What is chronic myelogenous leukemia? | Hematologic System Diseases | NCLEX-RN | Khan Academy
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- Опубліковано 22 сер 2024
- Learn what is chronic myelogenous leukemia as well as how to identify its signs and symptoms, diagnose it, and treat it. By Raja Narayan. Visit us (www.khanacademy...) for health and medicine content or (www.khanacademy...) for MCAT related content. These videos do not provide medical advice and are for informational purposes only. The videos are not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of a qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read or seen in any Khan Academy video. Created by Raja Narayan.
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I just like to add one thing about your video regarding elevated WBC in CML. The increased WBCs production in the bone marrow are actually defect cells, which couldn't function normally to fight Bacteria, fungi, or viruses and result in fever with opportunistic infection
awesome..i wish teachers were this good in classrooms..o how i wish!!
HASAN AL MONEM
i had 500k wbc when i was diagnosed, its now 6 months later and im fine just have to take medication daily.
I've had CML for over 27 years, did the Hydroxyurea for a few weeks and then Interferon for almost 10 years. Been on Gleevec (Imatinib) since December 2001 and am VERY grateful for that. But am upset that they say things about Imatinib like "as a rsult, you can actually cure cancer, cure CML". Imatinib puts us in a remission, but we are not cured.
Exactly! I didn’t care for that statement either!!
Please can you give me your telegram or IG or anything because i want to contact you regarding CML
100% these meds cost a lot, have serious side effects and as a CML person too, there is the occasional health scares.
These are such amazing videos! Thank you for sharing your knowledge with us.
Had Cml
For ten years now been taking Glevece for the last ten years every day
beverly dawson I’ve been recently diagnosed with CML. My doctor said it’s possible that in 2 years I may be able to go off Gleevec if my numbers are low enough. He has had several patients that have done this with success. (They still need regular blood tests to make sure they stay in remission). Has you doctor mentioned this to you? I’m hoping that I’ll be able to do this some day...
Hey, Can you tell me after how much time after diagnosis were you able to return to normal life
Love when they explain mechanisms that are responsible for generating certain symptoms - so much easier to memorize. Very good vids on leukemias.
Always a life saver. Do you update old videos if there are new findings?
This was a wonderful video. Explains the cml information so good, very easy to understand
The very best I have watched.
Thank you
I will be starting this topic tonight. But I think I've understand everything after watching this videos.
This video is eye opening. Thank you very much for it.
Truly genuine explanation videos from the Admin. Thank Alot for making leukaemias easy to understand nd more conceptual.🙏🏻
This is a great video! Thank you
Great way of teaching!
Thnku so much sir😇😇😇
really helpful! Will you explain NHL for us? Thanks very much!
Very beneficial/informative Vedio on CML (high White Blood cells ) WBC what IF WBC R LOW Can U pls make Vedio on it...thankyou
Good job continue
So many kinds...my father had AML i have CML. He lasted 6 days after his diagnosis.
thank you so much sir
thanks! It really helped me doing homework, as always:)
I was just diagnosed with CMML, what's the difference and treatment options?
CML = usually involves neutrophils that go mad; CMML = involves monocytes that go mad.
I can't tell you about the treatment options for CMML but for CML it's initially Imatinib and as last resort if one meets the criteria a BM transplant.
Wondering if you could clear something up:
The previous video (on myeloproliferative disorders) states that the defect causing CML occurs after the myeloid stem cell phase. However this video states it's just after the pluripotent stem cell phase.
Which is it? If it's after the pluripotent stem cell phase then what would make it different from polycythemia vera?
Cheers
+guyhi11 CML occurs after myeloid stem cell phase
It occurs from pluripotent stem cell with both myeloid and lymphoid potential
It occurs in myeloid lineage of pleuropotent haemopoietic cell not directly pph..
I replied after 3 yrs😂😂😂
I don't get the part with the hepatomegaly and the BMR.
More cells = more nutrients used/ more waste products produced = more detox needed = liver works more?
Correct like this?
Extramedullary hematopoeisis occurs in liver and spleen because bone marrow cannot produce enough rbc
I love this videos so much!!!! Thhank you
I have cll. I am fighting with this deadly disease. Give suggestion.
Thank you so much
Soo soo good!
i like khanacademy video information, but u could try using a light background if possible :)
What do you know about Dasatinib?
I have a question. My mother for years had an issue with her Leukocyte, they were always extremely elevate despite not having any infection. Her pcp refered her to a specialist. The BCR-ABL was perform on her and it came back positive. But we were never inform until aroung a month after she was also diagnose with breast cancer and her Oncologist suggested for us to go bak to the specialist because he needes to clarify on the BCR-ABL test. We went to back to this doctor and he said that often time the BCR-ABL test can be a false positive. Since we were already dialing with her breast cancer issue we left it along. But as time progress I notice that my mom had all the symtoms associate with CML. She was tested the second time for BCR-ABL and it came back negative. Can someone be BCR-ABL positive on the first test and negative on the second test? Please help. Hope to hear from you soon.
Thanks.
Not a medic here but I'd say the only way of being indeed BCR-ABL+ and then to NOT be + anymore is that all the BCR-ABL+ cells got removed.
Nice way to explain and to understand
Abl is not a receptor tyrosine kinase, it's a non-receptor tyrosine kinase, which is that it is found in cytosol and nuclear plasma
Thank you
Thanks a lot! Great video
90% are alive at 5 years? What does it mean? Why can't we expect to live normal like 60 years where the enzime is blocked by the medicine.
thanks a lot 💐🦋💐💐
hi, what app do you use to make videos?
Why is CML considered cancer but polycythemia vera and essential thrombocythemia are not?? Thank you :)
They are considered cancer as of now, because they found mutations in PV and ET as well (like JAK2 and CALR). That's why those two together with myelofibrosis are known as MPN: myeloproliferative neoplasms. Hope this helped :)
@@AnneScrubsFan Good comment! Thanks!
thank you so much 😀 😀
Very good!! Thank you :)
Do you mean multipotent? Is it not only embryonic stem cells that are pluripotent?
greaaaaaaat thanks a lot !
Very nice
i love khan academy
Good
My son has the Philadelphia gene does this mean he can't be cured
But if the defect is at the cross you
Made then lymphoid series should also get proliferated, shouldn’t they?
MANAN VAID actually mutation occurs in pleuri potent hematopoietic stem cells destined to produce myeloid series
See pleuri potent cell can produce 2 types of cell myeloid series and lymphoid series...
@@ajiteshmishra472 good answer. Even the name of the disease itself clarifies his question. The mutation is only affecting myeloid destined cells.
Has anyone with CML ever had a MOMO pregnancy?
do you mean 'defective' cells
We DONT NEED TREATMENTS, WE NEED CURES. CANNABIS OIL WITH THE THC CURES MANY DISEASES & ILLNESSES.
I think that @2:35 he is actually describing AML no CML. Can someone verify this for me?
CML as well, I have it and when it was out of control my platelets were extremely high
oohhh god love
❤
GD
Thank you