Cholesterol's Secret Role in Atherosclerosis | Episode 46
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- Опубліковано 30 лип 2023
- Cholesterol is often considered the troublemaker in atherosclerosis. The medical world vilifies it and with some medications, aims to drive it to the brink of extinction in your body! Although not the inciting event in atherosclerosis, it does have an important role in the disease process and that's the main topic in this episode. I'll reveal "secrets" or rarely discussed aspects of cholesterol metabolism and how that may contribute to atherosclerosis. As usual, all is not quite what it seems in the marvelous complexity of the human body.Let me know what you think in the comments.
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#atherosclerosis #heartdisease #cholesterol #ldlcholesterol #inflammation #metabolichealth #reversedisease - Розваги
I almost never get the flu or colds, and if I do they're over in a few days. I made it through COIVD without any issues. However, about 6 months ago I started 10 mg of Rosuvastatin, and for the past 4 weeks I've had a sinus infection that refuses to go away. Not to mention that I do not get sinus infections, and have no allergies. Nothing else has changed in my life in the past year, so I suspect that my reduced cholesterol levels (120 down to 70) have affected my immune system. I've discovered a few publications that suggests this is possible -- especially in the context of flu vaccines and COVID. Thanks for your explanation of a possible connection.
This was what they saw in the study I referenced in terms of cytokines and LDL-chol. They happened to also use Rosuvastatin in the study, and a halving of LDL-cholesterol led to a modest increase in pro-inflammatory cytokines that was persistent even after stopping the statin. The study only went 14 days after the stopping of the statin but the pro-inflammatory signals were still elevated.
The tough part is to figure out what the pro-inflammatory cytokines are doing because it really depends on the context. With micro-organism infections it also depends on the type of micro-organism.
I love that people are paying such close attention to the details. Made my day!
@@vlmdrounds As it relates to mortalities and low LDL, what I'm hearing said a lot is that "a disease process like cancer causes mortality and in the process destroys LDL, which is why someone who dies from cancer likely has low LDL". I believe what you're saying is that this is getting the cart before the horse. I believe you're suggesting just the opposite: if LDL are destroyed first, then the outcome from that can be mortality due to a weakened immune system that can't kill the cancer. Am I close?
@@DaveYadaraf So with cancer, most cancer cells are also interested in growing and proliferating (just like a pathogen) and will suck up all the cholesterol it can! T cells and other immune cells are left to compete for resources and with lowered cholesterol, may not be able to mount an appropriate response and also cannot proliferate. Which is why cancer is usually seen as a failure of immuno-surveillance. So you're on the button. It's a pleasure to see such an interest, but even better, to see people really thinking about this in a much more nuanced and sophisticated manner. Way to go!!! 😀
The qustions i have to ask, why did you reduce your LDL particle level? (you don't messure colesterol, that's what 99,9% of people belive) mostly it's just a messure of total lipid particles (ldl, hdl and some triglyserids ) and this messurement is highly inacurate! It can vary greatly, and this is what they use to push for statins! Get a real messurement otherwise no point.
Hi Dr Loh,
When the cholesterol removed by the cell, is it taken up by HDL?
Correct, ABCA1 transfers the cholesterol to A1 on HDL. Hope that was helpful.
Magic, thank you.
So during an immune response would serum LDL be elevated as the cells are restricting it and also an elevation in serum HDL due to removal from the cells?
Also, really enjoying the shorter format.
@@conradnorton6799 Thank you for letting me know. It really helps me try to make these episodes more helpful
@@conradnorton6799 Good pick up! Yes, we could see an increase in serum levels of cholesterol as the cells are trying to restrict intracellular levels. This is likely transient, however. What people don't appreciate enough is how dynamic your lipoprotein spread is in just a few hours. So testing at different points in 1 day can give you major differences depending on the context and conditions.