Toxicology of Acetylcholinesterase Inhibitors (I) - Neurotransmission

Short video (Part I of the 3 part series) illustrating the cholinergic neurotransmission. The issue of the nerve agent VX, was recently raised publicly. VX is a very potent organophosphate inhibitor of acetylcholinesterase.
Acetylcholinesterase is a very important enzyme that hydrolyses acetylcholine in the synaptic clefts of cholinergic neurones. By so doing, it is able to terminate neuronal transmission. Acetylcholinesterase inhibitors prevent degradation of acetylcholine, and leads to an excess of cholinergic transmission.
Cholinergic excess results in a Toxidrome which is important to recognize and diagnose.
Essentially, these effects relate to effects at the muscarinic and nicotinic receptors.
Muscarinic effects include: lacrimation, pupil constriction, bradycardia, salivation, emesis, defecation, gastrointestinal cramps
Nicotinic effects include: sweating, pupil dilation, bronchodilation, tachycardia, hypertension, fasciculations,
weakness/paralysis leading to respiratory failure
The next video (Part II) will look at the different drugs and poisons that act this way.
• Toxicology of Acetylch...
The playlist for this 3 part series can be found here:
• Acetylcholinesterase I...
For more please visit www.pharmacologytutorials.com

[@fantaeskies]

Idk how to thank you for making me understand this concept, which nobody else could for the past 1½years 😭😭. Tysm

[@DGFishRfine1]

This video's extremely cheery music alongside the mechanism of some of the worlds most horrific biological weapons makes me giggle

[@pharmacologytutorials]

:)

[@surkey5055]

Nerve gas! 😊😊

[@christianobando750]

Upbeat music, clear animation, and cogent explanation made my physiology homework easier thank you!

[@farzadrahimi9005]

This was amazing, hats off for your excellent work.

[@Dr-Hafsa12345]

yes thanks

[@MariaSanchez-iq7bp]

Thanks

[@SonarTheBat]

Video: about neurotoxins.
Video: happy stock music.

[@Alys150]

this video changed my life, thank you xx

[@nurshakirara]

So informative! Finally i found the answer for my assignment

[@user-qs2zr4rl5u]

never heald a person in their life, but shure talk a storm

[@UAE8643]

Thank you so much

[@basharatali7640]

very very nice

[@said0757]

Why when I consume any food which contain choline or choline supplements my brain becomes in fire and I immediately feel depressed, anxious, memory declines and fatigue??!!

[@mygameis2cool4u]

really good thank u

[@guru253]

very k00l name

[@nischithagp3286]

Thank u for dis vedio 😁

[@muh.farid.120]

But in AD treatment/therapy we use inhibitor of those enzym so there are more acetycoline could pass to post-synaps

[@tiffariff]

exactly why I was looking this up as I’m a visual learning and came to that conclusion- cause otherwise why would this toxic level be the aim? lol.

[@GreenSeasonSun1]

Does anyone know the artist/song for this tune? Shazam gives me like a dozen different people....

[@divyachinnu113]

Tq

[@johnny_phouc_21]

The background music is not at all necessary.

[@Rickdeb707]

Why this is irreversible??

[@AznJsn82091]

"Acetylcholinesterase inhibitors act by preventing the action of acetylcholinesterase"
Uhh...what?

[@nanaoo6134]

Thanks