Hi Miss Sheekster, I love your accent (oh, and content too :-) ). What area are you from (not stalking here). You lose me sometimes but I'm learning a new dialect. It's a skill we have here in the great "melting pot".
Very interesting interview. As usual. I always find incredible the large number of lurkers that accompany each of your videos, compared to the number of "likes". Lurkers are typically members of the online community who observe, but do not participate by “liking” or commenting. Lurking allows users to learn the subject being discussed without letting the owner of the post identify them. They are lying hidden or moving about secretly and probably, later, some of them will be creating their own posts about the subjects and the state of the art research that you generously share online. :-)
I don't think you have done a video on Lutein and its possible role in healthy aging. Check out the study from 2019 "Effect of Lutein (Lute-gen) on proliferation rate and telomere length in vitro and possible mechanism of action". Quote from the paper...."Lute-gen’s effect on telomere attrition indicates that the antioxidant activity of lutein is beneficial and counteracts the effects of oxidation on telomeres in human primary cells." Keep up the great work! 😀
I enjoyed listening to this guy, very good cadence and informative, and for me, easy to understand, since I sometimes have trouble listening to people with British accents {I am American}. I will have to check out his book.
Eleonore is a known and speaks well. Her interviewees that speak in excess of 330 words a minute need a clearer picture to help read their lips simultaneously as they speak.
I think that this interview and Dr. Steele missed an opportunity to research and apply machine learning theory to the inputs (food) that people eat that form the baseline of agelessness. I’m talking about the whole food plant based diet that the longest living humans eat known as the Blue Zones. To be sure their is something happening on the epigenetic level of the people that eat a WFPB diet. I would like to know the biological mechanism that connects WFPB diet and biological age. Therapeutic drugs can only react to people who are ill and do not address the foundation of why they are ill. We know what people need to eat to lower their blood pressure and resting heart rate. Perhaps his next research topic could do this sort of work.
Less calories, less methionin and overall protein = less mTOR and IGF1 activity (fasting mimicking) Lots of phenolic compounds, which at least provide hormesis and at best are antioxidants, senolytics, inflammation reducing, gene repairing, Sugar binding etc Out of the blue Zones, only SDA are radically WFPB, the others include animal products, although rather sparsely.
Not really... Wholefoods and all the good habits we have only compress morbidity. Everybody must inevitably die of some kind of deterioration in their biology. This conversation is speaking in regards to superseding the maximal health and lifespan we are currently able to achieve with lifestyle and nutrition
Entropy concept in thermodynamic is analog to senescent cells. Nature dictates that the disorder always increases in any system regardless if it's a human being. Exergy or entropy minimization probably would be analog to healthspan.
I read that he thinks that 30~35 years was the lifespan in ancient times. However, two of the people in Abri CroMagnon were over fifty. Get real or get out!
I hope you enjoyed our conversation! See links in the description!
Hi Miss Sheekster, I love your accent (oh, and content too :-) ). What area are you from (not stalking here). You lose me sometimes but I'm learning a new dialect. It's a skill we have here in the great "melting pot".
Thanks for having me on your channel! It was a really great chat :)
Good job with the interview and really inspired by the pioneers in the ageing field.
Don't interview East Texan or Louisiana scientists they are either too, too, fast or slooow!
@James Robert Clark III Happy birthday! And hope you enjoy it :)
Very insightful content! I hope 2022 will be a great year for science innovations
This interview was absolutely incredible. Great video.
Thanks for the interview! Ageless was a great book and everyone should read it!
Fascinating talk. You could really sense his enthusiasm in these matters.
Good interview. Exactly what we need free thinking people from other diciplins especially scientists from a physics background.
"Sticky end", recycled into Owls.
My hair is regaining its colour, at 72. 💙💛❤🙏
What do you attribute the return in your hair?Sorry, I didn’t get the reference.
Loved interview. Thanks.
Great interview! How did you get him on your show? I read the book, loved it, and I've been trying for months to interview him.
Oh hi Lance ! I am following you in your journey! You, others and Sheekey permit to relativise aging. Keep going !
Thanks Lance, i just emailed!
She blinded him with science. But that wasn't a problem due to epigenetic reprogramming.
Nice
Simple, she is amazing!
Very interesting interview. As usual. I always find incredible the large number of lurkers that accompany each of your videos, compared to the number of "likes". Lurkers are typically members of the online community who observe, but do not participate by “liking” or commenting. Lurking allows users to learn the subject being discussed without letting the owner of the post identify them. They are lying hidden or moving about secretly and probably, later, some of them will be creating their own posts about the subjects and the state of the art research that you generously share online. :-)
This guy is great
Superb!
I don't think you have done a video on Lutein and its possible role in healthy aging. Check out the study from 2019 "Effect of Lutein (Lute-gen) on proliferation rate and telomere length in vitro and possible mechanism of action". Quote from the paper...."Lute-gen’s effect on telomere attrition indicates that the antioxidant activity of lutein is beneficial and counteracts the effects of oxidation on telomeres in human primary cells." Keep up the great work! 😀
I enjoyed listening to this guy, very good cadence and informative, and for me, easy to understand, since I sometimes have trouble listening to people with British accents {I am American}. I will have to check out his book.
Eleonore is a known and speaks well. Her interviewees that speak in excess of 330 words a minute need a clearer picture to help read their lips simultaneously as they speak.
I needed to play this at .75 speed tomorrow him
I think that this interview and Dr. Steele missed an opportunity to research and apply machine learning theory to the inputs (food) that people eat that form the baseline of agelessness. I’m talking about the whole food plant based diet that the longest living humans eat known as the Blue Zones. To be sure their is something happening on the epigenetic level of the people that eat a WFPB diet. I would like to know the biological mechanism that connects WFPB diet and biological age. Therapeutic drugs can only react to people who are ill and do not address the foundation of why they are ill. We know what people need to eat to lower their blood pressure and resting heart rate. Perhaps his next research topic could do this sort of work.
Less calories, less methionin and overall protein = less mTOR and IGF1 activity (fasting mimicking)
Lots of phenolic compounds, which at least provide hormesis and at best are antioxidants, senolytics, inflammation reducing, gene repairing, Sugar binding etc
Out of the blue Zones, only SDA are radically WFPB, the others include animal products, although rather sparsely.
0.75x
Hahaha sorry… :)
What do you guys think about Cryonics? I'm thinking in signing up to "Tomorrow Biostasis" for heart-brain preservation in London.
Good interview:)
had to check, yes playback speed is set to normal.
Definitely sensing a theme in these comments…
Immortality IMT crypto for the longevity field listened to the entire video from start to end
i feel the conversation is artificially accelerated
Fantastic as always. I’m always shocked that you don’t have more subscribers. I expect that will change in big way.
However, she has thousands of lurkers.... :-(
Something you are overlooking is the power of a well planned whole food plant based diet in preventing disease and disability.
Not really... Wholefoods and all the good habits we have only compress morbidity. Everybody must inevitably die of some kind of deterioration in their biology.
This conversation is speaking in regards to superseding the maximal health and lifespan we are currently able to achieve with lifestyle and nutrition
@@austaneousc5802 that’s true I was more thinking about staying alive and healthy until some of the therapies in the pipeline become available.
@@bgrune1 And that's totally fine, but that's just a different conversation. So they haven't really overlooked it, if you feel me.
22.30, we dont need lipofuscin, we got serrapeptase. Clean your bloodvessles
Doubling each eight years us 2^(years/8)
2^(80/8) =2¹⁰ = 1024
It seems that the chances of dying are less than one.
Entropy concept in thermodynamic is analog to senescent cells. Nature dictates that the disorder always increases in any system regardless if it's a human being. Exergy or entropy minimization probably would be analog to healthspan.
Interesting; thanks for the clarification.
If disorder always increased in living things then living things wouldn't be born and be able to grow in the first place
Evolution? Or the Creator?
Pls update your microphone/audio ;)
Great interview.
Random: Andrew Steele looks like Louis from Dexter (the nerd intern).
Extremely British! 😛
Oh My Gosh, he is SO Darn cute!
I read that he thinks that 30~35 years was the lifespan in ancient times. However, two of the people in Abri CroMagnon were over fifty. Get real or get out!
What is the evidence for evolution selecting for reproductive success as it a selection for individuals. Why would it select for reproductive fitness?
Because the more kids you have, the more chances there are for them to pass on your genes!