Dear Dr. Syed I have went through all of your lectures of Immunology, however I am still missing B cell development and maturation lectures. Can you please upload or suggest a good link. I went through Immunobiology, Janeway but I need good videos like yours to better understand the concepts!
Thank you for your note. All nucleated cells express MHC 1 this includes T and B cells. Otherwise these two cell types will become prone to viral attacks without possibility of infection control by immune system.
You are right, the heavy chains should be placed in the interior of the light chains. Just a little detail, it doesn't really ruin the lecture or makes the explanation less efficient. Thank you Dr. Syed, you were very clear!
Not sure if it is explained in the next video but TCR is consists of one heavy and one light (but you drawn it as 2 light) and the beta chain is similar to Ig heavy chain and alpha chain is similar to Ig light chain
Good evening sir, ligh chains are found on out side of heavy hains other wise your vedios are too good. Actually I'm a biotech student so your all vedies are not useful for me but some topics like immunology, microbiology are too usefull for me. You have explained them in so details which have i not found in books. Now, I'm preparing for iit jam and your vedios are usefull for me, thanks!
isn't the position of light chains on the outer side and the heavy in the inner side of the antibody molecule? except for that query, thank you very much. Very clear explanation
Yes you are correct. The light chains are depicted on the outer-side. However, in the 3D structure these things are kind of sitting interwoven with heavy chain.
First of all i would like to thank you for your very clear explanations about the immune system. The Videos were very helpful. I am only left with this one question to which i cannot find an definitive answer. Doe B and T cells als display MHC-I complexes in case they become ill? some scources say B cells have no MHC-1 while other say they do. Same about T cells. This made me confused.
Why light chain do not have N nucleotide addition during its rearrangement? What is the important of the allelic exclusion in TCR and BCR? and Why MHC do not have Ellelic exclusion? Why MHC I has 6 gene while MHC II has 12 genes?
i have looked at your video and i am really confused, you said that the variable region is where the antigen binds and the variable regions are always the same, so do you mean that the different immunoglobulins e.g. IgG,IgA,IgD etc all have the same variable region but each have a different constant region due to different heavy chains. i
Variable regions are variable for antigens and there are millions of idiotypes for variable regions. Heavy chains are only a few types. So the immunoglobulin nomenclature is primarily based on variations of the heavy chains.
TCR and Immunoglobulins
ua-cam.com/video/OSVuKVwZLgI/v-deo.html
I have seen it
Mohammad Wasim Khan - lecture 11 with B cell and immunoglobulin genetics is posted. I am preparing to post immunoglobulin functions now.
Thanks so much... I already took immunology but now I see some very simple basic things were left out... Keep it up!
The video quality is awesome and the audio is great ! I really enjoy watching your videos. You're the best Dr. Mobeen. Thanks again :-D
You are welcome Manisha. Glad lectures are useful. Study well!
your lecture is easy to understand. you made a complex things easy. thank you so much
My pleasure!! I have used a new camera. Let me know how is the video quality?
Hugely underrated channel
Thank you very much sir, I like your lectures too much .May Almighty Allah bless you
Dear Dr. Syed I have went through all of your lectures of Immunology, however I am still missing B cell development and maturation lectures. Can you please upload or suggest a good link. I went through Immunobiology, Janeway but I need good videos like yours to better understand the concepts!
Thank you for your note. All nucleated cells express MHC 1 this includes T and B cells. Otherwise these two cell types will become prone to viral attacks without possibility of infection control by immune system.
You are right, the heavy chains should be placed in the interior of the light chains. Just a little detail, it doesn't really ruin the lecture or makes the explanation less efficient. Thank you Dr. Syed, you were very clear!
it doesn't makes any difference as it looks like Y chain. you have the actual with light chains to pair.
Not sure if it is explained in the next video but TCR is consists of one heavy and one light (but you drawn it as 2 light) and the beta chain is similar to Ig heavy chain and alpha chain is similar to Ig light chain
thank you so much sir, i just had a question with the concept you just helped clarify
Good to know.
Good evening sir, ligh chains are found on out side of heavy hains other wise your vedios are too good. Actually I'm a biotech student so your all vedies are not useful for me but some topics like immunology, microbiology are too usefull for me. You have explained them in so details which have i not found in books. Now, I'm preparing for iit jam and your vedios are usefull for me, thanks!
Thumbs up if you paid school tuition this year to watch Dr. Mobeen Syed's lectures.
Thank you so much! Very clear and helpful!
+Aimee you are welcome. Study well!
StuartJCU you are welcome. I like Dora analogy!
Thank you...
:) thank you! so happy I found this video
You are welcome amny!
Dr. plz .. why APC are constitutively expressing MHC 2 ? they express it even if there is no pathogen ??!!
isn't the position of light chains on the outer side and the heavy in the inner side of the antibody molecule? except for that
query, thank you very much. Very clear explanation
Yes you are correct. The light chains are depicted on the outer-side. However, in the 3D structure these things are kind of sitting interwoven with heavy chain.
ya, true..thanks:-)
T-cell receptor for antigen binding alpha and beta chain both is light chain or one is heavy chain and one is light chain?
+m.safar Sayedy thank you for your well wishes. Visit drbeen.com for more lectures. Study well!
First of all i would like to thank you for your very clear explanations about the immune system. The Videos were very helpful.
I am only left with this one question to which i cannot find an definitive answer. Doe B and T cells als display MHC-I complexes in case they become ill?
some scources say B cells have no MHC-1 while other say they do. Same about T cells. This made me confused.
Why light chain do not have N nucleotide addition during its rearrangement?
What is the important of the allelic exclusion in TCR and BCR? and Why MHC do not have Ellelic exclusion?
Why MHC I has 6 gene while MHC II has 12 genes?
one more good lecture from u sir thank u.
where can i find PRRs
+raju sripathi please check on drbeen.com.
you help me out ..
Thank you so much I appreciate that
+maweh100 my pleasure. Visit drbeen.com for more lectures.
fc portion is called fragment crystallizable region
i have looked at your video and i am really confused,
you said that the variable region is where the antigen binds and the variable regions are always the same, so do you mean that the different immunoglobulins e.g. IgG,IgA,IgD etc all have the same variable region but each have a different constant region due to different heavy chains. i
Variable regions are variable for antigens and there are millions of idiotypes for variable regions. Heavy chains are only a few types. So the immunoglobulin nomenclature is primarily based on variations of the heavy chains.
Thank you for verification...
thanxxxxxxxxxxxxx doc. u r the best
Hlo sir,
Sometimes I feel jealousy...how u make complex things simple
Intresting...😉
first time to understand what is the meaning of CDrs
THE IMMUNOGLOBULIN STRUCTURE IS INCORRECTLY DRAWN
I think you by mistake written both alpha beta as VL CL
The light chains are outside the heavy chains..
Today What ??? This is also correct
Thank you so much! Very clear and helpful!