What Does Cancer Look Like?
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- Опубліковано 24 бер 2024
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Usually on Journey to the Microcosmos, we spend our time delving into the microscopic world and the surprising things that microbes have to teach us. But today, we would like to talk about Hank Green, and what was his cancer.
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Hank out here not just beating cancer but doxxing his cancer too.
Bump
bump
+
^
Yesss, expose those immature cells!
Honestly, the idea of cancer cells getting rebellious against the established order because of some nostalgia of their single-celled ancestors really is interesting.
It’s more like nostalgia for being a fetus. Cancer shows how dangerous being a man/womanchild really is.
Cells that become alienated from the greater "society" that is your body, and adopt self-serving "antisocial" behaviors.
Yes. Relatable
It's a very seducing idea, but it's also a very partial one.
From the perspective of aging multicellular organism, it's also a natural clock - the body self-destructing itself as it ages to leave more room for subsequent generations.
And there's also the issue that cancer cells aren't the only cells in our bodies to show a degree of individuality. Not all our cells work in perfect cooperation... and that's why there's so many auto-immune diseases.
The idea that cancer is an atavism of some sort makes sense intuitively, but the more you look at it, the more it just looks like a dysfunction.
The idea of the Noble Savage as cancer.
Shoutout to the pathology labs around the world! They're the department that carries out the staining & diagnosis of biopsies and bodily fluids. Pathologists (MDs who have specialised in laboratory medicine) then inspect the slides, order additional tests, and diagnose based on the results.
The pathology department often gets overlooked by the general public as they tend to work in the background rather than directly with the patients. This unfortunately also means that a lot of medical laboratories face substantial shortages in personel! So they can use all the love & attention we can give them.
You must be a dermatologist/oncologist/hematologist to speak so highly of pathologist. Thank you for your words.
There are way to many MLTs getting churned out. The job market anywhere near an accrediting program is heavily flooded and the opposite is true for the Histo community due in part to the fact that at surface level it isn't apparent just how integral a pathology lab is in the grand diagnosis/treatment system. We don't work for patients. We work for the doctor that performed your surgery. Over the years they have also incrementally made accreditation more difficult as time goes on. Its become discouraging to young people. The average age of an employee in an IHC or histolab is upper 50's maybe even 60 now. The Histo community is understaffed as a whole but its manageable. In another 10-15 years though the bulk of us will be retiring. The time to train and educate a new generation is here now but no one wants to address it publicly. It's like driving a car and waiting until it dies on the side of the road before you get more gas. It's too late at that point. Our low fuel light is on but no one seems to be concerned.
@@chokobo0047 to hopefully ease your concern, I took years after high school finding a career, and I fell in love with pathology and Im dead set on the path and steps to get there. A lot of people my age are actually pretty interested in the background stuff that goes on anywhere really, so I wouldnt stress too much about not having another influx of pathologists or the like
It doesn't help that the work of an MLT and MLS is poorly compensated in my opinion with a lot of schooling, training and stress. Many of my peers and myself have left the industry due to literally not being able to afford living in our city while working 10 hour shifts, though histology is generally better compensated than general lab scientist or core lab. @@chokobo0047
I’m just started a job as a cytogenetic tech and this video felt like it was calling my name
“This WAS my cancer.”
I got teary eyes hearing these words. goosebumps
As a cancer biologist who works on trying to understand how cancer cells invade and metastasize, I really do appreciate this video. Cancer cells are literally like its own organism, they move away to find more food and establish new home (yeah, that's essentially what metastases are!). I'm so glad Hank is doing better. But this video also shows how cancer research is so important. And the people who work in histology are also the unsung heroes for doing all the staining in the background just so the pathologist can look and diagnose. All very important work that needs to be recognised for!
There are many natural substances available that block Mets. There are many azoles and avermectins that are being used to treat. Fact.
I work in a pathology department for the last 4 years. I'm only the assistant admin but I love my job and the things I get to see. The pathologist i work with are so intelligent and some of the hardest working people I've ever worked with in my 25 years working experience. All though they don't see the patients they still care about those patients the same as if they did. It is a very rewarding job.
Y'all are true heroes. Especially during the pandemic. Thank you for what you do. c:
The fact that my body has had a couple of cancer cells grow inside me today but were killed by my immune cells before anything bad could happen 💀
Shout out to your WBCs ❤
Often HIV killed by the damaged immune system permitting the growth of rare “lottery win” chance cancers.
Or the fact that our bodies come in contact with many kinds of germs every day, the good ones and the bad ones. But our immune system protects the body, it works 24/7 and prevents further inflammation
No different than missing getting hit by a drunk driver because you stopped for 20 seconds to tie your shoes 3 blocks away. Life is random. We lull ourselves into thinking we're fully in control of everything, but you could just as easily wake up tomorrow morning and learn you have brain cancer. You just have to accept the possibility that something COULD happen at any moment to destroy you, or your life, or your livelihood, or your home, or your family/a family member. Life is random. But the fact that we have no control over these things doesn't have to be scary.
@@halonothing1it is absolutely not true that we have no control at all over whether we get cancer, even if we’ll never have complete control. Who told you cancer is completely random?
Quick rectification. PAX5 is a transcription factor, so it is not expressed on the surface of cells. BCL2 is a protein that regulates cell death (apoptosis), it is also not on the surface but inside the cell, in the cytoplasm. Finally, cyclin D1 is involved in the cell cycle and it is not expressed on the surface. CD15, CD30 and CD20 are expressed on the surface of the cells. You can still see the other proteins because before labelling them with amtibodies we permeabilize and fix the cell membrane.
Thank you!!
+
Most informative, thank you! How do you know this, if I may ask?
@@marcbuerkle reading scientific papers!
I'm a neuroimmunologist@@marcbuerkle
How did I not know this channel was hosted by Hank green until now lol
I never recognized the voice until now either!
Really? His voice is very distinctive.
he's reaching simon whatshisface levels
I knew the voice- couldn't 'retrieve' the face!
VERY thought provoking vid!
He definitely changed mics for this show. It does deepen his voice a little bit.
Man I remember when I logged into youtube one morning, and there was a new channel "Journey to the Microcosmos", where Hank was doing ASMR descriptions of tiny things and talking about how excited they were to have a fancy microscope. I remember when they upgraded, I remember so many things. 20k, 50k, 100k, 250k, and soon 1m. I LOVE this 'lab science' channel! It shows things that are in the world all around us, but that most of us would never see or know about. Here's hoping for many, MANY more years of Hank Green narrations!
I started following it when it was new, too. They were advertising it on the various scishows, if I remember right. It is very cool to see how it's grown over the years, and I'm glad they're getting the attention they deserve. Hank seems like a pretty cool dude (tm), and his team seem lovely, as well.
I worked for Mayo Clinic's Immunohistochemistry department as a diagnostic technologist, and this explanation was spot-on! I also worked in Fluorescent In-Situ Hybridization there, along with Next-Gen Sequencing. Now I'm with the University of Washington in Hematopathology, rediagnosing and combining all three kinds of techniques to diagnose cancers just like yours.
Love the shout out to us medical lab scientists; many people don't realize our job exists, and we are highly specialized staff working with physicians to come to diagnoses like yours. Keep doing your thing; I've loved all your channels since high school and keep inspiring others to learn to do cool science!!!
Y'all are true heroes, just sayin. Everyone in the medical department has an important job, even the cooks! I always do my best to treat medical staff with respect and patience (unless they give me reason not to. Long story.)
As a medical laboratory science graduate😂 I never had the chance to do.anything in lab after graduating from it💩 Im too depressed to even take my board exam.
But indeed this Job is amazing. 💩 I just somehow wish I aint this depressed
As someone living with CLL, this was really, really interesting. Thank you and I’m so glad your cancer has gone.
never knew he had cancer to begin with!
Good luck with your recovery from CLL. I'm rooting for you!
@@nobody.of.importance thank you Melody.
As a doctor who works with cancer terminal patients, thanks a lot for telling it this way, it is comforting and human…
As a pathologist, this beautiful video made me cry! Thank you. ¡Ay, es que me emocioné! it is always so uplifting to hear of a patient recovery :D
We are all so glad you are cancer free and back with us. Good on ya!
I am a principal scientist at a large pharma company where I develop novel IHC biomarker assays to help predict if an individual will benefit from our upcoming oncology drugs. Hank, you listing out the diagnostic markers at 3:30 gave me a big smile. A lot of work goes into the R&D for these tools, and its very rewarding hearing a recovering individual now in remission read out their own IHC pathology description.
Assuming you're telling the truth, since, y'know, this is youtube and all, y'all do important work. Keep it up.
Almost a year ago, I also operated on my first cancer. This one was on the skin and harmless, but still cancer. The operation was short and successful. Who knows what else awaits me at the end of my journey :)
Take care of yourself. You still have malign cells, check yourself more often
You operated on your own cancer? Not gonna lie your comment feels fake.
@@coronalight77 The doctors operated on me, I didn't do it myself :) Basal-cell carcinoma - that "disease" (better - the state of the organism) is in question
@user-fe1nr3ws1z The doctors said that everything was removed (on the surface of the skin it is easy to see) , but I will definitely check, thanks.
@@coronalight77assuming this was something like a stage 1 skin cancer and a bit of medical knowledge, it's not actually out of the realm of possibility, especially considering I basically did this myself with a DIY skin tag removal.
(Don't remove your own skin tags, folks. It hurts like you wouldn't believe and left me a nasty wound that took forever to heal.)
Congrats on beating your cancer and staying on to educate all the rest of us
The 'experts' are called Pathologists. We are medical doctors who specialize in laboratory science. It is a medical subspecialty with board exams and requires years of training.
Histotech here, this is such a great video that explains some of what we do in the lab!
Hank brothers dropping awesome videos today! What a badass thing to say "this is my cancer"!
"Was". Tenses are sometimes very important.
@@pattheplanter The writing on the thumbnail of the video literally says "is"
@@isstinna Not what he said in the video, though it was written in the thumbnail. "What a badass thing to write" doesn't work as well.
I'm always amazed by JTtM's capacity to teach us something new. Thank you, and thank you so much to Hank for putting these pieces of yourself under the microscope so we can all learn something new.
Had such a hard time reading" JTtM" because I'm so used to seeing "JtHM". It's a 2000s era comic book, tldr.
Never been so happy to hear the word "was"!
This AND John's tuberculosis video on Crash Course?!? I feel so spoiled today. Thank you both for all that you do (:
One thing that annoys me about modern people is that plenty of them think that cancer as a whole is a recent thing. “Cancer is because of processed food and not living clean” they say. When in fact cancer has been a part of life since the jump. They always either double down or open up when I tell them that we found osteosarcoma on fossils million upon millions of years old. Cancer been here forever and it’s not really going anywhere for the next couple of generations maybe. You could live the cleanest most straight edge life in existence and still get got like that.
Of course cancer has been around forever. Yet we know it’s mushroomed both in people and pets, and there’s loads of science showing how environmental factors, very much including diet, contribute. Ignore at your peril.
@@i.ehrenfest349 yes we have a lot of factors that go into increasing chances of cancer but those factors pending the person won’t do anything either. I wouldn’t exactly say cases are mushrooming either rather we’ve gotten so good at catching these things early and people screen more often that we’re catching more diagnoses what would’ve remained hidden for some time, and a great indicator for cancer seems to also be genetics. You have ww2 vets that drank and smoked every day and stay cancer free until a natural death of old age and triathletes that never poisoned their bodies ever and they catch lung cancer at 37 and die soon thereafter. Life’s not fair
@@i.ehrenfest349 You don't have to play the Smart ass dude, everyone is aware there are risk factors due to lifestyle and habits, the comment is aimed at people who victim-shame on cáncer patients almost blaming them for having it, whether they actually had a healthy life or not.
You are not discovering fire here dude, stop and move on.
Wild rats get more cancer than us. You can’t avoid it
microbes are more interesting than 99% of the stuff on youtube lmao
Plus, it's not brain rot, it's brain food
Your comment just made me poopoo my fanties! jajajajajaja
Seeing as each of us only bothers to watch .01% of what's on UA-cam yes. If your reading this that's true.
microbes are more interesting than anything on UA-cam imo. I'm a math head who has learned a great deal from UA-cam and I still think this. Microbes are solo effing amazing!!
Its also the masterful way these videos are produced. The music, the vibe, the editing. Its all very intriguing yet relaxing. I can watch these video when i wanna learn and be engaged, or i can put them in the background while i fall asleep! I hope they keep making them forever, no other channels fill this niche for me
Five years in remission from colon cancer. I learned so much about life and love from my own journey. Wishing you many years of health and well being, Hank.
Hank, if you've never seen the anime Cell's at Work, you should watch the episode about cancer, it's a really interesting take. Cancer is a destructive villain, but it's framed as almost sympathetic, not having asked to exist the way that it does, but not having any other choice.
Cool! I'm gonna go check this out right now!
I have been expecting them to make a video on cancer for a while now, very epic.
Thanks for taking us on this particularly personal journey, Hank. So grateful you made it through it. I had heard of the notion that cancer is like your cells reverting back to unicellular life but am glad to now know that's called the atavistic model of cancer. As a bonus I can add atavism, a tendency to revert to something ancient or ancestral, to my vocabulary.
Thanks for putting up the prostate cancer cell clip. So insightful to see what they are currently up to in me.
Time for bad cell jokes? Divide and conquer? 😆
“They were a single called organism whose most recent ancestors was me, but they were not me.”
Oof. Now that’s something to give people existential crises.
It is if you define "you" and build your identity around your body, while not questioning what even are "you" in the first place,
I think that existential crisis is healthy as to reflect upon what we are, be more existentially secure and truthful, and to solve such crisis is to rejuvenate our "meaning" on our own life, a recharge, a refresh of the soul? lol
This reminded me of a former colleague. She taught biology. Every time she, her family, or friends had a procedure, she asked for samples or x-ray photos to use in her lessons. She had quite a collection. I donated skin from when I had a particularly bad case of eczema. Some colleagues thought that she was a ghoul!
Thank you, Hank, for being so open about your cancer. Every person like you brings it into the open instead of it being a topic of whispers and embarrassment. Congratulations on your recovery.
Hank's cancer: You're freggin dead, pal
Hank: No, but you're content
Really a beautiful reflection on the disease in this context.
My cancer let me know... tumor was eating a hole in my right kidney... I started peeing lots of Blood and "clots". A cat scan found the exact spot. Now with my right kidney removed and my cancer not being an aggressive type.. I should be fine...
As someone who works in a pathology lab I was ready to give my explanations and corrections to Hank but then saw the comments already did that for me.
Very few people understand what goes on in my workplace so I’m glad to see people who understand
What a fascinating way of looking at cancer. Thank you for opening up about your own cancer story and I'm glad that you're doing well and managed to overcome your illness.
The HeLa cells remind me of the book 'The Immortal Life of Henrietta Lacks' - those cells are an episode's worth of a story all on their own.
What are HeLa cells?
I've googled it and it's blown my mind. 🤯
Hank, you are an amazing and lovely individual with a beautiful, inspirational and accessible voice. You're clearly genius levels of intelligent. I REALLY hope you will be okay! You truly deserve a stress-free life where you get to do what you love and learn in peace without being attacked by your own lymphocytes!
Hank Green's voice: Quiet mode.
It didn't sound like him the way I expected it to at first, but then after the intro it started to sound like him.
Glad you're in remission, Hank! Keep trucking on.
it's really annoying actually. he should just talk normally
@@MagicPlantsD1 hater that only comments about his voice…
@@MagicPlants how is this not talking normally
There are science communicators then there's Hank "here are my own cancer slides for free online science education" Green
My sister is one of many of those lab experts. In her case, she's a pathologist assistant. She receives, preps, grosses and describes allllllll the specimens. The people in that lab are very good at the parts they do to make those diagnoses accurate and fast. I am proud of her! 🎉
Thank you for sharing your fascinating story. I’m glad you’re still here!
Excellent episode from a spectacular channel! (So glad your treatment was a success, Hank! The world is a markedly better place with you, and James, and the rest of the team- in it!!)
Thank you so much for sharing this Hank. So glad that you're okay!
The Green brothers are all powerful. Hank Green dropping a journey through his own cancer the same day John Green drops his Crash Course lecture on Tuberculosis was almost too much for me.
I love you guys. Thank you for posting.
I love the Darwinian take on cancers. It's interesting how one's own cells can start to behave as parasitic single-celled organisms.
Thank you for another fabulous and thought-provoking clip. I look forward to sharing this with my students! It is wonderful that you have recovered and can continue to savor this remarkable thing that is life!
Thank you for sharing your cancer journey with us. You are no doubt an inspiration to others.
Congratulations 🎉. This is my first video and I am hooked 😊. Keep up the good work
Mind blown again! I love these.
It is unfortunate that you had to go through this, but, the way you've turned it around and used it to educate us about cancer is inspiring. Well done, Hank, and thank you for being open about it and turning this horrible illness into a way to educate others.
Bravo! So happy you beat it, and so glad you wanted to share. This was very informative. Thankyou.
Cancer as evolution, 🤯🤯🤯
Whoever wrote that concept gets a raise
But interestingly, I always thought cancer was the body trying to evolve but something went wrong. From what the vid said, it seems cancer is anti-evolution. Who would have thought!?!
It's wild you got these slides. Really interesting! I learned a lot!
You're a strong dude, Henry. May you continue having fun with and discovering microbes for decades to come!
I'm glad you are still with us, you have a very soothing voice on in this series
Not only am i a Hank green fan but also a pathologist. It's so cool to see one of my favourite creators step into my world, which is often overlooked. I never thought i would see a tray of slides on a UA-cam video.
Stay well Hank
Never seen your channel until right now, but this is a really great video. Your voice over and editing are great, and I especially love the music choice.
Congrats on beating your cancer!
Very interesting perspective. Thanks for sharing with us Hank
Thank you, Hank. I was looking for a video like this for a long time.
Thank you so much for sharing this, Hank. You rock.
"Volvox" sounds like a Pokémon & every time you say it I repeat, in a weird voice "VOLvox!" 🤔
Hank, I've been wanting to say this to you for a long time- you are such a valuable part of humanity and I'm so glad you beat your cancers ass. The world needs you and those like you now more than ever and I, personally, feel a great sense of relief just knowing that you're out there making intelligent videos for the world to watch and learn from. Thank you so much for all you do. ❤
Finding cancer usually isn't done with immunostaining though. It's done by staining all cells (usually with hematoxylin and eosin) where you stain the cytoplasm and nuclei, with that stain you look for cells that have abnormal size and nuclei and might be in the wrong location (among other things, this stuff is complicated and difficult).
Immunostaining is usually done to get more information: what cancer is it? How bad is it? Which treatments are viable?
What an informative, captivating video and strong story! Thank you for sharing it. In combination with some kurzgesagt videos on cancer, I've been learning a lot.
And as a side note: Being a lay person in microbiology who speaks English as a second language - though being not far from fluent in colloquial settings and in my own field of study - and although your pronounciation is very, very clear, I still dearly appreciate the thorough subtitling which makes it a whole lot easier for me (and I am sure: even for many native speakers) to follow along.
There is a certain nobility in using your own misfortune to educate others about cancer on the cellular level. Thank you, Hank Green, for this insightful episode!
Im so glad you beat cancer, this is one of my favourite channels and Id be gutted to lose it.
Thank you for showing us your Hodgkin/Hodgkin's/John Hodgman Lymphoma cells. This is really interesting with the extra dimension of it being you talking about the microcosmos of ... you. And that you're okay now, thankfully.
The odd thing is: these cells called neurons are thinking about these issues now.
Very insightful. Congratulations for beating cancer!
Thanks for the great video. Wish you best health, man. 🙏
“When you die, the cancer also dies… that, to me, is not a loss. That’s a draw…” - Norm Macdonald
Gotta love science on the internet
?
thanks hank, and everyone involved ❤
Glad you are doing better buddy!
cancer isn’t really evil, just selfish
Selfish is evil...
The imagery is mind blowing.
Thank you for the video
Dear Hank. When you first made your reappearance, I almost cried. I have been watching you and John way more than any actors/actresses in the past decade. Thank you for coming back.
Hank, you are an inspiration to all of us. Keep on keeping on! You are a badass
I'm currently studying Microbiology. Now, I'm thinking of taking up Oncology if ever I enter Medical practice. This video made me even more interested in the field.
Your cancer looks so similar to the cancer that took my mom as a kid. Also so much like the cancer that teamed up with diabetes to give a beloved pug a sad, but thankfully peaceful forever rest. This disease also claimed so many of my loved ones and my loved ones of my loved ones. Thank you for the candid insight. I think it can both be hard and comforting seeing and learning about the cell-level science behind something that touches so many of us. Life and biology can be so strange but so beautiful. No idea if you'll read this, but I am so glad you're still here kicking butt, Hank!!! Everyone who does read this please try to make sure the people you love know you love them!
I feel kind of dumb but I didn't realize you were Hank Green until like yesterday when I saw the 'ending channel update'. Thank you for this amazing channel/adventure into the micro-world. It's been amazing ❤
This is the best chanel on UA-cam. I absolutely love your videos
12:33 I was definitely thinking about how you went about requesting your slides 😅😊
Dang, Hank. Such a good script! And excellent editing.
I have been sick for like 2-3 months now and I’m terrified to find out if I have cancer or something… love you Hank. Glad you’re good.
Wow this was fascinating
You blew my mind Hank when you said, “reversion to single cellular life.” It makes sense. Great video.
What a powerful word.
"was"
I'm glad to hear that you are now stable.
Great to know you got over it mate!
I knew it! I can recognize Hank's voice anywhere.
Love you Hank
This was gorgeous and concise. I would love a full documentary on this topic! It's crazy to think the tree of life can go single cell>multicellular thing>animal>single cell! Less like a tree of life and more like a wheel...there's something Buddhist about that!
Anyone else just find out that the voice is Hank? Never out the two together. I follow you in instagram. Makes me so happy that it’s tou
I knew you were going to make this episode. May your remission be permanent, Hank.
Back in the mid-eighties I had to hand-carry my biopsy slides (and X-ray films!) to Big Cancer Hospital where I was going to be treated. Of course the first thing I did when I got my hands on them was to put them under our family's old light-reflector microscope. After all, my flight wasn't until the next day. They didn't look even close to as good as these slides! But still fascinating. Also all the CD14 typing and the like wasn't even being done yet. They hadn't yet even proved which cells for Hodgkin's turned cancerous. By the way, I had mixed cellularity, too.
This is a great video. Also, for a blood cancer like lymphoma, if chemo doesn’t work, a blood stem cell transplant is another treatment option. It’s utterly astonishing that as complex as our immune system is, if you have the same antigens on your cells as another person, your cancer can be cured by a transplant of their blood stem cells. I never stop being astonished at what happens in our bodies at the cellular level with no conscious input from us! Glad you are still with us, Hank. 🧡