Can we cure genetic diseases by rewriting DNA? | David R. Liu
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- Опубліковано 20 тра 2019
- In a story of scientific discovery, chemical biologist David R. Liu shares a breakthrough: his lab's development of base editors that can rewrite DNA. This crucial step in genome editing takes the promise of CRISPR to the next level: if CRISPR proteins are molecular scissors, programmed to cut specific DNA sequences, then base editors are pencils, capable of directly rewriting one DNA letter into another. Learn more about how these molecular machines work -- and their potential to treat or even cure genetic diseases.
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This guy and his team (of STUDENTS!) should win the Nobel Prize for their efforts if they do, indeed, prove fruitful. If they don't, that would be a tragedy, indeed. Having said that, my hat is off to those brave individuals who continued to work through this obstacle despite mountainous odds.
yeah ...but i think everyone of them are doing great job.feng zhang, doudna ,charpentier,church , everyone must be given noble prize.
Without crispr, this would be impossible. CRISPR is an important milstone in biology. If the downstream should be recognized, it would only be appropriate to award nobel price to CRISPR team. It opens the doors and is the true pioneer.
Are you from 1870?
Update: Doudna and Charpentier have won the Nobel Prize in Chemistry for their work on CRISPR!! 🥳🥳
Thank you sir..
A huge thanks to all of the scientists who are struggling to make our lives, community, and the world a better place to live in
Mark Caseon lmao
تعليق اكثر من رائع اشكرك ❤️
@@markcaseon7136 why
No their not, they're bidding on Satan to take you to the lake of fire
You can't be that stupid you think the only scientific breakthrough is going to be for man's good sorry that's not going to happen never has happened and never will happen there's always going to be the money factor to make something bigger and better
I plan to study molecular biology, and I hope to contribute to this great field, which can potentially save many lives.
How is it going?)
@@almoore2506 Just graduated with my bachelor's degree and starting a master's soon, so I guess it's going well!
@@Saeedd01awesome! where are you studying and what is your masters in?
@@spiral9530 I'm moving to Germany for master's, and it's gonna still be a general molecular bio program at first before I specialize for the thesis work or PhD
Good Luck👍
Very much look forward to this. The blind will see, the deaf will hear, the lame will walk, cancer disappear. I welcome this brave new world.
Rejoy Panakkal we all know what it can achieve. Unfortunately we are years away though as a few individuals will need to work out how to make as much money from it as possible. Plus there are millions of do-gooders that stand in the way of progress too...
Wesley Thomas how bout this as a “Do Gooder,” might say.., what happens to the people who have been “bio-engineered” who are giants, maybe giants who are only big & strong but have little or no ability to think? How bout this scenario, various “categories” of humans, such as Servants, Nannies, Techies, Parents, Medical, etc.. People who do exactly what they are programmed to do, and nothing more. Once we have all medical illnesses cured, what’s to keep unethical scientists from playing with humanity’s genomes to “answer society’s needs”? so to speak. I think it’s fascinating to think of all genetic illnesses being destroyed, but man has never been satisfied, has he?
That's called eugenics. It's a disgrace to humanuty, not an advancement
@Martyr4JesusTheChrist There is no evidence of a god. This must be addressed before anything else.
Yes it would be like becomeing imortal in some aspecs
Thank God for people like David R. Liu and people around him, we often forget to thank these scientists for their research ❤👌
are you thanking god or thanking the scientists?
Prof. David Liu, is so articulate that this entire presentation could even be absorbed by me as a layman.
This removes suffering and hardship from the world, whether it’s improving food or healing humans with genetic diseases. Even modifying is so that we live longer, are more intelligent, stronger etc. Ethically speaking, if everyone has access to this treatment, and I think they will due to the massive savings on the health industry, this is a win win. Better humans means less suffering, more happiness, and success for our species. I’m ready
I remember when he came to our University as an assistant professor to present his research. At the time he was doing organic chemistry reactions on DNA complexes. It is nice to see how his work has developed.
we are blessed to have such great scientists working for humanity
I was wondering this for a looong time! I need to watch this
@duster well, i doubt rewriting DNA too, but it would wonderful for a human to not be borned with genetical disease.
Amazing. Thank you to all the scientists working on this potentially life saving work. You’re doing the most important work there is.
Deep Gratitude to the team of students who see the world changing for better and to work hard to see that change in reality. 🙏
This guy deserves a nobel prize !! I wish one day i would be able to think, work, educate, talk like him!!
U have ur mail in ballot with u on the couch?
probably the best presentation I have ever witnessed!
I came here after reading their new paper (prime editing) in Nature, october 21st. looks good
Genetic scientists are terrific. I think in the near future more and more patients who suffer from various gene-related diseases can become healthy. It’s really an awesome presentation to make people know what gene engineering is likely to do. Thank you very much.
No it’s very unlikely man I’m sorry but it’s better to deal with what you have then try to change it if it’s not life threatening
@JCPS UA-cam channel its not a true disease.
More important. We can go beyond just curing genetic diseases
Can it cure skin damage from acne from chemical products?
I genuinely stood up to applaud for this genius biologist and his students at midnight.
Me too man. I was clapping with the audience too
Bless Dr. Liu and his teams.
Thanks Dr Liu for the marvelous mind-blowing talk.
It’s incredible how they’re able to accomplish those things
This is amazing and seems like a much more efficient method compared to the current Crispr method of cutting and pasting DNA. I hope this means that gene-editing will become much safer for human use in the near future.
This has the potential to save children and adults with genetic diseases and disorders. This is why higher education is important.
I think it's really milestone in the history of genetic disease. 😊He and his team really did a great job ☺
We are thankful and grateful to these incredible human beings.
In fact, Great , Thank You and Your Great Teamwork.
The work of David R. Liu and their team is an incredible feat of determination and dedication. Towards the end, it was mentioned the importance of using this technology ethically. Gene editing has proved to be controversial and ethically questioned due to the potential for abuse and expansion beyond the original intentions. How would we maintain the true nature of this technology, using it only to treat debilitating diseases? I believe there is a fine line between what can ethically be manipulated and what crosses over that line into performance-based preference. As health care professionals, we lead the implementation of this technology into our work. I am both eager to help cure illness and yet worried about the potentially consequences we may face as a society for interfering.
A very big applause to those great minds who worked so damn hard to make this extraordinary technology a reality🥰🔥❤️
Damn impressed... This man and his team should win a Nobel price..
Thank you so much. Am asad bashir, student of MPhil biotechnology from university of kotli azad kashmir. Your lecture helped me a lot to understand base editors.
Thank you so much for your dedication to the vision of better future😊
Proud of you my dear Professor ♥️♥️♥️
Master class absolute master class new follower gained thank you Sir I'm Researching hard in many fields!
someone give this man a nobel prize he totally deserve it!!!!!!
That's cool. Thank. Such research is the future of medicine!
Very good Ted x talk!
wow, goosebumps. Thanks for this wonderful presentation
Our spectrum as mankind is very big. A human can produce work that is either the highest of the highs or the lowest of the lows, this man is another hero in the field imo. This was groundbreaking stuff
I wanna edit my self with crispr.
@@markcaseon7136😂😂😂
@@markcaseon7136Too late 😄
Amazing thank you 🙏🏼
Amazing talk! Great scientist!
love this well done
keep up the great work!
That's more than awesome~ Will be the blessing to millions of patients. Scientists are the light!
His eyes from a lot of information, knowledge, and awareness outside him, in front of him, is a smart man
Could mental disorders be cured by this
@@akshorts2115 ❤️❤️🔥✨
Yes, he should definitely be awarded with a noble prize!
Could help billions!❣️
Brilliant, only problem is that it happened too fast! I want in on this, by the time I’ve graduated there will be nothing left to work on
Hayley Âû science is not as fast as we think it is... you def have time to work on it
Some scientists were saying the same at the end of the 19th century... guess what came right after? Quantum and general relativity :p
We know virtually nothing about what genes should be (working variances) let alone what they could be. And besides even with this method like those before there is still many problems involved. One the construct is very large so much so I can't imagine it fitting into any viral vectors for easy transfection. Two being the problem with any gene therapy is it's diminishing expression. And three how do we transfect a large enough amount of cells for saturated persistence. So no worries plenty of work left to do.
I remember when I was in high school and our teacher put the movie “GATACA” for us to watch. And I always wondered...... will we reach a point where normal “non-altered” humans become illegal?
Why we would non altered people be illegal?
No, because who needs to make a disadvantage illegal? They'll just be unable to compete and die out over time as everybody opts to be genetically perfect demigods.
I just realized GATACA are the letters in DNA. I feel kinda stupid now.
@Martyr4JesusTheChrist Boy howdy, I do love when I stumble into a rat's nest of stupid.
But I'm not interested in delving into whether a credentialed theist can construct a computer simulation of genetic mutations that validates his pre-existing beliefs. I'm gonna limit my response to asking you whether you have ever designed, engineered, and constructed an internal combustion engine? Even if you have never built this complex system that you don't fully understand I'll bet you can figure out how to change a bad spark plug.
That's what they are doing. Replacing bad spark plugs.
@Martyr4JesusTheChrist Hey don't think your stupid, but do think you have bias in your thinking. Humans have been around for over 100,000 years the evidence is there. Life on earth has been around for millions at least. You realize that DNA mutations and corrections both take place. Your argument only has one side of the equation. Somatic and Germ line mutations are different and have different outcomes for survivability. Hardly a simple accounting problem. Keep an open critical mind regardless of your belief system and that's not easy.
wonderful!!!
This guy is amazing! He is a leading figure in upcoming genomic revolution!
Perfect! I was studying for biotechnology
Me too.. !
@Martyr4JesusTheChrist how?
same
Amazing! We need this technology ASAP, for a popular price :)
David R Liu,may God continue to bless your developing mind, may you never give up and may the funding you seek always arrive in abundance .PD
This feel surreal like the introduction of prometheus movie. “The M theory” “ molecular machines” and we are only at the 2nd decade of 21st century.
Maybe it’s already been in use for different applications but only revealed today
6:05 go into the darkness to heal, sound familiar?
This is so cool and it can help people
Let's get busy with launching this to the public Dave.
If a person agrees to be a subject to this and is willing to be a subject then he should be able to do it
I'm just learning this field in high school now.
.me too
When does this take place?
Ted talks are great and they should be part of the national curriculum in uk and every were
Also should be part of the curriculum: "everywhere"
Dude.i cuddnt re write it man when i relised i was like some ones gunna say something lol thanxs mr u made me happy in correcting me hahaha hope ur good tho my freind
The research and innovation in biochemistry performed by this scientist is truly remarkable. The adversity this lab overcame is astounding. However, I think an important question remains. Instead of can we cure genetic disease, I wonder if we should be asking the question should we cure genetic disease by rewriting DNA. At least, this will be a question as science advances into the future. The technological advances in medicine over the last 20 years have been incredible, life-changing, and lifesaving. I think everyone deserves to live a happy healthy life if this is their choosing, but those with genetic mutations do not necessarily get the choice. I believe the advancements with regards to base editing of the human genome is a great step in that direction. Possible issues with such capabilities of rewriting DNA poses the possibility of alternative use of such technology compared to the original intentions. Alternative use may embody using this technology to edit stem cells to give our offspring characteristics, traits that are desired such as height, strength, personality, intellectual ability, or appearance. So how do we prevent the alternative use of such technology in the future? Should we prevent the alternative use of such technology? These are questions I cannot answer other than possibly legislation. Regardless of the way in which the use of this technology is performed, it is hard to argue with the fact that humans would be interrupting evolution. Is this ethical? I believe the use of this base editing technology is ethical if it is used with the intentions of giving individuals with severely life-threatening conditions the opportunity do you live a long, happy, healthy life. If this technology is used to give individuals an advantage over other individuals, then I believe the use of this technology becomes unethical because at this point there is a violation of a biomedical principle known as justice. Distributive justice describes fairness in what people receive. If this technology were to become commercially used to give our offspring desirable traits, which likely would be restricted based on financial means, then there would exist an inequity. As a future physician, I take issue with this concept of use of medical technology. EW
also guess the next step will be about acquiring data.
for year=1..n
do
for each h in humans
do
- store h.genome
- store h.healthIssues
done
- cluster genomes by issues
- extract majorily present sequence on individuals not showing specific issue
done
----
application then:
if found malevolent sequence ->
replace by most commonly sequence not showing particular feature to cure
...
and then, at some point benevolent data could be acquired and non-optimalities are being treated as issues.
... research funding for the next 100 years secured. I fear a significant loss of variety in the mid- to distant future though :(
I wish I could like this a million times 👏👏👏👏👏👏
Superb...
God bless those scientists and everryone wokring hard to make our lifes better and better,,,,,really thank you so so so so much....its truly inspire me to study harder and harder to make somthing useful to serve this huminity.....godbless you all.
Потрясающая работа!
Very good presentation. Let's do this. Someone will, if not us. Humans have many diseases, that have genetic origins. Etc. Etc.
7:17 , It seems that the PURPLE protein can be built in a system that protects single stranded DNA, while the blue protein just binds to DS. Is there a possbility to bind the Purple protein to a transcription factor, or certain DNA damage repair proteins?
Cosmos,life and consciousness are quantum(Dirac),molecular(Dawkins) and memetic(Dennet) respectively
Awesome research, David. Congratulations from Brasil.
@Martyr4JesusTheChrist r u sure about that? This is a serious complaint. Tell me your argument. why is this a quack science?
@Martyr4JesusTheChrist and hasnt yet been built, as the researcher himself said. So that's why I said awesome RESEARCH. There is still work to be done. Are u so innocent that I need to explain this to you?
@Martyr4JesusTheChrist understood. I'll read about It.
@Martyr4JesusTheChrist at least i must read first to chat with u after all these arguments. I thank u for The information and for not being disrespectfull as well.
this man is a genius
Amazing!
amazing.
Well I was thinking the same thing to find the cure of genetic diseases.. i.e. rewriting dna, sending proteins which change the mutant sequence of proteins..
Yes, yes we can. Will it stop there though? No, no it won’t.
It will start being a great thing so I think now is the best time to be around for the start of this amazing tech. But as with all things humans make it will become a twisted mutated monster of its original self.
As some one with Muscular dystrophy this means a cure is not that far off as they already started human trials of CrispR ( I think)
@XMckingwill Well said. I hope they discover a cure soon my friend
@Martyr4JesusTheChrist well, entropy affects the entire universe and will ultimately cause its destruction so it makes sense that over very long time frames it would also affect genes, however, this doesn't mean using gene editing is an intrinsically bad thing.
The reason can be seen by taking the essence of your argument "believing they can alter and modify a system as severely complex as DNA which THEY NEVER MADE NOR KNOW HOW IT FULLY WORKS but only VERY LITTLE, therefore it is nonsense and won't work" (correct me if this is not your argument ) to its logical extreme.
If we do this it argues for the END of medicine, Doctors, Hospital etc, since Like DNA the human body is EXTREMELY complex, we have never made such a thing nor do we know how it fully works, yet we still have been able to modify the human body with chemicals (medicine), implants etc . . through which we have cured and/or manage various illnesses, and as you know the human body is extremely susceptible to entropy which is literally what causes aging.
Since this is the case why would this not also apply to DNA which carries the very info that builds the human body which we ALREADY modify to cure illnesses?
And what I meant by this tech mutating into a monster was in reference to people abusing this technology not that it would mutate humans into monsters lol.
you also lost many points by bringing supernatural nonsense into your argument. from a book that says there are talking snakes and that doesn't even know what stars are.
@Martyr4JesusTheChrist No I have not committed intellectual suicide. I honestly I don't think you understand what entropy is nor how it works.
@Martyr4JesusTheChrist yeah watched that vid and it was utter nonsense, first half talks about the genome couldn't have come from randomness, but new flash IT DIDNT. all i heard for the first half was "DNA is complex and we don't fully understand it, therefore it was designed"
Very fascinating research and advancements into the field of genetics. It seems appropriate to use this technology to “fix” genetic mutations leading to diseases like he listed such as Progeria. This editing capability could lead to a tricky and convoluted path of knowing what type of genetic alterations are ethical or not. Is it ethical to decrease an individual's suffering? Is it ethical to enhance an individual's genome that will allow it to live a diseased free life? It is appropriate to reference the four ethical principles which are beneficence, non-maleficence, autonomy, and justice. Beneficence, non-maleficence, and autonomy are three of the medical ethical pillars that need to be addressed when discussing genetic alteration technology and advancements.
Beneficence is the concept that physicians have a moral duty to provide care that is in the best interest of their patients. It could be argued that genetic alteration with the intent of alleviating disease is in the best interest of the patient. If gene editing is governed by an international ethical committee ensuring that the technology is used sparingly and only for the alleviation of disease, it does not violate the ethical pillar of beneficence.
Non-maleficence is the obligation of a physician to do no harm. Genetic editing has the potential to disrupt normal embryologic development; thus, having hypothetical ability to harm a patient. If genetic alteration was conducted in a error-free way, then non-maleficence would not be violated.
Lastly, autonomy is granting patient’s the right to make informed decisions about their medical care. On the first glance, one may think that autonomy is being violated in gene editing. The question is asked: how can one elect for genetic editing to occur if it is conducted during development and before birth? We must remember that minors do not have decision making capacity. The autonomy of a minor is limited due to their age. Is there difference in a parent electing for their infant to receive vaccinations and a parent electing for genetic editing to be performed?
Genetic alteration is a field full of ethical considerations. It is imperative to consider the three concepts of beneficence, non-maleficence, and autonomy when pondering the ethical replications of genetic editing.
I completely agree with your thoughtful comment about the ethical considerations surrounding genetic editing. While it's exciting to consider the potential of this technology to cure genetic diseases and alleviate suffering, it's also important to consider the potential risks and unintended consequences. You make a great point about the three ethical principles that need to be considered when discussing genetic alteration technology: beneficence, non-maleficence, and autonomy. It's clear that the use of genetic editing technology must be governed by a framework that prioritizes the well-being of patients and considers the potential risks and benefits. I also appreciated your discussion of autonomy and the complex question of who has the right to make decisions about genetic editing. While minors may not have full decision-making capacity, their autonomy should still be respected to the extent possible, and decisions about genetic editing should be made in consultation with experts in medical ethics and genetics. Overall, I think your comment highlights the importance of having open and transparent discussions about the ethical implications of new technologies like genetic editing. We need to approach these advancements with caution and ensure that they are used in ways that are consistent with our values and principles.
It's so awesome! But we need to think of the risks also this can involve. But also the wonderful things it can cure. So.. Can we cure cancer already with this or is there some more science that needs to be done before that?
@Martyr4JesusTheChrist
Hi. Well.. You copy stuff here that you don't really understand. You don't understand evolution. One book i recommend is: The greatest show on earth by Richard dawkins. ;) Read it! Evolution is a *fact* and we know we are the result of it. ;) We are made of star stuff because dying stars created the heavier elements in collapsing stars, and then we are now temporary carbon based life forms on this beautiful earth. So evolution rocks. ;) Be thankful and read about it. Peace out
@Arhan Might be one, but not the one in the bible.. Why would they ask someone to sacrifice other people and such.. That's no true god.
if you were mind blown by CRISPR this discovery will do even more
So, one question, how many cells should be repaired to treat the disease?
You would focus on human stem cells for most illnesses. Our cells get replaced by these over time. To stop offspring from getting it you would edit germ line cells.. Sperm and egg of carrying parent.
Will this work to cure myopia?
Great💪🏻
Why until now not used to treat genetic mutation disorders?
I never heard of any case treated
My brother is suffering from DMD
Can we expect cure for this desiese?
What about cystic fibrosis
Dear brain scientists a question to you: do you Think an adult brain would react/adapt to an update to the genome in neurons in the brain After trying to cure a polygenetic disorder like some intellectual disabilities or autism ?
Would very much apreciate your opinion to this!
Good question
Did u get the answer
Yes?
I had asked my hematologist/oncologist if base editing could work on Polcythemia Vera, and she kinda deferred
This is soooo tough
Can u base edit my Itchthyosis diseases?
I'm happy special cos of children. They got illness cancer so much .
I looking at this cos my child has a genetic disease known as grin2b disorder. Hopefully this can be a cure one day.
Wont be surprised if in the future a full therapy of such a drug cocktail sets you back about $1million. It will be priced as such because you literally save and realize and make possible the earning potential for a human being who will normally be productive in society for 60 years atleast.
the way to ameliorate microscopie is change the light with a differente chained waves by create new neutron proton achitecture in stabilizing the gluons in bombarding then with neutrino mu .......
Great work though very late wish many people will live a happy life
WOW this is amazing!
Hope treatment of Neurofibromatosis will come soon.
Thank you so much! I just am in art school and passionate by this kind of topics. I can’t believe all my friends are just getting high and partying and I never met someone that is substancially cool and really transforming the world and enhancing human experience! I admire the students who set up this advanced technology so so much!
Would love to meet bio-engineers, y’all really should be celebrated!
I was watching a video of a guy with neurofibromasis, and when I understood that there was a gene specialized in stopping the body from producing tumors, that’s when I realized that instead of cutting people open to remove tumors we should take care of the gene responsible for that.
Researching on this I discover that there’s already so much done about it, I am so excited for the future. I think the apocalypse should wait a little because humans are full of surprises and I curious to see more
I used to have sickle cell anemia nd it would cause so many problems. It's good to know that there are cures being made for it because it's one of the lesser known diseases
Did you get cured?
Yea @@KumariKumari-fw7nc
This lab got a Nobel nod yet?