Great video. Thanks! I have VWD Type 2M with severe symptoms. The standard of care for this type is Humate-P as this type is only variably responsive to DDAVP. I even keep Humate-P at home and take it with me when I travel because hospitals don't always have it on hand. Surgeries are particularly difficult because DDAVP requires a strict fluid intake which is often impossible to adhere to when you have to get IV fluids and/or blood transfusions during and after the procedure. Everyone who has VWD should work closely with a benign hematologist who specializes in bleeding disorders because surgeons and anesthesiologists often don't understand the nuances and you need to have a plan going into the surgery. Oncologist/hematologists are often focused on cancer and they don't have a lot of experience with the VWD subtypes. Also, fun fact... type 2M gets misdiagnosed more often as Type 1 than it gets correctly diagnosed as Type 2M. This type doesn't necessarily have missing multimers, just abnormal ones. There is a large variabilty in bleeding patterns and laboratory phenotypes. Genetic testing can help.
You are the best teacher in UA-cam as well as in globe,we are only depending on you're lovely and precise notes,not college professors,keep it up be happy and healthy forever
Sir thumbs up for you The best ever explaination All videos of you are a great gift for all the poor knowledged medical students for life Big fan of you❤❤❤❤👍👍👍👌👌👏👏👏 The one n only authentic source for me out of many others
Thank you!❤❤,,,,,best explanation of subtypes,,,,,most abundant platelet surface receptor is Gp2b/3a complex(40,000-90,000 copies per cell with an additional pool that can be recruited by agonist-induced platelet activation) and qualitative or quantitative deficiency of it leads to a coagulopathy named glanzmann's thrombasthenia,,,,,,,
Hii, i really love your videos :)) can i ask what books is your references for this? I am a medtech student and we have a case study concerning this. Thank you so much!
U made it all so easy! Thank u 💌 just one request, can u please explain the vwf:Rco/vwf:Ag ratio a bit more please? Why its increased in type 1 and type 2N and decreased in type 2A , 2B, 2M? thanks!
Why would you have low factor eight and factor seven lacking in vWD, I always end up having to get plasma & blood transitions??? What happens when you can't have DDAVP
i have been diagnosed with VWD type 3 it is very severe and need to get humate p infusions for the 7-10 days I get my menstrual cycle. My parents have had genetic testing and only my mother has the gene for VWD. My dad does not. My question is, don’t both parents need to pass this in order for their child to have VWD type 3? How does it work? Thank you!
@@MedicosisPerfectionalis Thanks, so much but it’s not your fault. I don’t get bleeds too often so I’m fine. I did get injections everyday after surgery.
This guy teaches a technical, dry topic with wisdom and hilarity! :-D
Thank you so much ☺️
Yeah! Like, "We gotta keep the blood stream PG-13." How can you forget an analogy like that? 😁
Great video. Thanks! I have VWD Type 2M with severe symptoms. The standard of care for this type is Humate-P as this type is only variably responsive to DDAVP. I even keep Humate-P at home and take it with me when I travel because hospitals don't always have it on hand.
Surgeries are particularly difficult because DDAVP requires a strict fluid intake which is often impossible to adhere to when you have to get IV fluids and/or blood transfusions during and after the procedure. Everyone who has VWD should work closely with a benign hematologist who specializes in bleeding disorders because surgeons and anesthesiologists often don't understand the nuances and you need to have a plan going into the surgery. Oncologist/hematologists are often focused on cancer and they don't have a lot of experience with the VWD subtypes.
Also, fun fact... type 2M gets misdiagnosed more often as Type 1 than it gets correctly diagnosed as Type 2M. This type doesn't necessarily have missing multimers, just abnormal ones. There is a large variabilty in bleeding patterns and laboratory phenotypes. Genetic testing can help.
You are the best teacher in UA-cam as well as in globe,we are only depending on you're lovely and precise notes,not college professors,keep it up be happy and healthy forever
Thank you so much, brother!
I appreciate you!
@@MedicosisPerfectionalis most welcome Sir,,I note you're 2 lectures daily base thanks,achieve first position from day first up to 4th years MBBS
I'm still a med student but I thoroughly enjoyed this video.
You made it so easy, thank you
Glad it was helpful!
I'm not a med student but I have type 2b and I love learning about my condition
Thank you so much for watching!
I wish you all the best!
Words can’t expess how much I’m grateful for you , you have made medical school much easier (:
Much of love from your home country
Sir thumbs up for you
The best ever explaination
All videos of you are a great gift for all the poor knowledged medical students for life
Big fan of you❤❤❤❤👍👍👍👌👌👏👏👏
The one n only authentic source for me out of many others
Thank you so much 😊
i can never stop admiring your work, thank you so much
I am honored!
Never skip the ads ❤ that's how I show my gratitude ❤
I appreciate you so much!
Ur style for lecturing are Amazing. Allah blessing u. From Kurdistan/iraq
Thank you so much! I appreciate you!
Would you please help me by sharing?
Thank you!❤❤,,,,,best explanation of subtypes,,,,,most abundant platelet surface receptor is Gp2b/3a complex(40,000-90,000 copies per cell with an additional pool that can be recruited by agonist-induced platelet activation) and qualitative or quantitative deficiency of it leads to a coagulopathy named glanzmann's thrombasthenia,,,,,,,
Thank you so much for your kind words!
You’re absolutely correct
Really exellent vedio .... bleeding disorders were always a nightmare for me... not any more
I am so delighted!
12:26 subtypes ❤️
Thanks for your efforts ❤️❤️
Thank you!
Can't believe that you used "The Good, the Bad and the Ugly" movie reference. Love your videos, they are great :D
Thank you so much ☺️
I love you, 😭😭❤️❤️❤️
I stady to my exam from here.. and I'm sure I'll passsssss 😭😭😭❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️
Thank you so much 😊
Good luck to you!
i am nursing student but after i watch your so many video iam happy and i have confidence tq so much 😘😊👍 and clap 🖐️🖐️🖐️tq again
Nice video! Just one correction: Type 2N is also autosomal recessive. Carriers do not have symptoms
Thank you so Much man best explanation ever
love this playlist
My pleasure 😇
The best ever......and u don’t need to retire...lol...
Haha 😂
Thank you so much 😊
Hii, i really love your videos :)) can i ask what books is your references for this? I am a medtech student and we have a case study concerning this. Thank you so much!
Hi my family history all members have Von Willebrand disease factor 8. We can take Covid-19 vaccine or not.lot of confusion please help me
I and most of my family have type 2N. Our doctors have us use Wilate, not Desmopressin.
U made it all so easy! Thank u 💌
just one request, can u please explain the vwf:Rco/vwf:Ag ratio a bit more please? Why its increased in type 1 and type 2N and decreased in type 2A , 2B, 2M? thanks!
Just divide vWf: Rco by vWF: Ag, and you get the answer.
There is no scientific explanation here, it's just a mathematical ratio
Medicosis Perfectionalis thanku ! Didnt notice it before ☺
How about if you VWB factor is super high (over 500) and factor VIII is normal. Which type would that be?
i watch your videos whenever i feel low.....
:)
But since type 1 is a quantitative defect, why will there be decrease in vwf activity, should it be only in antigen?
the most abundant receptor on the surface of PLT is Gp2b/3a receptor
Thanks prof! Really enjoyed the video.
Thank you so much 😊
Why would you have low factor eight and factor seven lacking in vWD, I always end up having to get plasma & blood transitions??? What happens when you can't have DDAVP
You are amazing.
Thanks alooooooooooot
You’re very welcome!
Would you please help me by sharing my videos with others?
On the type 2N, why did you not mention about the effect of abnormal vwf on platelet adhesion?
i have been diagnosed with VWD type 3 it is very severe and need to get humate p infusions for the 7-10 days I get my menstrual cycle. My parents have had genetic testing and only my mother has the gene for VWD. My dad does not. My question is, don’t both parents need to pass this in order for their child to have VWD type 3? How does it work? Thank you!
You are the best!
Thank you so much 😊
hey. 🖐️🖐️ doctor do you please make video of DIC please 🙏🙏
Coming soon
@@MedicosisPerfectionalis thank you doctor🙏🙏 i wait 🙏🙏
My pleasure 😇
I have Von Willebrand’s disease type 3.
I am so sorry 😐
@@MedicosisPerfectionalis Thanks, so much but it’s not your fault. I don’t get bleeds too often so I’m fine. I did get injections everyday after surgery.
Plz Send me your mobile no I have type 2
What's is the answer
2N is autosomal recessive
please make videos on cancers of all the systems!
Which tests should be done to distinguish vWD 2b from pseudo vWD?
amazing sir!thank you👏💖
My pleasure 😇
Why does it say to give desmopressin with type three???
This is stated in the table. It is wrong and should be corrected. Does repression should never be given in type three.
Pefect
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2M has normal multimers
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You sound down in this video :(
I am doing well 😊
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