Basically, you're lectures will most likely help me become a doctor. When that happens and if you're still around, I'm making a fat donation! You are literally a dream maker!
Oy my God this guy teaches way better than any lecturer l have. He is a superstar and worth donating to. Keep it up once l am done with my school l must will for sure donate
I love your videos!!! It is the most clear explanation of biochem I have ever seen. I have been staring at the book for hours, and went to my prof's office many times and got nothing. I feel it's such a waste of money and time to go a university while better teachers are out there teach for free or with much lower cost. Stupid outdated and rigid education system
hexokinase (so far what ive learned) only plays a part in a specific step in glycolysis. Hexokinase doesnt really form G6P, its just an enzyme that does a job in a particular way, meaning u shouldnt see it as hexokinase forms G6P, its more liek what hexokinase does to glucose forms G6P. There are multiple pathways to creating G6P and degradation of glycogen bypasses the need for hexokinase because another mecanism is used instead- as explained in this video. During glycolysis, hexokinase takes glucose and phosphorylates it into G6P by adding a phosphate group at the 6th carbon on glucose. This reaction seen in this video, however, doesnt start with glucose, it starts with glycogen. So theres no need for hexokinase because theres already a phosphate group on the glucose 1 phosphate sugar, only it is on carbon 1 and not carbon 6, which is why the whole 3rd step in the video transforms G1P into G6P. Basically, this process is different because glucose is a 6-carbon sugar without phosphate group, whereas in this situation *glycogen phosphorylate* will be adding a phosphate group to the glucose that was cleaved from the alpha 1-4 glycosidic bond, creating G1P. Hexokinase cant rlly work with G1P (in this context), only with glucose. hope this helps whoevers having the same question :)
Thank you a lot! I think there should be an H2O in the reaction that is catalyzed by alpha-1,6-glucosidase, when a glucose molecule is released. :) The remaining glycogen + H2O ---(alpha-1,6-glucosidase)--> glucose + The remaining glycogen
So in both the glycogenesis and glycogenolysis videos, you said that the phosphoryl group is essentially moved from carbon 1 to carbon 6. Is it because the phosphoryl group always starts at carbon 1 relative to the oxygen?
Would the free glucose that was released from it's alpha 1,6- glycobond not just be exported straight out of the liver? Or is this model representative of muscle cells? Thanks for the videos. Very concise and efficient
At the first I will thank you so much for this encrideble explanation and for your time which u spend to explain these lectures❤❤❤ but I have a question is the transferase and alpha1,4-glucosidase the same thing with the debranching enzyme??? #aklectures
Why does hexokinase form glucose-1-phosphate just so phophoglucomutase can convert it to glucose-6-phosphate from the α(1-->6) cleaved glucose by α(1-->6) glucosidase? Wouldn't it be more efficient if hexokinase just forms the glucose-6-phosphate just like it does in glycolysis?
I was wondering the same thing. Hopefully some magical person comes and explains. If you have an idea why since you made this comment 3months ago, I'd appreciate the answer...though when I come to think of it I'll probably not need the info once today's exam is done, hahaha.
they have different function dear ….. hexokinase is convert glucose to glucose -6-phosphate by using ATP but the function of phosphoglucomutase just transfer p group fromone side to another in the same molecule و الله أعلم
Hi your way of teaching is excellent but in this lecture i have 2 questions 1st is that is the degradation of glycogen is started only at the alpha 1-6 chain or it is also occured at alpha 1-4 chain at same time? 2nd glucose is converted to glucose 6 phosphate by any cell to capture it inside cell and to prevent from escaping. in third step glucose 6 phosphate is synthesised now can u explain me that how it is transported to other cells from liver. How could it escaped out from liver cell when in form of glucose 6 phosphate
And also glycogen is broken down to provide glucose so if we produce glucose 6 phosphate in third step how it converted in to glucose as we mention conversion of glucose to glucose 6 phosphate as irreversible reaction
Andrei Munteanu if glucose 6 P is in muscle cells how could glucose 6 phosphatase of liver will reverse it as glucose 6 P form is only present inside cells so they can't escape out
Ehsan Humayun Yes, there is no g-6-phosphatase in the muscle cell, and in fact muscle cells don't have the ability to rise the blood sugar level unless g-6-p undergoes anerobic glycolysis, gets transformed into lactate that travels to the liver or the kidneys where it becomes glucose by GNG.
Honestly you couldn’t have explained better. You saved biochemistry in my medicine studies, THANK YOU!
Not all heroes wear capes. Thanks a lot!
he should wear a cape tho
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bob higgins you won't get a degree by watching his videos
papers...
For a paper actually...
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This guy is worth donation we should all at least support by any amount of money we can afford
The interesting thing is that this guy is good at everything , he is an asset for science
7 years later and i'm commenting because your videos have been so incredibly helpful for the mcat. thank you so much for these.
Forever grateful to you, sir. Thank you for being a GREAT teacher!
Basically, you're lectures will most likely help me become a doctor. When that happens and if you're still around, I'm making a fat donation! You are literally a dream maker!
Saving medical students once again AK Lectures. Keep it up!!!
this dominates my textbook.
didn't understand anything after 30 minutes reading
learned it here in 13:25
Oy my God this guy teaches way better than any lecturer l have. He is a superstar and worth donating to. Keep it up once l am done with my school l must will for sure donate
I freaked out earlier today since I could not catch up with the materials... And I found your series.... THANK YOU! THANK YOU SO MUCH!!!
i wish he would put his older lectures in a playlist too bc this material is way over my head.
Thanks a lot....In few minutes you explain what our Professors explain in hours.
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@Ak LECTURES
Sir!. You are doing a great Job... Your way to teach is outstanding...!
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things made so simpler! wayy to go #AKLectures :) thank you!!
+Aanal Bhatt you're welcome! :-) glad to hear that
Incredibly helpful! Thank you, Andrey K!✊🙏
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I love your videos!!! It is the most clear explanation of biochem I have ever seen. I have been staring at the book for hours, and went to my prof's office many times and got nothing. I feel it's such a waste of money and time to go a university while better teachers are out there teach for free or with much lower cost. Stupid outdated and rigid education system
Any other medical students here? This guy has literally saved me. I hate biochemistry but he makes it slightly more tolerable.
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Wonderfully explained the most difficult and boring subject "BIOCHEMISTRY" in Highly digestible form. Thank you SIR
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I swear that you are better than my lecturer 😌
وحش ايمن :)
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8:58 doesnt hexokinase form glucose-6-phoshate?
why does it form directly the glucose-1-P?
Because of the fact that it was just cleaved from the 6th carbon on the linear chain leaving the first carbon open and reactive
hexokinase (so far what ive learned) only plays a part in a specific step in glycolysis. Hexokinase doesnt really form G6P, its just an enzyme that does a job in a particular way, meaning u shouldnt see it as hexokinase forms G6P, its more liek what hexokinase does to glucose forms G6P. There are multiple pathways to creating G6P and degradation of glycogen bypasses the need for hexokinase because another mecanism is used instead- as explained in this video.
During glycolysis, hexokinase takes glucose and phosphorylates it into G6P by adding a phosphate group at the 6th carbon on glucose.
This reaction seen in this video, however, doesnt start with glucose, it starts with glycogen. So theres no need for hexokinase because theres already a phosphate group on the glucose 1 phosphate sugar, only it is on carbon 1 and not carbon 6, which is why the whole 3rd step in the video transforms G1P into G6P.
Basically, this process is different because glucose is a 6-carbon sugar without phosphate group, whereas in this situation *glycogen phosphorylate* will be adding a phosphate group to the glucose that was cleaved from the alpha 1-4 glycosidic bond, creating G1P. Hexokinase cant rlly work with G1P (in this context), only with glucose. hope this helps whoevers having the same question :)
Im not sure if my university teaches glycogen breakdown or my mental breakdown
great video!! Thank you very much for the clear n very digestible information!👌✌
Excellent job this helped so much!
Thank you!! Everything are so clear!
thank you so much i was desperate with biochemistry :P big thanks you are the best !
Awesome lecture. Thank you sir..
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You were sent from heaven, I am sure of it.
So blessed . tysm for these lectures
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Awesome videos!
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really helped thank you
Thank you a lot!
I think there should be an H2O in the reaction that is catalyzed by alpha-1,6-glucosidase, when a glucose molecule is released. :)
The remaining glycogen + H2O ---(alpha-1,6-glucosidase)--> glucose + The remaining glycogen
Thanks
AMAZING THANK YOU
So in both the glycogenesis and glycogenolysis videos, you said that the phosphoryl group is essentially moved from carbon 1 to carbon 6. Is it because the phosphoryl group always starts at carbon 1 relative to the oxygen?
Can you make a video on "Breakdown of starch" ? Please @AK lectures
u r the best sir
incredibly amazing:') big thanks
Thank you sir
awesome just awesome
Thank you!!!!! Just a simple Q: Step 3 is it reversible?
thank you so much
Would the free glucose that was released from it's alpha 1,6- glycobond not just be exported straight out of the liver? Or is this model representative of muscle cells? Thanks for the videos. Very concise and efficient
At the first I will thank you so much for this encrideble explanation and for your time which u spend to explain these lectures❤❤❤ but I have a question is the transferase and alpha1,4-glucosidase the same thing with the debranching enzyme???
#aklectures
it's alpha-1,6-glucosidase; and yes, they're both debranching enzymes! :D
Andrey K for president !!!!!
Thank you so much 💓
dude you are awesome
Why does hexokinase form glucose-1-phosphate just so phophoglucomutase can convert it to glucose-6-phosphate from the α(1-->6) cleaved glucose by α(1-->6) glucosidase? Wouldn't it be more efficient if hexokinase just forms the glucose-6-phosphate just like it does in glycolysis?
I was wondering the same thing. Hopefully some magical person comes and explains. If you have an idea why since you made this comment 3months ago, I'd appreciate the answer...though when I come to think of it I'll probably not need the info once today's exam is done, hahaha.
enzymes and substrate have absolute specificity...one enzyme can not catalayse another substrate
they have different function dear ….. hexokinase is convert glucose to glucose -6-phosphate by using ATP but the function of phosphoglucomutase just transfer p group fromone side to another in the same molecule و الله أعلم
Thank you!
Great video!! thank you! :)
Thanks 💙💙💙💙💙💙
Thank you !!
Fabulous lectures thank u,
btw... are u Ukranian?
Nope.
Hi your way of teaching is excellent
but in this lecture i have 2 questions
1st is that is the degradation of glycogen is started only at the alpha 1-6 chain or it is also occured at alpha 1-4 chain at same time?
2nd glucose is converted to glucose 6 phosphate by any cell to capture it inside cell and to prevent from escaping. in third step glucose 6 phosphate is synthesised now can u explain me that how it is transported to other cells from liver. How could it escaped out from liver cell when in form of glucose 6 phosphate
bravo from Pakistan
Thanku sir ☺☺☺
Awesome *-*
Why does hexokinase form glucose-6-phosphate in glycolysis but it forms glucose-1-phosphate in this situation?
what primay first product formed by glycogen decomposition????
Is the remaining residual core not broken down further?
what is the name of the enzyme in eukaryotes that replaces transferase and alpha 1-6 glucosidase? is it hexokinase? +Ak Lectures
Love it
at about 4:28 you said Glucose and I think you meant glycogen
can y give some notes in your video in pdf from
Take screenshot at 10:31
And also glycogen is broken down to provide glucose so if we produce glucose 6 phosphate in third step how it converted in to glucose as we mention conversion of glucose to glucose 6 phosphate as irreversible reaction
+Ehsan Humayun Glucose to G6P is a reversible reaction catalysed by Hexokinase
Ehsan Humayun There is a glucose-6-phosphatase in the liver that cleaves the phosphate off if there is any need to rise the blood sugar level.
Andrei Munteanu if glucose 6 P is in muscle cells how could glucose 6 phosphatase of liver will reverse it as glucose 6 P form is only present inside cells so they can't escape out
Ehsan Humayun Yes, there is no g-6-phosphatase in the muscle cell, and in fact muscle cells don't have the ability to rise the blood sugar level unless g-6-p undergoes anerobic glycolysis, gets transformed into lactate that travels to the liver or the kidneys where it becomes glucose by GNG.
do u follow stryer for this references?
Can you plz send notes of this??!!!
Youll find it on my website
@@AKLECTURES OK thank you so much