Are scientists being honest about aging research?
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- Опубліковано 1 жов 2024
- Coleen T. Murphy, a professor at Princeton University, specializes in genomics and molecular biology and is the author of How We Age: The Science of Longevity.
In this wide-ranging interview we discuss the significance of declining cellular repair mechanisms that over time lead to visible signs of aging. Prof. Murphy has a particular interest in reproductive aging and cognitive function during aging, considering the former as an often overlooked aspect that begins midlife. Her work with the model organism C. elegans, a nematode worm, has led to important insights into the genetics of aging due to its short lifespan and visible aging process. She believes that translating such findings into mammalian models and eventually human applications is crucial.
Prof. Murphy also expresses concern about the way longevity science is portrayed and criticizes some researchers for failing accurately to describe the true implications of their work. She says there is a need for honesty and realism from scientists to maintain public trust, especially in the field of aging and longevity where bold claims can often outpace reality. Researchers, she insists, should not over-promise results that science cannot yet deliver.
We also address the potential for 'exercise in a pill' and Prof. Murphy highlights recent research indicating that certain proteins can rescue memory function in aged mice. She also argues that without taking care of our planet and its inhabitants, the quest for longevity loses much of its significance.
Prof Murphy's book:
How We Age: The Science of Longevity
amzn.to/3HVhzNa
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Discounts & Affiliation disclosure: This podcast is supported by sponsorship and affiliate arrangements with a select number of companies. The income helps to cover production costs and ensures that our interviews, sharing information about human longevity, remain free for all to listen.
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Topics covered in this interview include:
Murphy provides her definition of aging, focusing on the declining efficacy of repair mechanisms. [00:01:15-00:02:25]
Personal motivations for engaging in aging research, emphasizing the interdisciplinary interest in aging and its impacts on human life. [00:02:43-00:03:53]
The central role of aging research in addressing a gamut of age-related diseases, highlighting a shared approach to dealing with these ailments. [00:10:36-00:11:29]
Skepticism around outlandish longevity claims arises, cautioning against eroding the public’s faith with unrealistic aspirations of reversing aging or achieving immortality. [00:13:55-00:14:18]
Lifestyle choices and their impact on longevity, including the practicality of harsh dietary regimens. [00:17:49-00:20:37]
Exciting translational research developments, where genetic discoveries in model organisms have potential pharmaceutical implications for extending human healthspan. [00:22:48-00:25:06]
The relevance and benefits of using model organisms such as C. elegans in aging research, and how these can lead to safer and more efficient human trials. [00:25:18-00:28:05]
Personal health strategies derived from research are touched upon, discussing the significance of exercise, diet, and emerging knowledge of mitochondrial health. [00:28:39-00:36:23]
Reflections on the need for a sustainable, livable world, tying the pursuit of longevity to the overall environmental and societal well-being. [00:41:58-00:42:54]
The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.
The question about reproductive aging... wrongly addressed here @6:40. Bowes, quote, "once we have produced offspring to continue our gene pool".
He is NOT aware about the self.imposed limitations of that question. It excludes apriori any aspect of culture, the role of culture to produce that offspring in a very hostile - physically and biologically - environment. He completely neglects the important role of knowledge. Even in elephants the grandma can not reproduce herself, but her knowledge is absolutely crucial to the survival of everyone else. Bowes' question therefore is limited to organisms without any culture, and those are bacteria. As a materialist reductionist it is impossible to even address proper questions. Everything turns into BS.
And Mrs. Murphy in response to his question at @6:40? quote: "of course" ....
It is a waste of time to expect any meaningful outcome of such discussions
Hello - seems you have thought much of aging - please could update any researchers and scientists that follow closely and think that are close to best understanding of causes and maybe what best for slowing. Thanks on any update.
Very disappointing. Her research priorities appear to be directed towards creating new drugs rather than promoting metabolic health through informed lifestyle choices. Feels dishonest to me... the very thing she ostensibly rails against. Oh well... nothing new there 😞
Yeah ... I hear you she did point out that the NIH does almost all the funding. So go figure it'll be the government ordained ways to eat according to the current SAD.
That has not got us very far.
Yeah ... nothing new.
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on the comment about the rich living longer - there's probably a threshold effect where simply having reasonable financially security and having health care available would raise lifespans for billions by a huge amount, and for 10s of millions in the US. As it is now the longevity/health community is really comprised of the well off, people who can already access health care and good food. So much good could be done if we could solve the problem of ensuring a sane political system which is not a lap dog for special interest or crazy ideology. One simple result would be regulating the food supply which in the US kills more people than everything else combined
*Promo sm*
We can Cure Aging it's common sense we know our Hormones and everhthing else goes down with age. Dying of old age isn't build into the fabric of the universe! there is mechanism's that we can fix and rejuvenate the body. Remember! the Body is the most advance machine in the world and if you give the body what it needs, it will do the work for us.
Live Long And Beat Aging Before It Kills Us!