great video, but what would happen if the switch 1 and 2 residues were mutated such that they could no longer interact with gamma phosphate of gtp? i think the g-protein would stay inactivated since there is no conformational change but not sure
May be.. but i am not also sure...... moreover mutation in G protein has been found to cause unregulated signalling which leads to cancer ( so that mutation always keeps G Protein on)
To be honest i dont find any good reason to answer.... But instead of ATP we use GTP for Translation... UTP for sugar Activation.. CTP for Lipid Activation...
this ocurs in the cytosol. the g-protein gets activated by a signal from the GPCR which is membrane bound (and so is the gprotein by the alpha and gamma subunits)
This is amazing and so easy to understand, I even think that high schoolers could easily understand this, Thank you!
thanks for appreciation..Glad it helps ✌️
very well made video, This explanation was quick and straight forward. Thank you.
Excellent, excellent, excellent. Thank you!
excellent explanation and animation ...precise and quick and easy..
Amazingly videos with amazing explanations. Can you please share references because we need references for our seminars 😅
Alberts Cell Biology
Lodish Cell Biology
@@hussainbiology thank you so much
@@akankshasingh4437 my pleasure
Thank you, Hussain.
My pleasure...
You are the best sir, I really appreciate your work🙌 thankyou
Excellent video.
thanks
Wao super and creative animation
thanks for appreciation..Glad to know that it helps ✌️
great video, but what would happen if the switch 1 and 2 residues were mutated such that they could no longer interact with gamma phosphate of gtp? i think the g-protein would stay inactivated since there is no conformational change but not sure
May be.. but i am not also sure......
moreover mutation in G protein has been found to cause unregulated signalling which leads to cancer ( so that mutation always keeps G Protein on)
Superb explanation and really appreciate animation 👍👍👍
thanks for appreciation...Glad to know that it helps.
@@hussainbiology 😃
Most helpful ☺️
thanks for appreciation..Glad it helps ✌️
Very useful Thank you sir
Are there any specific reason to use GTP while translation process instead of ATP?
To be honest i dont find any good reason to answer....
But instead of ATP we use GTP for Translation...
UTP for sugar Activation..
CTP for Lipid Activation...
I learned the answer, the reason is GTP has allosteric structure...
@@Its-me-Rosie I learned that too now...
Still i will dig more and get to you if i find something new...
Thank you !
✌️
Most welcome
thanks a lot sir
Appreciable...bro
can you please tell where does this process occur (at which organelle of the cell)
+ if there's a video about general protein switching (not only G-proteins)
thanks for appreciated efforts!
this ocurs in the cytosol. the g-protein gets activated by a signal from the GPCR which is membrane bound (and so is the gprotein by the alpha and gamma subunits)