I’m a her2 +3 stage 1A. My first round of chemo was administered via IV. My second round will be via mediport. I’m scheduled for medi port surgery on Tuesday. The chemotherapy is horrendous. I have a weak stomach to begin with. I lost 8 lbs in 7 days. When they say fight, I think……it’s not a fight. It’s equivalent to my vehicle going off a cliff and hoping I survive when it comes to a stop. Well today I feel better and consider myself a survivor. Strap yourself in and hang in there. Prepare in advance with vomit bags, water, tucks pads, and station yourself near a bathroom that no one else uses. Blow and wipe your nose gently. I now have a nose sore from the wateriness associated with vomiting. Hopefully my oncologist will be able to help with that. Nausea patches are not covered by my insurance and cost over 1k. Yes you read correctly. $1k. I have 2 nausea medications that are psych meds which are used for nausea. No I do not have any mental illness. Hopefully this info helps. My nurse practitioner did NOT prepare me for this. ❤
This sounds really rough and is not typical. The anti-nausea guidelines specify that a very old, inexpensive medication called olanzapine is extremely effective. Some medical teams are not using this medication for a variety of reasons, but this is a reasonable request you might make. We're hoping your next cycle goes better. Make sure to subscribe to stay tuned for our upcoming video on managing nausea.
@@yerbba thank you for your response and recommendation. My oncologist reduced my chemo meds by 20% to see if this helps reduce the side effects. The steroids are still in my system, so I won’t know for another day. You are greatly appreciated. Thanks again.
Great video, I'm a male patient of breast cancer since 2018. I made mastectomy in the left breast the tumor was IDC (invasive ductal carcinoma) G.II which diagnosed as her2+3 and took chemo, then radio, then targeted therapy along with hormonal therapy (Tamoxifen), after 2 years there was a recurrent tumor (ulcerating adenocarcinoma) under skin in the previous scar, doctors changed the hormonal therapy to something stronger ( Femara and Zoladex) after another surgery... 2 weeks ago there was another recurrent small nodule 9.2×9.3×3mm of ( metastatic adenocarcinoma) in the same place and I got rid of it by another surgery!! I'm really broken 😔 Is there an effective treatment for my case?
You've been through so much. There are other options for you, yes. It would be worth talking with your medical team about the CDK4/6 inhibitors, which get added to the letrozole (Femara). We don't, of course, have a lot of data in men, but these medications are highly effective in women. There's no reason to think this is not an option in your case. Another option would be repeated radiation therapy using a different kind of energy since it's several years later. All that being said, recall that I can't give specific advice since you are not my patient. Chemotherapy is also an option for you. It's different from what you received with your original diagnosis. Wishing you well.
@@yerbba I thought radiation increases the risk of adenocarcinoma tumors which are more aggressive and difficult to treat? As by the time they are caught they are larger and have spread more. I was told this was one of the rare cancers you can get from radiation treatments.
Thank you for another of your informative videos. I appreciate that you made it 2 years ago and may not look at comments but I have a couple of quests re targeted therapy (I was recently diagnosed with early stage HER2 +ve ER & PR -ve ultra sound, PET scan and physical examination suggest no lymph gland involvement). I am half way through 6 cycles of chemotherapy which will be followed by surgery and possibly radiation therapy. I will start on 18 3 weekly Herceptin with my next chemo cycle. This seems like a very aggressive treatment plan (I am in France and feel I am getting first class care) I have read research articles that suggest 6 months of Herceptin to be almost as effective as 12 months. What is your view on that? Also is it possible to take a break from the 3 weekly treatments - if so what do you suggest would be the maximum time. Thank you
Great questions. Herceptin (trastuzumab) for a full year is the current standard. We generally don't recommend missing more than one treatment. If someone does miss treatments, redoing the initial higher dose may be appropriate. I hope this is helpful.
@@yerbba Many thanks. I appreciate your taking the time to reply. I don’t know if it makes any difference but I didn’t add I am in the elderly age bracket (ie over 70)
Great explanation and such a calming voice. Thank you. Could you please tell me what is the standard approach for a her2 positive with a high KI67 (70 %)? Can it be cured? Thank you in advance.
Thanks for writing. In early stage breast cancer (Stages I to III), as well as with DCIS, the goal of treatment is cure. Cure is more likely in early stage disease, but everyone gets treated in the hopes of cure. In people with advanced disease (Stage IV), the goal is to maintain the best quality of life for as long as possible.
Hello dr I wanna now the prognosis of that case her2 +ve er pr -ve Firstly we discovered the case it in breast in 2012 we did mastectomy +( taxotre +17 dose herceptin) +radation Then it recur in 2021 at lymp node in neck & with small nodule in mediastational & all the organ are intact After 3 months of chemo (taxotre +herceptin) the pet scan show complete cure wz no trace of the tumor And we still on herceptin for longer period
It sounds like the treatment has been effective so far. Very encouraging. It's hard to say what will happen in the future, but I think close follow up and time will tell. It can be really hard to live with the uncertainty of course.
Hello Dr my friend was diagnosed with her2 negative breast cancer she had 16 round of chemo and now every 3weeks of target therapy for a year what treatments next is nothing her dr have told her Do you agree?
If the tumor is estrogen receptor positive and/or progesterone receptor positive, endocrine therapy may be part of your friend's treatment plan. If the tumor is not, she will be all done!
Dear Dr.Griggs, I came across a medical journal which speaks about brain metastases from breast cancer especially a Her2+ breast cancer. What care in terms of diagnostic test or other checks I need to take to ensure such a condition is avoided or at least checked to rule out brain metastases. Thank you.
ER-positive, PR-positive, HER2-negative metastatic breast cancer means that the cancer cells grow in response to estrogen and progesterone but do not overexpress the HER2 protein. This type of cancer is generally slower growing and considered by many people to be less "aggressive." This type of breast cancer can be treated with hormonal therapies like tamoxifen, aromatase inhibitors, or CDK4/6 inhibitors.
Your chance of cure is determined by several things other than the ER and PR status and the HER2 status. Other things associated with your chance of cure include the size of the tumor and whether or not, and how many, lymph nodes are positive. The grade of the tumor also matters. It's important to know that the purpose of your treatment is cure.
Hi, what’s the current treatment for the invasive ductal carcinoma with a Her-2 positive and ER/PR positive status (triple positive)? After the mastectomy? And what would be the overall prognosis for that? I would really appreciate any feedback. Thank you.
In general, people with HER2-positive breast cancer receive HER2-directed therapy along with chemotherapy. The HER2-targeted therapy will be given for up to a year as long as there are no negative effects on your body. Your team will follow your heart health. With hormone receptor-positive tumors (regardless of HER2 status), endocrine therapy will also be recommended. Without knowing more details about the tumor and being part of your medical team, it is hard to estimate a prognosis.
My tumour was her2positive on biopsy but her2negative on the tumour biopsy. I am currently receiving herceptin but dont understand why apart from the reason 'just in case' i feel i am being overtreated and that my heart risk due to type 1 diabetes and family history of heart disease is too high. My treatment team know of my concerns but won't engage with me to discuss. I had EC prior to mastectomy which didnt shrink the tumour. I was refused phesgo and herceptin prior to surgery because i didnt have a taxane, and was refused kadcyla after surgery for the same reason. I am told i have high risk of recurrence in next 2 years. Tumour profile was IDC 24mm grade 3 Er8 Pr4 her2 negative after fish. Is it worth my while having a ctdna test? I was not offered a multi gene tumour assay. I feel like i am working in the dark. Oncologist says she has no data with which to back up herceptin recommendation. I have had 6 and want to stop soon due to heart risk and fear of overtreatment. Is there a video about change in her2 status?
Thanks for taking the time to share your experience. It sounds like you've felt "voiceless" in your care. You're correct, medical experts will offer HER2-directed therapy if there is any chance that the tumor might be HER2-positive. It is likely that you will be offered a follow up test to check on the health of your heart. In the absence of a response to EC, it is likely that your team wants to offer you anything that can improve your outcome. It's not possible to say that a cDNA test should be done. It is not clear that treatment can or should be omitted (or skipped) on the basis of cDNA tests. The genomic assays have not been validated for use in clarifying HER2 status in patients such as you. Hoping this is helpful as you navigate what is undoubtedly a challenging time.
@@yerbba could you be more specific ? They recommended two chemos, target therapy, immunotherapy, then surgery. The doctor told us, there is no prognostic because her and the board never saw anyone with only mucinous her2+
Geez when they brought up the image of a women's chest and where the tube gets inserted I thought wow! Did a guy draw this? The breasts are huge! A little offensive to me and a bit unrealistic. Other then that the content was good.
I’m a her2 +3 stage 1A. My first round of chemo was administered via IV. My second round will be via mediport. I’m scheduled for medi port surgery on Tuesday. The chemotherapy is horrendous. I have a weak stomach to begin with. I lost 8 lbs in 7 days. When they say fight, I think……it’s not a fight. It’s equivalent to my vehicle going off a cliff and hoping I survive when it comes to a stop. Well today I feel better and consider myself a survivor. Strap yourself in and hang in there. Prepare in advance with vomit bags, water, tucks pads, and station yourself near a bathroom that no one else uses. Blow and wipe your nose gently. I now have a nose sore from the wateriness associated with vomiting. Hopefully my oncologist will be able to help with that. Nausea patches are not covered by my insurance and cost over 1k. Yes you read correctly. $1k. I have 2 nausea medications that are psych meds which are used for nausea. No I do not have any mental illness. Hopefully this info helps. My nurse practitioner did NOT prepare me for this. ❤
This sounds really rough and is not typical. The anti-nausea guidelines specify that a very old, inexpensive medication called olanzapine is extremely effective. Some medical teams are not using this medication for a variety of reasons, but this is a reasonable request you might make. We're hoping your next cycle goes better. Make sure to subscribe to stay tuned for our upcoming video on managing nausea.
@@yerbba thank you for your response and recommendation. My oncologist reduced my chemo meds by 20% to see if this helps reduce the side effects. The steroids are still in my system, so I won’t know for another day. You are greatly appreciated. Thanks again.
I was diagnosed with her2 positive in 11/09/23. I started chemo via a port. I do hope it is cured and never see the recurrence of this monster
We share your wish for a cancer-free future.
Great video, I'm a male patient of breast cancer since 2018. I made mastectomy in the left breast the tumor was IDC (invasive ductal carcinoma) G.II which diagnosed as her2+3 and took chemo, then radio, then targeted therapy along with hormonal therapy (Tamoxifen), after 2 years there was a recurrent tumor (ulcerating adenocarcinoma) under skin in the previous scar, doctors changed the hormonal therapy to something stronger ( Femara and Zoladex) after another surgery... 2 weeks ago there was another recurrent small nodule 9.2×9.3×3mm of ( metastatic adenocarcinoma) in the same place and I got rid of it by another surgery!! I'm really broken 😔 Is there an effective treatment for my case?
You've been through so much. There are other options for you, yes. It would be worth talking with your medical team about the CDK4/6 inhibitors, which get added to the letrozole (Femara). We don't, of course, have a lot of data in men, but these medications are highly effective in women. There's no reason to think this is not an option in your case. Another option would be repeated radiation therapy using a different kind of energy since it's several years later. All that being said, recall that I can't give specific advice since you are not my patient. Chemotherapy is also an option for you. It's different from what you received with your original diagnosis. Wishing you well.
@@yerbba I thought radiation increases the risk of adenocarcinoma tumors which are more aggressive and difficult to treat? As by the time they are caught they are larger and have spread more. I was told this was one of the rare cancers you can get from radiation treatments.
Thank you for another of your informative videos. I appreciate that you made it 2 years ago and may not look at comments but I have a couple of quests re targeted therapy (I was recently diagnosed with early stage HER2 +ve ER & PR -ve ultra sound, PET scan and physical examination suggest no lymph gland involvement). I am half way through 6 cycles of chemotherapy which will be followed by surgery and possibly radiation therapy. I will start on 18 3 weekly Herceptin with my next chemo cycle. This seems like a very aggressive treatment plan (I am in France and feel I am getting first class care) I have read research articles that suggest 6 months of Herceptin to be almost as effective as 12 months. What is your view on that?
Also is it possible to take a break from the 3 weekly treatments - if so what do you suggest would be the maximum time.
Thank you
Great questions. Herceptin (trastuzumab) for a full year is the current standard. We generally don't recommend missing more than one treatment. If someone does miss treatments, redoing the initial higher dose may be appropriate. I hope this is helpful.
@@yerbba Many thanks. I appreciate your taking the time to reply. I don’t know if it makes any difference but I didn’t add I am in the elderly age bracket (ie over 70)
I wouldn't miss any treatments. The treatment is terrific and I am sure you will fully recover and get back to leading a normal life 💙💎🙏
Great explanation and such a calming voice. Thank you. Could you please tell me what is the standard approach for a her2 positive with a high KI67 (70 %)? Can it be cured? Thank you in advance.
Thanks for writing. In early stage breast cancer (Stages I to III), as well as with DCIS, the goal of treatment is cure. Cure is more likely in early stage disease, but everyone gets treated in the hopes of cure. In people with advanced disease (Stage IV), the goal is to maintain the best quality of life for as long as possible.
Thank you...wonderful!
Glad you enjoyed the video!
Excellent
Thank you so much 😀
Hello dr
I wanna now the prognosis of that case
her2 +ve er pr -ve
Firstly we discovered the case it in breast in 2012 we did mastectomy +( taxotre +17 dose herceptin) +radation
Then it recur in 2021 at lymp node in neck & with small nodule in mediastational & all the organ are intact
After 3 months of chemo (taxotre +herceptin) the pet scan show complete cure wz no trace of the tumor
And we still on herceptin for longer period
@Elena Vigilla Shame on you, SPAMMER!
It sounds like the treatment has been effective so far. Very encouraging. It's hard to say what will happen in the future, but I think close follow up and time will tell. It can be really hard to live with the uncertainty of course.
Hello Dr my friend was diagnosed with her2 negative breast cancer she had 16 round of chemo and now every 3weeks of target therapy for a year what treatments next is nothing her dr have told her
Do you agree?
If the tumor is estrogen receptor positive and/or progesterone receptor positive, endocrine therapy may be part of your friend's treatment plan. If the tumor is not, she will be all done!
Dear Dr.Griggs, I came across a medical journal which speaks about brain metastases from breast cancer especially a Her2+ breast cancer. What care in terms of diagnostic test or other checks I need to take to ensure such a condition is avoided or at least checked to rule out brain metastases. Thank you.
Thanks for writing…it helps other gents not feel so alone. Hoping that you are happy with your care.
Mam,,ER Positive,, Pgr positive,,Her2 negative metastatic breast cancer means??is it very aggressive??? Which treatment is better???
ER-positive, PR-positive, HER2-negative metastatic breast cancer means that the cancer cells grow in response to estrogen and progesterone but do not overexpress the HER2 protein. This type of cancer is generally slower growing and considered by many people to be less "aggressive." This type of breast cancer can be treated with hormonal therapies like tamoxifen, aromatase inhibitors, or CDK4/6 inhibitors.
My ER and PR are positive ,HER 2 is negative , does it will be cured ? Hope to receive your reply
Your chance of cure is determined by several things other than the ER and PR status and the HER2 status. Other things associated with your chance of cure include the size of the tumor and whether or not, and how many, lymph nodes are positive. The grade of the tumor also matters. It's important to know that the purpose of your treatment is cure.
Hi, what’s the current treatment for the invasive ductal carcinoma with a Her-2 positive and ER/PR positive status (triple positive)? After the mastectomy? And what would be the overall prognosis for that? I would really appreciate any feedback. Thank you.
In general, people with HER2-positive breast cancer receive HER2-directed therapy along with chemotherapy. The HER2-targeted therapy will be given for up to a year as long as there are no negative effects on your body. Your team will follow your heart health. With hormone receptor-positive tumors (regardless of HER2 status), endocrine therapy will also be recommended. Without knowing more details about the tumor and being part of your medical team, it is hard to estimate a prognosis.
My tumour was her2positive on biopsy but her2negative on the tumour biopsy. I am currently receiving herceptin but dont understand why apart from the reason 'just in case' i feel i am being overtreated and that my heart risk due to type 1 diabetes and family history of heart disease is too high. My treatment team know of my concerns but won't engage with me to discuss. I had EC prior to mastectomy which didnt shrink the tumour. I was refused phesgo and herceptin prior to surgery because i didnt have a taxane, and was refused kadcyla after surgery for the same reason. I am told i have high risk of recurrence in next 2 years. Tumour profile was IDC 24mm grade 3 Er8 Pr4 her2 negative after fish. Is it worth my while having a ctdna test? I was not offered a multi gene tumour assay. I feel like i am working in the dark. Oncologist says she has no data with which to back up herceptin recommendation. I have had 6 and want to stop soon due to heart risk and fear of overtreatment. Is there a video about change in her2 status?
Thanks for taking the time to share your experience. It sounds like you've felt "voiceless" in your care. You're correct, medical experts will offer HER2-directed therapy if there is any chance that the tumor might be HER2-positive. It is likely that you will be offered a follow up test to check on the health of your heart. In the absence of a response to EC, it is likely that your team wants to offer you anything that can improve your outcome.
It's not possible to say that a cDNA test should be done. It is not clear that treatment can or should be omitted (or skipped) on the basis of cDNA tests. The genomic assays have not been validated for use in clarifying HER2 status in patients such as you.
Hoping this is helpful as you navigate what is undoubtedly a challenging time.
Doctor, my sister has mucinous her2+. Her doctor said she never saw that? What would you recommend ?
HER2-positive mucinous cancers are really rare. It would be reasonable to have the tumor reassessed before making treatment decisions.
@@yerbba could you be more specific ? They recommended two chemos, target therapy, immunotherapy, then surgery. The doctor told us, there is no prognostic because her and the board never saw anyone with only mucinous her2+
@@yerbba thank you very much
My status is maintenance/remission and I receive a PHESGO shot in my leg every 21 days
Thanks for watching. All the best to you.
Great.
Thank you for watching
not very clear!
We are completely open to clarifying any specifics that would be helpful.
Geez when they brought up the image of a women's chest and where the tube gets inserted I thought wow! Did a guy draw this? The breasts are huge! A little offensive to me and a bit unrealistic. Other then that the content was good.
All breasts are different, and it is hard to find pics out there of smaller breasts! Thanks for watching.
@@yerbba 5:36