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Sir can you please tell if the indentine that we learned in neuro muscular junction and t tubules are same I am confused as here we are also talking about muscles
great explanation sir.i can't find anything here in video which annoy me.because i have seen alot of videos on this topic and watching every video i was like WTH.because they were not clearing my concepts.thanq.
Sir, kindly explain what "nearest neighbour effect" is....found it while going through excitation contraction coupling mechanism in Braunwald... Haven't understood it.
It is not related to EC coupling; it's related to the myofilaments in the sarcomere. Basically, the thin and thick filaments are close by in the sarcomere. Their components have been described as the "neighbours". For instance, myosin cross-bridges. One myosin cross bridge has the neighbouring cross bridges. And the activity of a cross-bridge, and its contribution in tension generation, is said to depend on the status of its "nearest neighbouring" cross bridges. There is said to be a positive co-operativity among these nearest neighbouring units, in the process of contraction. This has also been studied on the troponin-tropomyosin complexes that regulate the 'active sites' on the thin filaments. I think, it will require another short video, with diagrammatic visuals, to explain it in further details.
Sarcoplasmic reticulum is the system of tubule networks. T-tubules are membrane extensions. L-tubules are placed longitudinally, and are considered to be a part of this network.
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i have never understood this thing in physiology since my first year thank u sir for making this video!!!!!!!!!
Thnq for such a nyc xplaination sir
Wonderful
Very well explained sir🙏🙏
Amazing
Thx!
Sir can you please tell if the indentine that we learned in neuro muscular junction and t tubules are same I am confused as here we are also talking about muscles
Thanks a lot sir .....sir please tell me how should i study m a student of MD Physiology ...
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Thanks lot sir
great explanation sir.i can't find anything here in video which annoy me.because i have seen alot of videos on this topic and watching every video i was like WTH.because they were not clearing my concepts.thanq.
Sir, kindly explain what "nearest neighbour effect" is....found it while going through excitation contraction coupling mechanism in Braunwald... Haven't understood it.
It is not related to EC coupling; it's related to the myofilaments in the sarcomere. Basically, the thin and thick filaments are close by in the sarcomere. Their components have been described as the "neighbours". For instance, myosin cross-bridges. One myosin cross bridge has the neighbouring cross bridges. And the activity of a cross-bridge, and its contribution in tension generation, is said to depend on the status of its "nearest neighbouring" cross bridges. There is said to be a positive co-operativity among these nearest neighbouring units, in the process of contraction. This has also been studied on the troponin-tropomyosin complexes that regulate the 'active sites' on the thin filaments.
I think, it will require another short video, with diagrammatic visuals, to explain it in further details.
Kindly explain this with a video and also explain the mechanism of arterial pulse plus mechanism of generation of different waves.
Thank you sir 😀
Sir how do these dhpr n ryr interact?
It's a mechanical interaction.
Sir splendid lecture...clear ECC
Thnk u so.much sir...
Sir make more vdos...Ur vdos are very helpful
Rajitha Sirigiri Sure. Already there are a few topics suggested by students. I shall record and upload them one by one.
Thanks,
Regards,
Thank you so so much sir 🙌🙌🙌🙏🙏🙏
Is L- tubule a part of sarcoplasmic reticulum ?
Sarcoplasmic reticulum is the system of tubule networks. T-tubules are membrane extensions.
L-tubules are placed longitudinally, and are considered to be a part of this network.
@@VivekSirsPhysiology
Sir
RYR is present on L tubule or sarcoplasmic reticulum
What we can say?
RyR is present in the membrane of T-tubule, which is very much a part of the sarcoplasmic reticulum.
@@VivekSirsPhysiology Thank you sir