I am fascinated by his research but it wasn't very well explained how working with pro-cyclists has helped his research. I think I would have asked what effect pro-cycling or even cycling exercise has on this metabolic blocking process to kill cancer cells.
I’d ask him why it is that he reminds me of another exercise physiologist who trained professional cyclists in the 1990s and 2000s with so-called revolutionary training methods. Amazing how Pog is able to rip the legs off everyone on under-raced legs and lots of zone 2 training.
The timing of this excellent video could not be more significant for me, a 62 year old active cyclist with chronic lymphocytic leukemia (CLL). I was diagnosed in October 2021 and have just had my 18 month review this very day (14th July 2023). I'm very happy to report I'm in remission and my gut says that besides my miracle chemo drug, my recovery is due in no small measure to intense exercise including regular spin sessions, gym work and, of course, road cycling. I think it certainly helped me tolerate the chemo so well with no side effects after the first few months. I would very much welcome any relevant resources that explains more on the research discussed here in layman's terms.
Valter Longo's research on fasting prior and post chemo seems relevant on the input side. Other cells will go into hybernate mode so they won't consume the chemo whereas the fasting does not affect the cancer cells. If you do exercise as well, preventing lactate, and further carcinogenesis then super.
Absolutely incredible research and show... I am Stage 4 pulmonary adenocarcinoma. (lung cancer) ... non smoker.. (for those who judge).. I was originally told that I had 4 months... I am an old roadie, and refused to put my bike down, I have done ten sessions of radiation and 3 series of chemotherapies and one series of immunotherapy, Next month I will be starting a series of directed chemotherapy. I ride. I ride because I still can, my bike has, in my brain kept me alive. I am now ten years into my cancer journey, abused but not beaten. I am certain my bike has kept me going, I understand the words he is saying, but not certain I could use them in a sentence... If blocking lactate is the goal.. why is riding helping me?.. ok.. I am not really producing a lot of lactate (I don't think... I'm 61 years old, one lung and abused... aka not fast, but I do long, long 200+ km rides) Can you shed some light as to what might be going on? I think reducing/ controlling glucose is good... and increasing mitochondrial function... good. But I don't know how much lactate and me have in common. I guess maybe more than I think, my right lung is not functional, the smaller left lung has taken on the task of keeping me upright on the bike.
They should really have answered what the exact relationship between lactate and elite cyclist is. But it's not hard to guess at: exercise probably increases your body's ability to metabolise lactate effectively, thereby becoming better at clearing lactate. So, lactate goes up during exercise, but that also builds your body's ability to clear it.
Good question, from what I’ve heard from Dr San Milan, I hypothesize that increase in mitochondrial density increases the amount of lactate shuttling power. Essentially clearing the amount present in the cell/body.
I think the goal of this research is to find a way to control lactate production in cancer cells, so they need to understand they way it is cleared in an athlete cells. It does not mean that an athlete could have cancer because o lactate produced during exercise.
Fascinating interview, Iñigo is so interesting to listen to. I was diagnosed with a tumour in my right lung a year ago, and it was suspected to be cancer. Following a thoracotamy and lobectomy to remove the tumour, it was thankfully benign. However, as I had cycled for most of my 60 years, my lung function was really high, even though a third of the right lung was a tumour. Because of this, the surgeon had no issues operating and put my speedy recovery down to my overall fitness, too. I was discharged 3 days after the operation and on my indoor trainer 2 weeks later. Recently completed the Ride Clywd Sportive and raised over £1600 for Macmillan.
I’m 11 years from my diagnosis of advanced bowel cancer, 2 large tumours, 1 extending beyond the bowel and into the surrounding tissues. I was a keen cyclist before my discovering I had cancer, I regularly rode 80+ miles in the Peak District on Summer Sundays. The day after I was diagnosed I hit the bike and rode as hard as I could though surgery, 6 months of chemotherapy and 2 years of treatment overall. I came out of that time leaner (10+kg lighter) and much faster. Cycling saved me mentally and kept me physically strong.
My story is the same... keep the bike on the road!! I am 10 years with stage four lung cancer... with a prognosis of 4 months... my bike and everything it gives back to me... has kept me alive. Keep on riding! when they tell me I failed another CTScan... I ride harder. f them
Two interviews with Iñigo, two smashing successes. Please continue to feature interviews with him and other experts. The repertoire of knowledge and content we receive from GCN is outstanding. Bravo!
Love love love love. He is quite literally the boss. Cycling saved my life physically and certainly mentally when I had cancer and nothing makes me happier than hearing this guy talk about bringing these two things together. Hope for the future is what we all need. ❤
I work in this field. I work on mitochondrial function. Very well explained, I have to teach some of this over the next month. About ten years back an opposing tack to blocking lactate was used to enhance mitochondrial function (search DCA). Worked really well on rats, not so well in humans. I have yet to see both approaches used at the same time. I didn't expect to see this topic here, so good job.
Dear GCN legends, from Saudi Arabia, i send you my best wishes. That's why i love GCN, it's not a training sessions only, but a life of health and hope. 4 years ago, i was 92 kg, a very high cholesterol, with a poor fitness, watched lots of fantastic clips. Solo outdoor training, indoor training, then joined groups, now i am a professional player, 69 kg, with a great ftp. Bye to cholesterol and over weight. Love love GCN.
Thank you, Simon, for this amazing and informative interview with Dr. San Millan. I never thought a GCN cycling video would lead me to an internationally renowned Ph.D. in applied physiologist in my home state of Colorado that studies how the top pro cyclists boost mitochondrial function and impact longevity and could be a link to curing cancer. At age 61, I successfully finished my 10th Ironman distance race on 9-11, 2022, and in January 2023, I was diagnosed with a stage 4 brain tumor and operated on at CU Anschutz. Except for the two days of the surgery, I have exercised every day and continue to do what I love; swim, Bike and run. I've already run a half marathon, raced at an Olympic distance triathlon and have many more events on my schedule. I attribute my recovery to my mindset, specifically my mental strength, determination, and physical endurance. I am confident that the professor's research will provide vital clues and answers for how to cure this dreaded disease.
This was so brilliantly explained, something so complicated makes it simplified and so interesting. There's a reason Pog has him as a coach, because he truly is brilliant. I always get overloaded with the science data in sports, but a coach like that I can see how he makes it so easy to digest
@nluisa Legitimate scientists build on earlier research and routinely credit or cite their prediscessors. This is because the results of scientific studies are always open to questioning by other researchers. Skepticism is valued and questions tested using the scientific method, the process recognized in this interview. Anyone, especially as "scientist" or "expert" who tells you that a thesis is completely settled and discourages or demonizes those who question his or her findings is not a scientist, but an activist. Phyllis Boone MSN ANP-BC Retired
Thank you Simon again for the interview with Dr. San Millan. My Biochemistry professors back in the early 90s always told me the regulation of all these pathways is the most important concept to understand. We could not have imagined at the time that these concepts would be a great weapon against cancer. Please continue to have interviews with Dr. San Millan as often as you can. BRILLIANT VIDEO!
Love the deeper conversations on nutrition, psychology, and now around metabolism in relationship to cancer. Cancer has been a burden on all of humanity for hundreds of years. Finding a cure will bring us all to a more fulfilling life experience on this planet.
Truly great content 👍 I work in development for a global pharmaceutical company I really appreciate the long form version of this he’s so effusive and explains his work and interests so well
This man is absolutely incredible. Despite entering, sometimes, into technical details I cannot grasp, generally he's able to explain to "mere mortals" the general concepts. And if his (and others, like he recalls more than once) work really goes through, what an advance it will really be. FANTASTIC video!!
Kudos to Dr Inigo and other doctor/scientist out there. I really like how he mention that "I will not cure cancer of course, but at least we open new door." A TRUE scientist and a person this world need more of.
I wish Inigo had been my science teacher I would have got top marks, he’s so knowledgable and makes a very complicated subject easy to understand thanks GCN great content 🥰
So interesting and informative, greatly appreciate GCN going a bit beyond the realm of actual cycling. So important to be informed and for true science to be so clearly explained be a real caring expert. Thank you GCN!!
As a 70+ year old fighting cancer fires, stamping out metastasizing skin cancer cells, seeing in recent times that various scientists are explaining that sugar, glucose and exercise are vitally linked with cancer are revelations which younger people should be paying very close attention too. GCN must keep up the message that exercise plus the liberal use of sun blocking agents are vital.
Wow!!! I knew my father was a "genius" ;) lol... But seriously, Wow, very interesting and informative. And I do think my father is a maverick. Started road cycling again at around 50. Had a serious brain trauma injury in 1999 (fell off his bike), got back to cycling after therapy...2006, cancer #1 required surgery, resulted in removal of a kidney. Got back on the bike...2016, cancer #2 one round of radiation, went into remission, kept cycling...2020 comes back, chemo. Went into remission, keeps cycling. My father celebrated this May his 79th birthday and is and avid road cyclist. He rides to stay mentally and physically healthy, and truthfully in his case we think it's what keeping him alive and he would agree. Thank you for sharing this video @inigosanmillan
Very interesting! The more differing approaches to curing cancer the better! Every idea starts off as speculation but surely another lane to venture down is better than just relying on previous theories.
Fascinating! My whole family has died from cancer. Needless to say I'm super high cancer risk. It gives me hope to hear that new avenues are being researched after the, let's be honest, depressing lack of success through Gene research! Good luck for the future!
Bicycling is the safest, most efficient way to train the body's metabolism to its highest possible levels where cancer-fighting mechanisms might be engaged. Elite cyclists should be studied. I'm dubious about "pro" cyclists being included because their systems may be compromised by any number of hazardous, perhaps illegal, substances. I hope this research gains support for the possible medical results and the boost our sport may enjoy when positive health benefits, vis-a-vis cancer-fighting effects, are confirmed.
The scary part is.. if the medical companies don’t see maximum profit, from the expected results from the research, the research is never going to be funded, and a possible cure will never see the light of day 😢 Money talks🤷♂️
Great interview Simon very interesting and brilliantly explained by Dr Inigo :-) is there a scale lactate threshold we can work with / Age / Size expected for the average person or is it just different for everyone?
Lance Armstrong's would be a case study. Having had stage 3 cancer which spread to his lungs and brain, although he underwent chemo he is cancer free to date.. Wonder if what is discussed in video was what had help him in his recovery.
Phenomenal discussion. I would listen to Dr Millan all day. Science is fascinating and the future of cancer research and prevention seems brighter by the day thanks for people like this.
Thank you Si and GCN. I live and breathe this stuff. Inigo is definitely not going to be popular with cancer geneticists. 😂😂 How about another episode to tie how cycling affects cellular metabolism and provides sustained health benefits and helps counter a wide variety of pathologies from diabetes to cardiovascular pathologies as well oncology. Great content .. this increases awareness and multiple levels. Also, one doesn't need to be a Tour d France level athlete to reap the health benefits cycling brings to ones life.
The fundamental question pertaining to cycling is: "How does this research benefit Pogi and the UAE team"? I imagine that they may produce less lactic acid.... therefore improving their performance?
Nothing to do with this video but thank you Hank for saying hello to me this morning outside GCN mega base. You're a star for not telling me where to get off on your way into work. 👏👏👏
Great content and hence exercise of any kind is great for health. But what I love most is Si intensity to listen when Inigo talks about gene expression and pathways.! All Si is missing is his trusty old lab coat.
Great Video! With several teams now sponsored by oil rich companies (which will soon be criticised by the non cycling public in view of the "Just Stop Oil" crowd and their like) it would be great that under the UAE sponsorship all these rich petro dollar teams gave Dr Inigo and his fellow researchers the funds they need.
Very interesting video. However I really struggle to understand exactly how knowledge of these athletes helped to understand anything about the reprogramming of cancer cells towards lactate metabolism. You can't study the energy metabolism in the cells of these athletes. But besides that, the energy metabolism of cancerous cells , like Inigo said, is reprogrammed towards lactate production rather than the Krebs cycle and oxidative phosphorylation like in healthy cells. This difference is between healthy cells and cancerous cells, but how does knowledge from athletes come in handy there? Just really curious what insights were so useful for the researchers.
He spoke only about the glucose molecule in his metabolic discussion, but did not discuss the impact of fructose. Fructose has been directly linked to metabolic dysfunction leading to many diseases including diabetes. His research seems to be focused only on the impact of lactate on cancer cells. Will his studies be correlated to other areas of metabolic dysfunction?
I loved this, very interesting and.as a scientist it's not too complicated for the lay person and gives enough for someone who works in the area as a general interest. That said, we. are a long way from a therapy in this area I guess. Will watch with interest. Thanks GCN
Every time GCN has Iñigo on, my IQ increases. This is fascinating content and the work that he is doing with cancer research is incredible. Thank you, GCN. And thank you, Dr. San Millán for your work in cancer research.
It is a fact that cancer cells thrive on sugars like glucose and fructose. A lot of what we consume has high amounts of those sugars which for the sedentary person can be potentially dangerous.
Cancer cells genetically reprogram themselves in order to be able to consume more glucose than surrounding cells, to be able to grow and multiply faster, basically giving them a competitive advantage, so tumors can grow (unfortunately). So the fact that cancer cells use more glucose isn't due to ingestion of sugar.
@@gcn These deep dives are both accessible and insightful. It would be interesting to have more expert content on other sports science and nutrition areas. Stephen Seiler comes to mind, for instance.
Maybe you guys could look into Dr Thomas Seyfried's research (his theory - in a nutshell ) is that cancer is a metabolic disease rather than a genetic one.
Most of the research and understanding on these pathways has come from an sports science perspective. In order to understand and improve elite performance. Its just dawned on the wider medical field that this knowledge might have a wider application. I think some of this disconnect comes from funding: if you are studying performance you can get funding from players in that area, if you are a cancer scientist (up until recently) it's likely you would struggle to get cancer research funding if you wanted to research metabolic function. As far as I understand it, it's not per say the fact they were researching elite athletes rather than "normal people" that matters but the fact that that's where there was an interest/ opportunity for funding.
As I understand it, the elite athletes effectively have the “perfect” metabolic function and so by studying then you can then observe where it goes wrong in patients with diseases such as cancer, diabetes etc. I think!
So, is this also the explanation that doing sports (low intensity of course) is a prevention against cancer? As a well trained person is able to clear lactate well...
For those interested in this Dr. Thomas Seyfried has way better explanations on this metabolic role in cancer. And has performed countless of research and found no cancer type can survive with no glucose and glutamine, If you rule those 2 sources out cancer dies, however normal cells can live without these 2 factors. There are plenty of interviews with him on youtube. Lactid acid plays a role in creating cancer in the first place as it is the lack of oxygen that starts the cycle of creating cancer cells. As it seems to be an old cell survival mechanism for cells when living in low oxygen environment.
Thank you for keeping on with THE Doctor - what a brilliant mind. I'm in awe, and I hope he and his colleagues are on the right track- genetics certainly doesn't seem to be the only answer to much of anything, so it makes sense there'd be more to curing/preventing cancer than just straight up gene therapy. I'd actually like to hear more about this.
What would you ask Iñigo?🧪
What's the most popular "illegal" substance used by the pros.
What are his thoughts on fenbendazole as a potential cure?
I am fascinated by his research but it wasn't very well explained how working with pro-cyclists has helped his research. I think I would have asked what effect pro-cycling or even cycling exercise has on this metabolic blocking process to kill cancer cells.
When was the last timed you doped and got away with it.
I’d ask him why it is that he reminds me of another exercise physiologist who trained professional cyclists in the 1990s and 2000s with so-called revolutionary training methods. Amazing how Pog is able to rip the legs off everyone on under-raced legs and lots of zone 2 training.
The timing of this excellent video could not be more significant for me, a 62 year old active cyclist with chronic lymphocytic leukemia (CLL). I was diagnosed in October 2021 and have just had my 18 month review this very day (14th July 2023). I'm very happy to report I'm in remission and my gut says that besides my miracle chemo drug, my recovery is due in no small measure to intense exercise including regular spin sessions, gym work and, of course, road cycling. I think it certainly helped me tolerate the chemo so well with no side effects after the first few months. I would very much welcome any relevant resources that explains more on the research discussed here in layman's terms.
www.ncbi.nlm.nih.gov/pmc/articles/PMC4783224/
Amazing spirit!
Valter Longo's research on fasting prior and post chemo seems relevant on the input side. Other cells will go into hybernate mode so they won't consume the chemo whereas the fasting does not affect the cancer cells. If you do exercise as well, preventing lactate, and further carcinogenesis then super.
Search home made kefir yogurt. Make yourself at home this yogurt. It's life-saving, especially for cancer patients, especially after recovery.
Here is how you do chefir at home: ua-cam.com/video/L6ALXFkSvLc/v-deo.html.
Absolutely incredible research and show... I am Stage 4 pulmonary adenocarcinoma. (lung cancer) ... non smoker.. (for those who judge).. I was originally told that I had 4 months... I am an old roadie, and refused to put my bike down, I have done ten sessions of radiation and 3 series of chemotherapies and one series of immunotherapy, Next month I will be starting a series of directed chemotherapy. I ride. I ride because I still can, my bike has, in my brain kept me alive. I am now ten years into my cancer journey, abused but not beaten. I am certain my bike has kept me going, I understand the words he is saying, but not certain I could use them in a sentence... If blocking lactate is the goal.. why is riding helping me?.. ok.. I am not really producing a lot of lactate (I don't think... I'm 61 years old, one lung and abused... aka not fast, but I do long, long 200+ km rides) Can you shed some light as to what might be going on? I think reducing/ controlling glucose is good... and increasing mitochondrial function... good. But I don't know how much lactate and me have in common. I guess maybe more than I think, my right lung is not functional, the smaller left lung has taken on the task of keeping me upright on the bike.
They should really have answered what the exact relationship between lactate and elite cyclist is. But it's not hard to guess at: exercise probably increases your body's ability to metabolise lactate effectively, thereby becoming better at clearing lactate. So, lactate goes up during exercise, but that also builds your body's ability to clear it.
Good question, from what I’ve heard from Dr San Milan, I hypothesize that increase in mitochondrial density increases the amount of lactate shuttling power. Essentially clearing the amount present in the cell/body.
I think the goal of this research is to find a way to control lactate production in cancer cells, so they need to understand they way it is cleared in an athlete cells. It does not mean that an athlete could have cancer because o lactate produced during exercise.
Fascinating interview, Iñigo is so interesting to listen to.
I was diagnosed with a tumour in my right lung a year ago, and it was suspected to be cancer. Following a thoracotamy and lobectomy to remove the tumour, it was thankfully benign. However, as I had cycled for most of my 60 years, my lung function was really high, even though a third of the right lung was a tumour. Because of this, the surgeon had no issues operating and put my speedy recovery down to my overall fitness, too. I was discharged 3 days after the operation and on my indoor trainer 2 weeks later. Recently completed the Ride Clywd Sportive and raised over £1600 for Macmillan.
Amazing story
You are the man!
I’m 11 years from my diagnosis of advanced bowel cancer, 2 large tumours, 1 extending beyond the bowel and into the surrounding tissues. I was a keen cyclist before my discovering I had cancer, I regularly rode 80+ miles in the Peak District on Summer Sundays. The day after I was diagnosed I hit the bike and rode as hard as I could though surgery, 6 months of chemotherapy and 2 years of treatment overall. I came out of that time leaner (10+kg lighter) and much faster. Cycling saved me mentally and kept me physically strong.
My story is the same... keep the bike on the road!! I am 10 years with stage four lung cancer... with a prognosis of 4 months... my bike and everything it gives back to me... has kept me alive. Keep on riding! when they tell me I failed another CTScan... I ride harder. f them
Two interviews with Iñigo, two smashing successes. Please continue to feature interviews with him and other experts. The repertoire of knowledge and content we receive from GCN is outstanding. Bravo!
Thank you GCN for keep bringing Iñigo back. These videos are so interesting and educational at the same time. Chapeau.
Don't move that!
Love love love love. He is quite literally the boss. Cycling saved my life physically and certainly mentally when I had cancer and nothing makes me happier than hearing this guy talk about bringing these two things together. Hope for the future is what we all need. ❤
I work in this field. I work on mitochondrial function. Very well explained, I have to teach some of this over the next month. About ten years back an opposing tack to blocking lactate was used to enhance mitochondrial function (search DCA). Worked really well on rats, not so well in humans. I have yet to see both approaches used at the same time. I didn't expect to see this topic here, so good job.
Dear GCN legends, from Saudi Arabia, i send you my best wishes. That's why i love GCN, it's not a training sessions only, but a life of health and hope.
4 years ago, i was 92 kg, a very high cholesterol, with a poor fitness, watched lots of fantastic clips. Solo outdoor training, indoor training, then joined groups, now i am a professional player, 69 kg, with a great ftp. Bye to cholesterol and over weight.
Love love GCN.
Thank you, Simon, for this amazing and informative interview with Dr. San Millan. I never thought a GCN cycling video would lead me to an internationally renowned Ph.D. in applied physiologist in my home state of Colorado that studies how the top pro cyclists boost mitochondrial function and impact longevity and could be a link to curing cancer. At age 61, I successfully finished my 10th Ironman distance race on 9-11, 2022, and in January 2023, I was diagnosed with a stage 4 brain tumor and operated on at CU Anschutz. Except for the two days of the surgery, I have exercised every day and continue to do what I love; swim, Bike and run. I've already run a half marathon, raced at an Olympic distance triathlon and have many more events on my schedule. I attribute my recovery to my mindset, specifically my mental strength, determination, and physical endurance. I am confident that the professor's research will provide vital clues and answers for how to cure this dreaded disease.
I love every interview that you've done with Dr San Millán, as well as other outlets. He's brilliant and kind. Please have him on as much as you can.
Let's recognize Si's interviewing skill as well as the hopeful information from Inigo. Throughly enjoyed this presentation.
This was so brilliantly explained, something so complicated makes it simplified and so interesting. There's a reason Pog has him as a coach, because he truly is brilliant. I always get overloaded with the science data in sports, but a coach like that I can see how he makes it so easy to digest
We love sitting down with Iñigo! Always a fountain of knowledge, did you catch our previous meetings? 👉 ua-cam.com/video/NQrlEWW8WvE/v-deo.html
I love the fact he keeps on quoting and refering to other scientists work. It isn't often seen in the science community.
@nluisa Legitimate scientists build on earlier research and routinely credit or cite their prediscessors. This is because the results of scientific studies are always open to questioning by other researchers. Skepticism is valued and questions tested using the scientific method, the process recognized in this interview. Anyone, especially as "scientist" or "expert" who tells you that a thesis is completely settled and discourages or demonizes those who question his or her findings is not a scientist, but an activist. Phyllis Boone MSN ANP-BC Retired
Thank you Simon again for the interview with Dr. San Millan. My Biochemistry professors back in the early 90s always told me the regulation of all these pathways is the most important concept to understand. We could not have imagined at the time that these concepts would be a great weapon against cancer. Please continue to have interviews with Dr. San Millan as often as you can. BRILLIANT VIDEO!
Love the deeper conversations on nutrition, psychology, and now around metabolism in relationship to cancer.
Cancer has been a burden on all of humanity for hundreds of years.
Finding a cure will bring us all to a more fulfilling life experience on this planet.
Cancer has been around longer than humans have.
Chemotherapy has been around for decades. It cures cancer. I'm one of those survivors.
Truly great content 👍 I work in development for a global pharmaceutical company I really appreciate the long form version of this he’s so effusive and explains his work and interests so well
Honestly unreal, my mom goes in 1 week from today to have a cancerous tumor removed from her pancreas. Let's go cycling!
Love love love these interviews with Inigo, please keep this variety of content going ❤
Great stuff! Si's occasional serious health-related videos are why I'm still subbed, less Shimano ads and more of this lol
GCN keeps bringing up their game. This is awesome and I’ll be sharing the video for sure!
Great interview. Hope to see this in translational research some day.
This man is absolutely incredible. Despite entering, sometimes, into technical details I cannot grasp, generally he's able to explain to "mere mortals" the general concepts. And if his (and others, like he recalls more than once) work really goes through, what an advance it will really be. FANTASTIC video!!
Kudos to Dr Inigo and other doctor/scientist out there. I really like how he mention that "I will not cure cancer of course, but at least we open new door." A TRUE scientist and a person this world need more of.
I wish Inigo had been my science teacher I would have got top marks, he’s so knowledgable and makes a very complicated subject easy to understand thanks GCN great content 🥰
This and previous interview with Dr I S M some of the most "grown up" and interesting videos I think GCN have produced. Excellent, Thank You.
Great coverage GCN!
Love this guy, so humble but so pioneering in everything he does!
So interesting and informative, greatly appreciate GCN going a bit beyond the realm of actual cycling. So important to be informed and for true science to be so clearly explained be a real caring expert.
Thank you GCN!!
As a 70+ year old fighting cancer fires, stamping out metastasizing skin cancer cells, seeing in recent times that various scientists are explaining that sugar, glucose and exercise are vitally linked with cancer are revelations which younger people should be paying very close attention too.
GCN must keep up the message that exercise plus the liberal use of sun blocking agents are vital.
OUTSTANDING!!! As a 2 time cancer survivor this gives me huge hope. Proof that not all superheroes wear capes ❤
More Iñigo and his research on GCN please! Top stuff
One of the best GCN’s to date, IMHO.
Wow!!! I knew my father was a "genius" ;) lol... But seriously, Wow, very interesting and informative. And I do think my father is a maverick. Started road cycling again at around 50. Had a serious brain trauma injury in 1999 (fell off his bike), got back to cycling after therapy...2006, cancer #1 required surgery, resulted in removal of a kidney. Got back on the bike...2016, cancer #2 one round of radiation, went into remission, kept cycling...2020 comes back, chemo. Went into remission, keeps cycling. My father celebrated this May his 79th birthday and is and avid road cyclist. He rides to stay mentally and physically healthy, and truthfully in his case we think it's what keeping him alive and he would agree. Thank you for sharing this video @inigosanmillan
Very interesting! The more differing approaches to curing cancer the better! Every idea starts off as speculation but surely another lane to venture down is better than just relying on previous theories.
Fascinating! My whole family has died from cancer. Needless to say I'm super high cancer risk. It gives me hope to hear that new avenues are being researched after the, let's be honest, depressing lack of success through Gene research! Good luck for the future!
I absolutely love this video. It is not something I expected at GCN and it is a pleasant surprise. More of this content would be awesome!
Bicycling is the safest, most efficient way to train the body's metabolism to its highest possible levels where cancer-fighting mechanisms might be engaged. Elite cyclists should be studied. I'm dubious about "pro" cyclists being included because their systems may be compromised by any number of hazardous, perhaps illegal, substances. I hope this research gains support for the possible medical results and the boost our sport may enjoy when positive health benefits, vis-a-vis cancer-fighting effects, are confirmed.
And that's one of the reasons why I study moleculare medicine...very interesting video, thank you
Thank you Si and Dr I....as a survivor , and again a patient , the research means a lot . Life is experimental , eh?
These are the best videos GCN makes. Keep it up.
I could listen to Iñigo all day.
The scary part is.. if the medical companies don’t see maximum profit, from the expected results from the research, the research is never going to be funded, and a possible cure will never see the light of day 😢
Money talks🤷♂️
Just fascinating !!! Thank you GCN and Inigo.
Great interview Simon very interesting and brilliantly explained by Dr Inigo :-) is there a scale lactate threshold we can work with / Age / Size expected for the average person or is it just different for everyone?
Absolutely fascinating. I could listen to Dr Inigo for days.
Thank you for the interesting interview!
Fascinating! Thanks for the essential research you are doing and thanks GCN for the oppotunity to personally grow. Please more videos like this
Absolutely brilliant best gcn video for ages
Lance Armstrong's would be a case study. Having had stage 3 cancer which spread to his lungs and brain, although he underwent chemo he is cancer free to date.. Wonder if what is discussed in video was what had help him in his recovery.
Listening to Dr MIllan is awesome! Bring on more experts!
Really interesting video. Thanks GCN.
holy cow, this was incredibly insightful and informative. thanks!!
Thank you. Brilliant and fascinating interview. Wish it had been longer 😀
Phenomenal discussion. I would listen to Dr Millan all day. Science is fascinating and the future of cancer research and prevention seems brighter by the day thanks for people like this.
Thank you Si and GCN. I live and breathe this stuff. Inigo is definitely not going to be popular with cancer geneticists. 😂😂
How about another episode to tie how cycling affects cellular metabolism and provides sustained health benefits and helps counter a wide variety of pathologies from diabetes to cardiovascular pathologies as well oncology.
Great content .. this increases awareness and multiple levels. Also, one doesn't need to be a Tour d France level athlete to reap the health benefits cycling brings to ones life.
The fundamental question pertaining to cycling is:
"How does this research benefit Pogi and the UAE team"?
I imagine that they may produce less lactic acid.... therefore improving their performance?
That is soo promising! Keep doing great work sir 👏👏
At 6:30, he lowkey called Pogacar a machine... XD
Chapeau GCN for bringing this man into the lime light ✨️
Very good report. Excellent questions and answers.
All respects to Dr Inigo. He is a big scientist and he shares things in very clear way.
wow, really fascinating! Great video, thanks Sy!!
Nothing to do with this video but thank you Hank for saying hello to me this morning outside GCN mega base. You're a star for not telling me where to get off on your way into work. 👏👏👏
Fantastic informative interview 👍🏻very much like Jane mcllellands protocol for blocking cancer pathways.
Great content and hence exercise of any kind is great for health. But what I love most is Si intensity to listen when Inigo talks about gene expression and pathways.! All Si is missing is his trusty old lab coat.
More like this please GCN, great thought provoking content 👍
Great Video!
With several teams now sponsored by oil rich companies (which will soon be criticised by the non cycling public in view of the "Just Stop Oil" crowd and their like) it would be great that under the UAE sponsorship all these rich petro dollar teams gave Dr Inigo and his fellow researchers the funds they need.
extremely interesting video, my family has been ravaged by cancer and is still being ravaged so any sign of a future cure brings hope.
Man, I'd love to see Iñigo on the Huberman lab podcast :)
Brilliant video
Something completely different to the usual but well worth watching
The man is an absolute legend, chapeau!
This is increasingly prominent in low carb circles, but a nice crossover between cycling and metabolic disease. Interesting.
Great video I'm sure it could bring hope to a lot of people out there 🙂
Great interview Thanks!
Very interesting video. However I really struggle to understand exactly how knowledge of these athletes helped to understand anything about the reprogramming of cancer cells towards lactate metabolism. You can't study the energy metabolism in the cells of these athletes. But besides that, the energy metabolism of cancerous cells , like Inigo said, is reprogrammed towards lactate production rather than the Krebs cycle and oxidative phosphorylation like in healthy cells. This difference is between healthy cells and cancerous cells, but how does knowledge from athletes come in handy there? Just really curious what insights were so useful for the researchers.
I would like to hear the opinion of other researchers as well.
He spoke only about the glucose molecule in his metabolic discussion, but did not discuss the impact of fructose. Fructose has been directly linked to metabolic dysfunction leading to many diseases including diabetes. His research seems to be focused only on the impact of lactate on cancer cells. Will his studies be correlated to other areas of metabolic dysfunction?
I loved this, very interesting and.as a scientist it's not too complicated for the lay person and gives enough for someone who works in the area as a general interest. That said, we. are a long way from a therapy in this area I guess. Will watch with interest. Thanks GCN
Every time GCN has Iñigo on, my IQ increases. This is fascinating content and the work that he is doing with cancer research is incredible. Thank you, GCN. And thank you, Dr. San Millán for your work in cancer research.
Fascinating :) Thanks for your hard work guys God bless you :)
It is a fact that cancer cells thrive on sugars like glucose and fructose. A lot of what we consume has high amounts of those sugars which for the sedentary person can be potentially dangerous.
Cancer cells genetically reprogram themselves in order to be able to consume more glucose than surrounding cells, to be able to grow and multiply faster, basically giving them a competitive advantage, so tumors can grow (unfortunately). So the fact that cancer cells use more glucose isn't due to ingestion of sugar.
He literally said this is not the case in the video and its a misconception.
Correct!
That was fantastic please do more
Wow that was really interesting, thank you.
I love these deep looks. Great video, thank you.
And we long filming them 🙌 What topics would you like to see us dive into next?
@@gcn These deep dives are both accessible and insightful. It would be interesting to have more expert content on other sports science and nutrition areas. Stephen Seiler comes to mind, for instance.
The science of Autophagy and the associated practice of proper Fasting is an enemy of Cancer.
Truly amazing!
Yes yes, this is not the first time Cancer doctors shared secrets with cycling, EPO comes to mind
Sounds great - let's hope they are onto something (quickly).
Maybe you guys could look into Dr Thomas Seyfried's research (his theory - in a nutshell ) is that cancer is a metabolic disease rather than a genetic one.
More of these videos please!!!🙏
Are these lactate blockers used in the tour???
Fascinating interview. However I’m still unclear how they are utilizing the data from elite athletes to further their research or theories.
Most of the research and understanding on these pathways has come from an sports science perspective. In order to understand and improve elite performance. Its just dawned on the wider medical field that this knowledge might have a wider application. I think some of this disconnect comes from funding: if you are studying performance you can get funding from players in that area, if you are a cancer scientist (up until recently) it's likely you would struggle to get cancer research funding if you wanted to research metabolic function. As far as I understand it, it's not per say the fact they were researching elite athletes rather than "normal people" that matters but the fact that that's where there was an interest/ opportunity for funding.
As I understand it, the elite athletes effectively have the “perfect” metabolic function and so by studying then you can then observe where it goes wrong in patients with diseases such as cancer, diabetes etc. I think!
how awesome this video!
They must be using something like the Norwegian method for Tadej
So, is this also the explanation that doing sports (low intensity of course) is a prevention against cancer? As a well trained person is able to clear lactate well...
Interesting insight!
No, too simplistic.
Amazing content.
That was very interesting and informative. Thank you.
For those interested in this Dr. Thomas Seyfried has way better explanations on this metabolic role in cancer.
And has performed countless of research and found no cancer type can survive with no glucose and glutamine, If you rule those 2 sources out cancer dies, however normal cells can live without these 2 factors.
There are plenty of interviews with him on youtube. Lactid acid plays a role in creating cancer in the first place as it is the lack of oxygen that starts the cycle of creating cancer cells. As it seems to be an old cell survival mechanism for cells when living in low oxygen environment.
Thank you for keeping on with THE Doctor - what a brilliant mind. I'm in awe, and I hope he and his colleagues are on the right track- genetics certainly doesn't seem to be the only answer to much of anything, so it makes sense there'd be more to curing/preventing cancer than just straight up gene therapy. I'd actually like to hear more about this.
What an amazing story! 🙂