Lecture 10b: amphetamine
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- Опубліковано 10 лип 2024
- Here is another lecture video for my class on the psychological aspects of drug use and abuse. This one is the second in my two-part series on stimulants. It focuses on on different types of amphetamines, including methamphetamine. As usual, the lecture video covers the natural and social history of these drugs, as well as some important aspects of their pharmacology and psychology.
speed has been a boon for my mental health but no doctor has been able to help me. But Psilocybin has been the real guide I needed!
The dilemna is the paranoia involved in the medical racket, where ASKing contraindicates the rationale of using amphetamines. I think it's bullcrap, both my guy n I have got adds simply by saying, I'm distractible, start things and finish them later, and the KICKER is: it's MADDENING when I go into another room and FORGET WHAT I WANTED. This is attention deficit n my guy says they NEVER prescribed them to adults in the 1970s or '80s, in any case anyone can get a beneficial return from taking stimulant alkaloids but the abuse potential is such that a certain amount of people will get stimulated but then waste their time listening to music or repetitive stuff like housecleaning or cleaning, which altho repetitive still beats masturbating lol
@@tinafoster8665 i have a wank every morning. gets rid of that toxic below the belt shit...
@@whiterabbit1632 hehe hey you must be a stockbroker, dealing with all very acidic above the shoulders mustard shyt, gotta feed the geese to keep the RYTHM below the belt cuz IF YOU DON'T, you will split your differential, fall out of balance and tip the f*** over, or WORSE YET, implode. And you DON'T want that, implosions are very ugly, ask Chris Benoit
@@tinafoster8665 and my request for soiled lingerie?
@@tinafoster8665 You could always delivery them in person? Fresh from the oven...
dexEdrine, i used to have a prescription for those, i loved them. . . . . there are so many stimulants and phenethylamines i wish i could get my hands on!!!!!
If people have their adhd properly medicated and managed they're less likely to self medicate with other drugs
more people need to know this!
Yup
So is Euphoria an improper symptom caused by overdose of a prescribed Amphetamine medication?
NO, euphoria literally means feeling good, feeling normal. We, who are not chemically imbalanced, feel Euphoric most of our lives. So those who feel Euphoria from Amphetamines are merely feeling what its like to be normal.
I truly thought Mothers little helper, was about diazapam (Valium) but it makes a lot more sense for it to be about amphetamine. Specially since it's an upper and Valium is more of a depressant/downer
I think it was, the abuse of benzodiazepines is BEYOND EPIDEMIC n the withdrawal of them IS HORRIBLE because you can't sleep. At least with stimulants, withdrawal produces lassitude n fatigue, and you CAN sleep
It's that it was fairly new then for people to take "happy pills"... Whether it be valium, speed, codeine, etc.
@@tinafoster8665 oh lack of sleep isn't the worst part. It sucks, months of very little sleep leave you basically a delerious zombie. But benzo's have so much more pain to offer you! Near constant panic attacks, feelings oh impending doom, feeling you will literally die any moment, but you are right, because you can. Extended psychosis, can't breath. Horrify night terrors. I don't think I could do it again. I don't know how I didn't kill myself or at least relapse on alcohol just to try to find SOME relief. I wouldn't wish benzo withdrawal on my worst enemy.
Valium was the mothers little helper. They handed it out like candy. My grandmom had a prescription. She became really dependent on it. Any time she tried to stop, she was hospitalized. Spent the rest of her life on benzos until she died from a stroke 10 years ago.
At 13:06 that's how they look..As usual I'm drunk and full of pills.
The Benzedrine inhaler should be brought back.
Concerta is methylphenidate XR, not amphetamine.
As someone who uses methamphetamine and dextroamphetamine too much, if I had a choice between methylphenidate and MDMA, I'd chose the MDMA. Methylphenidate might be more of a traditional stimulant but you can just tell it's not an amphetamine and MDMA is. I can see why you would include methylphenidate while distinguishing MDMA but yeah just my 2 cents.
MDMA is pretty litt😂😂🤙👁️👁️
@MATTHEW575M That depends on the route of synthesis, by favourising the D enat. you will yield more D-Amph. Dont ask me how i got no idea ;)
MDMA is not an amphetamine.
@@user-uf4lf2bp8t Yes it is, it’s a meth analogue simple as that. Get your info straight and stop defending your precious “Molly”. MDMA is a straight up neurotoxin
@@SATAN99TH I'm not defending MDMA and I've never done it, but your comment is blatant disinformation. Does eating salt have the same effect as eating pure sodium metal or drinking chlorine? No, because molecular differences mean something. Meth is dopaminergic, MDMA has a completely different effect profile since it has a completely different effect on the brain I.E serotonergic effects. I never disputed that MDMA is neurotoxic when used often. Meth isn't actually an amphetamine either. It's a substituted amphetamine, just like MDMA, cathinone, ephedrine and bupropion.
Wow, super informative. Also, pregalone in small dosages helps with stimulant toleramce.
pityo gonzalez you mean Pregabalin? If so it doesn’t help much at all and will just end up causing more side effects down the road.
Compounds that should be further looked into for psychostimulant pharmacotherapy should be:
9-methyl-beta-carboline
BPC-157
Bromantane
One of the best overviews, thank you
Thanks for the kind words
@@keithdonohue4631 Acknowledging compliments is polite. I would argue that its far more useful to you & your audience to acknowledge comments that put light to your errors in presented content.
Researchers who passively continue supporting or proselytizing false information fail to serve themselves in their development as cogent professional researchers, & they maintain disinformation that can be destructive even fatal to their audience.
The polite “grooming comments” and the “tow the line” pharmacology will only augur-in your channel, plus it’s boring.
Thats my two cents.
@@BushyHairedStranger I think that I understand the general point that you are trying to make, but I wonder if you could give me some specific examples of the errors that I have made. I’m sure that there are some, but it would be helpful to know which ones most concern you. Thanks.
Great work, thanks a lot!
Thanks for the kind words. I am trying to catch up on my video-blogging, so hopefully I will have some new videos out, soon.
That would be greatly appreciated, yours looks like a really solid material on the subject, very interesting indeed. No rush though, as far as I'm concerned - I've just had a look at your channel and it seems like I will have enough to watch for quite some time;) Thanks a lot, my very best wishes!
great video, very interesting :)
I appreciate your effort in creating and sharing this. It is difficult to find accurate information on this subject. While I am sure your intentions were good, I did notice some mistakes. The following is a list of the most unambiguous errors:
Edeleanu never named the substance amphetamine. He was not employed by SKF and was not the one to discover the pharmaceutical effects of amphetamine. He was simply the first to synthesize it and describe its synthesis in 1887 at the University of Berlin. Edeleanu went on to become a very succesfull innovator in the petrochemical industry and his methods continue to be used today.
The discovery of amphetamine's pharmaceutical properties happened 40 years later. Therefore, amphetamine was not used in WWI.
Gordon Alles discovered the pharmaceutical effects of amphetamine in 1927 and received a patent in 1932. SKF bought the rights and began marketing Benzedrine shortly thereafter. Amphetamine sulfate was only used by the Allies in WWII, the Axis powers used methamphetamine instead.
Amphetamine sulfate is not "chemically modified" to obtain dextroamphetamine: Amphetamine sulfate IS 50% dextroamphetamine sulfate. The two isomers are just separated.
Amphetamine sulfate is not usually "tinkered with" to get methamphetamine. Methamphetamine hydrochloride was synthesized independently and studied separately from amphetamine sulfate. Manufacturers offered it as an alternative in markets where SKF controlled the patent to amphetamine or in markets where amphetamine was unavailable, such as in Nazi Germany where the brand Pervitin was sold.
MDA and MDMA are hallucinogens with stimulant properties. Gordon Alles subsequently also discovered their effects, and was rather bemused by them. An interesting fact is that the effects of more then half of substituted amphetamines are not predominantly "amphetamine like" (stimulating). This is not a mistake, just an interesting fact.
You meant to say amphetamine has a longer "duration of action" then cocaine. While it also has a longer halflife, it is the duration of action or the "high" that is relevant to what you say next.
"Faces of Meth" is a problematic for multiple reasons. It has received academic criticisms for racial bias, invasion of privacy, and promoting public shaming of addicts. Most importantly, it is simply not an accurate portrayal of the vast majority of people dependent on amphetamine. Most amphetamine abuse is discreet, utilitarian, and externally invisible. It affects people of all races, ages and socioeconomic conditions. Most are either gainfully employed or enrolled in some form of education with the intention of becoming gainfully employed. These people are equally at risk, even if they don't look like they were hit by a bus prior to having had their mugshot taken.
There is unncecesary silence from 40:35 to 41:24
Again this is all intended as constructive criticism and I appreciate your overall effort.
i wish i was gordon alles, or at least had his skills. . . .
Does tablets compounds change with time and could be come dangerous
10:32 Efroxine hydrochloride is just a trademark for meth
i took vywanse alot, now i had whitrawalsymptoms like methaddicts, i cant take it anymore, the comedown was too horrible, to traumatizing, still the most articles i read are talking about it like a cure for depression...
I’m so sorry. That sounds like a terrible experience to go through.
Very helpful!!
Thanks for the kind words. It's been a while since I updated my lectures, but I am happy to see that people are still watching them and finding them useful. By the way, is this *the* Mitch Earleywine? I'm a big fan. I did my PhD, at Florida State, with Al Lang, and we read more than a few of your papers. I also really liked your UNDERSTANDING MARIJUANA book, and I used to assign it to students in my Drugs & Alcohol class (these days, I'm full-time clinical, which explains why I haven't updated my video lectures!) Anyway, it's always good to get a compliment - especially from a scholar who really influenced me.
Yes! For what it’s worth!
The clinical work is always admirable. Nobody knows what goes on in the trenches. Thanks for doing it!
Thanks! I hope that I can bring both the art and the science to my clinical practice. I have good colleagues and supervisors, and they promote a practical, empirically-informed approach to the work. At this stage of the process (I'm only a couple of months in), that's probably the most important thing for me.
Theres quiet a bit of disinformation here!! Montana Meth Project!! That’s entirely set up by cops! No scientific data there at all!! Zero! None! Zilch!! Its 100% anti-amphetamine propaganda, nothing more. Theres no such thing as meth mouth! Saying that someone with poor dental hygiene who uses meth is a victim of meth mouth is ridiculous! Any fool can do the work to prove that argument is factually incorrect and absolutely biased. Stimulants are no more dangerous than most drugs! Alcohol is far more toxic and deadly than Methamphetamine!! Why wasn’t that fact shown!??
The song mother's Little helper is actually about Valium according to many sources. You're the first one who's claimed it's amphetamines... But you could be right.
Actually, I think you may be right. In the years since I made this lecture, I have learned a little bit more about that song, and I think it probably was meant to refer to Valium. That said, use of amphetamines, to increase energy and mood, and diazepam, to relax or manage anxiety, was pretty common in the 50s, 60s, and later.
@@keithdonohue4631 Still common today. Xanax instead of Valium usually though. . Great video I watched the whole thing.
@@davidwinfield7387 Thanks for watching the video. And yes, I think you are right about the continued overuse of anti-anxiety drugs.
Grrreat
Thanks!
I take it everyday
CARL HART M.D. please reference this individual and his work prior to posting any more stimulant videos, thanks.
My friend, I have listened extensively to Dr. Hart, and I would argue with you that he would be happy of the dissemination of information that is valuable and informative, regardless of credit or plaudits.
@@AANVC I spoke in person with Dr. Hart at the New York Academy of Medicine last December. We were there to listen to Matt Johnson, of Johns Hopkins, speak about his current research on Psychedelics.
Amphetamines and the decades of propaganda came up in our conversation in the hallway during the 1st conference break. We all agreed that “Faces of Meth” did nothing but shame those suffering far more than drug addiction. The individuals in those images were almost ALL homeless and suffering from the impacts of childhood traumas going back decades. Tooth loss is not a symptom of Amphetamine use. Nor are the dozens of other claims pumped out by groups like ‘The Montana Meth Project’ these are people who have investments in detox treatment programs and incarceration facilities. They make their millions $$ off the suffering of the poor. The amount of propaganda pumped out about Meth is staggering! Its sickening.
@@AANVC …so why is so much of this antiquated information on addiction still being pumped out into society?
10:11, it'd probably be ideal for progesterone oriented premenstrual lethargy... And mood elevation for the more uninitiated to amphetamines. It also can help with constipation, just saying. Other than that, I'm not sure how helpful it is for menstrual related discomforts 😉
Great lecture, one correction though: cocaine is not an amphetamine technically they are different in pharmacology
Hmmm... did I say that cocaine was an amphetamine? If so then that was a mistake. I grouped these drugs together (as most sources do), because they are classed as stimulants.
Share the time stamp. I don’t think he said that?
The scripters of the drug game
Leave a thumbs up if you
Both my aunts that did those are... interesting. So is my neighbor.
Steroid users are... interesting too
mothers little helper = valium. and efroxine was an antidepressant/stimulant
Slimmers found them useful but became addicted .coming off them was not nice
Amphetamine use in the US is near 1970 levels. I fear that another amphetamine crackdown is coming…
Really interesting, but please use a better microphone.
Never had covid and I've been prescribed adderall for 4 years. Never took the vakscheen either.
I'm in Phx and I don't think you can even get busted with the stuff here ...Lol..I don't know what it is but it wouldn't get a fly high.. but it looks like meth comes back in the pipe like the real thing so I'm told so. maybe this is the fake meth capital of the world...Lol.
i know what you are talking about, it puts you to sleep. . . .
Is it possible that a person after prolonged use of dieting pills become... fascist, crazy and irrational? Selfish, self-centered, etc?
I guess that I can't speculate about all diet pills, but abuse of diet pills that are made up of stimulant medications can lead to anxiety, irritability, and paranoia.
@@keithdonohue4631 thank you. I am after some blogs of anorexia and bulimia nervosa for a long time. I guess there's some drug trafficking going on there. I once found one of those pills in my sister's room, among other products. I have an eating disorder as well, but mine works mostly with food I find "dirty" because of religious trauma growing up.
@@AlineSanchezRamirezBaruc-xm6qb I'm sorry. That sounds very hard. If you want some more information on eating disorders, I recommend you check out: www.nami.org/About-Mental-Illness/Mental-Health-Conditions/Eating-Disorders
@@keithdonohue4631 Take them away from Reddit American men. I am SICK of those fat bitches. I am Brazilian and we don't like Reddit American people. We quite hate them
@@keithdonohue4631 thank you, Sir ❤