💘 Big thanks again to all channel supporters and followers! Let me know any feedback and recommendations for future videos. www.patreon.com/totalsynthesis; instagram.com/totalsynthesis_official/
This ligand looks way too small and „simple“ to be selective / without side effects🙈 If you continue to cover novel drug classes, I would love to see an in-depth video on psychoplastogens and the work by David E. Olson.
The audio level on the video is about 10 dB lower than what it should be. I had to turn up my volume quite a lot. Not a huge deal, but should be easy enough to correct in the future.
Whew, thanks for letting me know it was ok to slow down and try and digest all this info. I have a good background in Chemistry but your explanations become hypnotic sometimes by how much info you pack into each step.
I can understand - given the video format and the different level of experience of viewers, I rather pack too much than overexplain everything (else videos get too long and boring)
The possibility of exercise-mimetics that increase overall fitness by just taking a pill is incredibly exciting. Also, this made me think of the Ecdysteroids which have been found to increase strength through ERβ. Really makes you think about the important role of estrogen in strength, muscle growth and endurance. :P
When you mentioned that it can also lead to muscle loss and loss of bone density it immediately made me think of my Grave's disease which destroyed my body (went from 175lbs to 120lbs) for a year and a half, and it did the exact same thing to me (all while torturing me). I lost what fat I did have, a LOT of muscle mass (especially upper body muscles like biceps/triceps, chest, core, and back muscles, which I still need to work to recover) and lost bone density too. Safe to say I will never take Ozempic lol. Ive read it also can eat up your connective tissues on top of the fat, muscle, and bone density loss, like wtf are people doing... fixing one problem of obesity, which I do understand is a serious thing, by potentially damaging and weakening the literal structural integrity of your body (bones, muscles, connective tissue)... idk man sounds insane to me.
ozempic doesn't cause muscle loss and reduction in Bone density itself, glp1 agonists are simply appetite suppressants and not "fat burners" and that's why they're so effective. regular people who don't have any damn idea about dieting and how to follow a proper calorie deficit can just take it and abuse it thus starving themselves for days on end. it's not the drug itself that is causing the muscle and bone density loss it's the fact people abuse it and starve themselves while on it
as someone who had Grave's disease (hyperthyroidism), you do not want your metabolism to go into overdrive. It messes you up in so many ways, it's very debilitating and destroys your body. I went from 175lbs to 120lbs and lost the little fat I had(obvs), but also lost a lot of upper body and core muscle strength, and even bone density... there's a tonne of other symptoms but yeah your metabolism on overdrive just destroys your body in a lot of ways (i had the overheating too, sensitivity to heat, was always sweating)
They probably won't be as effective as SLU-PP-332, but do we know of any phytochemicals or other compounds that are naturally present in our food system that act as agonists for ERRα?
Actually yes, many dietary ingredients were reported as potential hits/ inhibitors: journals.sagepub.com/doi/full/10.1177/2472555216689772. One of them who might be promising is genistein, an isoflavone present in soybeans amongst others. Similar to resveratrol, it has a bunch of supposed effects incl. angiogenesis inhibition but I don't think there has been hard evidence of beneficial effects (only activity in molecular assays)
I remember reading it’s theorized to do so by stimulating autophagy pathways, which is similar to how several other small molecule and peptide Alzheimer’s candidates work. The caveat seems to be that it only seems to have measurable effects at huge, consistent doses and that it, like pretty much anything, seems to have some carcinogenic properties at those doses
@@praxiquot It certainly does something: www.ncbi.nlm.nih.gov/pmc/articles/PMC6164842/. But it's advisable to avoid resveratol and other natural polyphenols as dietary supplements.
Yea same, never had a BMI greater than 18. Practically impossible to put on weight, I live in AU were the average person is overweight; and i happen to eat around the same portions.
do you constantly feel hot, or sensitive to heat, sweat all the time? Do you go from energetic to exhausted after a few hours of getting up? Feel hungry/thirsty all the time.but.never gain weight (or even lose weight?) If it's yes to these maybe get your thyroid checked, it's a simple blood test of a single hormone. It could be many things but your thyroid is closely connected to your metabolism, so who knows.
@@maximtiburziano872 certain azo dyes can break down into aromatic amines when reduced, although i guess you are mostly right i’ve got trust issues from learning about drugs like phenylhydrazine
I have just discovered this video and your entire channel and am thrilled What interests me about this topic regarding SLU-PP-332 is: What dose was administered to the rat daily in this experiment, and what dose would need to be (safely) administered to a human daily to see an effect - 1 mg, 1 g, 1 kg?
Thanks mate!! The doses used in rats were 30-50mg/kg b.i.d. (twice daily) which if you linearly extrapolate to humans, would be pretty freaking high. However it can't be said without many other preclinical tests which dose could be efficacious as well as safe in humans. Time will tell!
@@totalsynthesis woah that is way too much for obese humans are you sure you didn't mean MCG/kg not mg /kg edit I just read the research paper it was mg that's crazy so that would be like 3-6grams per day for 260lb obese male human trials will have to see how much oxidative stress this may cause with such a huge intake and more oxygen/blood flow how this energy expenditure will be I think there are many unknowns to justify taking such a huge dosage at the same rate as the trial. Plus what about essential fatty acids will that block that how will this affect our complex brain functions when essential fatty acids are consumed?
Btw in case he doesn't mention it in the video, the levels of resveratrol in red wine is so low as to be essentially ineffective. So don't justify your glass of red wine with "anti-oxidants" or "resveratrol". If you're gonna drink just have your drink lol
💘 Big thanks again to all channel supporters and followers! Let me know any feedback and recommendations for future videos.
www.patreon.com/totalsynthesis; instagram.com/totalsynthesis_official/
This ligand looks way too small and „simple“ to be selective / without side effects🙈
If you continue to cover novel drug classes, I would love to see an in-depth video on psychoplastogens and the work by David E. Olson.
Thanks for the suggestion!
ligmand
@@yeetyeet7070 😂😂😂😂 ligmand nutz
@@totalsynthesishaha the drug has PP in the codename
yep I also found that hilarious @@MandrakeFernflower
Wow this is a great video, it’s hard to find good pharmacology videos on here. Keep it up!
Thanks!
The audio level on the video is about 10 dB lower than what it should be. I had to turn up my volume quite a lot. Not a huge deal, but should be easy enough to correct in the future.
My audio struggles continue lol - thanks for letting me know!
Whew, thanks for letting me know it was ok to slow down and try and digest all this info. I have a good background in Chemistry but your explanations become hypnotic sometimes by how much info you pack into each step.
I can understand - given the video format and the different level of experience of viewers, I rather pack too much than overexplain everything (else videos get too long and boring)
The possibility of exercise-mimetics that increase overall fitness by just taking a pill is incredibly exciting. Also, this made me think of the Ecdysteroids which have been found to increase strength through ERβ. Really makes you think about the important role of estrogen in strength, muscle growth and endurance. :P
When you mentioned that it can also lead to muscle loss and loss of bone density it immediately made me think of my Grave's disease which destroyed my body (went from 175lbs to 120lbs) for a year and a half, and it did the exact same thing to me (all while torturing me). I lost what fat I did have, a LOT of muscle mass (especially upper body muscles like biceps/triceps, chest, core, and back muscles, which I still need to work to recover) and lost bone density too.
Safe to say I will never take Ozempic lol. Ive read it also can eat up your connective tissues on top of the fat, muscle, and bone density loss, like wtf are people doing... fixing one problem of obesity, which I do understand is a serious thing, by potentially damaging and weakening the literal structural integrity of your body (bones, muscles, connective tissue)... idk man sounds insane to me.
thanks for sharing!
ozempic doesn't cause muscle loss and reduction in Bone density itself, glp1 agonists are simply appetite suppressants and not "fat burners" and that's why they're so effective. regular people who don't have any damn idea about dieting and how to follow a proper calorie deficit can just take it and abuse it thus starving themselves for days on end. it's not the drug itself that is causing the muscle and bone density loss it's the fact people abuse it and starve themselves while on it
Yeah should be banned for non diabetics. Esp over 50 yo who dont weight train
This reminds me so much of the drug that increases your metabolism to where people overheating die super quickly.
You probably mean DNP - that one is crazy
as someone who had Grave's disease (hyperthyroidism), you do not want your metabolism to go into overdrive. It messes you up in so many ways, it's very debilitating and destroys your body. I went from 175lbs to 120lbs and lost the little fat I had(obvs), but also lost a lot of upper body and core muscle strength, and even bone density... there's a tonne of other symptoms but yeah your metabolism on overdrive just destroys your body in a lot of ways (i had the overheating too, sensitivity to heat, was always sweating)
I wish I could afford ozempic, losing weight is so frustrating. But hey, at least buying less food saves money
Those results look very promising. A very accessible (probably] not-yet-banned PED for the black market stonks
seeing more plates more dates in this channel of all places is wild
😂😂😂
Cool! Very interesting video. I’ll get some for myself. ;)
They probably won't be as effective as SLU-PP-332, but do we know of any phytochemicals or other compounds that are naturally present in our food system that act as agonists for ERRα?
Actually yes, many dietary ingredients were reported as potential hits/ inhibitors: journals.sagepub.com/doi/full/10.1177/2472555216689772. One of them who might be promising is genistein, an isoflavone present in soybeans amongst others. Similar to resveratrol, it has a bunch of supposed effects incl. angiogenesis inhibition but I don't think there has been hard evidence of beneficial effects (only activity in molecular assays)
Do you know what the effective Dosage is?
No one knows either a safe or effective dose because there have been no studies in humans yet!
Many say around 50-100mcg and have also seen 200 across daily intake
Surprisingly, resveratrol has the ability to disaggregate amyloid fibrils, although the mechanism behind this is not yet known.
This thing can do anything! (and nothing at the same time)
I remember reading it’s theorized to do so by stimulating autophagy pathways, which is similar to how several other small molecule and peptide Alzheimer’s candidates work. The caveat seems to be that it only seems to have measurable effects at huge, consistent doses and that it, like pretty much anything, seems to have some carcinogenic properties at those doses
Certainly seems like a pan-assay-interference compound of some kind.@@totalsynthesis
@@praxiquot It certainly does something:
www.ncbi.nlm.nih.gov/pmc/articles/PMC6164842/.
But it's advisable to avoid resveratol and other natural polyphenols as dietary supplements.
lol I have the opposite problem, I can't stop loosing weight - inflation and depression are the best diet for weight loss!
RIP
Are you from Turkey :D?
@@pallaskedisiCokiyi ahahah no but I think it's safe to assume we are a lot feeling this way 😅
Yea same, never had a BMI greater than 18. Practically impossible to put on weight, I live in AU were the average person is overweight; and i happen to eat around the same portions.
do you constantly feel hot, or sensitive to heat, sweat all the time? Do you go from energetic to exhausted after a few hours of getting up? Feel hungry/thirsty all the time.but.never gain weight (or even lose weight?) If it's yes to these maybe get your thyroid checked, it's a simple blood test of a single hormone. It could be many things but your thyroid is closely connected to your metabolism, so who knows.
Will you be doing a synthesis of this?
Nope, maybe some black market crazy folks will though
I see a nitrogen-nitrogen bond in an organic chemical, im scared
This one is harmless!
Hydrazones and azos are harmless. The second being pretty colorful
@@maximtiburziano872 certain azo dyes can break down into aromatic amines when reduced, although i guess you are mostly right i’ve got trust issues from learning about drugs like phenylhydrazine
I have just discovered this video and your entire channel and am thrilled
What interests me about this topic regarding SLU-PP-332 is: What dose was administered to the rat daily in this experiment, and what dose would need to be (safely) administered to a human daily to see an effect - 1 mg, 1 g, 1 kg?
Thanks mate!! The doses used in rats were 30-50mg/kg b.i.d. (twice daily) which if you linearly extrapolate to humans, would be pretty freaking high. However it can't be said without many other preclinical tests which dose could be efficacious as well as safe in humans. Time will tell!
@@totalsynthesis woah that is way too much for obese humans are you sure you didn't mean MCG/kg not mg /kg
edit I just read the research paper it was mg that's crazy so that would be like 3-6grams per day for 260lb obese male human trials will have to see how much oxidative stress this may cause with such a huge intake and more oxygen/blood flow how this energy expenditure will be I think there are many unknowns to justify taking such a huge dosage at the same rate as the trial. Plus what about essential fatty acids will that block that how will this affect our complex brain functions when essential fatty acids are consumed?
Btw in case he doesn't mention it in the video, the levels of resveratrol in red wine is so low as to be essentially ineffective. So don't justify your glass of red wine with "anti-oxidants" or "resveratrol". If you're gonna drink just have your drink lol
Does it come in a dropper bottle
I’m currently taking slu-pp-322 and I’m getting leaner and holding on to muscle
Damn brah you crazy. GL
@@totalsynthesis have checked out chase irons on YT lol I run 500mcg daily
What dosage and oral or injection?
@@MO-ss5mj oral at 500mcg.
@@MO-ss5mj 500mcg I think my comments get deleted
superb
omg, this is the future of Content Creators 😂 everyone would like to consume this, I guess how much it is going to cost 😅
This is about to get wild.
Honestly if it works in humans as advertised, side effects would be an acceptable risk.
I am here to "leave a comment if you want to know more about the hyped obesity drugs"
Thanks, your interest is noted!!
Yum
I sink u r smart