Nobel Prize in Chemistry 2022 (Recap)
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- Опубліковано 4 жов 2022
- The Nobel Prize in Chemistry for 2022 has been awarded to Barry Sharpless, Morten Meldal, and Carolyn Bertozzi for their contributions to Click-Chemistry and Bioorthogonal Chemistry.
Click chemistry gets its name from the fact that both reagents essentially 'click' together!
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#nobelprize #nobelprize2022 #nobelprizewinners
Nice!! why is it called click chemistry?
because it is so easy, you can basically 'click' the two pieces together!
@@That_Chemist Additionally, reaction kinetics for these reactions are usually very fast. Modern click reactions are done in microseconds under very dilute conditions, the reaction is literally as fast as a click sound.
@@That_Chemist It's called click chemistry for the chance of someone in the future explaining it in a UA-cam video and adding a satisfying click sound to an animated version of the reaction.
Sharpless actually thought about reactions that would connect any two molecules as easily and specifically as clicking a seatbelt 🤓
@@That_Chemist aaa
Ah yes click chemistry, a total synthesist’s wet dream.
Surreal to see my PhD advisor’s work during his PhD featured! Bioorthogonal chemistry never ceases to be cool.
same!!
Sharpless epoxidation is one of the coolest assymetric reactions. Kudos to the laureates.
It works very well. I loathe that the substrates I was working on required trimethylphosphite to quench. It does NOT smell nice.
@@MattyT_86 That's a tradeoff there. What were you working on?
When will we see click chemistry on UA-cam? Who knows...
I should've recorded my lab when we did this reaction a week ago... would've probably been one of the first...
İ clicked the like button.
Sodium azide and acetonitrile are easy to get, maybe that could work?
I had Sharpless as a prof for half of organic 1 and 2. He was an amazing lecturer and people in 1983 were already sure he would win a Nobel for asymmetric epoxidation reaction. He was hilarious and the undergrads collected the funny things he said and left a stack where lecture notes were picked up before class.
Could you do a more in-depth video about click-chemistry?
I will see what I can do
I'd like it too
Sharpless nice. I have a feeling we might also see macmillan recieving a second nobel prize for his photoredox catalysis work.
and his proximity labeling work - I think if click chemistry had been awarded in another decade, he also would have got recognition for his new diazirine work
bertozzi was one of the profs in my organic 2 course! cool to see her getting the nobel prize
That's a great summary. Keep it up!
Big love from Denmark, I haven't seen any news article about Meldal winning the nobel prize, sadly :(
We talked about these 3 in my organic and inorganic chemistry courses! Honestly it's so cool to see how new techniques are being madeoto this day!
I think it is an outrage that the late, great Rolf Huisgen was never awarded the Nobel Prize for his discovery of 1,3-dipolar cycloadditions. 😡
He was so close! only 2 years away :(
he likely would have been included had he been alive. Nobel prizes are never awarded posthumously.
@@BradSchmor That's a shame honestly
My lab collaborates with Dr. Bertozzi lol but we're a biology lab. She does more chemistry than us but it's all in the Ngly1 deficiency field
Well job chemists #nobelprizewinners and congratulations to your hard work. This process is nothing to easy.... Your contribution is too good. And so inspiration to all this young generation . Thank you.. 💙
I'd love to see a Nobel prizes series from you! Great Work
My O-Chem professor was talking with us about this work just this morning. She was focusing on how click chemistry without the need of a copper catalyst could be used to label cells, particularly in cancer research. If you know anything about that prosses or the theories involved I would love to hear you talk about it.
Not less, he is tooooo Sharp :0
Such a great combination of biochem and Orgchem Bertozzi has done. Could you make a detailed video on her research work in bioorthogonal chemistry?
Sounds better than Clickbait chemistry.
"One weird trick to evacuate your entire school!"
You should do a vid on Barry Sharpless lore! There's so much out there. Everyone who has met the guy says he's a trip.
Click Chemistry sounds like the name of an awesome science communication YT channel
That is true
Proud to study at Copenhagen University :D
Lots of information put together in chemistry. Love ❤️❤️❤️❤️ from Bangladesh.
I wouldn't normally watch coverage of this, but from That Chemist, I click.
I appreciate your kind words :)
Congratulations to the laureates, But who were the other nominees for noble prizes this year? Where can i find this info?(in chemistry)
very nice video! maybe I'm a bit slow, but I didn't understand the importance of click chemistry between azides and alkenes. it sounds preety meh to me.
I did enjoyed the "fun facts" though.
If you could imagine how click chemistry is beneficial to humankind then pls explain more about its uses and utility in next decades and what applications would come up ?
Wow Sharpless again
Same reaction
@@ashishsinha3257 nah, different reaction
@@jacobtierney4419 u killed me 😂🤣
I've had the pleasure of seeing Bertozzi and Sharpless lecture as guests at my school. Truly a great day for chemistry.
Which school you are attending pls
Thanks for the nice summary, which will spare me all the explanations in the next couple of days! The azide resonance structure made me cringe a bit, but it's probably due to the rapid upload and ChemDraw.
Glad it was helpful! I prefer to draw N3 instead of just abbreviating it
Maybe feature Sharpless in the next Chempilation? Almost all of my colleagues credited THAT accident being the one reason they keep their goggles on regardless of how trivial the tasks are
Good one yeah - the safety glasses
Huisgen cycloaddition reaction, click chemistry is a philosophy. Although Huisgen reaction is the most common example of click chemistry. So sad for Huisgen.
RIP - he was only 2 years away
I was searching for this comment. Agree 100%
Mhm mhm... I see, very interesting 🤔 I indubitably understand the facts. Click Chemistry is fascinating 🧐
Dammit, Barry, leave a little Nobel Prize for the rest of us!
Based Barry
Explosions and Fire likes this process
Those are the best pictures you could get of them?
proximity labeling with higher energy carbines sounds likes national defense.
Haha
Nobel Prize in Chemistry Tier list when ?
You realize Thomas Klapötke is sitting there reading the body of literature of click chemistry and going "alkynes bonded to azides via metal counterions? Hold my beer!" While a lot of people are thinking of this as a way to make all sorts of useful chemicals, to me it looks like a GREAT way to make high-RE-factor explosives - especially if you can "click" multiple azide groups onto a molecule.
Can you use lighter colours.. its hard to see the colours against the black background
I'm almost sure that I understood nearly none of this. But congratulations to everyone who does understand it. And to the laureates as well.
"Install azide in biological context" does have an ominous ring to it.
Now I hope you will not make any "tier" list of chemistry Nobel laureates..
that's actually a great idea - I will do that for this Saturday as per your suggestion :)
Kary Mullis, inventor of polymerase chain reaction...he really loved to use LSD, so he goes in A tier. A for Acid.
Marie Curie. First woman to win a Nobel, first person to win one in two different scientific disciplines. Instant S tier.
Fritz Haber. Received Nobel for inventing the process that makes ammonia. Goes to F tier because he also invented chemical warfare.
Adolf Friedrich Johann Butenandt. Received Nobel for his work on sex hormones. Definite S tier.
OK 😊
i understood a couple words
Didn't address the main question I had the whole time -- where does the name come from??
see the pinned comment!
Neat
Thanks Chuck :)
you should have called the copper compound by its fun name, no not DBX 1
1:06 or, by the looks of those three nitrogens, new ways to blow shit up
sometimes the resulting triazoles are unstable, but triazoles are found in pharmaceuticals, so as long as it isn't low-molecular weight, then you shouldn't be concerned
yo mr white
Business professional here, all this talk reminded me why I never wanted to take another science class after AP chemistry in HS 😊 congrats to the winners!
Ah, ok. So the two guys did some incomprehensible thing and the other woman did a better incomprehensible thing, all for incomprehensible purposes. Got it!
Sad… No Germans this year… 😢
Poor Valery Fokin lol
Don't forget M.G.
@@StanislavPresolski Yikes, MG too.
No offense to Morten Meldal, but I feel he's a fill-in for Rolf Huisgen, who died in 2020 - I've never heard of him until today.
Nobel prize in chemistry is not about chemistry but about medicine,if your discovery can be used in medical industry then you will get Nobel prize .
Facts.
What the fuck is a prize?
It should have gone to that guy who discovered the bacteria that can eat plastic
That'd be biology rather than chemistry wouldn't it?