@carinaekstrom1 antibiotics don't work against viruses. It's common in nature mainly because it has much lower mortality in birds than in humans. So basically, if it was as bad in birds, infected birds would just die and not infect a lot of others. But instead they are relatively healthy so it just spreads and then reduces. It is possible that it will go extinct in time if enough birds will get immunity and it doesn't mutate fast enough. But that's not expected to happen soon.
Edit: in captivity, we destroy the sick birds, so it doesn't spread.
@@carinaekstrom1 it's MORE common in nature because in captivity, we kill every bird we suspect to have the virus and all birds it contacted.
The following information has been presented to the Priminister of Australia. The very latest research into covid vaccines. Very worrying. Uploaded to Utube 26th Nov 2024
Kevin McKernan on DNA contamination
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"Priminister" 🤦🏻♂️
@mrkeogh prime minister Anthony Albinese.
💙
Based on a paper from 2024 (and 2004 and previous) for the shift at position 226 (and 228), it seems that to confer human transmissibility a change from glutamine to leucine at residue 226 and from glycine to serine at residue 228 is sufficient. One of the changes in the virus in the young Canadian was Q226H which is a glutamine to histidine shift. That increases transmissibility, but isn't optimal. His virus also apparently had E190D and E627K. That there are 7 226 changes and 2 190 changes that increase human transmission potential, it just emphasizes how important it is to be vigilant about human cases, and monitoring the changes changes in cows, birds (many species) and swine, and also in animals that come into contact with dairy cattle or milk (rodents, birds and cats).
The surmise that the ambiguity in the sequence may mean it mutated in the patient seems reasonable, though not certain. If it did, the risk is less as he did not seem to transmit it to anyone (or anything) else. That's the good news.
I would hope that the mRNA (and other) vaccine developers are developing new H5N1 vaccines based on this information, just in case. I also have read that the two current vaccines seem to be very much less effective against the variants, which greatly increases the concern. The current vaccines might provide some protection, but still be far from optimal.
The bad news is that the proposed "leaders" for HHS, NIH, CDC and FDA are antivaxxers, and are particularly hostile to mRNA. We may need to look to Europe or Asia to develop the new vaccines. Getting those approved here may face significant hurdles and delays or roadblocks.
Thank you for this added context and information. Will pin to make sure others know as well.
@@Medcram Thank you so much for keeping all of us informed along the spectrum from the concerned citizens, to the scientists, to the fellow healthcare professionals. I'm sorry you have to deal with sooooo many friggin' idiots who can barely read at a 3rd grade level.
Please keep doing what you're doing; we'll need your insight and information esp come January and beyond.
I have studied much science over my lifetime. Excellent discussion here. But…… I do question mRNA vax now. I had a bad reaction in my arm to it, which then flared my lymphnodes on that side that had to be monitored for over a year with CT and THEN….. I got breast cancer on that same side. Have now had a double mastectomy and going through all that. Is it independent of the mRNA? Due to the lymphnode reaction, I do not think so, but we will never know. Will I take another mRNA? NO!!! Just in case!!! I will have to be an extreme hermit next time.
Thanks for your detailed analysis and I thank MedCram for all these wonderful videos❤
You don’t know how to make bone and you’re worried about viruses 😂
The cool thing about disregarding this one, like the last one, and refusing the mystery juice is not getting myocarditis, pericarditis, mitral regurgitation, tachycardia, atrial fibrillation, arrhythmia, cardiac arrest, micro blood clotting, severe tinnitus, neurological disease, loss of hearing, vestibular neuritis, aortic stenosis, extreme fatigue & exhaustion, anaphylaxis, guillain barre syndrome, bell’s palsy, cranial nerve palsy, loss of vision, dysgeusia, paralysis, hemiparesis, transverse myelitis, strokes, pulmonary embolism, stillbirth & miscarriage, hyperprogressive disease, aneurysms, etc,. etc,.
I mean we make normal and effective flu vaccines without mana. Why not put the vaccine for this in the normal anual shot?
if wisdom was a tree, you would be a bush
@@17sapun He's already a nut.
You've poisoned your mind with conspiracy nuttery.
@@TheDanEdwardsI see this comment has been repeated verbatim over and over? Bot?
The is something to be watched very carefully. Plan accordingly.
I don't believe anything they say any more.
But your Truth President is soon in charge? Doesn't that change everything for you?
@@friedrichjunztHow did you arrive at this conclusion? Trust no one. Make everyone transparent and accountable.
Don't worry, the outstanding people at the WHO, are as always, on top of things......🤯.
who?
@@nicevideomancanadaworld health organization
IMHO: I think this was H2H transmission 6-9 months ago.
Uh…based on what? If H2H spread was happening this would be showing up in wastewater all over the place and flu activity I assure you would not be low
With the infection of a teen, does that mean that this particular mutation is highly contagious more so than in the past?
Potentially. It matters on which mutation happened at that site as well.
I'm going through a raunchy flu (my COVID test swabs looked negative) right now, despite having gotten a flu shot about 2 weeks ago, (Nov 6, day after election I was in a bad mood and instead of moving in bed decided to get my covered yearly shots [influenza and moderna COVID booster, and a possibly missed or outdated hepatitis C shot because I was born in 1990] before trump destroys the ACA.) how would I even bother going through getting a PCR to find out what gene sequence my flu is from? Or if that would even be worthwhile at this point?
The gloom is caused by your shots . You wil feel better later so stay in bed
I think something was going around in early November. Maybe you got what I got.
Prior to 1850, there was no influenza. There was also no diabetes, heart disease, and no cancer. These were only discovered from rare cases. Once causes were identified, chronic illness coincided with for-profit healthcare. Think about that.
GuI hooit descimayes the White House in Kanuary
Not buying it. The dog and pony show is over.
Amen!
Yeah but the so called "Doc" has much more ching to make on utoob videos $$
Their coming after us
don't comply
if you got the COVID jab, it's too late for you
😎
You know the pharmaceutical companies are salivating at such a fortuitous , I mean unfortunate, set of events.
Not if there’s no supply chain to get the goods to market…..
It's a little bit disconcerting here, in Arizona, this time of year due to all of the yearly seasonal Canadian visitors, aka Snowbirds. They overwinter for months at a time in our much more pleasant Arizona winter climate. We may be in for some ridiculously predictable H5N1 human transmission. A question I have regarding the infected Canadian teen... Is the "teen" a family member of a Latino poultry facility worker? The news media is silent regarding this possibility.
@chrisu.5097 Whether the patient is of Latino descent is immaterial. If he had been from a family of poultry workers would be however. I don't think there are Latino- and - non-Latino poultry processing plants in BC. If I were you I would take advantage ofvthe edit feature here. Whether you intended to or not, sounds as if you're vilifying Latinos for some reason here. Perhaps you speak like this all the time, so you're completely unaware of how racist your remark sounds.
I hope that the authorities are working on vaccines for H5N1
Why aren’t they already conducting clinical trials for a human vaccine?
Hmm, Ivermectin and Zinc . ;-)
Name one reliable, verifiable, or replicable study that has shown Ivermectin is a viable treatment for any virus let alone bird flu.
@americanfreedom1777 , And Vit D levels at 50 and a good dose of sunshine everyday if you have it.
@homeshows , They're studying it for cancers (breast, rectal, etc... That's how effective Ivermectin is with the cells.