Metabolism | Electron Transport Chain: DETAILED | Part 1
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- Опубліковано 28 тра 2017
- Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
In this lecture Professor Zach Murphy will present on part 1 of this three part series on the Electron Transport Chain (ETC). This will be a detailed discussion on the ETC and the regulatory steps used throughout this process. We hope you enjoy this lecture and be sure to support us below!
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4 years ago, and medical students up until today are still surviving with this. We can't thank you enough sir
Honestly
2024 and stillll
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And the Teacher of the decade award goes to...
century*
History*
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🎯 Key Takeaways for quick navigation:
00:17 🧬 *The electron transport chain occurs in the inner mitochondrial membrane, specifically in the folded structures called cristae.*
01:40 🔄 *The process starts with glycolysis, converting glucose to pyruvate, and further to acetyl coenzyme A, generating NADH and FADH2 in the Krebs cycle.*
04:53 ⚡ *NADH and FADH2, carrying high-energy electrons, enter the electron transport chain, starting with NADH being oxidized to NAD+.*
06:57 🔄 *Coenzyme Q (Q) receives electrons from NADH and is reduced to QH2, then passes electrons to complex 3 (cytochrome B) in the chain.*
10:57 ⚙️ *Complex 1 (NADH dehydrogenase) and Complex 2 (Succinate dehydrogenase) pass electrons down the chain, with Complex 1 pumping protons into the intermembrane space.*
14:03 🔄 *QH2 passes electrons to cytochrome B, pumping more protons, and then hands off electrons to cytochrome C, continuing the chain.*
18:07 🔗 *Cytochrome C transfers electrons to cytochrome oxidase (Complex 4), leading to the final step where oxygen is involved, forming water.*
22:46 🌬️ *Oxygen is the final electron acceptor in the electron transport chain, forming water when combined with electrons and protons.*
23:40 ⚡ *Energy released during electron transfer at complex 4 is used to pump protons across the inner mitochondrial membrane.*
27:34 🔄 *Protons are pumped out at Complex 1, Complex 3, and Complex 4, contributing to a higher proton concentration in the intermembrane space than the mitochondrial matrix.*
28:30 📊 *Proton concentration gradient across the inner mitochondrial membrane establishes a concentration gradient, a crucial aspect in ATP synthesis.*
28:57 🔄 *NADH produced in glycolysis needs a specific mechanism to enter mitochondria for electron transport, a topic to be covered in the next video.*
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Thank you so much! Please spread the word about this channel. We really appreciate your support 👍
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*God !*
Wow
I have to say, it took me some time to realize that the NADH gives one proton to FMN, but i was confused as to why it was FMNH2 and not FMNH since it's getting one proton and 2 electrons from NADH. And in the video he doesn't explain where he got the second proton from. I finally understood that the NADH actually combines with a proton from the matrix which has an abundance of protons. So it's NADH + H+ to FMN = FMNH2.
yes NADH, H
nice thanks for this :>
Thanks, this had me confused for a minute, too!
if so, where the proton that is being pumped out comes from:(? if we pass to protons on fmn
@@gosiascios6720 Hydronium ions in the mitochondrial matrix will give up their H+ proton, complex II also generates additional H+ protons which the other three will pump :)
BORN TO TEACH. PERIOD. Thank you a lot Sir, I nearly quit the understanding of ETC but you've made this topic the easiest one you could ever get. GOD will richly bless you.😍😍🥰
You´re saving my academic life at this point
You know it's hella information when the ninja nerd needs a part 2 and 3...God save us all😂😂😂
كل الكلام والوصف قليل بحقك حرفيا اعجز عن وصفك شكرا من القلب 🙏🤍
في الدقيقة 8:46 لماذا FMN اصبح FMNH2 على الرغم من انه اخذ الهيدروجين من NADH و ليس NADH2
I'm blown away by your explanation sir. I have urge to show this to my biochem teacher and scream she needs to explain it like this instead of just using smart board in the classroom. I swear you explain so clearly and you enjoy it too. I loved it sir, tha kyiu so much 😭❤🔥
If you can teach all this stuff so well and so elegantly, and that too almost in no time, I can only imagine how much effort you put in to this! Thank you a lot! ❤️
You helped me with Immunology and now Biochemistry, my god what would I be without your videos...I always draw with you and now I can even explain the things myself! You are the best teacher and I will be thankfull forever...telling all my friends you exist
interesting that u are taking immunology before biochemistry haha
@@zzoldd I just like Immunology more than Biochem so I took the exam later :)
@@zzoldd I’m taking both at the same time bruhh
I studying this for 3 years just for exam amd forgot it and read it again ..... Now I underdstood at peak level I wish that should have more viewers.... !!!!!!
The best explanations ever seen on ETC
"Okay, I'll take the potato"
- Oxygen, 2017
Your videos have gotten me through my last undergrad semester between animal physiology and biochem. Literally thank you so much
the best thing about your teaching is that it seems like 'the things were meant to happen that way', so easy explaination....I tell all of my friends to subscribe ur channel....thank u....Love from India
You are a GPA saver ...u saved me ....6 hours more to write my midsem ...thank you. ..I wish my biochemistry teacher was like u😢😢😢😢
Thank you for uploading and creating such beautiful content! I'm so amazed and glad to find your channel.
You are awesome. No one teaches biochemistry like that. Kudos! Keep going ahead👍.Thanks for sharing your knowledge. You deserve all the praise and glory.
You make it look simple!! You got a talent man! Thank you and the team !!
Thank you again, for wonderful, crystal clear and easy explanation. You are the best!
You're officially me hero. Thanks for being a fantastic and fun teacher. If anyone can get me through grad school, it's YOU!
This man here saved my whole life we literally need this in almost every module in med school!!! Thank you🙏🙏
I have no idea how you don't have more views on your channel! Your videos are amazing and extremely helpful!
Literally a life saver . If all lecturers taught like you medschool would be a 100 times easier,
6 years later and you’re still saving the world. Truly not all superheroes wear capes. Some set up a UA-cam channel and teach millions of students biochemistry . Thank you ❤❤❤❤
Literally carrying me through Biochemistry... bless you good sir
Most of the profs in my uni cannot teach. Thank you for your videos. They are so helpful!
You make them ridiculously simple. thanks for your time and effort
i'm preppin for my licensure exam and I'm reviewing thru these videos. very detailed and very easy to understand. thank you!
i regret only coming across your channel this year. your channel would have helped me had a solid foundation of different pathways before id gone off to college. happy that i found u now tho great work!
I've watched countless videos and no one comes close to explaining the ETC as well as you do. Once I get those stacks, I will be sure to donate to your channel.
"O.K. I'll take the potato" That gave me the laugh I needed right about now Haha!
Extremely well explicated, great job!
You've got yourself a new subscriber. This is great man, thanks!
I liked it before even watching it 😂
as someone with adhd who finds it hard to concentrate in 2 hours lectures, i can't thank you enough for your incredibly well-made videos. you're helping so many future doctors, thank you Sir!
Best biochem videos on The internet! Thank you so much
we looooovvvvvve you man, I'm a medical student and can't imagine my second and third year how terrible they would be without you guys
Weirdly, this is the beeeeeeeeeeeeest teacher ever!! He knows how to transfer the information!!! We can't thank you enough sir
👏👏👏 thanks man. Your working so hard for us
Finally got this concept. Thanks man you're a legend👏🏻
you are a pure talent, thanks for your great efforts bro
You're the GOAT! Getting me thru med school biochem thanks so much man :)
Your videos are phenomenal --> saving my uni biochemistry grades! Thank you!
I am dentistry student and I was not able to understand this subject but thanks to you I understood very well THANK YOU SO MUCH
I have a degree in biochemistry from UC Berkeley. This is one of the best descriptions and elaborations of the ETC (OxPhos) I have ever seen. Kudos to you. And ... it shows NADH (and FAD) not NAD+ are critical. Also show the need for Fe (Iron).
Thank you so much for the explanation. But I'm wondering where does the energy released from complex II go? Is it just dissipated as heat and lost to the surroundings? Or is there any physiological significance in this?
i cannot believe how AMAZING your videos are
I AM REALLY ENJOYING TO LEARN ,and the way you teach is superb ...u rock the ninja nerds
You are really great
I didnt even understand when my teacher teaches
Thanks to you i will get good scores in metabolism
awsome lecture!!!!!!!!! never stop please
Very nice analysis sir
GOD BLESS YOU
YOU GOT ME THE MOMENT I SAW YOUR VISUAL DRAWINGS! IM OFFICIALLY PART OF YOUR STUDENT NOW!!.. Haha
you are amazing, I understand everything now
Man you are a lifesaver!
15:07 whenever I hear complex names..
thanks for the great explanation !
wowwwwwww...amazing
js luv the way u explain everything .soo helpful👌👌👌
professor turn-ons: black markers ....
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but man srsly...you a lifesaver..i just love your style so much.
I have been watching your videos and their very very helpful to me in particular. You're doing a very good job, keep it up.
But I want to ask a question, how many moles of ATP can be generated from one molecule of maltose?
Thank you, I'll pass throught directly to second video.
Thanks sir, as always it is so useful.
Great educational content. Thank you!.
You are so great
Actually you are the best ever , you make it so easy for me
Very well, its amazing explanation.
But the textbooks are more complicated.
At complex 1, FMNH2 pass electrons to Fe-S clusters then to CoQ.
Complex 3 has Q cycle mechanism to passes electrons, then at complex 4 electrons-> CuA -> heme a -> heme a3 -> CuB -> O2 and water molecule formed
What an amazing complicated proccess
Absolutely amazing thank you sir
The comments here are years ago but the videos are still helpful till date. Thank you Murphy
very helpful channel.
Thank you for the best explanation
I literally love this human
u r ma professor
for my hole semeter.
thank u sooooo much .
I watched all the videos.
Wow this video was amazing! I’m actually so excited after watching it! I’m looking forward to starting Med school this September! (In 32 days 1st learning session)! Love from 🇬🇧 ! I’m heading to part 2 of this vid!!!
brooo please enjoy you last summer dont think about this
Your video is helpful as usual
Just one problem complex II isn't supposed to have FMN as a component and it's not the reverse of krebs cycle reaction. It's the same and CoQ take the hydrogen directly from FADH2 it's mentioned like this in our book and in lippincott's too.
I’ve been interested in biochemistry since I watched your videos 😍😍☺️
A LIVING LEGEND THANKYOU SIR
your a genius i watch all your UA-cam videos you should put an interview up. Explaining your resume' for your teaching professional career.
Thanks a lot for such great videos.... I would like to request u to upload videos on bioenergetics and biological oxidation it would really helps me a lot
Thnks lecturer understood very well
Is there a way to watch these videos in order from the beginning , in order to build upon knowledge? Thank you very much.
Thank you for making student life easier 🙏
Thank u for having u in our life
Professor Zarch, Thank you so much
This is the next level
Thank you!! :D
This guy is the grown ben from never I have ever 💜💜best teacher ever
you are the best i love your teaching
I cant understand why this channel has so less views...There are so many fucking videos in you tube with no proper explanations...This video deserves a million views.....
Thank you 🙏🏻🙏🏻🙏🏻
Amazing!
you're amazing ZACH!!!!!
hi does it have 2 Q complexes or does Q drop off electrons from one to III then comes back for the electrons from II ?
Thank you so much, you are the best mann❤
great. continue. best wishes
Great lecture! One question: What happens to the protons from FADH2 after they are picked up by FMN in complex 2?
This is only my own guess.. I think the protons might stay in the matrix, to maybe control the concentrations of protons in matrix and in intermembrane space.
Bravo👏👏 had given up on the etc buh💃💃no explanation is better than this
Thank you so much ☝️ from India SPECIFICALLY 😁😄
Thanks so much!!
Thanks sir, may god help you in everything
thank you
Great Great explanation