Great work! My background is chemical engineering, biochem tech elective, master's public health, recovering alcoholic, permanently &total disabled veteran with a mental condition and I have been drinking kava for three years wondering if I have relapsed as an alcoholic. I immensely appreciate how wonderfully you present this topic. I just moved home to Ohio where there were zero kava locations from Florida where kava is abundant. Ohio just opened it's first Kava location outside of Cleveland and I have resumed drinking kava. I think Kava increases GABA receptors. FYI Kava research is swiftly increasing if you could bring this topic to your channel soon. Thank you.
I disagree with the other commenter. There is no clear cut term for what a relapse is. Like if I was a meth addict am I relapsing if i have sex because both work on dopamine? Am i relapsing on heroin because i ate a poppy seed bagel that had alkaloids? Or I nutted and my body released endorphins which are our own body supply of opiates? This is just stupid @rodrigoalmanza66 , plain old stupid bad faith logic. It genuinely baffles me how one can be so willfully ignorant and wrong but be so confident... Dunning-Kruger Effect in full force right here!!! "The major kavalactones potentiate GABAA receptors, which may underlie the anxiolytic and sedative properties of kava. Further, inhibition of the reuptake of norepinephrine and dopamine, binding to the CB1 receptor, inhibition of voltage-gated sodium and calcium channels, and monoamine oxidase B reversible inhibition are additional pharmacological actions that have been reported for kavalactones." Then am I relapsing on Benzos because my anti-psychotic also affects GABA??!?!?!?! YOU. ARE. ACTUALLY. DUMB. To answer, YOU decide that honestly, who am I or who is anybody to decide that this or that substance is a relapse but that one isn't?
This is absolutely fascinating. I learned a lot of stuff, and your method of presentation is really clear and easy to follow. I think anyone who drinks regularly should watch this, as it really is scary what alcohol does to the brain and body. Thanks so much for taking the time to put this together.
Really well done and told, I'm no scholar but I love parmacology, it is so interesting to understand how different substances/groups affect you wildly differently. The human body is the greatest feat of engineering our planet will ever produce IMO. So many intricacies makes US so special, it honestly is mind-boggling.
This is great. would be helpful to have a level 4 or a separate video diving deeper into the details of alcohol, barbiturates, and benzodiazepines. I think your content will show up in more search results especially to people who need this the most and are looking up the specific drugs
I've suffered with anxiety and depression my whole life. Which led to migraines every week and back pain. I've been taking gaba for 5 weeks and I haven't had a migraine and no back pain. I started with 200 mg a day and after 5 weeks I have to increase the dose. I'm so happy with the results but my concern is that I'm just going to constantly have to increase the dose. If anyone's had similar experience with pain and using Gabba and have used it long term I'd love to hear from you.😊 I would also add it doesn't seem to mix well with alcohol for me. Even just having a couple beers with Gabba in my system seems to put me in a haze. So I haven't had a drink in over 3 weeks.
Can you offer advice I have been prescribed gabapentin for nerve damage as I was in constant pain all day 24 hours a day I was trying to do it natural for the first 2 years but this January I had to go to the doctor he prescribed Gabapentin March 18th and on the 5th day no pain so looking at the prefix Gaba coupled with the fact that I don't want to be on this the rest of my life do you think Gabapentin can help me
@@deltalady33 yes I think Gabba can help you but it will be a temporary fix. I recommend you reading the book unlearn your pain. My pain is gone way down since starting this book
Thanks! I did take a clip before 10:30 , and while i enjoy your `lecture` style i am not clear on the physics post vesicle. Positive ions don't really flow; negative electrons do leaving behind the positive ion which is why it is voltage and NOT current.
First of all, thanks so much for your generous support and thoughtful comment. If I understand your question correctly, I think it may stem from a slight misunderstanding. In neurons, both positive and negative ions move (i.e. flow) back and forth across the membrane through ion channels, contributing to the voltage changes. Unlike in electrical wires where only electrons flow, in neurons it's these ion movements that create the electrical signals. Does that answer your question?
THANK YOU! First one of your vids and I’m thrilled it was an advanced enough video. Love the way you separate topics into the levels in general and this was really well explained. I’ll definitely be back and share it!
I have been thinking of glutamate and GABA as being corollaries of Chochma and Binah respectively , in the kabbalistic system, of how both the body and universe works . I would be glad to carry on this conversation with those who are curious
I think the pace is soothing, if I don’t understand anything, I Can go back and listen again, your explanation is really helpful and your calming energy is just like GABA too!
@@senseofmindshow Thanks you for the useful information about GABA and neurotransmitter it is very useful. I have a question now as you said “Benzodiazepines enhance the binding of GABA to its receptor” now after we consume Benzodiazepines medication for 2 weeks and then stop consuming further will “enhance binding of GABA to its receptor” also fade away or will enhance binding continues if so for how long ? Thanks in advance
Can you do one focused only on benzodiazepines? Lots of people are tapering off once their body hits tolerance after taking as prescribed for years. Not addicts, but regular people who work, have families, never abused and had their lives ruined by rapid cold turkey tapers. There is now a black box warning stating these should never be used for more than 4 weeks. Tough for those who were prescribed for decades because of a few anxiety attacks.
I was diagnosed with PTSD, so I regularly deal with anxiety attacks. Since my father was addicted to alcohol and Xanax, and was the main cause of my PTSD. I have always avoided benzo's like Xanax, they terrify me. I found a natural drug called Kanna. It's a succulent that the people of Africa have been using for thousands of years. This stuff wipes out an anxiety within 10 minutes, without the worry of withdrawal. Many are cautious about it, rightfully so, the original method of using the powder is to snort it, which makes you feel like you're doing something much harder. I personally leave it under my tongue until my anxiety starts to fade, and then I swallow it. I highly recommend looking into it as an alternative, that way you can taper without the worry of anxiety attacks coming back.
Haha much appreciated. I know I went a little overboard with the subscribe requests in this one 😅 I’ve toned it down in newer videos 😎. Thanks for watching!
OCD is pathological primarily via the nigrostriatal pathway … SSRI help calm the anxiety via increased serotonin but some mild dopamine blockade can help That’s why there is some benefit to taking seroquel … its not as high potency as other D2 blockers but subtle enough to calm the brain
Very interesting and informative Currently tapering off a benzo and as a biologist I am very curious about how the brain reacts in withdrawal specifically the down- regulation of the gaba receptors… the symptoms are intense and disturbing and recovery takes a long time…. Do you know why that is?
Gabapentin don't but gavipintin does easy to get it keeps you from anxiety it keeps glutamate down phenibut works real good I'm on kolonipin and the pharmacy ran out i ordered phenibut and thank God it helped
I have discovered that my body is making antibodies to the enzyme GAD - glutamic acid decarboxylase. Have you ever heard of anyone taking GABA with positive results to help calm the excitatory symptoms such as tremors. Thanks for any thoughts.
The presentation is great, but I wanted to know if it's possible to come up with a way to hinder the activities of alcohol to the brain, if possible, how will it be?
Good question! I hadn’t looked into this specific question until just now. While it appears that there are no FDA-approved gaba-targeting drugs for the treatment of alcohol use disorder, there are some currently being investigated. They include “baclofen” and “topiramate”. Here’s a technical article with more info: www.science.org/doi/pdf/10.1126/sciadv.aax4043 As far as gaba itself goes, I’m not sure if there is any evidence that it helps someone stop drinking or not.
I’m not sure and since I’m not a medical professional, I don’t give any medical advice. I would recommend consulting a doctor who knows your particular situation.
Great explanation of the mechanics of why and how alcohol affects ppl the way it does. This makes me think bartenders need similar training as police officers, in regards to spotting alcohol intoxication levels.
The first 5 min is superfluous information I prefer to skip to about 4:55 in the video. Additionally the playback flows much better at 1.25 vs normal speed.
Interesting how this intricate system came about by accident over billions of years and not the result of some intelligent being creating it. Literally blows your mind doesn’t it?
🎉❤Lovely work; clear & simple ~ in Oriental Medicine the Brain 🧠 is NOT in charge ~ rather it is a servant of the HEART 🧡 ~ the seat of KINDNESS & LOVE ~ in that state the mind / brain is CALM & its hormone -nerve-chemical balance is in harmony ❤🐝🙏‼️. David Ford DrOM
Suggestion: Chloride (anion) not chlorine (molecule/element). The former is the flow of negative charge through the GABA-A chloride pore; the latter doesn't. Well done otherwise
How on earth did certain humans discover all this? :) And ... then we have to remember all this while raising kids, finding a partner in life. I live in a world where mechanical stuff like my toilet breaks down, my car breaks down - the other day the extraction fan in the kitchen broke down-did you know it has a condensator with microfarads in them these days (?!), and I'm the one who has to repair all that stuff. I must be doing so much stuff wrong in life ...
And in a country blessed with a enlightened dictator, the tiny % of their people who would be interested in all this are just send off into war, or thrown in jail, murdered, etc. 60% of humanity enjoys the privilege of living under a dictatorship .. and they are growing: en.wikipedia.org/wiki/Democracy_Index
Thank you , however, I've watched a lot of videos on this topic. THIS is the most complicated and boring I've ever watched! It is more for biology students than the public guess that's why it says advanced
I'm positive that cations do not flow down the axon once the action potential is reached, I think your diagram is misleading with the arrows (17:30 ish), might want rethink that whole electricity thing and focus on the electrons, enjoyed the video otherwise
Great work! My background is chemical engineering, biochem tech elective, master's public health, recovering alcoholic, permanently &total disabled veteran with a mental condition and I have been drinking kava for three years wondering if I have relapsed as an alcoholic. I immensely appreciate how wonderfully you present this topic. I just moved home to Ohio where there were zero kava locations from Florida where kava is abundant. Ohio just opened it's first Kava location outside of Cleveland and I have resumed drinking kava. I think Kava increases GABA receptors. FYI Kava research is swiftly increasing if you could bring this topic to your channel soon. Thank you.
Yes, you relapsed because it's GABA, No KAVA.
I disagree with the other commenter. There is no clear cut term for what a relapse is. Like if I was a meth addict am I relapsing if i have sex because both work on dopamine? Am i relapsing on heroin because i ate a poppy seed bagel that had alkaloids? Or I nutted and my body released endorphins which are our own body supply of opiates? This is just stupid @rodrigoalmanza66 , plain old stupid bad faith logic. It genuinely baffles me how one can be so willfully ignorant and wrong but be so confident... Dunning-Kruger Effect in full force right here!!!
"The major kavalactones potentiate GABAA receptors, which may underlie the anxiolytic and sedative properties of kava. Further, inhibition of the reuptake of norepinephrine and dopamine, binding to the CB1 receptor, inhibition of voltage-gated sodium and calcium channels, and monoamine oxidase B reversible inhibition are additional pharmacological actions that have been reported for kavalactones."
Then am I relapsing on Benzos because my anti-psychotic also affects GABA??!?!?!?! YOU. ARE. ACTUALLY. DUMB.
To answer, YOU decide that honestly, who am I or who is anybody to decide that this or that substance is a relapse but that one isn't?
This is absolutely fascinating. I learned a lot of stuff, and your method of presentation is really clear and easy to follow. I think anyone who drinks regularly should watch this, as it really is scary what alcohol does to the brain and body. Thanks so much for taking the time to put this together.
Really well done and told, I'm no scholar but I love parmacology, it is so interesting to understand how different substances/groups affect you wildly differently. The human body is the greatest feat of engineering our planet will ever produce IMO. So many intricacies makes US so special, it honestly is mind-boggling.
This is great. would be helpful to have a level 4 or a separate video diving deeper into the details of alcohol, barbiturates, and benzodiazepines.
I think your content will show up in more search results especially to people who need this the most and are looking up the specific drugs
Thank you man you explained this very well I understand
I've suffered with anxiety and depression my whole life. Which led to migraines every week and back pain. I've been taking gaba for 5 weeks and I haven't had a migraine and no back pain. I started with 200 mg a day and after 5 weeks I have to increase the dose. I'm so happy with the results but my concern is that I'm just going to constantly have to increase the dose. If anyone's had similar experience with pain and using Gabba and have used it long term I'd love to hear from you.😊
I would also add it doesn't seem to mix well with alcohol for me. Even just having a couple beers with Gabba in my system seems to put me in a haze. So I haven't had a drink in over 3 weeks.
Can you offer advice I have been prescribed gabapentin for nerve damage as I was in constant pain all day 24 hours a day I was trying to do it natural for the first 2 years but this January I had to go to the doctor he prescribed Gabapentin March 18th and on the 5th day no pain so looking at the prefix Gaba coupled with the fact that I don't want to be on this the rest of my life do you think Gabapentin can help me
It's just so do you think Gaba could help me
@@deltalady33 yes I think Gabba can help you but it will be a temporary fix. I recommend you reading the book unlearn your pain. My pain is gone way down since starting this book
@@stevenking8923 thank you so much
Thanks! I did take a clip before 10:30 , and while i enjoy your `lecture` style i am not clear on the physics post vesicle. Positive ions don't really flow; negative electrons do leaving behind the positive ion which is why it is voltage and NOT current.
First of all, thanks so much for your generous support and thoughtful comment. If I understand your question correctly, I think it may stem from a slight misunderstanding. In neurons, both positive and negative ions move (i.e. flow) back and forth across the membrane through ion channels, contributing to the voltage changes. Unlike in electrical wires where only electrons flow, in neurons it's these ion movements that create the electrical signals. Does that answer your question?
THANK YOU! First one of your vids and I’m thrilled it was an advanced enough video. Love the way you separate topics into the levels in general and this was really well explained. I’ll definitely be back and share it!
That's great to hear, thank you!
Really great presentation, I learned a lot. Thank you!
Thank you for watching!!
@@senseofmindshowi use gabapentin.
I have been thinking of glutamate and GABA as being corollaries of Chochma and Binah respectively , in the kabbalistic system, of how both the body and universe works . I would be glad to carry on this conversation with those who are curious
Thanks mate i learnd in half houre what i havent learnd in three weeks from my teacher 😅😅😅
I think the pace is soothing, if I don’t understand anything, I Can go back and listen again, your explanation is really helpful and your calming energy is just like GABA too!
Thanks so much!
@@senseofmindshow Thanks you for the useful information about GABA and neurotransmitter it is very useful. I have a question now as you said “Benzodiazepines enhance the binding of GABA to its receptor” now after we consume Benzodiazepines medication for 2 weeks and then stop consuming further will “enhance binding of GABA to its receptor” also fade away or will enhance binding continues if so for how long ? Thanks in advance
Fascinating presentation - thank you.
Thank you very much for watching.
Can you do one focused only on benzodiazepines? Lots of people are tapering off once their body hits tolerance after taking as prescribed for years. Not addicts, but regular people who work, have families, never abused and had their lives ruined by rapid cold turkey tapers. There is now a black box warning stating these should never be used for more than 4 weeks. Tough for those who were prescribed for decades because of a few anxiety attacks.
I was diagnosed with PTSD, so I regularly deal with anxiety attacks. Since my father was addicted to alcohol and Xanax, and was the main cause of my PTSD. I have always avoided benzo's like Xanax, they terrify me.
I found a natural drug called Kanna. It's a succulent that the people of Africa have been using for thousands of years. This stuff wipes out an anxiety within 10 minutes, without the worry of withdrawal.
Many are cautious about it, rightfully so, the original method of using the powder is to snort it, which makes you feel like you're doing something much harder. I personally leave it under my tongue until my anxiety starts to fade, and then I swallow it.
I highly recommend looking into it as an alternative, that way you can taper without the worry of anxiety attacks coming back.
Excellent content, thanks for posting.
Much appreciated. And thanks for watching!
Awesome...so well explained!
I love benzo's so much! I wish I could take them every day
This guy KNOWS when to remind us to subscribe. Pretty fun to think about ;)
Great content by the way, I had this sudden urge to subscribe!
Haha much appreciated. I know I went a little overboard with the subscribe requests in this one 😅 I’ve toned it down in newer videos 😎. Thanks for watching!
How do we treat ocd ? It is high glutamate and low gaba right? How do we improve situation on that?
OCD is pathological primarily via the nigrostriatal pathway … SSRI help calm the anxiety via increased serotonin but some mild dopamine blockade can help
That’s why there is some benefit to taking seroquel … its not as high potency as other D2 blockers but subtle enough to calm the brain
thank you for this really helpful and informative video
Thank you so much for checking it out!
This is an amazingly informative video. Do you have any videos on cbd used for aura headaches.
You deffently do your homework brother. Thanks for the info.
What do you think about b3 combient with gaba?
Very interesting and informative
Currently tapering off a benzo and as a biologist I am very curious about how the brain reacts in withdrawal specifically the down- regulation of the gaba receptors… the symptoms are intense and disturbing and recovery takes a long time…. Do you know why that is?
im taking gaba in hopes to help my tinnitus your thoughts
Did it helped?
Great video! Thanks 🙏
They say GABA supplement does not cross the blood brain. If that be the case then what good is that supplement ?
Take it with vitamin c and b vitamin complex You could also add magnesium it'll get across
Gabapentin don't but gavipintin does easy to get it keeps you from anxiety it keeps glutamate down phenibut works real good I'm on kolonipin and the pharmacy ran out i ordered phenibut and thank God it helped
Do you have any info on pituitary and it’s emotional or other relationship to adenomas?
I have discovered that my body is making antibodies to the enzyme GAD - glutamic acid decarboxylase. Have you ever heard of anyone taking GABA with positive results to help calm the excitatory symptoms such as tremors. Thanks for any thoughts.
The presentation is great, but I wanted to know if it's possible to come up with a way to hinder the activities of alcohol to the brain, if possible, how will it be?
Drink water.
I got confused so does Gabba help with alcohol to stop a person from drinking
Good question! I hadn’t looked into this specific question until just now. While it appears that there are no FDA-approved gaba-targeting drugs for the treatment of alcohol use disorder, there are some currently being investigated. They include “baclofen” and “topiramate”. Here’s a technical article with more info: www.science.org/doi/pdf/10.1126/sciadv.aax4043
As far as gaba itself goes, I’m not sure if there is any evidence that it helps someone stop drinking or not.
@@senseofmindshow Thank you
Yesss
More on dopamine and etoh please!
Noted! Thank you so much for the suggestion!
Do you think gaba supplements and 5htp supplements are safer to use than ssri and benzodiazepines while nursing?
I’m not sure and since I’m not a medical professional, I don’t give any medical advice. I would recommend consulting a doctor who knows your particular situation.
How can this help OCD?
Great explanation of the mechanics of why and how alcohol affects ppl the way it does. This makes me think bartenders need similar training as police officers, in regards to spotting alcohol intoxication levels.
That's a great point. Although I bet that bartenders get a pretty good intuition for it, considering how often they see highly intoxicated people.
next time i drink im going to sit and over think about the molecular process in response to alcohol
My son has OCD... What really seems to help him. Is benzodiazopines or alcohol? Which means maybe increasing Gaba for Would help him. Your thoughts?
Alcohol binds to dopaminergic receptors too..
thank you
The first 5 min is superfluous information I prefer to skip to about 4:55 in the video. Additionally the playback flows much better at 1.25 vs normal speed.
Interesting how this intricate system came about by accident over billions of years and not the result of some intelligent being creating it. Literally blows your mind doesn’t it?
Following
Happy to hear it!!
🎉❤Lovely work; clear & simple ~ in Oriental Medicine the Brain 🧠 is NOT in charge ~ rather it is a servant of the HEART 🧡 ~ the seat of KINDNESS & LOVE ~ in that state the mind / brain is CALM & its hormone -nerve-chemical balance is in harmony ❤🐝🙏‼️. David Ford DrOM
Suggestion:
Chloride (anion) not chlorine (molecule/element).
The former is the flow of negative charge through the GABA-A chloride pore; the latter doesn't.
Well done otherwise
Ghb is better than alcool
At first. Then, you are addicted downregulating GABA B.
🧐🤔🤗😌
How on earth did certain humans discover all this? :)
And ... then we have to remember all this while raising kids, finding a partner in life. I live in a world where mechanical stuff like my toilet breaks down, my car breaks down - the other day the extraction fan in the kitchen broke down-did you know it has a condensator with microfarads in them these days (?!), and I'm the one who has to repair all that stuff. I must be doing so much stuff wrong in life ...
And in a country blessed with a enlightened dictator, the tiny % of their people who would be interested in all this are just send off into war, or thrown in jail, murdered, etc. 60% of humanity enjoys the privilege of living under a dictatorship .. and they are growing: en.wikipedia.org/wiki/Democracy_Index
Thank you , however, I've watched a lot of videos on this topic. THIS is the most complicated and boring I've ever watched! It is more for biology students than the public guess that's why it says advanced
You must not be smart enough to understand the subject.
I found your presentation extremely boring. Good information.
Thanks for the feedback! I think you may find my newer videos more exciting :)
@@senseofmindshow I just rewatch this one for reference. I need more information. I am about to find a new one you made.
I'm positive that cations do not flow down the axon once the action potential is reached, I think your diagram is misleading with the arrows (17:30 ish), might want rethink that whole electricity thing and focus on the electrons, enjoyed the video otherwise