What is Pyruvate Dehydrogenase Complex (PDH Complex)? | Oxidative Decarboxylation of Pyruvate

This video provides a tutorial on role of Pyruvate Dehydrogenase Complex (PDH Complex) in Oxidative Decarboxylation of Pyruvate to Acetyl-CoA. PDH complex consists of three enzymes and five coenzymes. E1enzyme - pyruvate dehydrogenase (PDH) bound to thiamine pyrophosphate (TPP), E2 enzyme - dihydrolipoyl transacetylase covalently bound to lipoic acid and coenzyme A and E3 enzyme - dihydrolipoyl dehydrogenase bound to cofactors FAD and NAD+. There are five steps of oxidative decarbodation of pyruvate to acetyl-CoA. The reaction is carried out by PDH complex with E1, E2 and E3 enzymes. Furthermore, PDH enzyme is activated and inhibited by PDH phosphatase (PDP) and PDH kinase (PDK) enzyme, respectively.
The following topics are covered in this lesson,
1. Pyruvate dehydrogenase complex (PDH complex)
2. Pyruvate dehydrogenase (PDH) - E1enzyme
3. Dihydrolipoyl transacetylase - E2 enzyme
4. Dihydrolipoyl dehydrogenase - E3 enzyme
5. Five steps of oxidative decarboxylation of pyruvate to acetyl-CoA
6. Pyruvate dehydrogenase kinase (PDK)
7. Pyruvate dehydrogenase phosphatase (PDP)
8. Pyruvate dehydrogenase deficiency
9. Arsenic poisoning

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[@abhyarthanabehera4802]

Thank you. But I have a doubt. The step catalyzed by E2, how hydroxyethyl TPP (oxidised form) can reduce oxidised lipoate? In books the heTPP is in reduced form (CH3-CHOH-TPP)

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