So for the regular viewers you'll know is a bit different to what we normally do. I'm titling this series Biochemistry Of Performance. While you're under no obligation to like this video, if you DID like it, leaving a like and a comment are both very useful for the algorithm but also as a way of voting for things you like. It took a lot of hours from both Alex and I (Eoin) so it's useful to know what's worth putting work towards.
I've been binging you guys so much your voices now narrate my self-talk and daydreaming. Happened once before with physicist-futurist Isaac Arthur. Trust me, yours is way better. Anyhow, keep it up! Thank you for your passion. You're re-energizing this old powerlifter.
ACTN3 is simply the most researched gene, there are numerous genes that contribute to sports performance. It might be the case that having RR is correlated with having other beneficial gene presentations, but it might not. To try and make sports predictions based on one gene alone is quite a leap of faith.
It's definitely significant though. As the difference between long distance runners and power athletes is quite significant. But of course one gene doesn't show the whole picture.
Having non working copies of the gene is better at keeping you warm because of the vascularity of slow twitch muscle. Probably why populations who are in colder climates are more likely to have at least one non working copy of the actn3 gene.
I have the Sprinter Gene, High VO2 Max a lower than average endurance according to my genes, but I have massive endurance and have worked out during work for decades. I play the long game. My grip is ridiculous. This video is absolutely fantastic.
How would you classify yourself in the Ecto, Endo, and Mesodorph body type? I'm very curious how those would overlay the RR, RX, vs XX genes. I'm a mesodroph with XX (TT) so I'm type 2, but my thighs/glutes and chest put on mass quite easily. Downside is I'm quite sore for longer it seems -- which this video also says. But also giving muscle growth is tied to total output (reps x weight) I can train "harder" (more weight pushed all said and done) than most anyone I've been around especially when weight goes to 80% of 1-rep max, my reps balloon over the others despite their 1rep max being 10-20% higher than mine.
I have the RX genotype, my 23andme says "your muscle composition is common in elite power athletes" yet throughout my life I've found that I'm better at endurance based sports and aerobic exercise. I CAN do power based sports, but I tend to get muscle injuries very easily, and I honestly barely even notice any gains, I've never been a muscular guy and my muscles tend to stay the same size regardless of how physically active I am. I've taken up endurance running recently and I've found that it suits me well. Maybe it is because I only produce 50% of the ACTN3 protein. Great video by the way!
I wanna get this test done but I can’t right now cuz my mom won’t allow it but based off everything in my life I think I have the RX. One reason is because I play sports and people tell me I’m fast. I’m 5’6 and can touch a 10 foot rim and if I don’t slack I can grab it. But I’m a very skinny kid almost all my peers have way more muscle than me. Even after a year of working out kids at my school working out the same amount of time have way better results. I think if I was truly RR I’d be explosive and very prone to putting on muscle. Ik it sounds stupid but I’m just going off what I think
These tests don’t really matter much for the common person. If you eat right, workout and recover correctly, your body will make the necessary adaptations to what you expose it to. Although there a TON of variables associated with “making it to the big leagues” other than genetic tests, these tests can let you know if you can compete and make a difference at the highest levels, such as the Olympics or in a professional league.
While I'm not interested in athletics (though I respect skill, focus and discipline) I am into genomics. Love the way you translate a topic that is so often too abstract into something meaningful.
My experience so far having the XX isnt so bad. I love lifting. Been at it for about 3 years and I've got a 315 bench, 465 squat, and a 500 lb deadlift, might not be the best but im still improving and if youre in my boat, dont let this gene tell you you cant do something. Theres a lot more factors at play than a single gene.
Similar. I'm not lifting as much as you, but everyone thinks I'm very strong for my size. I have also always been very fast so there must be more to the story. I also used to box and was easily able to drop guys way bigger than me. You're right...there is way more going on here.
I have the TT genotype of the ACTN3 gene (uncommon in elite athletes) and the GG genotype of the APOA2 gene (I gain weight if I eat over 22g/day of saturated fat). It sucks in today's world, but if we were living in the wild it means: I could run long distance to find food without feeling tired, I'd be more resistant to cold weather and rain, every time I'd be able to eat an animal the fat would be stored as energy, and my energy would be used more efficiently. So at first glance it sucks, but I'm basically a freakin' survival beast. All depends on how we see it.
@@andrewbrennan4423 Yes, 23andme gave me the results about the APOA2 gene and not that many people have the GG Type, it depends on your race (Europeans are more prone than others). Basically, here's what they say about it on their site: GG Likely to weigh more on a diet high in saturated fat. People with this variant: Europeans: 15.4% - Africans 6.2% - East Asians 0.7% - Latinos 9.8% - South Asians 6.0% AG Likely similar weight on diets high or low in saturated fat. People with this variant: Europeans: 47.3% - Africans 37.7% - East Asians 14.8% - Latinos 43.0% - South Asians 36.3% AA Likely similar weight on diets high or low in saturated fat. People with this variant: Europeans: 37.3% - Africans 56.1% - East Asians 84.5% - Latinos 47.2% - South Asians 57.7% About the GG variant:
The gene is based off survival . I’m a double dom CC for anc3 and find my best physical state was back when I did HIIT and only muscle training over anything endurance. I would honestly prefer to be able to run longer without being exhausted. Lol
Would love to see more videos like this, really hoping it get some more views to justify a series. Havent seen a topic on the matter of genetics being presented in such a digestible manner. Really curious what else is there to dive into, there must be alot to uncover
Oh yeah definitely like this type of short concise, to the point video. I'd love to see more of these but only for these types of information like there's no elaboration involved just pure direct information. Good video guys! I wonder what type I have XD
I found that I can look at my raw data on the desktop version of 23andMe’s site. Not only did I find more detail on my ACTN3 gene, but also other genes that were not mentioned in their wellness reports. The data in genes I wanted to see were summed up like this - ACTN3 (CC), MSTN (TT), COMT (AA), ACE (GG) From what I can comprehend, I can produce a fair amount of force and recover well, and I’m split almost evenly between type-I and type-II muscle fibers - high endurance and high force, I guess. My brain has high dopamine levels, but I can get anxious and stressed to an equal extent. My myostatin gene is normal, not much to say there…
@@MrCrystalm8 COMT (rs4680) is a gene that determines how well your body cycles through dopamine and adrenaline; many call it the Warrior-Worrier gene. AA, high accumulation rate of dopamine/adrenaline GG, low accumulation rate of dopamine/adrenaline MSTN is a gene that controls your body’s rate of muscle growth and strength output by deploying myostatin to prevent excessive gains. Those who have a certain mutation, resulting in a lack of MSTN, can grow muscle and gain strength without training at all. ACE (rs4343) is associated with your adrenal response - how quickly you can get riled up. ACE is also associated with blood pressure, which could induce slightly greater pumps, and more water retention, depending on your version of the SNP (rs). GG, quick adrenal response, high blood pressure AA, slow adrenal response, extends to lasting energy
I just learned today that I have the "Sprinter gene" when looking through my ancestry results and I have been stuck on studying this gene since. It makes me sad to find out so late as I never participated in any sports as a kid.
I have high amounts of ACTN3. I ran the 100 meters in high school and in junior high , I ran the 200 and 400 and played power forward in basketball (everyone hit their growth spurt in grade 8). My dad played tight end and outside linebacker in American football in high school, left back center and center back in soccer and was an the 100 meters in track and field. My dad played Center Back in college at a D1 program. On my mom’s side, my uncle played cornerback, special teams (punt rush) and running back in American football in high school and threw discus in track and field. He payed Cornerback and special teams (punt rush) in college at a D1 program and was one of the first DB’s to play D1 ball from his Alma Mater.
I have the double CC Actn3 Without really training specifically, say for Cycling. I was exceptionally strong right out of the gate. After one summer of club rides, sone speed workouts, I was shockingly fast. Constantly dropping seasoned cyclists on steel climbs, on flats, I was able to just ride people off of my wheel. I never learned how to technically/mechanically sprint on the flats, but, I could wind it up to around 36-37 mph.. and just grind to the finish line. I played baseball as a child and teenager, I was fast, had a good arm and could crush the ball despite being on the smaller stature side of the players. I played football, I was impossible to tackle, I was exceptionally fast. Strength wise- I worked at a lumberyard and realized something was different when by then end of the summer of my 13th year, I was incredibly muscular yet not bulky. I also have exceptionally hard and heavy bone density, in the measured realm of 2.5 times the normal bone density. When I’d collide with other kids, they would get hurt.. I’d feel bad for them, we were friends. I was always athletic, I still am, at almost 60 years old I’m trying to find my endurance capabilities, but it could be detrimental to chase that goal. Who knows.
Great video guys! it was extremely informative and I'm thoroughly enjoying all of the content you're putting out! I possess the XX variant, but it hasn't stopped me from clean and jerking over twice my body weight as a natural athlete. Determination of an individual's athletic potential is extremely complicated and should not be reduced to one mutation. Just because one has the RR allele doesn't necessarily mean that they will outperform someone with the XX allele given that they have both "maxed out" their full potentials. This should be made clear as to not discourage anyone from further progressing in their training. However, on average the RR allele clearly confers an advantage to overall athletic performance than not having it, but to what extent? Hard to say (ie. if we could isolate ONLY the ACTN3 gene as a predictor of performance ... 2%, 5%, 10% increased potential?).
Nice! Then I haven’t lost hope yet. I am a competitive olympic weightlifter and when I found out I held the XX genotype I was sooo discouraged, but I see now many people with XX aren’t reduced to just being skinny distance runners.
I found the 2-3 injuries per 1000 hours running very interesting. Compared to my own experience of less competitive/more recreational 20 years of running it seems sound. I'm considering an injury to be those sever enough to interrupt training.
I have same TT so I now just do carnivore and not much greens. I don’t need greens I like them but I can’t digest them. Which me being vegan a long time ago actually fucked me up. I store fat like no one else. Even if I restrict or expend. I stay the same. Now going into carnivore I did lose wait but now I need to balance out my omegas so my adrenal gland’s don’t get to stressed out. I like my diet now. I am eating more food of what my body needs to function efficiently and we’ll I have almost no problem except I need to find ways to reduce my stress. Me on this diet makes me more hyper aware then I have ever experienced. So it’s new for me.
I've the TT (XX) gene. I've been getting ankle injuries in my early 30s. Playing basketball, running, rugby. Constantly struggling to build muscle mass - remains lean at best, yet after a decade of training, high strength level (possibly combined with central nervous system), but now realise I've high endurance at high weight - eg 10 sets of 132kg bench for reps or 300-400kg sled push for six-seven tracks etc. May be an interesting thought, that if XX train for years, they can then endure higher volume, longer times, more training - don't know, but I keep being able to endure. I'm also tall 6'4.5, completely Irish genetically so don't know where two XX snuck in; long wingspan, when started running, slower, but can go for longer. It's a strange mix considering the anatomy of Europeans (tall, stocky etc). And I shiver in the cold so that's bollocks - could because I'm the Gael in Gaelic ergo, glistening red and ginger. Flexible, yes, but won't flexibly endure a bloody tackle.
Just got my dna test results back and found out I have two working copies of the gene. Probably explains why I’ve had a six pack since I hit puberty lol
Fantastic video! For those of us with 23andme, which rs number should we be looking at and how does the genotype (CC,TT,CT) correspond to the variant (RR,XX,RX)?
You want to look for the polymorphism rs1815739 if you're looking through the raw files or using something like Promethease. "C" is the wild type and "T" is the stop codon mutated type associated with the ACTN3 deficient R577X genotype.
@@muskoks5385 thanks! I am looking through the raw files and noticed four different rs numbers for ACTN3 that give C or T as genotype options. I am CC for rs1815739 but TT for the rest. I assume just having one “T” is enough though?
@@bradhobbs_ I only know the polymorphism I mentioned, I don't think the others have as strong effect as the T allele on R577X. Also it goes to mention that heterozygotes (C;T that is) will not be that affected since they still have a functional copy and thus won't be totally deficient in ACTN3 like T;T homozygotes are.
XX here and this video needs to be understood as being focused exclusively on athletics. There is far more data to be covered via far better quality video creators that cover the full scope of what realities the XX mutation means in training and everyday life. Personal example: at one point 20 years ago, I was morbidly obese, weighing over 325 lbs. Through relearning how to eat and train, I developed a lifestyle that has kept me in the best shape of my life well into my 40s. M currently a lean 160 lbs and stronger than I’ve ever been. However I have next to no slow twitch muscle and get strains easily. So there’s trade offs. My point is that the Debbie Downer video here paints a poor reality for those with the XX mutation.
Mostly commenting for the algo but Eoin if you could get a pop filter for your mic that would really improve the audio quality. Bad audio sticks out like a sore thumb in these higher quality videos where the commentary is the central focus (when compared with vlog style content).
I fucked up by using the yeti, all I could hear was the audio once it was edited. We have better mics for the podcast which I should've used. Lesson learned
I've only seen studies breaking down the differences between XX vs. RR/RX as you covered here, but is there actually a significant difference between RR vs RX as you tongue-in-cheek suggested at the end?
Hey Lads I know that genes are a quite deterministic subject matter, either you have them or you don't, but if I for example am a XX, is there a way to mitigate the negative Performance effects of these genes, that is turning on or off through lifestyle habits and training? Or is it one that, if I have them I'm gonna be shit at sports regardless?
Sooooooo ehhhhh individual differences can be greater than intergroup differences so its not impossible to still be good. Just keep training in the way that makes the most sense and you'll be alright
I’m so confused. I am TT, but I have a 40 inch vertical jump and can accelerate like Tyreek Hill. I’m starting to think the 23andme sequencing is not accurate at times….
I get this results from 23andme but I’m not doing any sport Mohamed, your genetic muscle composition is common in elite power athletes. Studies have found that almost all elite power athletes (including sprinters, throwers, and jumpers) have a specific genetic variant in a gene related to muscle composition. You have the same genetic variant as these elite athletes
I thought this video was good, I'm just not entirely sure what I should do with the info... Should I do a 23andMe test then base my training around the results? 🤔
Not everything that you learn has to be applicable. Sometimes it's fun to get to know little facts about nuanced topics That being said, a takeaway from this video to people with an XX could be to manage their stress (and hence cortisol) a bit more
@@atrumluminarium bs if you have a certain muscle u should train in the most optimal way for your body if you want results. I wont do 10×10@ 100kg if i want strength gains
I’m so confused. I did the test and I have 2 copies of the ACTN3 gene, I am overweight, have never excelled at sports and I’m incredibly weak. Does this mean I should become a power athlete???
Very interesting but reading too much into it is probably not beneficial. Most western africans have a RR mutation but it's obviously not feasible that they could all become elite athletes. Also the XX mutation is not highly prevalent in most populations so most people should make decent athletes if they put the time in. For very special cases where a person with an XX mutation has made it into the elite ranks of their respective discipline it might be beneficial to look into their mutation to adjust training methods. But for most non athletes this is probably not relevant. I'll assume that people with the XX mutation can build up muscles mass and strength just fine. They'll just be a bit slower than people with the RR mutation.
So for the regular viewers you'll know is a bit different to what we normally do. I'm titling this series Biochemistry Of Performance.
While you're under no obligation to like this video, if you DID like it, leaving a like and a comment are both very useful for the algorithm but also as a way of voting for things you like.
It took a lot of hours from both Alex and I (Eoin) so it's useful to know what's worth putting work towards.
10/10 content and editing. Brilliant work. Looking forward to the rest of the series.
Excellent video as usual lads, I’d definitely love to see more of these types of videos.
Super interesting video lads. Might get a 23andme done out of interest now
I loved this video. Definitely would like more.
I like it a lot. Anything involving genetics is always fun
I have the ACTN3 XX Allele, this video has made me really depressed, thanks lads
At least you're more flexible and more cold resistant/shiver more efficiently.
I have the ACTN3 RR and this video made me want to eat a donut. We're more than our Genes
@@badmonkey222 is CC the same as RR? I’m kinda lost lol
@@Tyrannis_Gaming yes
How do you know which actn3 gene you have. Im curious
I've been binging you guys so much your voices now narrate my self-talk and daydreaming. Happened once before with physicist-futurist Isaac Arthur. Trust me, yours is way better. Anyhow, keep it up! Thank you for your passion. You're re-energizing this old powerlifter.
Thanks Scott!
Absolutely nailed the format!
Thanks Erico 🤟
ACTN3 is simply the most researched gene, there are numerous genes that contribute to sports performance. It might be the case that having RR is correlated with having other beneficial gene presentations, but it might not. To try and make sports predictions based on one gene alone is quite a leap of faith.
It's definitely significant though. As the difference between long distance runners and power athletes is quite significant. But of course one gene doesn't show the whole picture.
Having non working copies of the gene is better at keeping you warm because of the vascularity of slow twitch muscle.
Probably why populations who are in colder climates are more likely to have at least one non working copy of the actn3 gene.
The editing is top notch though. More videos like this
I have the Sprinter Gene, High VO2 Max a lower than average endurance according to my genes, but I have massive endurance and have worked out during work for decades. I play the long game. My grip is ridiculous. This video is absolutely fantastic.
How do you check it?
How would you classify yourself in the Ecto, Endo, and Mesodorph body type?
I'm very curious how those would overlay the RR, RX, vs XX genes.
I'm a mesodroph with XX (TT) so I'm type 2, but my thighs/glutes and chest put on mass quite easily. Downside is I'm quite sore for longer it seems -- which this video also says. But also giving muscle growth is tied to total output (reps x weight) I can train "harder" (more weight pushed all said and done) than most anyone I've been around especially when weight goes to 80% of 1-rep max, my reps balloon over the others despite their 1rep max being 10-20% higher than mine.
@@heraldtoimmortal1985do an ancestry DNA test or 23andme
@@paul_devosmeso etc is pseudo science
As an arboriculturalist, the ACTN tree is my absolute favorite.
Lmao
I have the RX genotype, my 23andme says "your muscle composition is common in elite power athletes" yet throughout my life I've found that I'm better at endurance based sports and aerobic exercise. I CAN do power based sports, but I tend to get muscle injuries very easily, and I honestly barely even notice any gains, I've never been a muscular guy and my muscles tend to stay the same size regardless of how physically active I am. I've taken up endurance running recently and I've found that it suits me well. Maybe it is because I only produce 50% of the ACTN3 protein. Great video by the way!
There is a lot more genetics involved in building muscle.
How did you find out you have RX?
@@ArrozConPollllo 23andme
I wanna get this test done but I can’t right now cuz my mom won’t allow it but based off everything in my life I think I have the RX. One reason is because I play sports and people tell me I’m fast. I’m 5’6 and can touch a 10 foot rim and if I don’t slack I can grab it. But I’m a very skinny kid almost all my peers have way more muscle than me. Even after a year of working out kids at my school working out the same amount of time have way better results. I think if I was truly RR I’d be explosive and very prone to putting on muscle. Ik it sounds stupid but I’m just going off what I think
These tests don’t really matter much for the common person. If you eat right, workout and recover correctly, your body will make the necessary adaptations to what you expose it to.
Although there a TON of variables associated with “making it to the big leagues” other than genetic tests, these tests can let you know if you can compete and make a difference at the highest levels, such as the Olympics or in a professional league.
While I'm not interested in athletics (though I respect skill, focus and discipline) I am into genomics. Love the way you translate a topic that is so often too abstract into something meaningful.
casual flex at the end there 😏 good vid lads
Incredible video guys, very interesting topic I’ve never heard of
Thanks Mr. Coke
ACTN3 positive crew 💪🏽
My experience so far having the XX isnt so bad. I love lifting. Been at it for about 3 years and I've got a 315 bench, 465 squat, and a 500 lb deadlift, might not be the best but im still improving and if youre in my boat, dont let this gene tell you you cant do something. Theres a lot more factors at play than a single gene.
Similar. I'm not lifting as much as you, but everyone thinks I'm very strong for my size. I have also always been very fast so there must be more to the story. I also used to box and was easily able to drop guys way bigger than me. You're right...there is way more going on here.
Good vid, proper length, proper storytelling, proper editing, very informative and no distractions. Great job!
I have the TT genotype of the ACTN3 gene (uncommon in elite athletes) and the GG genotype of the APOA2 gene (I gain weight if I eat over 22g/day of saturated fat). It sucks in today's world, but if we were living in the wild it means: I could run long distance to find food without feeling tired, I'd be more resistant to cold weather and rain, every time I'd be able to eat an animal the fat would be stored as energy, and my energy would be used more efficiently. So at first glance it sucks, but I'm basically a freakin' survival beast. All depends on how we see it.
What's the GG do? 23&Me or something more niche?
@@andrewbrennan4423 Yes, 23andme gave me the results about the APOA2 gene and not that many people have the GG Type, it depends on your race (Europeans are more prone than others).
Basically, here's what they say about it on their site:
GG
Likely to weigh more on a diet high in saturated fat.
People with this variant:
Europeans: 15.4% - Africans 6.2% - East Asians 0.7% - Latinos 9.8% - South Asians 6.0%
AG
Likely similar weight on diets high or low in saturated fat.
People with this variant:
Europeans: 47.3% - Africans 37.7% - East Asians 14.8% - Latinos 43.0% - South Asians 36.3%
AA
Likely similar weight on diets high or low in saturated fat.
People with this variant:
Europeans: 37.3% - Africans 56.1% - East Asians 84.5% - Latinos 47.2% - South Asians 57.7%
About the GG variant:
The gene is based off survival . I’m a double dom CC for anc3 and find my best physical state was back when I did HIIT and only muscle training over anything endurance. I would honestly prefer to be able to run longer without being exhausted. Lol
Love this!! I too am a survival beast!! You made my day and it's only 8AM!!
Would love to see more videos like this, really hoping it get some more views to justify a series.
Havent seen a topic on the matter of genetics being presented in such a digestible manner. Really curious what else is there to dive into, there must be alot to uncover
I was considering gene doping next 🤔
This is very informative, but I'd really love to see more comp commentary. I fully watched all the previous ones and need more lol
Oh yeah definitely like this type of short concise, to the point video. I'd love to see more of these but only for these types of information like there's no elaboration involved just pure direct information. Good video guys! I wonder what type I have XD
We gotta vote Eoin & Dr. Boffa as official commentators to the sport of weightlifting
Amazing video Lads! Crisp animation and a chilling narration
This was fantastic and so easy to digest. Please make this a regular series!
Not sure why this took 5 days to show up in my feed. It's fantastic. Keep up the great work!
Double RR here 💪🏽 plus an insane other genes
How do you check
I found that I can look at my raw data on the desktop version of 23andMe’s site. Not only did I find more detail on my ACTN3 gene, but also other genes that were not mentioned in their wellness reports. The data in genes I wanted to see were summed up like this - ACTN3 (CC), MSTN (TT), COMT (AA), ACE (GG)
From what I can comprehend, I can produce a fair amount of force and recover well, and I’m split almost evenly between type-I and type-II muscle fibers - high endurance and high force, I guess. My brain has high dopamine levels, but I can get anxious and stressed to an equal extent. My myostatin gene is normal, not much to say there…
wot are the other genes for?
@@MrCrystalm8
COMT (rs4680) is a gene that determines how well your body cycles through dopamine and adrenaline; many call it the Warrior-Worrier gene.
AA, high accumulation rate of dopamine/adrenaline
GG, low accumulation rate of dopamine/adrenaline
MSTN is a gene that controls your body’s rate of muscle growth and strength output by deploying myostatin to prevent excessive gains. Those who have a certain mutation, resulting in a lack of MSTN, can grow muscle and gain strength without training at all.
ACE (rs4343) is associated with your adrenal response - how quickly you can get riled up. ACE is also associated with blood pressure, which could induce slightly greater pumps, and more water retention, depending on your version of the SNP (rs).
GG, quick adrenal response, high blood pressure
AA, slow adrenal response, extends to lasting energy
@@tengu9959 Im GG for MSTN
@tengu9959 I can find those genes in the 23andMe? Thank you so much
Great information and straight to the point. Keep up the good work lads!
I just learned today that I have the "Sprinter gene" when looking through my ancestry results and I have been stuck on studying this gene since. It makes me sad to find out so late as I never participated in any sports as a kid.
never too late. start now.
How did you find out? With that 23andme thing? I wanne find out myself, i’v always been pretty strong
@@DDG-Downfall AncestryDNA
@@DDG-Downfall Which test would you recommend for ginding out genetics and athletic ability? 23andme is good enough isn’t it?
Me to just found out through ancestry dna
I have high amounts of ACTN3. I ran the 100 meters in high school and in junior high , I ran the 200 and 400 and played power forward in basketball (everyone hit their growth spurt in grade 8). My dad played tight end and outside linebacker in American football in high school, left back center and center back in soccer and was an the 100 meters in track and field. My dad played Center Back in college at a D1 program. On my mom’s side, my uncle played cornerback, special teams (punt rush) and running back in American football in high school and threw discus in track and field. He payed Cornerback and special teams (punt rush) in college at a D1 program and was one of the first DB’s to play D1 ball from his Alma Mater.
Linked the discussed literature in the description, please! I often find myself going to the papers!
I love how Irish say three like tree!!! Also I thought the title was about acne but it’s actually the same of that gene haha
I have the
double CC Actn3
Without really training specifically, say for Cycling. I was exceptionally strong right out of the gate. After one summer of club rides, sone speed workouts, I was shockingly fast. Constantly dropping seasoned cyclists on steel climbs, on flats, I was able to just ride people off of my wheel. I never learned how to technically/mechanically sprint on the flats, but, I could wind it up to around 36-37 mph.. and just grind to the finish line.
I played baseball as a child and teenager, I was fast, had a good arm and could crush the ball despite being on the smaller stature side of the players.
I played football, I was impossible to tackle, I was exceptionally fast.
Strength wise- I worked at a lumberyard and realized something was different when by then end of the summer of my 13th year, I was incredibly muscular yet not bulky. I also have exceptionally hard and heavy bone density, in the measured realm of 2.5 times the normal bone density. When I’d collide with other kids, they would get hurt.. I’d feel bad for them, we were friends.
I was always athletic, I still am, at almost 60 years old I’m trying to find my endurance capabilities, but it could be detrimental to chase that goal. Who knows.
Very good video and I'm very interested to know a bit about this kind of things, keep it up
Great video boys, looking forward to more of these “Biochemistry of Performance” vids
Great video, love the breakdown of information and how clear the video was
Doing my part for The Republic of Sikastan
Great video guys! it was extremely informative and I'm thoroughly enjoying all of the content you're putting out! I possess the XX variant, but it hasn't stopped me from clean and jerking over twice my body weight as a natural athlete. Determination of an individual's athletic potential is extremely complicated and should not be reduced to one mutation. Just because one has the RR allele doesn't necessarily mean that they will outperform someone with the XX allele given that they have both "maxed out" their full potentials. This should be made clear as to not discourage anyone from further progressing in their training. However, on average the RR allele clearly confers an advantage to overall athletic performance than not having it, but to what extent? Hard to say (ie. if we could isolate ONLY the ACTN3 gene as a predictor of performance ... 2%, 5%, 10% increased potential?).
I have this same xx gene, started lifting, you motivate to keep going !
Nice! Then I haven’t lost hope yet. I am a competitive olympic weightlifter and when I found out I held the XX genotype I was sooo discouraged, but I see now many people with XX aren’t reduced to just being skinny distance runners.
@@is0t0pe55 genes aren't everything, go to your full potential! Never give up !
Yes! You never know your full potential until you go at.
Really cool video, thank you 🙏👊🏻💯
I see the viltrumite gene on that sheet too 👀👀👀
Very interesting stuff! More plz
I found the 2-3 injuries per 1000 hours running very interesting. Compared to my own experience of less competitive/more recreational 20 years of running it seems sound. I'm considering an injury to be those sever enough to interrupt training.
Awesome video! Really informative and easy to understand even if english is not native language
Awesome video, Fellas. Cheers
I found out I have RX.
This explain why injuries that really hurt others don't stop me
RX is normal though. RR is perfect, RX is normal, XX is trash
I have same TT so I now just do carnivore and not much greens. I don’t need greens I like them but I can’t digest them. Which me being vegan a long time ago actually fucked me up.
I store fat like no one else. Even if I restrict or expend. I stay the same. Now going into carnivore I did lose wait but now I need to balance out my omegas so my adrenal gland’s don’t get to stressed out. I like my diet now. I am eating more food of what my body needs to function efficiently and we’ll I have almost no problem except I need to find ways to reduce my stress. Me on this diet makes me more hyper aware then I have ever experienced. So it’s new for me.
ACTN🌲 GENE FTW!!!!!
the video ending is the hardest flex ever
If this wasn't visual, I wouldn't be able to hear the difference between Gurphs R's and his Or's xD
I've the TT (XX) gene. I've been getting ankle injuries in my early 30s. Playing basketball, running, rugby. Constantly struggling to build muscle mass - remains lean at best, yet after a decade of training, high strength level (possibly combined with central nervous system), but now realise I've high endurance at high weight - eg 10 sets of 132kg bench for reps or 300-400kg sled push for six-seven tracks etc. May be an interesting thought, that if XX train for years, they can then endure higher volume, longer times, more training - don't know, but I keep being able to endure. I'm also tall 6'4.5, completely Irish genetically so don't know where two XX snuck in; long wingspan, when started running, slower, but can go for longer. It's a strange mix considering the anatomy of Europeans (tall, stocky etc).
And I shiver in the cold so that's bollocks - could because I'm the Gael in Gaelic ergo, glistening red and ginger.
Flexible, yes, but won't flexibly endure a bloody tackle.
Try carnivore I am on it. I like it. For TT it’s a more efficient way of eating.
More testosterone does indeed equal "more better".
Great vidjo lads. More like this please.
Very interesting, plz more Biochemistry of Performance 👍🏽
I just looked this up on google and now this pops up
Please do more videos like this!
the legendary ACTN-Tree gene
commment for the algo. Great video guys!!!
Well explained!
Hm a Snatch grip power Jerk.... Never seen this exercise on my plan 😂
Based chemistry
No wonder when I’m tried adrenaline fucks me up and just lash out out of nowhere I should have been a boxer a long time ago
Excellent video guys, very interesting
Very much enjoyed this
Love this content!
Damn, i have the XX gene. There goes any hope in competing in MMA professionally
Just got my dna test results back and found out I have two working copies of the gene.
Probably explains why I’ve had a six pack since I hit puberty lol
I suppose that would explain my 40in vert in my 20's and early 30's...
Hit em with the mic drop ending
I am 100% certain I am xx... great video!
I have RR, I believe it has affected my personality too
Ooooh intersting series!
Found out today that I have RR gene - no wonder I can build muscle fast and injure myself when running 🤣😢
Which test would you recommend for ginding out genetics and athletic ability? 23andme is good enough isn’t it?
I’m CC also same here . Don’t ask me to run I’ll lift 😂
Makes me want to do a 23 and me
Right haha
Sick content
The 23andme test when i asked them they said it does not tell you if you have yhe rr allele how did ypu fijd out if you have it
Fantastic video! For those of us with 23andme, which rs number should we be looking at and how does the genotype (CC,TT,CT) correspond to the variant (RR,XX,RX)?
So C is functional copy and T would be the mutation. 23andme will say something like have muscle fibres of an elite athlete or something
You want to look for the polymorphism rs1815739 if you're looking through the raw files or using something like Promethease. "C" is the wild type and "T" is the stop codon mutated type associated with the ACTN3 deficient R577X genotype.
@@muskoks5385 thanks! I am looking through the raw files and noticed four different rs numbers for ACTN3 that give C or T as genotype options. I am CC for rs1815739 but TT for the rest. I assume just having one “T” is enough though?
@@bradhobbs_ I only know the polymorphism I mentioned, I don't think the others have as strong effect as the T allele on R577X. Also it goes to mention that heterozygotes (C;T that is) will not be that affected since they still have a functional copy and thus won't be totally deficient in ACTN3 like T;T homozygotes are.
@@bradhobbs_ can you tell me the rs SNP IDs for the other ones btw?
what sports would be best for each of the three possible combos?
XX (CC)
RX (CT)
RR (CC)
More of this content!
So how much sauce do I need to counteract being an xx plebe?
Nice video hope you can cover the TR3N++, AN∆V£R Gene mutation
What other gene variations could be confounding factors for the presence (or absence) of ACTN3 RR variant?
I have allele (T,T) but I seem to put muscle on very easily 🤔
XX here and this video needs to be understood as being focused exclusively on athletics. There is far more data to be covered via far better quality video creators that cover the full scope of what realities the XX mutation means in training and everyday life.
Personal example: at one point 20 years ago, I was morbidly obese, weighing over 325 lbs. Through relearning how to eat and train, I developed a lifestyle that has kept me in the best shape of my life well into my 40s. M currently a lean 160 lbs and stronger than I’ve ever been. However I have next to no slow twitch muscle and get strains easily. So there’s trade offs.
My point is that the Debbie Downer video here paints a poor reality for those with the XX mutation.
Thank you for confirming that there is definitely no benefit intelligence from being XX 😂
Which test would you recommend for ginding out genetics and athletic ability? 23andme is good enough isn’t it?
Mostly commenting for the algo but Eoin if you could get a pop filter for your mic that would really improve the audio quality. Bad audio sticks out like a sore thumb in these higher quality videos where the commentary is the central focus (when compared with vlog style content).
I fucked up by using the yeti, all I could hear was the audio once it was edited. We have better mics for the podcast which I should've used. Lesson learned
Love it!
Video gud, me enjoy.
Seriously, well done.
I've only seen studies breaking down the differences between XX vs. RR/RX as you covered here, but is there actually a significant difference between RR vs RX as you tongue-in-cheek suggested at the end?
@Gluten Intolerant that assertion seems spurious, but it'd be interesting to see some data on it
Hey Lads I know that genes are a quite deterministic subject matter, either you have them or you don't, but if I for example am a XX, is there a way to mitigate the negative Performance effects of these genes, that is turning on or off through lifestyle habits and training? Or is it one that, if I have them I'm gonna be shit at sports regardless?
Sooooooo ehhhhh individual differences can be greater than intergroup differences so its not impossible to still be good. Just keep training in the way that makes the most sense and you'll be alright
@@bouncygangsta bro how to know which allele we have... I mean RR or RX or XX?
I’m so confused. I am TT, but I have a 40 inch vertical jump and can accelerate like Tyreek Hill. I’m starting to think the 23andme sequencing is not accurate at times….
I get this results from 23andme but I’m not doing any sport
Mohamed, your genetic muscle composition is common in elite power athletes.
Studies have found that almost all elite power athletes (including sprinters, throwers, and jumpers) have a specific genetic variant in a gene related to muscle composition. You have the same genetic variant as these elite athletes
I wonder if this could be related to my repeated bouts of rhabdomyolysis.
Good stuff
Really good video
I like this style better.
What were the type of injuries recorded as being more frequent in the studies that compared the RR, RX, XX variant athletes?
gr8 vid hail sikastan
Ive got the sprinter gene woohoo! Hate running though so....
Which is better, RR or RX or what?
Very succint video
I thought this video was good, I'm just not entirely sure what I should do with the info...
Should I do a 23andMe test then base my training around the results? 🤔
Not everything that you learn has to be applicable. Sometimes it's fun to get to know little facts about nuanced topics
That being said, a takeaway from this video to people with an XX could be to manage their stress (and hence cortisol) a bit more
@@atrumluminarium bs if you have a certain muscle u should train in the most optimal way for your body if you want results. I wont do 10×10@ 100kg if i want strength gains
@@joys8634 not sure how this is related to my reply
Nothing really, just keep training smart 😁
@@sikastrength cheers lads!
I’m so confused. I did the test and I have 2 copies of the ACTN3 gene, I am overweight, have never excelled at sports and I’m incredibly weak. Does this mean I should become a power athlete???
Where can i find links to the studies?
Very interesting but reading too much into it is probably not beneficial. Most western africans have a RR mutation but it's obviously not feasible that they could all become elite athletes. Also the XX mutation is not highly prevalent in most populations so most people should make decent athletes if they put the time in. For very special cases where a person with an XX mutation has made it into the elite ranks of their respective discipline it might be beneficial to look into their mutation to adjust training methods. But for most non athletes this is probably not relevant. I'll assume that people with the XX mutation can build up muscles mass and strength just fine. They'll just be a bit slower than people with the RR mutation.