AKT Signaling Pathway | Regulation and Downstream Effects

Biomedical lesson on AKT (Protein Kinase B) signaling, regulation and downstream effects. The AKT signalling pathway is a highly conserved pathway that induces several important functions including glucose uptake and utilization, protein synthesis, fatty acid synthesis, glycogenesis and cell survival and proliferation.
Hey everyone. This lesson introduces the AKT (PKB) signalling pathway, how the pathway is regulated and controlled, and what are the major cellular outcomes of AKT signaling. Additionally, we also discuss how diseases such as cancer can be associated with abnormal AKT signaling.
If you find this video helpful, please consider liking the video and subscribing to my channel :)
Subscribe for more free medical lessons / @jjmedicine
-------------------------------------------------------------------------------------------------------------
For books and more information on these topics
www.amazon.com...
Support future lessons (and get other cool stuff) ➜ / jjmedicine
Follow me on Twitter! ➜ / jj_medicine
Come join me on Facebook! ➜ / jj-medicine-1006426481...
Start your own website with BlueHost ➜ www.bluehost.c...
Check out the best tool to help grow your UA-cam channel (it’s helped me!)
www.tubebuddy....
-------------------------------------------------------------------------------------------------------------
Check out some of my other lessons.
Medical Terminology - The Basics - Lesson 1:
• Medical Terminology - ...
Fatty Acid Synthesis Pathway:
• Fatty Acid Synthesis P...
Wnt/B Catenin Signaling Pathway:
• Wnt/β-Catenin Signalin...
Upper vs. Lower Motor Neuron Lesions:
• Upper and Lower Motor ...
Lesson on the Purine Synthesis and Salvage Pathway:
• Purine Synthesis and S...
Gastrulation | Formation of Germ Layers:
• Gastrulation | Formati...
Introductory lesson on Autophagy (Macroautophagy):
• Autophagy | Macroautop...
Infectious Disease Playlist
• Infectious Diseases
Dermatology Playlist
• Dermatology
Pharmacology Playlist
• Pharmacology
Hematology Playlist
• Hematology
Rheumatology Playlist
• Rheumatology
Endocrinology Playlist
• Endocrinology
Nephrology Playlist
• Nephrology
----------------------------------------------------------------------------------------------------
**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
----------------------------------------------------------------------------------------------------
Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe!
JJ

[@Clash_In_Saff]

Just started my research masters, this video is sweeter to my eyes and ears than any of my greatest youthful crushes.

[@dena3107]

I have an exam about this today and I was always confused about certain parts in this pathway. This video clearly and succinctly explains the pathway, thank you so much!

[@ikyhwh]

I'm glad you saved the simple explanation for the end because it helped me digest such a detailed explanation of all of the macronutrients it regulates by blocking them... I think 😅
Black seed oil 👍

[@shashidharnrao]

fantastic video on how AKT Kinase works. I learnt a lot. The author has a very lucid style of explanation. Thank you for posting.

[@xinjunwu7941]

thank you for spending time and sharing your knowledge with us.

[@renzofernandoalvafigueroa4031]

A very clearly and useful lesson, greetings from PERU

[@alexisteja9920]

You are amazing! I wish I can be able to explain this clearly to my students just like you did. Thank you!

[@aang7505]

1. AKT is an inhibitor of TSC1/2
2. TSC1/2 is an inhibitor if Rheb.
3. Rheb is an activator of mTORC1
AKT inhibits the inhibitor of Rheb (TSC1/2). Thereby allowing more Rheb to activate mTORC1 allowing for more activation of TSC1/2 as compared to if AKT was NOT present

[@fatimareginamenasilva1204]

Very didactic and summarized explanation. Thank you¹

[@holeung973]

thx sir today my biochem exam has actually have akt pathway

[@fieldtripinmyparty]

simply perfect. i wish you could do a similar video to the pathways involved in HSP90 alpha.

[@daniamawa7230]

Thank you sooooo much!!

[@shangfanggao6880]

Super clear! Bravo!

[@mohamed_mekawyy]

شكراً جززززيلااااااا

[@Firdos7]

Thanks

[@mohammedal-hammadi5085]

Thank you, it's pretty clear

[@varshaps3165]

Thank you so much for this lecture. It was really really helpful ☺️☺️

[@rory1234gilmore]

Great. Thank you so much

[@alexanderdiederichs7332]

Is GSK3 the same as GSK3-ß from Wnt-signaling (Activation of Akt leads to inactivation of beta-Catenin Destruction Complex, leading to a proliferative signal through a accumulation of beta-Catenin in the nucleus)? This would be an additional way how Akt stimulates cell proliferation?

[@dubstepXpower]

Thanks mate, great videos

[@NaushadAli-md3sy]

Very good explanation.

[@lipeiqi3432]

Why both Glycogen synthesis and Glycolysis are activated?

[@josefinatanco7312]

Very helpfull!! thank you so much

[@edenx4775]

Great video!

[@abdullabhuyan9276]

Great Job! Really helpful! But in the part relation to Glycogen synthesis is little bit confusing to me. If possible please clear me! Does by GSK3 phosphorylation, GSK3 become inactive? and GS become phosphorylated or dephosphorylated?

[@navit4578]

ថឪ

[@jolienlansens1176]

nice video! What's the source of the image i can refer to?

[@ishayadav2466]

Love u so much ...Thank you

[@salmanisthebest1]

Very helpful. Thank you

[@nachinathan3846]

Amazign work!!!

[@anmarraheem3824]

Your videos are awesome
Keep up the good work!
Thank you

[@soul5626]

thanku

[@oliviamccarthy6339]

Dear JJ Medicine, I wonder whether there is an email address I am able to contact you regarding your authorisation to use illustration elements of this material for scientific publication please? Any help is greatly appreciated. Kind regards, Olivia

[@chasadisum]

Cool 😎 best ever video

[@srihadjrah3960]

Sncak vidio aktifkan dong?

[@nibeditasarkar9831]

In writing

[@drhafizabdulkhaliq]

10/10

[@harrygriffin1098]

i’m 16. why am i here lol

[@ronfisher9915]

Enjoy the content bruh