THANK YOU this explains it so well!! I have much to memorize for my exams and I've been feeling really dumb lately because I could not for the life of me understand the steps, but these visuals along with the simple description was AMAZING. I actually get it now. Thank you so much to whoever made this, truly.
I came here after my lecturer confused the hell outta me on this - honestly, I've never been more glad! This video nicely explain everything with simple animations!! Thanks xx
I know that proteins are produced by the ribosomes, and that the ribosomes reside in the cytoplasm, not within the nucleus. So I can imagine that a protein that has been produced by the ribosome, but that belongs in the nucleus, would have to be transported INTO the nucleus. What I'm not clear on what kind of protein would have to be transported out of the nucleus. I imagine that any protein in the nucleus is supposed to stay there, since all proteins are produced in the cytoplasm and wouldn't be moved to the nucleus unless needed there.
NTF2 binds RanGDP in the cytoplasm and then ferries it into the nucleus by virtue of the fact that NTF2 can also bind FG repeats on nucleoporins similarly to NTRs (Bayliss et al., 1999). NTF2 has a much lower affinity for RanGTP than RanGDP, and thus travels empty back to the cytoplasm after its cargo (RanGDP) is converted to RanGTP by RCC1 inside the nucleus triggering its release.
Assuming NTF2 has interactions with NPC proteins that allows it to slide into only nucleus side and bring RanGDP back. Then another protein is supposed to bring NTF2 back that is only able to pass to cytoplasm side. And another protein is gonna have bring that protein back to nucleus and so on. Where does this loop end? lol
NTF2 binds RanGDP in the cytoplasm and then ferries it into the nucleus by virtue of the fact that NTF2 can also bind FG repeats on nucleoporins similarly to NTRs (Bayliss et al., 1999). NTF2 has a much lower affinity for RanGTP than RanGDP, and thus travels empty back to the cytoplasm after its cargo (RanGDP) is converted to RanGTP by RCC1 inside the nucleus triggering its release.
@vaidehi rathod I was studying for a lecture when I was watching this video. I graduated recently. I am so quick to forget everything I learned. I have no idea whats going on in this video. I forgot what a protein even is hahahah. Thanks anyway
THANK YOU this explains it so well!! I have much to memorize for my exams and I've been feeling really dumb lately because I could not for the life of me understand the steps, but these visuals along with the simple description was AMAZING. I actually get it now. Thank you so much to whoever made this, truly.
This one is actually good. After reading Bruce Alberts and then watching this made me crystal clear about the role of Ran.
could you just say me the page of bruce alberts pls
@@krithikakeethu2458 in the edition number 6, this subject matter it's starting on the page number 649
is bruce alberts better than cooper? ( a genuine question)
@@aparnasingh7 IMO Alberts is better than cooper.
@@satyajitchowdhury3350 what about gerald karp?
This video is perfect!
I would like to import you into my nucleus.
I came here after my lecturer confused the hell outta me on this - honestly, I've never been more glad! This video nicely explain everything with simple animations!! Thanks xx
Awesome love this piece of work. I want more videos like this. Animation is good. Easy to understand. Thanks.
the best video of nuclear import and export
thanks !! it helped me clear up my concept... the last part was messy at the beginning after watching this video i was able to understand!!
An excellent video! Thank you very much, it helped a lot!
Helped me a lot .. very good explanation 👏 Thank you so much..
Thank you for saving my grade, this is amazing
Amazing work, thank you so much!
thank you 정말 this video helped me to understand this idea in the Biology Cell
Best explanation 👍
Very simple and helpful video
spot on! that was absolutely what i'm looking for
Great vid, thinking there are trillions of such processes per microsecond in one human body, then thinking how complex it all is at quantum level O_O
This helps me a lot thank you so much
I found this video right after I listened to my own teacher for 35 minutes explaining the same thing. this is way clearer thanks!
Flawless 👌🏻
wtf this blew me away thank you
You saved me, mind-blowing!!
Best video on this topic
Thank you for this instructive and helpful presentation! I am still struggling to memorize the flow chart due to too many roles and two compartments.
Just perfect which i was looking for.
Thank uu !! you're a life-saver
Thank you very much for this video ❤
Alaaa, me sirveee c: thank u so much!
Very clear and helpful thank you
Jst amazing thanks a lot 🙌🏻
A perfect vedeo❤️❤️💜
Perfection 👌🏾👌🏾
Excellent!
Wow 🙏
U r amazing!!
very clear video. i have only one question remaining. why does the importine with the cargo spontanouosly go to the nucleus?
can an import and an export take place in the same nuclear pore complexe ?
PERFECT EXPLAINATION!!!, ur a livfe saver!!! :))))))
Awesome classes
Great 🤍🥀
Awesome
omg it is awsome ...
thank you so much!
Cool nice
Спасибо, понятно даже мне
Best video so far.
Thank you
bro really helped me
Thank you guys ❤️❤️❤️
amazing
That one dude who disliked this was probably just too dumb to understand it
i didn't dislike but i'm the dude who is too dumb to understand XDD
Thank you❤️
THANK YOU
I know that proteins are produced by the ribosomes, and that the ribosomes reside in the cytoplasm, not within the nucleus. So I can imagine that a protein that has been produced by the ribosome, but that belongs in the nucleus, would have to be transported INTO the nucleus. What I'm not clear on what kind of protein would have to be transported out of the nucleus. I imagine that any protein in the nucleus is supposed to stay there, since all proteins are produced in the cytoplasm and wouldn't be moved to the nucleus unless needed there.
Thanks a lot ....
very nice video, but it could have been better with the precision between importin alpha and beta
Thanks you
doesn't RAN-GDP bind Bêta-importin BEFORE the importation and is then exchanged in the nucleus by GEF ? I'm confused now
Foda
you just save my life thank you
Do IDPs binds to the importin?
I only perfectly understand now but at end she had hurried to non discuss which molecule carry back Exportin.
incroyable
I need this video in Spanish 😩
يلي جاي من rbcs يطج لايك 😂😂😂
🖒🖒🖒😂😂😂😂😂
الله و البيو 😂😂😂😂
😂😂😂😂😂
لساتنا بلفصل الرابع😂😂😂😂
الفصل الرابع اعادة يا نس 😂😂😂
so what happens to the NTF2? wouldn't it build up in the nucleus this way? or is it exported back out through RanGTP
NTF2 binds RanGDP in the cytoplasm and then ferries it into the nucleus by virtue of the fact that NTF2 can also bind FG repeats on nucleoporins similarly to NTRs (Bayliss et al., 1999). NTF2 has a much lower affinity for RanGTP than RanGDP, and thus travels empty back to the cytoplasm after its cargo (RanGDP) is converted to RanGTP by RCC1 inside the nucleus triggering its release.
You saved my life guys :)
Assuming NTF2 has interactions with NPC proteins that allows it to slide into only nucleus side and bring RanGDP back. Then another protein is supposed to bring NTF2 back that is only able to pass to cytoplasm side. And another protein is gonna have bring that protein back to nucleus and so on. Where does this loop end? lol
NTF2 binds RanGDP in the cytoplasm and then ferries it into the nucleus by virtue of the fact that NTF2 can also bind FG repeats on nucleoporins similarly to NTRs (Bayliss et al., 1999). NTF2 has a much lower affinity for RanGTP than RanGDP, and thus travels empty back to the cytoplasm after its cargo (RanGDP) is converted to RanGTP by RCC1 inside the nucleus triggering its release.
@vaidehi rathod I was studying for a lecture when I was watching this video. I graduated recently. I am so quick to forget everything I learned. I have no idea whats going on in this video. I forgot what a protein even is hahahah. Thanks anyway
What happens to NTF2?
ANKARA TIP’LILARA SELAM OLSUN 🙂👋🏻
2:48
Noch irgendjemand von der Wiedemann Vorlesung hier?😂
RBCs
حدا جاي من نوطة RBC 's?
Bro!!! After this,there is absolutely a god one and only ❤️
I don't understand in inglish
I hope translate this video in Arabic
I wanna kiss this video... with tongue!! thank you!
Thank you