Eric Wieschaus (Princeton) Part 1: Patterning Development in the Embryo
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- Опубліковано 1 сер 2024
- www.ibiology.org/development-...
Following fertilization, the single celled embryo undergoes a number of mitotic divisions to produce a ball of cells called a blastula or blastoderm. Although these cells are all genetically identical, they gradually begin to express different gene products that reflect the regions of the adult body they will form. In my first lecture I discuss how these initial patterns of gene expression arise. In Drosophila, a maternally supplied transcription factor called Bicoid plays a particularly important role. Bcd RNA is anchored at the anterior end of the egg but is only translated after fertilization. From that anterior source, Bcd protein is thought to diffuse through the egg, establishing a concentration gradient that activates different genes at different thresholds. See more at www.ibioseminars.org - Наука та технологія
He is so nice and so enthusiastic about his topic that it is an absolute pleasure to learn what he explains.
Super helpful! Thank you so much!
I love the fact that despite being a Nobel Prize winner, Dr. Wieschaus' is so humble
It's quite evident that Prof. Wieschaus has a quiet & shy personality; usually that is an issue because lecturers like that are not able to draw the full attention of students but in his case, it's his enthusiasm & passion for the subject that keeps us drawn towards his lecture making it a pretty good learning experience!
All must pay attention when he tell us that in 2.5hrs the single cell increases to 6k cells,,,
I can't emphasize how helpful this channel to me throughout my first year of PhD. Thank you so much!
Oddly poetic and simply beautiful.
Prof. Wieschaus is so passionate, feeling grateful that this exists.
Such an informative lecture, you made me really excited about starting my master's degree with a lot of interesting questions about gene expression and how it affects the morphological development of drosophila in an embryo stages. Thanks again Dr. Eric.
Hey this is the dude my textbook credited for everything...
The video shown in Prof. Wieschaus' lecture is AMAZING
Thanks for the lesson, Professor. Amazing topic, the trapped maternal RNA and the bicoid protein gradient story blew my mind...
I appreciate this. Thanks you tube and The Professor. He soo smooth with his lectures. with this technology we don't even need to pay to go to school. we can just learn at home. =D
This lovely old man present fabulous biology in a romantic way! A lot's of Thanks for preparing this video!
This is very helpful. You're a life saver sir!
Thank you so much! This really helped!
Thank you for posting this, it was really helpful!
so so simple and helpful , maybe after 10 years people will never go to university , they will just watch IBIOLOGY
+Nour eddine you mean UA-cam.
@Dalai Llama the reason your hair turns grey is often due to the hydrogen peroxide radicals (toxic wastes) produced in your cells building up in melanocytes and killing them. melanocytes are colour producing cells, they make melanin which is responsible for skin tone, freckles and hair colour. when these cells surrounding the hairs die, they no longer produce colour in newly growing hair strands. so you notice that there is often patchiness in colour and grey etc. because they die in different places. i would say the hair turnover has to do with this phenomenon in that some places retain colour and live melanocytes more than others.
reference?
Nicely done. Thanks !
Thanks a lot. You have made it so simple and clear. I can meet my class with confidence and clarity.
Sir. thanks for the great information, which is very relevant and important topic,.Could you please explain about the anterior posterior patterning in drosophila and different types of gene expression.
"it doesn't look very interesting. The amazing thing though is..."
so softspoken and interesting...very nice to watch. i am thinking how software can generate structures using morphogenesis, instead of ordinary genetic algorithms.
Best explanation !!!!!!!!!!!!!!!!!!
wait why would a concentration gradient of a transcription factor allow activation of other genes ? changing the concentration may change the kinetics but it doesn't change the reaction ? Maybe hunchback promoter has a lower affinity than kruppel promoter ? so weird
I have a final tomorrow. Hope to God this vid will teach what i need to know.
I was taught that the hunchback protein was a result of maternal effect gene. Is that correct?
This man needs to be protected at all costs!!
what are some potential challenges in terms of technique, performing this kind of experiments. Thanks
Why is it 6000 nuclei? Would it not be 2^12 = 4096 or 2^13 = 8192?
Perhaps not all nuclei replicate the same number of times
Love the passion put in your lectures. Wish to contact you to ask for help with some online lectures on development. Meanwhile, I can enrich with your iBioseminars. Thanks
Thanks
if an iPSC can originate an entire organism, how come mother RNAs/proteins existent in egg's cytoplasm are important for cellularization process?
I like to pretend that the picture of the drosophila egg is life size and that the professor is actually really really small
keep it up
Bicoid RNA is all translated within 2hours after behind unanchored? or the protein spread takes 2h? How can the RNA be all transcribed in 1 region, if it is not unchored anymore? in 2 hours, the unachored Bicoid RNA does not spread around the remaining cytoplasm, becoming translated there? Cytoplasm must be like agarose lol
Where are parts 2 and 3?
ua-cam.com/video/cpOf5el9GIk/v-deo.html (part 2)
ua-cam.com/video/7IKsfE5sBTg/v-deo.html (part 3)
My boss was his student ^^
hard to believe that within 2 hours all unachored Bicoid RNA does not spread around the remaining cytoplasm, becoming translated there. Cytoplasm must be like agarose lol
Okay probably not an appropriate comment but I can't stop thinking that Lorl Morella from Orange Is The New Black HAS to be his long lost daughter. Just the way he speaks ;)
Why are only his eyebrows black and his facial hair/ hair on top of head is grey??
Answer that for a scientific question..
He sounds like MIchael Jackson
You are spot on! But I like his wife better (Trudi Schupbach).
I bet this man knows how to lay the pipe
obvigay
Very boring he turns something that seems interesting into a total snooze fest