Genetics loads the gun..lifestyle pulls the trigger. My mom lived till 104, I’m 84, still hiking with my daughters, feel grateful and blessed. Not the greatest knees, lol, due to a slip and fall, but use the hiking sticks, which works. Love Dr Sinclair’s work and book. Wishing everyone the best of health!
Yes I consider aging a desease I’m 68 look much younger and feel like 12 years old ... All my life I took care on what to eat and exercise ...I’m Belgium descendent Born in Paraguay South America . Only ate when feeling hungry healthy vegetables green tea from Paraguay No wheat ... (turned out to be gluten intolerant ) So from 5 years old did not eat bread it made me feel bad , stomach gastric acidity.. so I didn’t eat it )... now I feel like 12 and I am 68 years old ... I started to grow some gray hair after this Pandemic DUE TO HIGH STRESS ... like everyone else ... IF I CAN HELP OR CONTRIBUTE IN ANY WAY TO YOUR STUDIES PLEASE COUNT ON ME ... Oh and started to drink red wine 🍷 when I was 49 ... All my life walked and ran for I hour in city woods (parks ) huge ones CONGRATS DR FOR YOUR EXCELLENT CONTRIBUTION
Brilliant interview. My wife and I are following Dr. Sinclair's works. I'm closed to 60's and started taking NMN last year and got amazing results. We started record our anti-journey in our channel hope to spread out the message of Aging is treatable and the importance of extending healthspan. It's never too late to start.
Have you tried the better version nicotinimide ribosome? There is a lot more research and studies released on it being better it is what I use now from Tru Niagen.
We all must consider aging as a disease..😠 We all must support Dr. David Sinclair and all other Scientists around the world who are trying really hard to reverse the aging process in humans.. This is a really interesting stuff going on all over the world..👍 Love from India..🙏
Thank you Dr. Sinclair! I’ve read your book and watched as many of your videos I can find. This one is particularly detailed and helpful. Makes me feel I actually understand, at least conceptually, how NMN may keep me healthy longer. Gives me HOPE!
I hope that in 20-30 years we will see the advent of cellular engineering, first of all gradually eliminating and reversing the aging factors. Eventually, we will be able to reverse and stabilize human biology at ~20 years old, perhaps completely so in 50 years from now. Although I feel current improvements are minor, I think that Dr. Sinclair is establishing some groundwork on that. Eventually we will have to revise social norms and regulations as this transitions to full genetic and epigenetic engineering at a cell-by-cell level in mature organisms. Perhaps in 100 years from now, it will start to mix with synthetic life components (which will be nothing like we understand by hardware nowadays). Natural evolution is a cruel mistress with random actions and incapable of fundamental redesign, it is a certainty that we shall have to supplant it (as without the cruel 2 out of 3 death rate from natural selection, current society would eventually and inevitably lead to genome degradation across the entire species).
I love the work that you are doing Prof David Sinclair. I wish the world would be mote open to this kind of research & encourage you forward. Being a medical doctor first and holding a master’s degree in Healthy Aging makes me even more interested in this kind of research & I for sure would love to be a member of this group for sure..!!!
While his analogy with Wright brothers might be true, imagine if every time we made a major breakthrough in aviation, the brothers got rejuvenated by 20, 30 or 40 years. Would they be able to live long enough to see humanity reaching another solar system? Maybe. Just because immortality might be centuries away, it doesn't mean we won't live long enough to reach it.
Aging is a medical condition but western doctors will not be open to such radical concepts I’m sure of it yet I’m very excited about this science and the future of health care
People should not be concerned about population growth. People in poor conditions have many more children than people who are well off, as you can see by where most people on earth live and this a natural mechanism so when people are enjoying peace and health they will have less children, Sinclair is right it will level off
David this presentation is great especially the part about the silliness (or perhaps better word nastiness) of academic medicine. In our view, to really address aging academic medicine is essentially obsolete. The fact that the TAME study with Nir took ~4 years to get going says it all. So you know, we are older than you. In our view, your eye program has potentially very serious flaws wherein your actual thesis is correct but will fail after years of work. With this said we’d like to connect with you. We are a big fan of what you are doing-to be clear. However discretion is important as you know.
Wow! Thank you so much for sharing this! Could someone with paralysis benefit from the Yamanaka? I don't know about ethics and laws but think any human with nerve damage wouldn't mind being voluntary for that?
May I insert a caveat style amendment for the audience that to an extent it is wrong to call or view the as opposed to the nerves that run in the legs and arms etc., the cranial nerve no 1 (olfactory) and no 2 (optic) are not true peripheral nerves or central nervous system extensions and can be and should be seen as spinal cord type central nervous system tissue which vehemently resist repair and restoration in axonal damage, (MS type damages to CNS recovers due to its being limited to the myelin sheath). Therefore if there is regeneration of the first two (so called) cranial nerves then you are accomplishing a higher level outcome as opposed to the regular cranial or peripheral nerves which are well known to repair themselves spontaneously e.g. facial nerver palsies routinely recover.
I think it should be treated as disease. I also think that if you were to out line a program of supplements & eating etc, you could get thousands to follow & possibly get some usable data for the benefit of us all....I'm 78, & therefore probable more interested in get some solutions earlier than a younger person who is willing to wait.
It will do the opposite! . NADH inhibits sirtuin action, NAD+ increases them. That is why they came up with NMN and NR as niacin or niacinamide would increase NADH.
@@ruthhorowitz7522 The NADH is NAD+ with an extra Hydrogen so they are close but not the same molecule but you are correct in that the body keeps cycling between them as they transfer energy. I am uncertain on how that can be the case but Sinclair himself has stated that in other interviews. My own guess about a plausible mechanism is that NMN must turn into NAD+ first (that is a fact) and until that has been reduced to NADH won't be excreted while niacin, niacinamide or NADH could be excreted as they are (that is my guess).
Hunger drives up noradrenaline and cortisol increasing wakefulness so it is harder to go to sleep while fasting. However in theory intermittent fasting could help if the eating window is allocated towards the afternoon as it would reinforce the natural noradrenaline and cortisol patterns of the circadian rhythm. But as an imsomniac that had done tons of fasting both intermittent and extended my experience is that it doesn't help, it only makes sleep even harder if hungry. The good news at least for me is that since David Sinclair himself had insomnia and said in several interviews that he uses blue blocking glasses and melatonin at night to help with it. I looked into it and there is science backing blue blocking (search for melanopsin) so I tried it and had been sleeping well for a year. Not any blue blocking glasses would do (there are a lot of scams), mine block 95% of blue and 50% of green and for maximum effectiveness I have to wear them for 4 hours but this days 2 hours would do and even some days I may not wear them and as my circadian rhythm is finally working I will still sleep but it will take a bit longer. I also take melatonin and it helps but was already taking it since almost 20 years ago and wasn't being enough.
@@eruiluvatar236 thanks for the feedback on insomnia can you please tell me the name brand of the blue light blocking glasses you bought? Appreciate that!!!
@@anngv1400 As I was broke I searched aliexpress for the cheapest ones that were still effective. They are no longer in stock but you should be able of finding them searching for blue blocker glasses and looking for the deep amber almost orange looking ones. The clear or slightly yellow ones don't filter enough. The ones I got did have a transmission spectrum in the pictures, searching "blue blocking glasses 95" results in several ones that seem to have the same lenses as mine. There are better ones though. Mine were just 4$ (now they seem to go for about 7) and they do work great but I wish they covered the peripheral vision too as that might make them work even better. I want to get some Uvex S1933X Skyper SCT-Orange or Uvex S0360X some time.
David Thank you so much for everything you are doing for all of us, a question I have is, If you can reverse your age does that mean hair grows back and grey hait turms brown again ? Like we are obviously used to being impossible. I suppose at the time your test age was so much higher and you tried these drugs your hair was brown and the way it is today. I've been very ill a lot and I have lost my hair and it's grey , I feel very unfairly treated by life for that reason (Just being honest) but offcourse I want to move forward in life, Many Thanks >
Not 30, I'm sorry. Theres a distinct look between an older and young person. Their epidermis is fresh looking. An older person, no matter how hard they try has matured in a way that it's impossible to revert back. Anyway, hes a nice guy, but looks 50.
Genetics loads the gun..lifestyle pulls the trigger. My mom lived till 104, I’m 84, still hiking with my daughters, feel grateful and blessed. Not the greatest knees, lol, due to a slip and fall, but use the hiking sticks, which works. Love Dr Sinclair’s work and book. Wishing everyone the best of health!
Yes I consider aging a desease I’m 68 look much younger and feel like 12 years old ...
All my life I took care on what to eat and exercise ...I’m Belgium descendent Born in Paraguay South America . Only ate when feeling hungry healthy vegetables green tea from Paraguay No wheat ... (turned out to be gluten intolerant ) So from 5 years old did not eat bread it made me feel bad , stomach gastric acidity.. so I didn’t eat it )... now I feel like 12 and I am 68 years old ... I started to grow some gray hair after this Pandemic DUE TO HIGH STRESS ... like everyone else
... IF I CAN HELP OR CONTRIBUTE IN ANY WAY TO YOUR STUDIES PLEASE COUNT ON ME ... Oh and started to drink red wine 🍷 when I was 49 ... All my life walked and ran for I hour in city woods (parks ) huge ones
CONGRATS DR FOR YOUR EXCELLENT CONTRIBUTION
Brilliant interview. My wife and I are following Dr. Sinclair's works. I'm closed to 60's and started taking NMN last year and got amazing results. We started record our anti-journey in our channel hope to spread out the message of Aging is treatable and the importance of extending healthspan. It's never too late to start.
i'll check
Have you tried the better version nicotinimide ribosome? There is a lot more research and studies released on it being better it is what I use now from Tru Niagen.
I loooooove your videos. Keep up the good work
Yes David it should be treated as a disease and doctors be able to treat us for it. Thank you for the info and your time. So thankful for your work.
We all must consider aging as a disease..😠 We all must support Dr. David Sinclair and all other Scientists around the world who are trying really hard to reverse the aging process in humans.. This is a really interesting stuff going on all over the world..👍 Love from India..🙏
Funding should really be poured in to accelerate both the research and the clinical trials. We're all on the clock.
Amazing interview. The best I have seen for Prof. David Sinclair so far.
This man is the person who is closest to achieve immortality
Thank you Dr. Sinclair! I’ve read your book and watched as many of your videos I can find. This one is particularly detailed and helpful. Makes me feel I actually understand, at least conceptually, how NMN may keep me healthy longer. Gives me HOPE!
I hope that in 20-30 years we will see the advent of cellular engineering, first of all gradually eliminating and reversing the aging factors. Eventually, we will be able to reverse and stabilize human biology at ~20 years old, perhaps completely so in 50 years from now. Although I feel current improvements are minor, I think that Dr. Sinclair is establishing some groundwork on that.
Eventually we will have to revise social norms and regulations as this transitions to full genetic and epigenetic engineering at a cell-by-cell level in mature organisms. Perhaps in 100 years from now, it will start to mix with synthetic life components (which will be nothing like we understand by hardware nowadays). Natural evolution is a cruel mistress with random actions and incapable of fundamental redesign, it is a certainty that we shall have to supplant it (as without the cruel 2 out of 3 death rate from natural selection, current society would eventually and inevitably lead to genome degradation across the entire species).
I love the work that you are doing Prof David Sinclair. I wish the world would be mote open to this kind of research & encourage you forward. Being a medical doctor first and holding a master’s degree in Healthy Aging makes me even more interested in this kind of research & I for sure would love to be a member of this group for sure..!!!
I remember my teacher saying we born 100 years too early to be able not to age
All the companies are price gouging with NMN
While his analogy with Wright brothers might be true, imagine if every time we made a major breakthrough in aviation, the brothers got rejuvenated by 20, 30 or 40 years. Would they be able to live long enough to see humanity reaching another solar system?
Maybe.
Just because immortality might be centuries away, it doesn't mean we won't live long enough to reach it.
Aging is a medical condition but western doctors will not be open to such radical concepts I’m sure of it yet I’m very excited about this science and the future of health care
its like rna forgot to remember how looks like as a young person.
Can CRISPR-CAS9 TECHNOLOGY help build muscles in old peoples??..
It's a disease but can be slowed down with healthy living exercise live food avoid depression stay happy but it's very difficult.
People should not be concerned about population growth. People in poor conditions have many more children than people who are well off, as you can see by where most people on earth live and this a natural mechanism so when people are enjoying peace and health they will have less children, Sinclair is right it will level off
If aging is natural then we also should consider population growth to be natural..👍
@@debasishborthakur2141 Definitely
As a Lifestyle Medicine Practitioner yes aging is a disease, regular doctors no 👎
Treated, it is a disease sorry I can not help comment,you do great work and thank you.
David this presentation is great especially the part about the silliness (or perhaps better word nastiness) of academic medicine. In our view, to really address aging academic medicine is essentially obsolete. The fact that the TAME study with Nir took ~4 years to get going says it all.
So you know, we are older than you. In our view, your eye program has potentially very serious flaws wherein your actual thesis is correct but will fail after years of work. With this said we’d like to connect with you.
We are a big fan of what you are doing-to be clear. However discretion is important as you know.
Wow! Thank you so much for sharing this! Could someone with paralysis benefit from the Yamanaka? I don't know about ethics and laws but think any human with nerve damage wouldn't mind being voluntary for that?
Nerve death caused by paralysis is not reversible by yamanaka; only aging cells are reversible
Theres still hope in genetic engineering and nano robotics.
Is there even an answer to any of those questions??? It's one of those easy questions with literally no answer to.
reduce Aminos? So no proteine ? What should I eat then?
Yes .enbejeseser debe tratarse como una enfermedad y debe tratarese medicaments. Insomio es parte de enbejeser se puede tratar o curar con ayuno?
Estas preguntando si insomnio se cura con ayuno?
OFF COURSE,THE AGING IS DESEASE...
Why do some say that NMN is cancer
Man I can't wait for 5 years anti aging so I don't have to be a adult
Help me with my dad he has lung cancer please.
Will NADH do what NMN does.
May I insert a caveat style amendment for the audience that to an extent it is wrong to call or view the as opposed to the nerves that run in the legs and arms etc., the cranial nerve no 1 (olfactory) and no 2 (optic) are not true peripheral nerves or central nervous system extensions and can be and should be seen as spinal cord type central nervous system tissue which vehemently resist repair and restoration in axonal damage, (MS type damages to CNS recovers due to its being limited to the myelin sheath). Therefore if there is regeneration of the first two (so called) cranial nerves then you are accomplishing a higher level outcome as opposed to the regular cranial or peripheral nerves which are well known to repair themselves spontaneously e.g. facial nerver palsies routinely recover.
Feel sorry for the mice with crushed optical nerves 😞
Please send me some Metformin.
I think it should be treated as disease. I also think that if you were to out line a program of supplements & eating etc, you could get thousands to follow & possibly get some usable data for the benefit of us all....I'm 78, & therefore probable more interested in get some solutions earlier than a younger person who is willing to wait.
Where did this originally appear?
My 103- year old mother was. diagnosed with alzheimers in 2003. For the last 10 years she have been
Why is everyone's name Steve?
can i take NADH instead of NMN . i cant afford NMN. NADH is cheaper
but NADH does not have any anti aging properties!
Your body cannot absorb NADH.. it's big molecule..
It will do the opposite! . NADH inhibits sirtuin action, NAD+ increases them. That is why they came up with NMN and NR as niacin or niacinamide would increase NADH.
@@ruthhorowitz7522 The NADH is NAD+ with an extra Hydrogen so they are close but not the same molecule but you are correct in that the body keeps cycling between them as they transfer energy.
I am uncertain on how that can be the case but Sinclair himself has stated that in other interviews.
My own guess about a plausible mechanism is that NMN must turn into NAD+ first (that is a fact) and until that has been reduced to NADH won't be excreted while niacin, niacinamide or NADH could be excreted as they are (that is my guess).
60/100 is possible
Its really possible reverse age?
@@ruthhorowitz7522 i hope so
Yes, it should be treated as a reverseable process.
Can you cured insomnia with fasting?
Hunger drives up noradrenaline and cortisol increasing wakefulness so it is harder to go to sleep while fasting. However in theory intermittent fasting could help if the eating window is allocated towards the afternoon as it would reinforce the natural noradrenaline and cortisol patterns of the circadian rhythm.
But as an imsomniac that had done tons of fasting both intermittent and extended my experience is that it doesn't help, it only makes sleep even harder if hungry.
The good news at least for me is that since David Sinclair himself had insomnia and said in several interviews that he uses blue blocking glasses and melatonin at night to help with it. I looked into it and there is science backing blue blocking (search for melanopsin) so I tried it and had been sleeping well for a year. Not any blue blocking glasses would do (there are a lot of scams), mine block 95% of blue and 50% of green and for maximum effectiveness I have to wear them for 4 hours but this days 2 hours would do and even some days I may not wear them and as my circadian rhythm is finally working I will still sleep but it will take a bit longer. I also take melatonin and it helps but was already taking it since almost 20 years ago and wasn't being enough.
@@eruiluvatar236 thanks for the feedback on insomnia can you please tell me the name brand of the blue light blocking glasses you bought? Appreciate that!!!
@@anngv1400 As I was broke I searched aliexpress for the cheapest ones that were still effective. They are no longer in stock but you should be able of finding them searching for blue blocker glasses and looking for the deep amber almost orange looking ones. The clear or slightly yellow ones don't filter enough.
The ones I got did have a transmission spectrum in the pictures, searching "blue blocking glasses 95" results in several ones that seem to have the same lenses as mine.
There are better ones though. Mine were just 4$ (now they seem to go for about 7) and they do work great but I wish they covered the peripheral vision too as that might make them work even better. I want to get some Uvex S1933X Skyper SCT-Orange or Uvex S0360X some time.
David Thank you so much for everything you are doing for all of us, a question I have is, If you can reverse your age does that mean hair grows back and grey hait turms brown again ? Like we are obviously used to being impossible. I suppose at the time your test age was so much higher and you tried these drugs your hair was brown and the way it is today. I've been very ill a lot and I have lost my hair and it's grey , I feel very unfairly treated by life for that reason (Just being honest) but offcourse I want to move forward in life, Many Thanks >
This man looks younger than a couple of months ago. Thats crazy.
Maybe Sinclair already takes MIB 626?
Different lighting can make anyone seem younger in fairness. But Sinclair does look younger than his years no doubt.
No white hairs at 50?
This man looks 50, Comeon
Would look 20 years younger ,when the beard would be removed
Not 30, I'm sorry. Theres a distinct look between an older and young person. Their epidermis is fresh looking. An older person, no matter how hard they try has matured in a way that it's impossible to revert back. Anyway, hes a nice guy, but looks 50.