I think the initial motivation for Dr Longo was to make a diet that mimicked fasting 's benefits and be easier to do for cancer patients. i.e. turn off the factors that promoted growth. that's my understanding anyways.
I read his book. It is to get the benefits of fasting without the risks of fasting. Fasting for more a day or two may involve some risk because it stresses the body. However with the fasting mimicking diet you can fast for 5 days. If it activates stemcells that sounds pretty useful as stemcells implies pure rejuvenation. The list of longevity benefits from fasting is quite long. I just saw another video where autophagy is cancer protective as well.
I have done severe caloric restriction. I have also done 5 day fasts several times, where I ate absolutely nothing and only consumed water and black unsweetened coffee. So I can compare both experiences. Once you dip below a 1000 calories, I really don't notice any difference in hunger sensation between eating those 1000 calories and not eating anything at all. So I prefer to go all in and just not eat any calories, and only consume water and black coffee. If anything, the consumption of a few calories stimulates cravings. Its best to do a fast as cold turkey, at least from my experience.
If you eat a whole food, plant based diet with low calorie density (no oils, no nuts, no avocados), 1000 calories can actually seem like more food than you would imagine. I did an 800 calorie diet for several weeks and lost about 12 lbs. It was not the Prolon diet but I tried to eat alot of nutrient dense foods. I never felt like I was starving. I ate mostly mashed potatoes, oats, fruits and vegetables, and never felt like I was starving, just slightly hungry at times.
You missed the point of Longos keeping some foods in the fasting mimicking diet. These foods are highly nutritious anti-cancer and disease Foods that nourish the body during the 5-day fasting mimicking diet while still getting the benefits of a fast. On a water only extended fast you put severe stresses on your body which can be a detrimental. Longos eating plan avoids the severe stresses nourishes the body and still has the benefits of extended fasting.
@@beardumaw24 That's right. It is expecially targeted for people with pre existing conditions. I've many health problems, and when I've tried a 3 days water fast it was brutal for me. Maybe keeping a little food for a more extended period of time could be easier on my body.
I think its worth pointing out that Dr. Longo was clear that the diet was (at least originally) primarily aimed at sick, including those undergoing treatment for cancer, and was developed when it was clear that many older and sick people were unable or unwilling to fast, and in some cases may be the only healthy way they can fast. His book makes clear the benefit of time restricted eating and other forms of fasting for those who are healthy. I think in interviews he has talked about the 5 day fast being roughly equivalent to a 3-4 day conventional fast. As others btl have said, all the money from the products goes to charity or research, he does not profit from it.
I think that the affects was just one of the areas they are studying. With the FMD they can have a reliable home program to give to patience instead of expensive ones where they need to be monitored. The studies of combining the FMD with cancer treatment are still ongoing.
Yes! I came to say this. He created it because cancer patients would not fast and their doctors recommended they not fast, so he went to the next best thing. If you are healthy, go ahead and do a water only fast instead of buying the FMD. Also he has said many times that he is not in any way profiting from the FMD. He does not get paid by them, and the money his stock in the company earns gets directly donated to charity. He makes nothing if you buy it. He just helped create it and he believes in it
Dr Longo is a Doctor and he has been researching and studying autophgy in study groups for a while. You might want to read up on what he has done before he created this prolon diet. I think this might be the solution to getting regular people to want to try some form of fasting without giving up food. The science/result behind the FMD is different from Keto. So folks can have a choice to try both during different times. Also, I think the procedes form the sale is going back into research.
again, Thomas is not attacking or denoting any sort of mimicking diet, he’s just explaining what it is that Dr. Longo doesn’t tell you because he’s a scientist turned a businessman. I’m sure Longo has good intentions and wants to reach the masses with his research but I think, he got greedy and went about it the wrong way to charge nearly $200 for a five day program which when you actually look at what you’re getting, you can just simply go get those ingredients at whole foods and do it yourself for less than $100. So then you can start thinking to yourself, thanks for the research long ago but I can do this cheaper
@@smachamo5150 Think about the tons of people who find going after ingredients and following a protocol on their own overwhelming. So he's shared his research and formula with you, but also makes it exceptionally convenient for people who may feel intimidated by it. To me, that covers all bases. As far as actual cost, $200 is probably about right when you consider the preparation and shipping that happens on the business side. I'd be willing to bet the margins are not that great. Nobody would get rich off that.
@@FadGadget1 Even if all he was doing was books..I'm always leery of people saying: "Profits will be going to charity/research". What can I say...I'm way too jaded..lol!
The fasting mimicking diet was initially developed through a grant from the National Cancer Institute for use with cancer patients (short terms fasts protect patients against the toxic effects of chemo), which is why it was designed to mimick fasting and not possibly contribute to cachexia. It was then developed commercially for use mostly targeting metabolic syndrome. Your review was weirdly not positive in spite of a mostly positive review, with unexplained disses such as "weird things going on there" related to the use of almond meal as a price point thing (actually, it's almonds, not almond meal, for the crunchy bits), and I guess viewing it as some kind of moral failure that it doesn't give one the mental resilience of a "real fast". I have several patients who failed to correct their metabolic derangement on ketosis in spite of compliance (a couple due to SNPs on FTO re: increased insulin resistance with saturated fat), and for whom water fasting was too risky due to their diabetes and prediabetic reactive hypoglycemia. They all had significant reductions in inflammatory markers after three cycles of fasting mimicking, with robust maintenance of weight loss, waist circumference and biomarkers after returning to their normal diet. While Longo has financial interest in L-Nutra, profits are turned over to foundations. I'm not sure how tomato, squash and minestrone soups are "odd combinations of soups". "His own study" is "very biased"? How's that? Are you referring to Min Wei et.al. Sci Transl Med 2017? Yes, there are foods that will stimulate autophagy but in a statistically significant way not a clinically significant one. Eating chocolate while on a regular diet - no matter how healthy - is not going to give you any meaningful autophagy. Consuming leucine will immediately stop any autophagy. There is even doubt that 16/8 IF gives humans any at all.
I didn't find this review 'strangely not positive' at all. I thought he asked questions in a polite way that were genuine. I've understood that water fasting is actually more muscle sparing (depending on the length) than chronic low caloric intake diets. I've been led to believe that chronic low calorie diets lead the body to think there's not enough food and so it catabolizes muscle whereas a water fast leads the body to spare muscle in order to catch our food. I've never heard of people increasing their insulin resistance eating a higher fat and very low carb diet myself. I figure you know what you're talking about though since you've observed it in your patients. I would say that tomato soup is an odd soup to add since it's relatively high in plant toxins and some people who are sensitive to lectins, salicylates and oxalates. It does seem like they could've left out those...
I did this fast mimicking diet by Prolon (Valter Longo's firm) a few months ago and it did not convince me at all. Very expensive and the soups are so high carb that they kicked me out of ketosis all the time (and even tasted ugly!). So, I think I didn't have any autophagy at all. Also my body didn't show those great effects of rejuvination and fat loss I experienced with water fasting for two days. Moreover is the downside: You always always think of eating: When can I eat the next small meal? Why so few today? Instead of just leaving food aside and concentrate on other things when water fasting.
U don't have to buy the kit. Sylvie Pajot's video(s0 take the math out of the macros...she provides easy to assemble 'recipes'. It basically consists of salads and, if u don't mind turning on a stove burner...soups. Using fresh foods is prolly even better for u than the dehydrated diet packets in the kit.
I've done the Prolon FMD twice. The first time I actually lost a lot of weight - 190 to 178 (mostly water, I know). The 2nd time, about 3 months later, I didn't lose any weight.
After listening to a number of Dr Longo’s seminars I’m pretty sure part of the reason he came up with the mimicking fasting diet was to help ‘pacify’ all the oncologists who do not subscribe to fasting, as a form of treatment for cancer patients who are receiving chemotherapy. He mentions them on most of his UA-cam videos.
The hating in this video is strong. It seems you’re more insulted he is selling products (RIGHT in between you shilling a tea, lmao), than the usefulness of his diet (which was targeted to those who can’t/won’t fast btw). Funniest part: his product revenue goes to charity. Yours go to your pocket. And you mad, lmao
My favorite part is that you unashamedly promote research and work in this field by promoting the livelihood of the researchers. Conversely, there are those who would demotivate society by forbidding people from furthering themselves or making money.
The thing that interests me about the FMD is that, at least in the mice trials, he healed type 1 diabetes. No promises for adults, and the mice were put through a grueling fasting regimen. But for those of us with T1D, this is incredibly interesting.
Oh I didn't realize it had the potential to correct type 1 diabetes. That would be awesome if true. Hopefully some more research can uncover something in that direction. As I understand it, T1D is a horribly dangerous disease.
I really liked this video and yes a thumb up. I think this video is more useful than most videos I have seen about FMD. Let me crunch this already solid and compact video in few lines: 1:51 Five day increments 2:20 On FMD you eat foods that activate less MTOR. Also foods that do not activate IGF-1 pathways. 2:35 Get the benefits of fasting without the stress on body. 3:25 Day one about 1000 kcal. For the remaining four days 725 kcal a day. 3:31 Low protein. Low carbohydrate. Moderately high fat. 4:13 You are mostly limiting the amount of protein you eat. By limiting protein you are limiting IGF signal. 4:22 Additionally, this puts you into a state of ketosis. 4:48 In essence it is a low protein keto diet for five days. 4:55 Downregulating IGF-1 also reduces glucose signaling. 5:05 This can also promote stem cell renewal. 5:35 Fasting mimicking food #1: black or green tea A tea advertisement here 6:38 Fasting mimicking food #2 nut bars 6:40 macadamia nut butter 6:45 pulmonic acid, Omega-7 and fats 6:53 honey, why is it there? 7:00 Fructose can reduce some of the autophagic flux benefits we are after. 7:08 almond, why is it there? 7:11 phytic acid content 7:13 macadamia is already there so why add almond? 7:17 probably a profit margin thing 7:31 Fasting mimicking food #3 algal oil 7:50 Fasting mimicking food #4 soup blends 7:53 Fasting mimicking food #5 dark chocolate crisp bar 7:54 no sugar 7:56 strong autophagy driver 8:25 Autophagy doesn't just happen because you are in a calorie deprived state 8:30 There are specific foods that you can eat to trigger autophagy 8:42 chocolate and green tea are great autophagy drivers 8:50 Fasting mimicking food #6 kale crackers 8:52 low calorie keto thing 8:55 Fasting mimicking food #7 olives 8:57 good fat source 8:58 hydroxytirosol 9:00 Fasting mimicking food #8 glycerol drink 9:08 Glycerol drink is supposed to help drive up energy metabolism via glucogenesis 9:15 When you are in ketosis your body is utilizing different fuel substrates and using fats as fuel source 9:23 glycerol backbone 9:50 By consuming glycerol you are artificially triggering AMPK pathway 10:07 A low protein temporary plant-based keto diet would get a lot of results even without Volter Longo's name 10:15 In mice the fast mimicking diet has been shown to reduce cancer 10:20 Prevent bone loss, trigger neurogenesis 10:23 Activate remyelination of new neurons 10:29 Stem cell regeneration
The FMD is a good protocol with solid evidence behind it. For those unable to do a regular fast (>72hrs) it seems like a good alternative to do for 5 days once a month. For me there's no need as I don't need to mimic fasting :)
I was just researching this last night! Your video has perfect timing to add to my education on this. I have a lot of respect for Dr. Longo which is the only reason why I even considered it, but it's hella expensive (happy to hear he donated the proceeds, but still). I believe in Longo's research and recommendations, it just isn't for me - I don't think I could stop at the provided food. Glad there are good options out there for people though. Thanks for your review and breakdown of the science of this diet!
I've had pretty good results the past month "fasting" two days a week, taking in no more than 350 calories each day and low intensity cardio. Not really going for the fasting though, as much as I am the large calorie deficit.
I’m currently on day 14 of a 21 day water fast. I’ve been following Dr. Kongo for a while but I just found out about the fasting mimicking diet recently and it sounds interesting and worth a try. After referring I plan on trying this diet along with intermittent fasting to see how it makes me feel because people have been getting good results from it. Fasting will always my 1st option but it’s good to try other things too.
I learnt about fasting mimicking diet from a polish doctor Ewa Dabrowska. Years or research and experience. Unfortunately not many publications are translated to English but her work is amazing
He also says that fasting alone is not as good as his fmd, which sounds like marketing angle to me, he says he found fasting alone didnt provide the benefits as fmd.
I'm actually reading Dr. Valter Longo's book, The Longevity Diet, right now. So you had perfect timing TD! I think it would be a home-run if you and Dr. Gundry did a podcast video. Hit him up! You both seem to be on the cutting edge of health related matters.
I don't like that diet as it is low protein, instead you eat more carbs. The risk is: you may be losing muscle when you are on low protein for 5 days per week.
So for anyone who wanted some direct feedback on this. I did a keto diet about 2 years ago. I tracked my weight everyday and in 90 days I lost 41 pounds. Now I've put a little weight back on do I decided to do keto again this week. I peed on a keto strip, nothing. I did thr fasting mimicking diet for one day. Today I pee on the strip, it's deeeeep purple. One day! Holy crap. I can tell I'm in keto because yet again I went from cravings day one to no appetite day 2.
Depends on your goals. Reducing protein in a fast mimicking diet can promote autophagy and reboot stem cells, boosting the immune system. A protein sparing modified fast does not turn off mTOR; it likely increases it to spare muscle while the body is put into a self-fat burning mode. This wouldn't reset the immune system in the same way or promote the same pathways. There are so many variations of fasting all geared toward meeting different goals.
This diet is for those who can't do a water fast. I think it is actually harder because you will experience hunger and be focused on eating the next mini meal. The kits are very expensive; I heard over $200. I'll stick with water fasting. Some people are on meds and can't take them on an empty stomach. Others can't water fast for whatever reasons. For those, this diet is a life saver
for some patients perhaps. For me, having no diseases, I cannot limit myself: either I eat, or I fast! But perhaps, for a pre-fasting. Dr Désiré Mérien, who is now over 85, recommends a "food descent" before fasting. Then this would be a good option. None of the fabulous books written by this French doctor, who has guided over 30,000 fasters, has been translated into English.
Ive been fasting-mostly ADF-with carnivore eating for 14 weeks; lost 50 pounds. Recently did a 5 day water fast but did have to eat lettuce on day 4. All this to say I was skeptical of the FMD for the reasons Thomas outlines; I’d never eat those foods in the Prolon package. I did find diy foods and did those for a 3 day fast this week but haven’t lost weight whereas I always do with my water fasts so I can’t say if it works for weight loss. Thanks Thomas.
In general Thomas is always talking about losing weight, but I don't think that's a goal for himself. How do you GAIN healthy weight on keto? More calories?
I agree that his goal is to make money. I heard one and half hour interview where he continually talked about the benefits of FMD, but never said what it was. I then realized, I would only learn about it after buying his program. That turned me off. This cancer issue is bringing immense profit for even the non pharma people.
I just did this. Interesting side effect, back pain. Read could be electrolyte issues. Added some in and almost all good now. Also, they just created fast bars. Would be cool to see a video on your thoughts for those. I got samples and may use them to do OMAD.
I asked Dr Berg this weeks ago on the wrong thread. I watched the videos etc of the Dr Longo. Living in LA it’s the next best thing. Thanks, I actually did my own version no change at all.
You don't have to limit all protein to limit IFG signalling, since not all amino acids are equally implicated in IGF signalling. Limiting methionine and leucine would be one way of doing so, for instance.
what should we be eating for a low cal fasting mimicking diet. is 500 cal a day is good enough or should it be more like 250 calories . pls make a vid about how should we do fasting mimicking diet in a healthy way for cancer protection
As a scientist myself, I love you and your channel Thomas and I watch your videos daily but you cannot compare yourself and your business to real scientists like Dr Longo who actually dedicate himself to curing cancer patients.
Thomas still has a degree in Biochemistry I believe and works with the Military and several businesses. He presented his theory in a very respectful and detailed way
I'm also a scientist and disagree. Long is a snake oil salesman, and not one of his videos will explain the pathways. Delauer applies scientific reasoning consistently.
One thing missing from Fat mimicking diet is the absolute rest and healing comes from not processing anything at all for several days of course that needs to be accompanied with the proper restart procedures and to re-populate to get with the good bacteria. So if you’ve been eating a lot of processed foods an actual fast might be the best way to start after going keto for a while and then maybe later on with FMD...
I kind of disagree with you about phytic acid. It turns out that beans and legumes are among the best dietary predictors of longevity. Phytic Acid gets a bad reputation as being an "anti-nutrient". However this is not a bug but rather a feature. If you want to eat a good cancer-fighting diet that supports colon health, you need to get important gut nutrients as deep in your intestinal tract as possible, and when phytic acid binds nutrients, what it is really doing is protecting these nutrients through more of the digestive process and thereby feeding our deep gut. The whole "phytic acid is bad because it is an anti-nutrient" movement is one, I think, that a lot of people will regret later.
The lectins in all forms of seem are the most important thing to eliminate if you have any auto immune / leaky gut issue. Traditionally legumes were eaten hulled and fermented so they could be better digested.
How much protein is too much and can some animal products be used i.e. butter, egg yolks, heavy cream? Are micronutrient deficiencies a concern? So many questions to unpack!
I'm a huge fan of the channel and appreciate the analysis, but I feel the tone you used when talking about Dr. Longo was a bit off...sounded sort of passive-agressive and a lil uncomfortable to watch...
Ok, here's my take. Coming from a keto background, I thought it would be interesting to try out the Prolon 5 day FMD diet. Here's what happened: The morning before starting the 'fast', my ketones were 2.9. By the end of the 1st day, my ketones plummeted to 0.1!!! Now all the blah blah about the diet putting you in ketosis wasn't looking good. Even more shocking, by the day of day 5, my ketone were 0.0. Yes zero! I have never seen this value ever. I'm very disappointed and something in these soups seriously knocked me out of ketosis. Is there any study that shows people actually achieve ketosis (before and after values) or just hypothesis? Took me days to get my values back up via keto. As far as I'm concerned, this is just a low calorie vegan diet.
I’ve done 48s ,72s and 120 hours water fast and 5 days avocado fasting. It was easier for me the water fast than the avocado. By the 4 days eating avocados I wanted to throw up.
FMD? Surely one size doesn't fit all? Would my 240 lb. cousin do the same daily calorie count as me at 130 lb.? I intermittent fast daily and only eat about 1500 calories a day split between two meals. What should my total calorie expenditure be for a day and still be fasting mimicking?
Brilliant! Imagine the market if you could convince people that they can eat while they fast if they buy your food package. Got to hand it to him, he takes a gimmick to a whole new level. Next up, you can gamble all you want and never loose money.
Thanks for unpacking the great secret! This sounds a lot like the high-fiber keto diet that Naomi Whittel proposed. Really it shouldn't be such a mysterious secret. Better take it from whole foods like the one from Naomi instead of plastic bags of highly processed powders!
U don't need to buy Dr Longo's kit. Sylvie Pajot's video(s) take the math out of the macros....she gives simple and economical shopping list plus simple 'recipes'. U be eating mainly salads and soups. I've done this fast mimicking diet for 72 hrs each time, a total of 3x. Plan on doing again real soon.
I se you recommend Ujido Green tea while fasting. But there is 5 calories in it. Does this break a fast? And also i see severel tea types in my local store with 2-4 calories in it per 100ml water. Are this safe to consume during a fast? Or would it be optimal to consume zero calories during a fast? Is it calories in all tea types? Or is herb tea perhaps calorie free? Am not doing it for the weight lose, but for all the other healt benefits
Thank you. Very informative! I would think this is great for detoxing and refresh as you say. Possibly also for losing weight, but you'd have to make sure you're not replacing the body fat you aim to metabolize during the fasting period with diet fat. In other words, if you eat too much fat, that food fat will get metabolized first and this will restrict any weight loss.
@@DashingPartyCrasher I did check insulin, which remained elevated. Didn't lose a pound and nothing euphoric. Water fasts for me, the benefits are greater faster, low insulin, clear headed and after 3 days a huge surge in energy. I have done 5 days which were tremendous but hard. My body was fine it was my mind that caved. To much $ for soup & crackers.
I don't know if you're aware of this or not, but when you;re wearing a lavaliere, such as in this video and when you go to the stores for your runs, your audio sounds decent. But when you're speaking in your kitchen across your counter, your audio is horrible. Sounds like you're in the back of a deep dark tunnel. Who ever is your audio guy, I would suggest you bring this attention to him. After all of this time, he should have caught this and corrected it.
This video is the reason I hit the unsubscribe button. You are not qualified to review this man’s work and did yourself a disservice by attempting to. Remember who you are - a celebrity trainer and health author. You are not a noble prize award nominee. Dr Longo is a Jubilee winner for his revolutionary work in his field. I have a suggestion for a future video. Please review the diets of the blue zone populations Dr Longo has worked so closely with and compare these centenarians and their diets to the keto lifestyle approach you espouse. There must be an equivalent to the blue zones for people who follow the keto lifestyle you promote, right? Oh wait… there’s not.
I've been subscribed to your channel for 2 years, and value your information and advice. The one and only thing that I HATE is when you insert random unnecessary clips of rodents. At least give a warning. But do we really need the disturbing visuals?
I'm on a 18/6 keto and have been for a month. I'm finding it easy, is this my body just adapting, do I need to mix it up, because I'm worried if I do i lose all my progress.
Yeah, even Thomas says it is good to mix it up and only do that a few days a week, for example every other day. But for me, not fasting most of the day can be a challenge, because I've gotten so used to it.
@Bill Miller thankyou you for the advice il have a look at the channel and integrate this into my plan, mine is for weight loss and longevity as I have seen massive benefits already doing it this way but if I can be way more effective il do that. 👍
I think the initial motivation for Dr Longo was to make a diet that mimicked fasting 's benefits and be easier to do for cancer patients. i.e. turn off the factors that promoted growth.
that's my understanding anyways.
Thank you for mentioning this.
That makes sense.
It might be seen as unethical for a doctor to prescribe a complete fast to a cancer patient, so this diet is a safer approach.
I read his book. It is to get the benefits of fasting without the risks of fasting. Fasting for more a day or two may involve some risk because it stresses the body. However with the fasting mimicking diet you can fast for 5 days. If it activates stemcells that sounds pretty useful as stemcells implies pure rejuvenation. The list of longevity benefits from fasting is quite long. I just saw another video where autophagy is cancer protective as well.
I have done severe caloric restriction. I have also done 5 day fasts several times, where I ate absolutely nothing and only consumed water and black unsweetened coffee. So I can compare both experiences. Once you dip below a 1000 calories, I really don't notice any difference in hunger sensation between eating those 1000 calories and not eating anything at all. So I prefer to go all in and just not eat any calories, and only consume water and black coffee. If anything, the consumption of a few calories stimulates cravings. Its best to do a fast as cold turkey, at least from my experience.
If you eat a whole food, plant based diet with low calorie density (no oils, no nuts, no avocados), 1000 calories can actually seem like more food than you would imagine.
I did an 800 calorie diet for several weeks and lost about 12 lbs. It was not the Prolon diet but I tried to eat alot of nutrient dense foods. I never felt like I was starving. I ate mostly mashed potatoes, oats, fruits and vegetables, and never felt like I was starving, just slightly hungry at times.
Totally agree
You missed the point of Longos keeping some foods in the fasting mimicking diet. These foods are highly nutritious anti-cancer and disease Foods that nourish the body during the 5-day fasting mimicking diet while still getting the benefits of a fast. On a water only extended fast you put severe stresses on your body which can be a detrimental. Longos eating plan avoids the severe stresses nourishes the body and still has the benefits of extended fasting.
@@beardumaw24 That's right. It is expecially targeted for people with pre existing conditions. I've many health problems, and when I've tried a 3 days water fast it was brutal for me. Maybe keeping a little food for a more extended period of time could be easier on my body.
@@Magnulus76 Eeew!
I think its worth pointing out that Dr. Longo was clear that the diet was (at least originally) primarily aimed at sick, including those undergoing treatment for cancer, and was developed when it was clear that many older and sick people were unable or unwilling to fast, and in some cases may be the only healthy way they can fast. His book makes clear the benefit of time restricted eating and other forms of fasting for those who are healthy. I think in interviews he has talked about the 5 day fast being roughly equivalent to a 3-4 day conventional fast. As others btl have said, all the money from the products goes to charity or research, he does not profit from it.
What are the main keys is to fast a minimum of 13 Hours A-day in that is what cell helps kill off cancer cells.
Yea… this. Tomas guy is a pretty big hater, obvious in the video lol
I think that the affects was just one of the areas they are studying. With the FMD they can have a reliable home program to give to patience instead of expensive ones where they need to be monitored. The studies of combining the FMD with cancer treatment are still ongoing.
Yes! I came to say this. He created it because cancer patients would not fast and their doctors recommended they not fast, so he went to the next best thing. If you are healthy, go ahead and do a water only fast instead of buying the FMD. Also he has said many times that he is not in any way profiting from the FMD. He does not get paid by them, and the money his stock in the company earns gets directly donated to charity. He makes nothing if you buy it. He just helped create it and he believes in it
Cuban American from Miami Florida U.S.A. saying hello 👋🦜🌴🍍 I wish everyone a beautiful week up ahead. Dont give up on your goals and dreams.
Hi from Lakeland Florida!
Dr Longo is a Doctor and he has been researching and studying autophgy in study groups for a while. You might want to read up on what he has done before he created this prolon diet. I think this might be the solution to getting regular people to want to try some form of fasting without giving up food. The science/result behind the FMD is different from Keto. So folks can have a choice to try both during different times. Also, I think the procedes form the sale is going back into research.
Yes, the profits go toward further research.
He is not a MD. He has a PHD in biochemistry,
again, Thomas is not attacking or denoting any sort of mimicking diet, he’s just explaining what it is that Dr. Longo doesn’t tell you because he’s a scientist turned a businessman. I’m sure Longo has good intentions and wants to reach the masses with his research but I think, he got greedy and went about it the wrong way to charge nearly $200 for a five day program which when you actually look at what you’re getting, you can just simply go get those ingredients at whole foods and do it yourself for less than $100. So then you can start thinking to yourself, thanks for the research long ago but I can do this cheaper
@@smachamo5150 Think about the tons of people who find going after ingredients and following a protocol on their own overwhelming. So he's shared his research and formula with you, but also makes it exceptionally convenient for people who may feel intimidated by it. To me, that covers all bases. As far as actual cost, $200 is probably about right when you consider the preparation and shipping that happens on the business side. I'd be willing to bet the margins are not that great. Nobody would get rich off that.
Dr Longo is not monetising
ua-cam.com/video/d6PyyatqJSE/v-deo.html
Apparently all the money from the FMD goes back into research. He's not profiting from this personally.
Yes, that’s right. He donates his 60% part to research. Dr Longo is a serious scientist.
@@parkesclaudiaunselfishvill5977 Yeah, that's what I heard. He puts it all back into research.
That’s only book sales. All the other media formats such as radio, podcasts, seminars, published papers are generating him a personal fortune.
@@FadGadget1 Even if all he was doing was books..I'm always leery of people saying: "Profits will be going to charity/research".
What can I say...I'm way too jaded..lol!
Could u just eat avocado for 5 days?
The fasting mimicking diet was initially developed through a grant from the National Cancer Institute for use with cancer patients (short terms fasts protect patients against the toxic effects of chemo), which is why it was designed to mimick fasting and not possibly contribute to cachexia. It was then developed commercially for use mostly targeting metabolic syndrome. Your review was weirdly not positive in spite of a mostly positive review, with unexplained disses such as "weird things going on there" related to the use of almond meal as a price point thing (actually, it's almonds, not almond meal, for the crunchy bits), and I guess viewing it as some kind of moral failure that it doesn't give one the mental resilience of a "real fast". I have several patients who failed to correct their metabolic derangement on ketosis in spite of compliance (a couple due to SNPs on FTO re: increased insulin resistance with saturated fat), and for whom water fasting was too risky due to their diabetes and prediabetic reactive hypoglycemia. They all had significant reductions in inflammatory markers after three cycles of fasting mimicking, with robust maintenance of weight loss, waist circumference and biomarkers after returning to their normal diet. While Longo has financial interest in L-Nutra, profits are turned over to foundations. I'm not sure how tomato, squash and minestrone soups are "odd combinations of soups". "His own study" is "very biased"? How's that? Are you referring to Min Wei et.al. Sci Transl Med 2017? Yes, there are foods that will stimulate autophagy but in a statistically significant way not a clinically significant one. Eating chocolate while on a regular diet - no matter how healthy - is not going to give you any meaningful autophagy. Consuming leucine will immediately stop any autophagy. There is even doubt that 16/8 IF gives humans any at all.
I didn't find this review 'strangely not positive' at all. I thought he asked questions in a polite way that were genuine. I've understood that water fasting is actually more muscle sparing (depending on the length) than chronic low caloric intake diets. I've been led to believe that chronic low calorie diets lead the body to think there's not enough food and so it catabolizes muscle whereas a water fast leads the body to spare muscle in order to catch our food. I've never heard of people increasing their insulin resistance eating a higher fat and very low carb diet myself. I figure you know what you're talking about though since you've observed it in your patients. I would say that tomato soup is an odd soup to add since it's relatively high in plant toxins and some people who are sensitive to lectins, salicylates and oxalates. It does seem like they could've left out those...
did your patients improve a1c and/or blood glucose? t1 or t2 diabetics?
I did this fast mimicking diet by Prolon (Valter Longo's firm) a few months ago and it did not convince me at all. Very expensive and the soups are so high carb that they kicked me out of ketosis all the time (and even tasted ugly!). So, I think I didn't have any autophagy at all. Also my body didn't show those great effects of rejuvination and fat loss I experienced with water fasting for two days.
Moreover is the downside: You always always think of eating: When can I eat the next small meal? Why so few today? Instead of just leaving food aside and concentrate on other things when water fasting.
U don't have to buy the kit. Sylvie Pajot's video(s0 take the math out of the macros...she provides easy to assemble 'recipes'. It basically consists of salads and, if u don't mind turning on a stove burner...soups. Using fresh foods is prolly even better for u than the dehydrated diet packets in the kit.
Yeah I’ve just checked out the nutrition/ingredients and it’s more carb and didn’t look keto - very little fat but there were olives. Didn’t fancy it.
I've done the Prolon FMD twice. The first time I actually lost a lot of weight - 190 to 178 (mostly water, I know). The 2nd time, about 3 months later, I didn't lose any weight.
Thanks for your honesty. Did your clothes fit better?
After listening to a number of Dr Longo’s seminars I’m pretty sure part of the reason he came up with the mimicking fasting diet was to help ‘pacify’ all the oncologists who do not subscribe to fasting, as a form of treatment for cancer patients who are receiving chemotherapy. He mentions them on most of his UA-cam videos.
Also majority of those cancer patients never tried fasting. They can hardly do 16/8. Let alone true water fast
The hating in this video is strong. It seems you’re more insulted he is selling products (RIGHT in between you shilling a tea, lmao), than the usefulness of his diet (which was targeted to those who can’t/won’t fast btw).
Funniest part: his product revenue goes to charity. Yours go to your pocket. And you mad, lmao
Yes, there is a lot of passive aggressive undertone that is very off putting.
My favorite part is that you unashamedly promote research and work in this field by promoting the livelihood of the researchers. Conversely, there are those who would demotivate society by forbidding people from furthering themselves or making money.
Buying a fasting box seems absurd to me.
I bought a FMD kit awhile back (company no longer around)-it was helpful and easy. There are recipes online and you can “roll your own”. FMD.
That's because it is. You don't need to buy anything to not eat 🤦♂️
I’ve been trying to understand the fasting mimicking diet better and you explained it so well in this video! 👏🏻
Smelly Bell just finished that type of fast. Use the search & he'll tell you why he did it.
Another great vid Thomas!
The thing that interests me about the FMD is that, at least in the mice trials, he healed type 1 diabetes. No promises for adults, and the mice were put through a grueling fasting regimen. But for those of us with T1D, this is incredibly interesting.
Oh I didn't realize it had the potential to correct type 1 diabetes. That would be awesome if true. Hopefully some more research can uncover something in that direction. As I understand it, T1D is a horribly dangerous disease.
I really liked this video and yes a thumb up.
I think this video is more useful than most videos I have seen about FMD.
Let me crunch this already solid and compact video in few lines:
1:51 Five day increments
2:20 On FMD you eat foods that activate less MTOR. Also foods that do not activate IGF-1 pathways.
2:35 Get the benefits of fasting without the stress on body.
3:25 Day one about 1000 kcal. For the remaining four days 725 kcal a day.
3:31 Low protein. Low carbohydrate. Moderately high fat.
4:13 You are mostly limiting the amount of protein you eat. By limiting protein you are limiting IGF signal.
4:22 Additionally, this puts you into a state of ketosis.
4:48 In essence it is a low protein keto diet for five days.
4:55 Downregulating IGF-1 also reduces glucose signaling.
5:05 This can also promote stem cell renewal.
5:35 Fasting mimicking food #1: black or green tea
A tea advertisement here
6:38 Fasting mimicking food #2 nut bars
6:40 macadamia nut butter
6:45 pulmonic acid, Omega-7 and fats
6:53 honey, why is it there?
7:00 Fructose can reduce some of the autophagic flux benefits we are after.
7:08 almond, why is it there?
7:11 phytic acid content
7:13 macadamia is already there so why add almond?
7:17 probably a profit margin thing
7:31 Fasting mimicking food #3 algal oil
7:50 Fasting mimicking food #4 soup blends
7:53 Fasting mimicking food #5 dark chocolate crisp bar
7:54 no sugar
7:56 strong autophagy driver
8:25 Autophagy doesn't just happen because you are in a calorie deprived state
8:30 There are specific foods that you can eat to trigger autophagy
8:42 chocolate and green tea are great autophagy drivers
8:50 Fasting mimicking food #6 kale crackers
8:52 low calorie keto thing
8:55 Fasting mimicking food #7 olives
8:57 good fat source
8:58 hydroxytirosol
9:00 Fasting mimicking food #8 glycerol drink
9:08 Glycerol drink is supposed to help drive up energy metabolism via glucogenesis
9:15 When you are in ketosis your body is utilizing different fuel substrates and using fats as fuel source
9:23 glycerol backbone
9:50 By consuming glycerol you are artificially triggering AMPK pathway
10:07 A low protein temporary plant-based keto diet would get a lot of results even without Volter Longo's name
10:15 In mice the fast mimicking diet has been shown to reduce cancer
10:20 Prevent bone loss, trigger neurogenesis
10:23 Activate remyelination of new neurons
10:29 Stem cell regeneration
The FMD is a good protocol with solid evidence behind it. For those unable to do a regular fast (>72hrs) it seems like a good alternative to do for 5 days once a month. For me there's no need as I don't need to mimic fasting :)
I was just researching this last night! Your video has perfect timing to add to my education on this. I have a lot of respect for Dr. Longo which is the only reason why I even considered it, but it's hella expensive (happy to hear he donated the proceeds, but still). I believe in Longo's research and recommendations, it just isn't for me - I don't think I could stop at the provided food. Glad there are good options out there for people though. Thanks for your review and breakdown of the science of this diet!
This cleanse or reset would make me miserable... So much easier to eat nothing for 18-20 hours for me
At the end of fast mimicking for 5 days, you literally feel like a new person. It's hard, but it's insane!!
yea..i agree. i feel like i would rather just grit my teeth & stick to the full fasting👌🏼
Wow, these comments are incredible. Makes me want to look into Dr. Longo!
I've had pretty good results the past month "fasting" two days a week, taking in no more than 350 calories each day and low intensity cardio. Not really going for the fasting though, as much as I am the large calorie deficit.
I’m currently on day 14 of a 21 day water fast. I’ve been following Dr. Kongo for a while but I just found out about the fasting mimicking diet recently and it sounds interesting and worth a try. After referring I plan on trying this diet along with intermittent fasting to see how it makes me feel because people have been getting good results from it. Fasting will always my 1st option but it’s good to try other things too.
You’re a great teacher. Thank you for giving clear explanations.
I like when fitness and health experts respect eachother like this. Good review
I learnt about fasting mimicking diet from a polish doctor Ewa Dabrowska. Years or research and experience. Unfortunately not many publications are translated to English but her work is amazing
No! He uses the money to fund his research organization! So it is only indirectly supporting him.
Even better! Heck yes!
He also says that fasting alone is not as good as his fmd, which sounds like marketing angle to me, he says he found fasting alone didnt provide the benefits as fmd.
Thank you giving a short and concise explanation. This is great.
I'm actually reading Dr. Valter Longo's book, The Longevity Diet, right now. So you had perfect timing TD! I think it would be a home-run if you and Dr. Gundry did a podcast video. Hit him up! You both seem to be on the cutting edge of health related matters.
Did a three day fast and I followed it up with 800 cal of protein and sauerkraut and half an avocado and I’m losing weight while I’m having my protein
I don't like that diet as it is low protein, instead you eat more carbs. The risk is: you may be losing muscle when you are on low protein for 5 days per week.
Dr. Valuer Longo and a whole team of researchers studied fmd for about 20 years before launching the product. Not sure you can beat that's
So for anyone who wanted some direct feedback on this. I did a keto diet about 2 years ago. I tracked my weight everyday and in 90 days I lost 41 pounds.
Now I've put a little weight back on do I decided to do keto again this week. I peed on a keto strip, nothing. I did thr fasting mimicking diet for one day. Today I pee on the strip, it's deeeeep purple. One day! Holy crap.
I can tell I'm in keto because yet again I went from cravings day one to no appetite day 2.
This was very helpful/informative...thank you 👍
You could've given example of the products, brands you were explaining along.
Wouldn't a better fast mimic be the protein sparing modified fast? It isn't a true fast and doesn't do what this diet does but it helps.
Depends on your goals. Reducing protein in a fast mimicking diet can promote autophagy and reboot stem cells, boosting the immune system. A protein sparing modified fast does not turn off mTOR; it likely increases it to spare muscle while the body is put into a self-fat burning mode. This wouldn't reset the immune system in the same way or promote the same pathways. There are so many variations of fasting all geared toward meeting different goals.
Thanks for the Ujido Thomas. Good find.
I know this is an older video but going to say it anyway. Your awesome, thanks man.
Greetings from Egypt 🇪🇬 ❤️
This diet is for those who can't do a water fast. I think it is actually harder because you will experience hunger and be focused on eating the next mini meal. The kits are very expensive; I heard over $200. I'll stick with water fasting. Some people are on meds and can't take them on an empty stomach. Others can't water fast for whatever reasons. For those, this diet is a life saver
for some patients perhaps. For me, having no diseases, I cannot limit myself: either I eat, or I fast! But perhaps, for a pre-fasting. Dr Désiré Mérien, who is now over 85, recommends a "food descent" before fasting. Then this would be a good option. None of the fabulous books written by this French doctor, who has guided over 30,000 fasters, has been translated into English.
1 000 calorays / 5 days
▪︎cup a chilli wit *beyond* burga meat ,/ day
Minicang is a tweena between IF & 7 day fastang
AKA * portion control*
Could you use bone broth in place of the soups in the package?
Don't think so. Need to stay away from any animal products or will kick out of autophagy
@@m.e.myselfandi5120 Thanks!
Ive been fasting-mostly ADF-with carnivore eating for 14 weeks; lost 50 pounds. Recently did a 5 day water fast but did have to eat lettuce on day 4. All this to say I was skeptical of the FMD for the reasons Thomas outlines; I’d never eat those foods in the Prolon package. I did find diy foods and did those for a 3 day fast this week but haven’t lost weight whereas I always do with my water fasts so I can’t say if it works for weight loss. Thanks Thomas.
Should you continue working out during the FMD?
@Bill Miller thanks Bill, I most likely won’t during that 5 day fast because I won’t have the energy. I’ll probably just go for walks.
In general Thomas is always talking about losing weight, but I don't think that's a goal for himself. How do you GAIN healthy weight on keto? More calories?
I agree that his goal is to make money. I heard one and half hour interview where he continually talked about the benefits of FMD, but never said what it was. I then realized, I would only learn about it after buying his program. That turned me off. This cancer issue is bringing immense profit for even the non pharma people.
Can ginsang without a diet or fasting help?
I just did this. Interesting side effect, back pain. Read could be electrolyte issues. Added some in and almost all good now. Also, they just created fast bars. Would be cool to see a video on your thoughts for those. I got samples and may use them to do OMAD.
Going to give this a go, love keto feel amazing really won't to notch it up a level.
I asked Dr Berg this weeks ago on the wrong thread. I watched the videos etc of the Dr Longo. Living in LA it’s the next best thing. Thanks, I actually did my own version no change at all.
You don't have to limit all protein to limit IFG signalling, since not all amino acids are equally implicated in IGF signalling. Limiting methionine and leucine would be one way of doing so, for instance.
Why every time I watch one of his videos I have to break out a thesaurus 😂😂😂
what should we be eating for a low cal fasting mimicking diet. is 500 cal a day is good enough or should it be more like 250 calories . pls make a vid about how should we do fasting mimicking diet in a healthy way for cancer protection
Dr. Longo has mentioned 800-1100 calories in a few podcasts I’ve watched.
As a scientist myself, I love you and your channel Thomas and I watch your videos daily but you cannot compare yourself and your business to real scientists like Dr Longo who actually dedicate himself to curing cancer patients.
indeed i have lost a lot of respect for thomas after watching this video
Thomas still has a degree in Biochemistry I believe and works with the Military and several businesses. He presented his theory in a very respectful and detailed way
Dr Longo is not monetising this diet
ua-cam.com/video/d6PyyatqJSE/v-deo.html
What am I missing?
Is this whole video a lie?
I'm also a scientist and disagree. Long is a snake oil salesman, and not one of his videos will explain the pathways. Delauer applies scientific reasoning consistently.
One thing missing from Fat mimicking diet is the absolute rest and healing comes from not processing anything at all for several days of course that needs to be accompanied with the proper restart procedures and to re-populate to get with the good bacteria. So if you’ve been eating a lot of processed foods an actual fast might be the best way to start after going keto for a while and then maybe later on with FMD...
10:35 He is not the only one that has done research on FMD. There are many human clinical trials.
Ill just stick to a 5 day fast with some dead lifts until someone comes up with a pill.
I kind of disagree with you about phytic acid. It turns out that beans and legumes are among the best dietary predictors of longevity. Phytic Acid gets a bad reputation as being an "anti-nutrient". However this is not a bug but rather a feature. If you want to eat a good cancer-fighting diet that supports colon health, you need to get important gut nutrients as deep in your intestinal tract as possible, and when phytic acid binds nutrients, what it is really doing is protecting these nutrients through more of the digestive process and thereby feeding our deep gut.
The whole "phytic acid is bad because it is an anti-nutrient" movement is one, I think, that a lot of people will regret later.
The lectins in all forms of seem are the most important thing to eliminate if you have any auto immune / leaky gut issue.
Traditionally legumes were eaten hulled and fermented so they could be better digested.
If you're eating... you're not fasting.
This is just a fancy caloric restriction.
Shout out fr Jamaica
could/would this be effective to do every other day instead of almost a whole week straight?
There are plenty of carbs in those meals. It is NOT low carb.
@fab He literally said it is low carb, try again
@fab derrrrrp everyone knows that. I'm replying to what the guy says in the video
How much protein is too much and can some animal products be used i.e. butter, egg yolks, heavy cream? Are micronutrient deficiencies a concern? So many questions to unpack!
I'm a huge fan of the channel and appreciate the analysis, but I feel the tone you used when talking about Dr. Longo was a bit off...sounded sort of passive-agressive and a lil uncomfortable to watch...
Ok, here's my take. Coming from a keto background, I thought it would be interesting to try out the Prolon 5 day FMD diet. Here's what happened: The morning before starting the 'fast', my ketones were 2.9. By the end of the 1st day, my ketones plummeted to 0.1!!! Now all the blah blah about the diet putting you in ketosis wasn't looking good. Even more shocking, by the day of day 5, my ketone were 0.0. Yes zero! I have never seen this value ever. I'm very disappointed and something in these soups seriously knocked me out of ketosis. Is there any study that shows people actually achieve ketosis (before and after values) or just hypothesis? Took me days to get my values back up via keto. As far as I'm concerned, this is just a low calorie vegan diet.
What about using black coffee ?
Send me the link for the tea please
Excellent
I’ve done 48s ,72s and 120 hours water fast and 5 days avocado fasting. It was easier for me the water fast than the avocado. By the 4 days eating avocados I wanted to throw up.
How to get this diet/product?
Longo doesn't profit from it.
But what if the thyroid is affected???
Thank you, we really appreciate this😁👍
FMD? Surely one size doesn't fit all? Would my 240 lb. cousin do the same daily calorie count as me at 130 lb.? I intermittent fast daily and only eat about 1500 calories a day split between two meals. What should my total calorie expenditure be for a day and still be fasting mimicking?
Brilliant! Imagine the market if you could convince people that they can eat while they fast if they buy your food package. Got to hand it to him, he takes a gimmick to a whole new level. Next up, you can gamble all you want and never loose money.
Thanks for unpacking the great secret! This sounds a lot like the high-fiber keto diet that Naomi Whittel proposed. Really it shouldn't be such a mysterious secret. Better take it from whole foods like the one from Naomi instead of plastic bags of highly processed powders!
Sounds like the Atkins Diet.
YOURE LISTENING TO ME. JUST TALKED ABOUT THIS TO MY FRIENDS WTFFFFF
S u p e r. Genious Mr DeLauer💕
With all due respect WHY do you use that camera if you aren't going to be looking into it? It is beyond annoying. Love the channel.
U don't need to buy Dr Longo's kit. Sylvie Pajot's video(s) take the math out of the macros....she gives simple and economical shopping list plus simple 'recipes'. U be eating mainly salads and soups. I've done this fast mimicking diet for 72 hrs each time, a total of 3x. Plan on doing again real soon.
I se you recommend Ujido Green tea while fasting. But there is 5 calories in it. Does this break a fast? And also i see severel tea types in my local store with 2-4 calories in it per 100ml water. Are this safe to consume during a fast? Or would it be optimal to consume zero calories during a fast? Is it calories in all tea types? Or is herb tea perhaps calorie free? Am not doing it for the weight lose, but for all the other healt benefits
Would this be an unprocessed version of the Optavia diet/Medifast?
Completely different. The fasting mimicking diet is very low protein which is necessary to inhibit the mTOR pathway. Medifast is very high protein.
Thank you. Very informative! I would think this is great for detoxing and refresh as you say. Possibly also for losing weight, but you'd have to make sure you're not replacing the body fat you aim to metabolize during the fasting period with diet fat. In other words, if you eat too much fat, that food fat will get metabolized first and this will restrict any weight loss.
Another brilhant analysis 👌👏😎👍
Did nothing for me! Over priced. I did like the food and still buy the fast bars. 3 day water fasts are the greatest IMO.
Good to know. How did you know it did nothing for you -- were you checking your insulin levels, or measuring other things?
@@DashingPartyCrasher I did check insulin, which remained elevated. Didn't lose a pound and nothing euphoric. Water fasts for me, the benefits are greater faster, low insulin, clear headed and after 3 days a huge surge in energy. I have done 5 days which were tremendous but hard. My body was fine it was my mind that caved. To much $ for soup & crackers.
I don't know if you're aware of this or not, but when you;re wearing a lavaliere, such as in this video and when you go to the stores for your runs, your audio sounds decent. But when you're speaking in your kitchen across your counter, your audio is horrible. Sounds like you're in the back of a deep dark tunnel. Who ever is your audio guy, I would suggest you bring this attention to him. After all of this time, he should have caught this and corrected it.
he is cool but plz dumb down give us example food plans plz
No
This video is the reason I hit the unsubscribe button. You are not qualified to review this man’s work and did yourself a disservice by attempting to. Remember who you are - a celebrity trainer and health author. You are not a noble prize award nominee. Dr Longo is a Jubilee winner for his revolutionary work in his field. I have a suggestion for a future video. Please review the diets of the blue zone populations Dr Longo has worked so closely with and compare these centenarians and their diets to the keto lifestyle approach you espouse. There must be an equivalent to the blue zones for people who follow the keto lifestyle you promote, right? Oh wait… there’s not.
I've been subscribed to your channel for 2 years, and value your information and advice. The one and only thing that I HATE is when you insert random unnecessary clips of rodents. At least give a warning. But do we really need the disturbing visuals?
I'm on a 18/6 keto and have been for a month. I'm finding it easy, is this my body just adapting, do I need to mix it up, because I'm worried if I do i lose all my progress.
Yeah, even Thomas says it is good to mix it up and only do that a few days a week, for example every other day. But for me, not fasting most of the day can be a challenge, because I've gotten so used to it.
@Bill Miller I like what I'm doing now, so say if I add carbs at the end of the week would that be OK, and would around 100g of carbs be OK.
@Bill Miller thankyou you for the advice il have a look at the channel and integrate this into my plan, mine is for weight loss and longevity as I have seen massive benefits already doing it this way but if I can be way more effective il do that. 👍
Is a fat fast a type of FMD?
I think it is if you make sure to keep the calories in check.
#PrayForAmerica
Always thought it was pretty crazy how much he charges for a few thousand calories and something you could easily replicate yourself.
If you're eating you're not fasting 😍😍😍😍
Why bother mimic the fast? Just go all in and do the fast how it's intended.