Addison's Disease, Causes, Signs and Symptoms, Diagnosis and Treatment.
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- Опубліковано 31 тра 2024
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Chapters
0:00 Introduction
1:10 Causes of Addison's disease
3:09 Symptoms of Addison's disease
4:08 Diagnosis of Addison's disease
4:13 Treatment of Addison's disease
Addison's disease, also known as primary adrenal insufficiency,[4] is a rare long-term endocrine disorder characterized by inadequate production of the steroid hormones cortisol and aldosterone by the two outer layers of the cells of the adrenal glands (adrenal cortex), causing adrenal insufficiency.[5] Symptoms generally come on slowly and insidiously and may include abdominal pain and gastrointestinal abnormalities, weakness, and weight loss.[1] Darkening of the skin in certain areas may also occur.[1] Under certain circumstances, an adrenal crisis may occur with low blood pressure, vomiting, lower back pain, and loss of consciousness.[1] Mood changes may also occur. Rapid onset of symptoms indicates acute adrenal failure which is a serious and emergent condition.[5] An adrenal crisis can be triggered by stress, such as from an injury, surgery, or infection.[1]
Addison's disease arises from problems with the adrenal gland such that not enough of the steroid hormone cortisol and possibly aldosterone are produced.[1] In developed countries, the etiology of Addison's disease is often attributed to idiopathic damage by the body's own immune system, and in developing countries most often due to tuberculosis.[6][needs update] Other causes include certain medications, sepsis, and bleeding into both adrenal glands.[1][6] Secondary adrenal insufficiency is caused by not enough adrenocorticotropic hormone (ACTH) (produced by the pituitary gland) or corticotropin-releasing hormone (CRH) (produced by the hypothalamus).[1] Despite this distinction, adrenal crises can happen in all forms of adrenal insufficiency.[1] Addison's disease is generally diagnosed by blood tests, urine tests, and medical imaging.[1]
Addison's disease can be described in association with chronic mucocutaneous candidiasis, acquired hypoparathyroidism, diabetes mellitus, pernicious anemia, hypogonadism, chronic and active hepatitis, malabsorption, immunoglobulin abnormalities, alopecia, vitiligo, spontaneous myxedema, Graves' disease, and chronic lymphocytic thyroiditis.[7]
Treatment involves replacing the absent hormones.[1] This involves taking a synthetic corticosteroid, such as hydrocortisone or fludrocortisone.[1][2] These medications are usually taken by mouth.[1] Lifelong, continuous steroid replacement therapy is required, with regular follow-up treatment and monitoring for other health problems.[8] A high-salt diet may also be useful in some people.[1] If symptoms worsen, an injection of corticosteroid is recommended and people should carry a dose with them.[1] Often, large amounts of intravenous fluids with the sugar dextrose are also required.[1] Without treatment, an adrenal crisis can result in death.[1]
Addison's disease affects about 0.9 to 1.4 per 10,000 people in the developed world.[1][3] It occurs most frequently in middle-aged females.[1] Secondary adrenal insufficiency is more prevalent.[3] Long-term outcomes with treatment are typically favorable.[9] It is named after Thomas Addison, a graduate of the University of Edinburgh Medical School, who first described the condition in 1855.[10] The adjective "addisonian" is used to describe features of the condition, as well as people with Addison's disease.[11]
Nice and i love every video you create
Good day
Are there any other things that can couse this ? I had "Addisons" about 4 to 5 months after I gave birth to my firstborn. They did al kind of tests in the hospital(atch, mri, echo) But they never found what the couse was.
After 4 years I got pregnant again, gave birth and after a year or so, still taking medication, I got the feeling of "things" following me around, drove me crazy. Went for a check up, cortisol to high. Had to slowly stop taking my medicine,never took them again except when feeling a bit week. Still have the medicine but haven't taking them in years.
Never got an explanation on what coused it. Because they could not find anything that could be the cause.
Had headache's, verry sore body, realy tired and a lot of weightloss.
I had my A1C tested because i had dark cresses on my neck or i would have never known
i dont know if i have it because over a year i have weak legs and tremors, when i got emotional my body goes weaker and dont react like it was before, i feel like my emotions are wrong, i did t4 , brain scan, lumbar spine scan everything was ok
PLEASE go to an endocrinologist. You tell them what you're concerned about and don't let them medical gaslight you. I'm 43 and have been suffering for YEARS. My psychiatrist told me she couldn't think of anything else that I could have. All my blood work came back "normal" they just weren't testing for the right thing. It's fatal if not diagnosed and treated. I gained weight, then I had no appetite and lost a ton of weight. Also I started wiping my skin and it looked like a spray tan, also I had brown spots as well as vitiligo. I'm 43 and have suffered since I was a child.
Also my salt was low but my potassium was normal so you don't have to have all of the symptoms but what you're describing to me is how I started out years ago and I could barely get out of bed when I was in an addisonian crisis. I was throwing up I felt like I was going crazy and doctors literally told me it was anxiety and depression. I had 10 different diagnoses prior to getting my Addison's diagnosis😢 I kid you not it felt like I was dying.
@@Libby-Bambi25Same here
@@Libby-Bambi25what test did you did ?? I will do a saliva test soon .
@@organicfireorganicfire1236
ACTH, sodium and potassium. Although my potassium has ALWAYS been extremely low, 4.5 is considered in the normal range. anything 5 and above is high so... For me 4.5 is extremely high and my sodium was 130.
Anyone have high pottasium level?..
it's a sign along with low sodium
Yes
Yes...4.6. Just tested positive for Addison's Disease in the hospital.
@@territn8871 what other symptoms did you have? I was tested and I was 4.8 but my sodium was normal. I have hypoglycemia (2-3 days a week), ataxia, decreased coordination, fatigue, memory issues, loss/gain weight easily, dark skin around my nail beds, and more…. They are testing for everything else but no one mentioned Addison. I was even hospitalized for extreme disorientation- I couldn’t remember how to drive home, dehydration, and hypoglycemia
Wadhia
I pray to god i don't have this disease 🙏🥲
I have this disease still I thank Jesus lord ✝️🙏
@@amitkumarjal9167 are you Christian??
@@Ali1u585 Yes brother
@@amitkumarjal9167 i hope you recover amen ✝️
@@Ali1u585 Amen Jesus loves you brother ❤️✝️
Isn't this pretty much just a rebranding of AIDs?
@@RachelTaylor-pt7hp Hyperbole.
@@MarxIsDeadAndRotting - you're a troll, why don't you do a bit of reading & educate yourself before saying this is "just a rebranding of AIDs" & "Hyperbole" such hogwash comments!!