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How Keytruda Cancer Treatment Works (Update)
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- Опубліковано 14 жов 2018
- Keytruda (pembrolizumab) is an immunotherapy cancer treatment that stimulates the patient's immune system to help fight certain types of cancers. Because cancer cells can use certain proteins, like the PD-1 protein, to shield themselves from detection, this enables cancer cells to grow and spread. Keytruda blocks these proteins, preventing the cancer from hiding. The treatment is then able to help the immune system do its job: Find the cancer cells and destroy them. In this video, oncologist Dr. Stephen Lemon explains how Keytruda works, including what types of side effects patients may experience.
Keytruda is currently approved for the treatment of malignant Melanoma, as well for other types of cancers, including Non-small Cell Lung Cancer, Head and Neck Squamous Cell Cancer, Hodgkins Lymphoma, Bladder Cancer and other cancers that are positive for MSI.
Keytruda is developed by Merck. It's generic name is pembrolizumab. Stephen Lemon MD is a medical oncologist at the Overlake Hospital Cancer Treatment Center in Bellevue, WA.
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How Keytruda (pembrolizumab) Cancer Treatment Works (video transcript)
As more types of immunotherapy treatments are approved to fight cancer, patients want to learn more about specific immunotherapies, such as Keytruda.
Keytruda is an immunotherapy cancer drug treatment that’s showing a lot of promise. While Keytruda is the trade name, it’s generic name is pembrolizumab. And Keytruda is made by Merck.
So how does this treatment work?
Keytruda is an immunotherapy that works with your immune system to help fight certain cancers.
Your immune system is your body’s natural defense against disease to detect and fight infections and diseases, like cancer.
Cancer cells may use certain proteins, like the PD-1 protein, to shield themselves from detection enabling the cancer cells to grow and spread.
Keytruda works by blocking these proteins and prevents the cancer cells from hiding.
Keytruda is then able to help the immune system do its job: find the cancer cells and destroy them.
While Keytruda was first approved to treat malignant melanoma, it can now be used to treat several other types of cancers, including Non Small Cell Lung Cancer, Head and Neck Squamous Cell Cancer, Hodgkins Lymphoma, Bladder Cancer, Stomach, and other cancers positive for MSI.
How is Keytruda given?
Keytruda is given intravenously. The treatment itself usually takes around thirty minutes and is given every 3 weeks.
The duration of treatment depends on the type of cancer and the patient. Your doctor will decide how many treatments you’ll need.
Keytruda shows many clinical benefits such as knocking the cancer out, extending life and in improving cancer related quality of life.
So what types of side effects can Keytruda cause?
Side effects with Keytruda can be mild, or severe. Some of these side effects result from the body’s immune system attacking normal, healthy organs.
Some less sever, more common side effects may include fatigue, itching, rash, diarrhea, shortness of breath, decreased appetite, constipation and nausea.
More severe Immune-related side effects may include kidney problems, skin reactions, encephalitis, inflammation of the lung, colitis, hepatitis, thyroid issues and diabetes.
This treatment can sometimes cause an infusion reaction. Symptoms of an infusion reaction are chills, wheezing, skin irritations, flushing, rash, low blood pressure, low blood oxygen, and fever.
Women should not take Keytruda if they are pregnant or planning to become pregnant because it may cause fetal harm.
Keytruda helps patients live longer and better while offering hope.
If you’d like to know more about Keytruda, please talk to your doctor to find out if this
treatment is right for your cancer.
My dad had been on keytrude since January this year, everything looks fine so far, hope I can call it a miracle down the road
How is it going now?
Me too my mom is on it. I'm praying it works
I am on it. I go in for my 3rd treatment
Hey there Wayne!
How is your Father doing? I hope he's doing better!
Was Keytruda treatment good for him?
Please inform me if you can :)
@@taccarahwang8566 Hello Taccarah!
How's your Mother doing? I hope things are better!
Please can you tell me if Keytruda treatment was good for her?
Wish you the best!
My uncle was just cured of stage 4 colon cancer with this treatment. Absolutely amazing.. fucked up part he got lucky as he got submitted into a study, otherwise the treatment wouldn’t have been covered and he would have had to pay 100s of thousands for this treatment.
This stuff is a miracle. My mom just got on maintenance. She was so sick back in Aug. she would not be here if not for this drug.
eschatts1 I’m starting to use Keytruda this week, I’ve heard so many positive things about it I hope someday I call it a miracle too.
Nicole Idelfonso I pray for you. Make sure they keep monitoring you. The stuff stopped working on my mom. But it does not stop on all people. Once you start having a good response enjoy every single minute. It is a great gift. Please take care.
eschatts1 I’m sorry it stopped working for your mom, i just got my first dose two days ago. Thank you so much, i’ll take your advice.
@@Nicole231327 how r u two? R u getting better each day?
@@Nicole231327 how is the treatment going so far
First of all, Thank you for the info. I have started this treatment, having my 2nd visit next week.... After my 1st round my week was full of constipation 3x, my gosh that was so painful n relief when I could empty out, hubby got me laxative prescription frm my oncology nurse n what a god sent of normality n freedom, helped me with that relief 🙏🏼 Amine🙏🏼 I eat well, love my water n positively keep a healthy mindset💚💯. Onwards & Upwards, keepñ on!!💖
I had the same reaction after my first dose plus severe fatigue. I did not know what was causing the problem at first but it was solved with effective laxative - Lactulose. Overall, I am optimistic that I can tolerate the side effects.
How are you now?
My father will take this drug this week.... I'm so scared and confused about this treatment.....
@@FauziaPires Bless your father dear, I am going well n still get tired often n my body gets achy at night during sleep which wakes me up round midnight onwards, stay up a little then fall back asleep. All the best for your Dad's treatment going forward n wish him well n healing occurs for him 🙏🏼
I get my first dose this coming Thursday!
I just saw your comment from a year ago and am curious, how your treatment went? Did it go well, I hope?
Is it $200K ? I read an article that say it costs $200K
I have been on this drug for over a year. Only side affect is extreme fatigue. I am also in a trial that mixes Keytruda with TAVO. They injected my 8 tumors with TAVO, and then electrical shock the tumors. The 8 tumors are now gone, but unfortunately they found two more. So that is what we are working on now. They are not on the surface and can not be shocked as easily.
You'll beat it!
Hi Brian thanks for the info. How has this combination been working for you ?
How u r doing
@@PhatBoiiBeats Very well so far. I just now got home from a treatment. 12 tumors are down to 2 tumors and they have drastically shrunk. MRI showed great progress.
@@jaredjonas1353 Very well so far. I just now got home from a treatment. 12 tumors are down to 2 tumors and they have drastically shrunk. MRI showed great progress.
First dose last week, worse then 6 months of chemo, 11 days since treatment and have never felt worst. Gave me fever, chills, shaking, no appetite, nausea, tired. Will not do 2nd treatment.
Girl, might not be what u think it is. See,I had same issue. But u took my nausea meds half hour before getting up. Let em wonder where I went lol
But anyway, what I was getting at was span out certain activities. Foods ..etc. So I used my "Cancer " card to get my man to not yell at me kind of the opposite of that. Win, win
I was almost free of side effects.had like a sun burn feeling on my skin.try to do a couple more treatments and tell the doc. They add steroids if your having side effects that will help.
Oh my goodness.
So, I have my first dose next week.
I will be the first and only FANCONI ANEMIA patient trying it and they are using me as a guinea pig (in a good way) for others with similar blood disorders who may have cancer.
However, I am radically under weight and losing nutrition because I can't swallow, and I'm already quite fatigued and weak.
My diabetes may pose and issue perhaps too?!
And I already am told they have zero idea how my fanconi issue will react.
BUT without this, basically I have no other options left and would have 6 or 8 months or less.
So...as genuinely scared as I am, I am going in trusting the outcome is good and humble enough to accept if it's not. I know where I'm going if things don't go well with it.
Cheers!
@@jeremycbarnhart2305 Hi Jeremy thank you for this comment - how has the treatment been going for you ?
Do Dr.s get kickbacks for prescribing this?
My boyfriend decided to stop treatment for stage 3 lung cancer. He took 5 treatments this last one was rough on him. Fatigue/ weakness shortness of breath, some hair loss, constipation & vomiting. CT scan showed that the Cancer on lung shrunk but we're holding for the time being. The side effects were a bit too much 😔😔😔
May God bless you all
God is working don't give up!
I have NSCLC and I've been given Pembrolizumab as a first line of defense. I've only received one round so far, but within 1 to 2 weeks after, I'm eating like a horse. And I'm seriously packing the food down. I'm guessing that my immune system is suddenly working overtime and needs more energy. I'll be seeing my oncologist pretty soon, but that's my guess as to why I'm eating like a starved wolf.
Any update? Did it work I hope that u are fine
@@SupperGems One thing I found out about my appetite was that the tumor was robbing my body of nutrients, but once the drug got to work it was stopping that affect and I guess my body needed to satisfy the crave for nutrients. That eventually settled down. But after the second round of treatment, the tumor went from 35 mm down to 6 mm. There's a smaller tumor in the other lung that has so far gone from 12 mm down to 8 mm. Nevertheless it was tears of joy after the doctor gave me the results. After 5 rounds, they could "not" find the tumor. The smaller one is stubborn but no bigger. I just finished round 6 about 2 weeks ago. The treatments are every 6 weeks. And in about 3 weeks I get another ct scan. I'll be anxious to see the results. I'm just grateful that I can live a better quality of life by not receiving chemotherapy and achieving these results.
Worked for me, 11cm lung cancer tumour almost disappeared…will be having immunotherapy for the next 18 months, a few side effects … mainly arthritis induced by the immunotherapy…steroids have helped…it’s a small price to pay for the long term benefits which are mainly being alive !
Are anyone face that tumour swells & enlarge after first keytruda infusion???
My oncologist explained to me that this can happen after the first couple of treatments before seeing improvement.
One of my family member had this treatment. The tumors enlarged just after the first dose of keytruda but later after 3-4 cycles it became really good
How many doses you can take maximum
my mom had 1 treatment 3 days later on her death bed does not work for everyone
Thank you Dr osere on UA-cam for being responsible for the cure of my cancer,l highly recommend you to each and every other person here, Thank you Dr
How can we get this injection? Our doctor has prescribed for my mother kidney cancer
Did you get this for your mother ?
We just don’t understand cancer sufficiently. Most therapies are stabs in the dark since they work on some and not on others, they have limited effect and typically may offer only a few months of life. I pray one day we finally understand it.
why is it so expensive!!!!! Not fair to have the shot at life so close but then financially so far away.
According to the Cleveland Clinic, cancer starts when genes (that provide instructions to our cells) mutate and create cancerous cells. These cells create cancer clusters or tumors. Some cancerous cells break off and travel to other parts of the body. What the article curiously leaves out, is that the foods we eat, our environment, and toxic products have the ability to trigger changes in our genes and start the cancer process going. So it stands to reason that eating the right foods and avoiding toxic substances (like cigarettes, etc.) should be able to restore the function of our genes so that they no longer make cancerous cells.
There have been many people who had cancer and changed their diets and lifestyles to eliminate meat, stop smoking, etc., and eliminated the cancer in their bodies. It takes time to reverse, but it has worked many times for many people. Big Pharma and its "anti-cancer" movement call this a "conspiracy theory" because they do not want to start losing customers. So the people that cure themselves of cancer are written off as one-off flukes instead of being acknowledged as having figured out how to defeat cancer. Even the World Health Organization admits that cancer can be cured if treated early and effectively, they just want you to use drugs when you could make simple, dietary changes instead.
www.ncbi.nlm.nih.gov/pmc/articles/PMC2515569/
my.clevelandclinic.org/health/diseases/12194-cancer
theconversation.com/what-you-eat-can-reprogram-your-genes-an-expert-explains-the-emerging-science-of-nutrigenomics-165867#:~:text=Food%20also%20contains%20micronutrients%20such,that%20reside%20in%20the%20genome.&text=Like%20the%20switches%20that%20control,certain%20gene%20product%20is%20produced.
www.who.int/news-room/fact-sheets/detail/cancer
Exactly said ! Thank you.
How long did he take it
Where do they offer the treatment and what is the price? Where can I consult?
I am getting this treatment in USA. It is now available in all major Csncer centers. It is very expensive in USA. You could gat 20 treatments and it cost $200,000 per treatment but in India Tata Cancer Institute in Bombay it’s about $1500 per treatment. Big big difference in price. In America my insurance pays so it doesn’t cost me anything
@@sunilsrivastava3003how are you doing with the treatment? Is it working for you? This gives me hope for the future.
Around $13,000 per dose..
I had done 2 cycles does it shrink 5 cm tumour
Keytruda didn’t work for me I am going back to chemo
I am sorry to hear that. I hope you find a medicine that works for you. I will pray for you. Have a great day
I just got off chemo which I loved except I had eight rounds and my platelets were low. After chemo I was shopping, driving, washing, no restrictions except small nosebleeds. Now that I’m off chemo I haven had one.. The doctor took me off chemo. I’m to go on Keytruda with another drug. I had 1A cancer (endometriosis) came back three years later. Three medium nodules. This cancer came back exactly three years later. This is after going through surgery hysterectomy and going to every doctor’s appointment to one of the best hospitals in the state, UCSF. I was really bombed out but began to thank GOD because it could have been worse still 1A cancer that metastasized to the peritoneal. Says this cancer cannot be cured because where it metastasized only manages like you would manage high blood pressure, diabetes. Your still living - with the new medications people are living longer. Cancer isn’t always a death sentence. One thing the doctor would tell you being a cancer patient is to stop or watch the sugars, if your over weight to focus on loosing weight, have a healthy mind. Always forgive. Get a good support system. I’ll give say beleive in God.
Triggered am autoimmune side effect including joint pain, ( like rheumatoid arthritis) fatigue, rash, decreased appetite, sinus infection, and who knows what else.
Are you still taking it despite the side effects?
@@zinadavis5533 NO stopped after 4 infusions.
اين يمكن أن احده
How much sir
I started using Keytrude in January I'm doing fine. Chemo almost took me out. But think God I'm still here.
@@rommiemarble3558 how is it going so far?
$15,000 for 1mg. per treatment
Thanks to Dr Luna the healer who God used to cure me of cancer last year
الترجمة ؟؟
I am on this. Seems to be working but I have all the side effects.
How do feel now?
Please keep us updated. Thanks
@@khosrosadi5196 I was taken off for awhile to get my appetite back. Have not started back yet. Not sure if it was another drug I am on. Still working things out.
@@Nnamdxxx How are you doing
@@flash7308 They found another spot in my brain about a month ago. I have had it treated. Waiting on another scan to see if it worked. They have put me back on Keytruda. Had my first treatment about a month ago. Has not made me feel nauseated yet.
I"m next
Is anyone still alive?
Yes of course. Depending on the case, response rate can be quite dramatic for check point inhibitors. Hopefully these hammers will be refined so they work without the side effects in the future. Still too many are not good candidates. Works best for MSI high. Not all cancers have this property.
Ipi nivo for me.
It distroyed my husband.
Please explain
This drug killed my mother faster.
Diademglo she basically got all of the bad side effects of the drug. Extreme shortness of breath, rash on her skin and other things that didn’t work in her favor causing her cancer to go into over drive.. it spread to her bones and from there she went downhill fast. She was seemingly “fine” before she decided to take the risk that came with the drug. She became bed bound because her body began retaining fluids after having to get several transfusions, platelets and other nutrients her body could no longer retain.. it was awful watching her in those final moments.
WOW!!!
Im sorry 😥
They're wanting me to start this treatment,,,
Hank Picard do not be afraid, Keytruda is a miracle drug.
I heard rumors of this. Its not a 100 % bullet, pembroluzomab key has a chance hit you right back.
Its ok hank it only happens to few patients. Think youll be fine.