Metabolism of Fructose : Hereditary fructose intolerance , Fructokinase deficiency
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- Опубліковано 25 кві 2019
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Metabolism of Fructose: Hereditary fructose intolerance, Fructokinase deficiency
Fructose is an abundant sugar in the human diet.
This dietary monosaccharide is present naturally in fruits and vegetables, either as free fructose or as part of the disaccharide sucrose, and as its polymer inulin.
Sucrose (table sugar) is a disaccharide which when hydrolyzed yields fructose and glucose.
The metabolism of fructose from dietary sources is referred to as fructolysis.
There are two pathways for the metabolism of fructose; one occurs in muscle and adipose tissue, the other in liver.
In muscle and adipose tissue, fructose can be phosphorylated by hexokinase (which is capable of phosphorylating both glucose and fructose) to form fructose 6-phosphate which then enters glycolysis.
In liver, the cells contain mainly glucokinase instead of hexokinase and this enzyme phosphorylates only glucose. Thus in liver, fructose is metabolized instead by the fructose 1-phosphate pathway:
Fructose is converted to fructose 1-phosphate by fructokinase with the use of an ATP.
Fructose 1-phosphate is then split into glyceraldehyde and dihydroxyacetone phosphate by fructose 1-phosphate aldolase.
The dihydroxyacetone feeds into glycolysis at the triose phosphate isomerase step.
The glyceraldehyde is phosphorylated by triose kinase to glyceraldehyde 3-phosphate using another ATP and so also enters glycolysis.
#fructosemetabolism #metabolismoffructose #fructosemetabolismbiochemistry #biochemistryfructosemetabolism #metabolismfructose
Very informative & quality presentation I expect more such metabolic disorders lectures.thanks & salute
thank u
Excellent explanation, thank you.
This video is interconnecting metabolic pathway thankyou sir 🌟
God bless you sir you saved me 🥰 may you please give us more explanation about consumption of high fructose
Sir, I'm learning english but it's difficult to understand sometimes. Could you make a transcript of your videos, please? It would help me a lot to understand the accents of different English speakers and also in my medical career. Greetings from Mexico and thank you for the good explanations
i cannot tell you how much i love this video!!!! it answered all my questions so thankyou so much
Glad I could help!
Thank you! I had to come to this conclusion by myself instead of MDs....
Glad it was helpful!
Fantastic.. Amazing tnq a lot sir
Most welcome
Great Sir ❤
Where is avaleble it medicinea?
Well done
How to eliminate fructose from the body/liver?
I actually just found out I have this. I'm still trying to figure out what it is and how to mange it. Thanks for the video!
@danielle w. yes thats what i like to know too
@Danielle W. I did a test by simply drinking a glass of sugar and water, and then every 30
minutes for 3-4 hours i had to breathe into a thing. Did the thing give a high number, then i had fructose intolerance. But sadly i don’t what the thing was called or what the number was.
@@ey2379 bear in mind that dietary fructose intolerance is not the same as HEREDITARY fructose intolerance, which is a very rare inherited metabolic disorder. From the test you are talking about I think you are refering to dietary fructose intolerance which is less severe and it's not what this video explains.
@@nataliaoxley3119 oh yes that may be true. thanks for letting me know.
How cause jaundice and cirrhosis?
Hi, I'm suffering from hereditary fructose intolerance, is there a cure for it?
If you have hereditary fructose intolerance it is a condition you have for life and you must follow treatment which is a minimal fructose, sucrose and sorbitol diet. Your doctor and/or dietitian should be able to advise
Awsome🤗🤗
Thank you! Cheers!
Would being fructose intolerant make you more prone to inflammed fatty liver disease or NASH?
I have little idea but if it's the inherited metabolic condition you are talking about (and not a simply fructose intolerance in diet) you CAN have a bigger liver and fatty changes in the liver, but I guess it depends
@@nataliaoxley3119 I meant having the gene marker, yeah. I went through NASH and have one gene, but am not fructose intolerant. I do avoid it like the plague though. Thanks for your input.
I have Hereditary intolerance and NAFLD diagnosed at 23. I'm 36 now and have NASH.
gout?fatty liver and diabetics.
Sir please upload pharmacology of seretonin receptor agonists and antagonists
I researched my symptoms about, 16 years ago and diagnosed myself with fructose intolerance 16 years ago.
I was right. But it's much worse than I thought.