🎯 Key Takeaways for quick navigation: 02:29 👤 Androgen receptor binding preference leads to hair loss. 04:23 🛠️ Specific anti-androgen blockers are researched to target DHT receptors. 05:16 💼 Class coderone (breezula) is being explored for androgenetic alopecia. 07:19 🎯 Targeted therapy with blockers and stimulation offers potent approach. 08:43 🧪 Treatment customization and patient compliance are crucial for success. Made with HARPA AI
Please, please, please, talk more about mesotherapy. I think my doctor here in South America has never done a treatment based only in the use of mesotherapy, without any oral alpha reductase blocker. She said I will be doing mesotherapy each six months, but you guys said 2 months and maybe it is because two months is the ideal frame when mesotherapy is the only technique being used as a treatment. Please, talk about this. I may suggest my doctor that I will be doing it each two months. She will agree.
Please can you do a review on Nanoxidil, has it any improvement over the regular monoxidal. Thanks, this is the best channel for her loss I have came across, keep up the good work 🙂.
Hi Dr, I’ve been following you lately about this interesting topic. I totally now understand the difference between hair loss and shedding. However, I just wonder is there a thing called seasonal shedding, For example end of summer and fall? I know this is not Telogen effluvium, and could only relates to season or perhaps the hair enters the Telogen cycle in this specific time of the year. I would love if you can shed more lights on that topic. Thank you.
@@abhishekroy7100OM is getting popular these days and dont hav extensive study. So we need to wait for atleast another 4-5 years to know about exact outcome. So I'm sure none of the doctors Wil do an detailed video on this
Hey guys, what are your thoughts on DS Laboratories? In particular their shampoo and conditioner and the topicals like Spectral DNC-N and Spectral F-7?
Hi doctors, thank you for all the valuable information. I have a question: In regards to Finasteride frequency: in your previous video you said taking Finasteride daily "makes no sense" due to its long half-life. But you also say that when customizing the dosage "you may need to be more aggressive in the therapy." My question is: do you ever come across a patient that actually requires 1mg Finasteride/day, or 7mg a week? What is an example of "being aggressive with therapy" when it comes to Finasteride?
I've seen several hair loss dermatologists and they all recommend 1mg a day. Finasteride remains viable/works for approximately 24 hours or slightly less, so taking only a handful of days a week could be risky. I was only able to stabilize with a minimum (my doctor has me on more than 1mg a day) of 1mg.
Breezula, pyralutamide and gt20029 are super likely to get the fda approval. Breezula is starting phase 3 in the us, pyralutimide is starting phase 3 in the us and China, and gt20029 is currently in phase 2
You can buy pyra online already. Is it supposed to only block the androgen receptors most related to hairloss? Or would it mess with the expression of androgens throughout the body resulting in feeling Low T?
@@JulesLife ok, first don’t buy pyralutimide from 3rd parties because they can’t recreate the same compound as kintor, so it won’t be effective against hairloss. Now to answer your question, pyralutimide is a topical with a great safety profile. It doesn’t go systemic meaning it only works locally on the area it’s applied on. So since you’re only supposed to apply it on your scalp there is no reason it would affect androgens anywhere else on the body
@@sausagelizer4444 I have seen the third party testing papers and it seems good. That’s great to hear though! Assuming mine is legit then it might be amazing.
@@JulesLifethe third party stuff all seems ineffective. The only anti androgen that is actually highly effective that we can get on the market is RU58841
Please write the name of the hairloss androgen-receptor-specific drug under development. It was not clear from the discussion. I was aware that DHT is more selective for hairloss than T, but I wasn't aware that there are DHTs that are more selective for hairloss than other DHTs. Is that the point?
I had a hair transplant back in 2005. The procedure went well and the hair growth wss good. After about 5 years i noticed dry skin with a group of hairs clumped together.. it wss very odd. I didnt lose much but it definitely affected thd density. I dont know if that' was my native hair or yhe transplanted hair. I really have never recieved any explanation for this.. I started on oral finistride in 2018 and used it until 2023 and noticed ths hair thicknesses inproved and less shedding. I stopped oral finistride and started topical minoxidil and finistride. Its been about 5 months but i havent seen the sams results as oral finistride and I'm not sure i will. Any thoughts on why the dry skin and hair fall after the hair transplants?? I still have maintained much of my hair but the density is poor.
can you guys make a video on people wanting to go on finasteride as a preventative measure (pre-hairloss) and whether its effectiveness will diminish in the long term meaning that if you go on it too early that you will have unnecessary diminishing results?
Is there anything that can regrow hair....in the front area....The hairline. Also....for those hairs that have stopped growing...Is there anything that can restart them growing.. Finasteride has stopped all falling hair..but...I'm concerned about the other two issues.. Now, I have seen videos in which they claim...Minoxidil did nothing for them.. at all. If you will, give me an answer here...or do a video on it.. Thanks!
What do you think about topical spirolactone? I have seen people crush the pills and mix them with minoxidil. Spirolactone is supposed to be an androgen blocker
Guys, I have 6 bottles of Minoxidil on my table and too scared to use it. I have heard that once you start Minoxidil your hair can become dependent on it to such an extent that once or if you stop taking minoxidil you will be MORE bald than you were to begin with. In other words, that prexisting hairs that werent yet balding at onset of Minoxidil treatment, will be pushed into otherwise avoidable (when paired with other treatments) balding stages once you stop taking Minoxidil. Can you confirm or adress this topic?
Hi bit of a random q. Do corticosteroids increase hair loss. Specifically salbutamol for asthma? Just wondering if this will affect dht levels and the ability of finasteride to do it's job? There doesn't seem to be a lot of information about this tbh
I have a question, I use minoxidil 2% once a night and for the last 19 days and it makes me really lightheaded the night of and following day (but my shedding has slowed down already) could I still get some benefits if I used it every other day? to help remove the light headedness? I know the half life is 23 hours, so could every other day still bring benefits and be better than not using it at all?
Thats why Dutasteride is mote powerful than finasteride. Also Dutasteride doesnt cause severe sides effects like finasteride. Dutasteride has been also shown to reduce scarring of hairfollicles and scalp which is very interesting
@@meltedsnowman9637 Not low enough. This from a guy who experienced a permanent ejaculation disorder caused by finasteride. That was at 1.25 mg/day, without any breaks. I wish I had known about the 1 mg 3X/week, ten weeks on, two weeks off protocol. I'm using that now, after a long period of non-use.
@@EmreY25 - They said they both used finasteride at one time but neither has androgenetic alopecia. Dr Knudsen said minoxidil can help senescent alopecia which implies that he uses it, hence my question.
It's good to note that the emerging therapy on balding is definitely taking a new dimension on targeting the specific culprit creating baldness. 👍
👍
🎯 Key Takeaways for quick navigation:
02:29 👤 Androgen receptor binding preference leads to hair loss.
04:23 🛠️ Specific anti-androgen blockers are researched to target DHT receptors.
05:16 💼 Class coderone (breezula) is being explored for androgenetic alopecia.
07:19 🎯 Targeted therapy with blockers and stimulation offers potent approach.
08:43 🧪 Treatment customization and patient compliance are crucial for success.
Made with HARPA AI
*Clascoterone
Please, please, please, talk more about mesotherapy. I think my doctor here in South America has never done a treatment based only in the use of mesotherapy, without any oral alpha reductase blocker. She said I will be doing mesotherapy each six months, but you guys said 2 months and maybe it is because two months is the ideal frame when mesotherapy is the only technique being used as a treatment. Please, talk about this. I may suggest my doctor that I will be doing it each two months. She will agree.
Tell us more on peptides, please. ❤ your videos are realistically educational
Please can you do a review on Nanoxidil, has it any improvement over the regular monoxidal. Thanks, this is the best channel for her loss I have came across, keep up the good work 🙂.
Blocking Androgen receptor cause feminisation for men but it s benefic for Woman So could we use it to irradicate Androgen Alopecia for Women ??!!!
great content, will you be covering scube 3 in any follow up videos?
whats the name of this new product, which you cant use now. what is about prylumimaid?
Great videos, thank you for posting. What are your thoughts on CosmeRNA?
Hi Dr, I’ve been following you lately about this interesting topic. I totally now understand the difference between hair loss and shedding. However, I just wonder is there a thing called seasonal shedding, For example end of summer and fall? I know this is not Telogen effluvium, and could only relates to season or perhaps the hair enters the Telogen cycle in this specific time of the year. I would love if you can shed more lights on that topic. Thank you.
What happened to your partnership with the UK company?
Thanks for these great videos
Just one recommendation, the writing on the whiteboard is too small.
Dear, after a hair transplant, when can you start using hair fibers again? And when can you start microneedling again? Thanks in advance!
Please do an episode on oral minoxidil and its dose for male and female patients
they already have videos on it
@@GodofStories they talked vaguely not extensively and they didn't talk about the perfect dose of oral minoxidil for male and female
@@abhishekroy7100OM is getting popular these days and dont hav extensive study. So we need to wait for atleast another 4-5 years to know about exact outcome. So I'm sure none of the doctors Wil do an detailed video on this
Hey guys, what are your thoughts on DS Laboratories? In particular their shampoo and conditioner and the topicals like Spectral DNC-N and Spectral F-7?
Their growth stimulating shampoo is top notch, if you have fine hair it really thicknes it noticeably.
Hi doctors, thank you for all the valuable information. I have a question: In regards to Finasteride frequency: in your previous video you said taking Finasteride daily "makes no sense" due to its long half-life. But you also say that when customizing the dosage "you may need to be more aggressive in the therapy." My question is: do you ever come across a patient that actually requires 1mg Finasteride/day, or 7mg a week? What is an example of "being aggressive with therapy" when it comes to Finasteride?
I've seen several hair loss dermatologists and they all recommend 1mg a day. Finasteride remains viable/works for approximately 24 hours or slightly less, so taking only a handful of days a week could be risky. I was only able to stabilize with a minimum (my doctor has me on more than 1mg a day) of 1mg.
Hello. I enjoy your videos which are very informative. In addition to peptides, please can you also do a video on Polynucleotide hair treatments.
Do we know if statins, such as atorvastatin can reduce the effectiveness of finasteride?
Can I use red light therapy while using clobetasol topical on my scalp please?
Could addition of DMSO help with topical delivery?thank you for your informative videos. Love the channel!
Great video. What do you think of“laser” or light stimulation for the scalp? I assume its just another stimulation technique but does it work?
Any thoughts on SCUBE3 and Osteopontin signaling growth factors?
Breezula, pyralutamide and gt20029 are super likely to get the fda approval. Breezula is starting phase 3 in the us, pyralutimide is starting phase 3 in the us and China, and gt20029 is currently in phase 2
You can buy pyra online already. Is it supposed to only block the androgen receptors most related to hairloss? Or would it mess with the expression of androgens throughout the body resulting in feeling Low T?
@@JulesLife ok, first don’t buy pyralutimide from 3rd parties because they can’t recreate the same compound as kintor, so it won’t be effective against hairloss. Now to answer your question, pyralutimide is a topical with a great safety profile. It doesn’t go systemic meaning it only works locally on the area it’s applied on. So since you’re only supposed to apply it on your scalp there is no reason it would affect androgens anywhere else on the body
@@sausagelizer4444 I have seen the third party testing papers and it seems good. That’s great to hear though! Assuming mine is legit then it might be amazing.
@@JulesLifethe third party stuff all seems ineffective. The only anti androgen that is actually highly effective that we can get on the market is RU58841
What about for women
Can you touch on hair fibers. Are they safe? Do they potentially exacerbate hair loss? Thank you!
Please write the name of the hairloss androgen-receptor-specific drug under development. It was not clear from the discussion. I was aware that DHT is more selective for hairloss than T, but I wasn't aware that there are DHTs that are more selective for hairloss than other DHTs. Is that the point?
I had a hair transplant back in 2005. The procedure went well and the hair growth wss good. After about 5 years i noticed dry skin with a group of hairs clumped together.. it wss very odd. I didnt lose much but it definitely affected thd density. I dont know if that' was my native hair or yhe transplanted hair. I really have never recieved any explanation for this.. I started on oral finistride in 2018 and used it until 2023 and noticed ths hair thicknesses inproved and less shedding. I stopped oral finistride and started topical minoxidil and finistride. Its been about 5 months but i havent seen the sams results as oral finistride and I'm not sure i will. Any thoughts on why the dry skin and hair fall after the hair transplants?? I still have maintained much of my hair but the density is poor.
can you guys make a video on people wanting to go on finasteride as a preventative measure (pre-hairloss) and whether its effectiveness will diminish in the long term meaning that if you go on it too early that you will have unnecessary diminishing results?
Is there anything that can regrow hair....in the front area....The hairline. Also....for those hairs that have stopped growing...Is there anything that can restart them growing.. Finasteride has stopped all falling hair..but...I'm concerned about the other two issues.. Now, I have seen videos in which they claim...Minoxidil did nothing for them.. at all. If you will, give me an answer here...or do a video on it.. Thanks!
What do you think about topical spirolactone? I have seen people crush the pills and mix them with minoxidil. Spirolactone is supposed to be an androgen blocker
Would u recommend alopecia or oral minoxidil?????
Put chapters into your vids, a lot of the video is good old info most of the community knows already.
Guys, I have 6 bottles of Minoxidil on my table and too scared to use it. I have heard that once you start Minoxidil your hair can become dependent on it to such an extent that once or if you stop taking minoxidil you will be MORE bald than you were to begin with. In other words, that prexisting hairs that werent yet balding at onset of Minoxidil treatment, will be pushed into otherwise avoidable (when paired with other treatments) balding stages once you stop taking Minoxidil. Can you confirm or adress this topic?
Would the anti-androgen receptor stuff cause regrowth or would it just limit future losses?
Please talk about SAW PALMETTO!
Doesn’t work talk over
Good
Hi bit of a random q. Do corticosteroids increase hair loss. Specifically salbutamol for asthma? Just wondering if this will affect dht levels and the ability of finasteride to do it's job?
There doesn't seem to be a lot of information about this tbh
I have a question, I use minoxidil 2% once a night and for the last 19 days and it makes me really lightheaded the night of and following day (but my shedding has slowed down already) could I still get some benefits if I used it every other day? to help remove the light headedness? I know the half life is 23 hours, so could every other day still bring benefits and be better than not using it at all?
I've heard nonoxidil has less side effects, but I'm no expert, it's quite new and not many trials so far.
I use a microdose of finasteride due to side effects and use RU
Thats why Dutasteride is mote powerful than finasteride. Also Dutasteride doesnt cause severe sides effects like finasteride.
Dutasteride has been also shown to reduce scarring of hairfollicles and scalp which is very interesting
They both have a very low rate of side effects.
@@meltedsnowman9637 Not low enough. This from a guy who experienced a permanent ejaculation disorder caused by finasteride. That was at 1.25 mg/day, without any breaks. I wish I had known about the 1 mg 3X/week, ten weeks on, two weeks off protocol. I'm using that now, after a long period of non-use.
Bruuuuh it's totale thé opposite, dutasteride have muuch sides effects, what are You talking about ? 😂😅
@@meltedsnowman9637more with dutasteride
@@espada9noveno There is no evidence of that
Is 0.25mg 7am morning and 7pm evening better than 0.5mg evening for fin?
It’s not. They said it in another video where they talked about micro-dosing finasteride.
Sounds like a win for SARMS hahah.
Hi, is it safe to take both oral finasteride and oral minoxidil?
Is Dr Knudsen still using minoxidil? His senescent alopecia seems to have progressed a lot recently.
I think he’s got more things to worry about he looks like he’s just got out of the grave!😂
He's old he don't need hair at his age..
I think they both tried it at one point and stopped using it, it wasn't even that long
@@christianblake3997 not really
@@EmreY25 - They said they both used finasteride at one time but neither has androgenetic alopecia. Dr Knudsen said minoxidil can help senescent alopecia which implies that he uses it, hence my question.
unsubscribed at "cisgender"
You lost me at transgender, cisgender...
Same
You lost me at “cis gender” 👋
later, stay malding
Same. Nonsensical.
scube3
You lost all credibility after you said cisgender. 🥴🤦🏻
Personally I cannot stand Knudsen.
Hello, doc do you know if i can mix my ru58841 with trichosol as a vechile with also dutasteride in it? Thank you