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What is Pyruvate Dehydrogenase Complex (PDH Complex)? | Oxidative Decarboxylation of Pyruvate
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- Опубліковано 13 жов 2022
- This video provides a tutorial on role of Pyruvate Dehydrogenase Complex (PDH Complex) in Oxidative Decarboxylation of Pyruvate to Acetyl-CoA. PDH complex consists of three enzymes and five coenzymes. E1enzyme - pyruvate dehydrogenase (PDH) bound to thiamine pyrophosphate (TPP), E2 enzyme - dihydrolipoyl transacetylase covalently bound to lipoic acid and coenzyme A and E3 enzyme - dihydrolipoyl dehydrogenase bound to cofactors FAD and NAD+. There are five steps of oxidative decarbodation of pyruvate to acetyl-CoA. The reaction is carried out by PDH complex with E1, E2 and E3 enzymes. Furthermore, PDH enzyme is activated and inhibited by PDH phosphatase (PDP) and PDH kinase (PDK) enzyme, respectively.
The following topics are covered in this lesson,
1. Pyruvate dehydrogenase complex (PDH complex)
2. Pyruvate dehydrogenase (PDH) - E1enzyme
3. Dihydrolipoyl transacetylase - E2 enzyme
4. Dihydrolipoyl dehydrogenase - E3 enzyme
5. Five steps of oxidative decarboxylation of pyruvate to acetyl-CoA
6. Pyruvate dehydrogenase kinase (PDK)
7. Pyruvate dehydrogenase phosphatase (PDP)
8. Pyruvate dehydrogenase deficiency
9. Arsenic poisoning
As a first year med student struggling with biochemistry, I want to say your videos are very well explained and structured and help a lot with understanding complexes and principles!!! Thank you so much and please keep posting!
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Your explanation is clear. Thank you for helping me
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Tysm for the PDH Complex video🙏
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Very good explanation 👍
Thank you for the video! I think it'll really help me on my upcoming exam!
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Fanatastic explanation! Very helpful
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Amazing video, thank you so so much
This really helped me thank you !!! 🙏
Thank you. But I have a doubt. The step catalyzed by E2, how hydroxyethyl TPP (oxidised form) can reduce oxidised lipoate? In books the heTPP is in reduced form (CH3-CHOH-TPP)
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