Invasion, Metastasis and Angiogenesis

An animation explaining the steps in invasion, metastasis, and angiogenesis.
1. Loss of adhesion molecules such as e-cadherin
2. Upregulation of fibronectin/laminin receptors to bind basement membrane
3. Production of collagenases to break down Type IV collagen of basement membrane
4. Autocrine signaling promoting cytokinesis
5. Intravasation into blood vessel
6. Binding to platelets
7. Evasion of immune system
8. Upregulation of adhesion molecules
9. Weak adhesion/rolling
10. Strong adhesion
11. Extravasation
12. Release of angiogenic factors (vascular endothelial growth factor, VEGF)
13. Angiogenesis

[@priyak5242]

The audio effect is everything

[@shafeenaattar4050]

1 hr work in 2 mins perfect ❤️❤️

[@aulaspedrocolturato1179]

Amazing

[@GeekVargen]

Great overview on this subject!

[@rabbiashah9068]

love this.video.its amazing 😍😍

[@bassantmostafa3941]

fabulous !!

[@user-qx8te8wo9y]

Very nice 🌹🌹

[@hunters7638]

I Give this 100x thumb up !!!!!!!!!!

[@pelinkaya539]

It is amazing!!! Thank you!!

[@doct42]

👏👏👏👏

[@bassamalharbi2137]

Thanks 🙏

[@user-ih5qi7bk3y]

awesome!❤

[@shafeenaattar4050]

1 hr work in 2 mins perfect ❤️❤️