I just gave my cell signaling final exam yesterday and struggled with an essay question about insulin signaling. Today I discovered this helpful video. You can imagine my frustration.
@@hrishabhupadhyay751 it was about insulin but i didnt really understood how the signaling cascade was explained in my coursework and this vid really helped
This has been very helpful. Can u please share your reference? (P.S I wish I can cite your video but I need a book or a paper for an educational project). thank you
I love your videos and how you make sense of all the detailed information in the end! I also love the tool you use to draw your very comprehensive pathways, if you don't mind telling us what software you are using, i would like to use it for my own pathways. Thank you very much!
So understanding insulin resistance, I've been trying to find research on this, insulin is just don't trigger the cascade at the insulin receptor site? or it triggers but connects and doesn't trigger the AKT to inhibit the AS16 so GLUT 4 is unable to open the channel for glucose uptake. Is it autoimmune, is the body creating antibodies that latch onto the insulin to make is less effective?
during 7.25 hesaid that AKT is inhibiting the inhibitor means you activate the glycogen synthesis. so it means AKT has two roles which are inhibiting and phosphorylates the GSK3 ? is it???
No, AKT is inhibiting GSK3, which results in GS being turned on. AKT (serine/threonine-specific protein kinase) phosphorylates GSK3 at the inhibitory residue at serine-9 in GSK-3β & serine-21 in GSK-3α and thus makes it more difficult for GS3K to bind it's substrate and therefore reduces catalytic activity. So, AKT (Which is a serine phosphatase), phosphorylates these residues and decreases GSK3 activity. Glycogen Synthase (GS) is directly regulated by GSK3. GSK3 phosphorylates GS at inhibitory residues and therefore inactivate GS and turn off glycogen synthesis. Because GSK3 is inhibited, and not there to turn off GS, GS becomes activated as a result. I know it’s really easy to think about phosphorylation as only being “on” but a lot of inhibitory sites are also activated. The easiest way I remember it is ON-OFF-ON for AKT-GSK3-GS. Its an on sandwich.
Your description of the islets is true for mice, but not for humans. Humans there is a more even distribution of alpha and beta cells throughout the islet
despite all these molecules the whole picture still is unknown how Insulin affect other cellular structures and cells. More discoveries are needed to understand it
wait a minute so the protein as160 actually anhibits the transportation og GLUT4? i dont get it? i thought it was the opposite. plz can someone esplain me?
This is brilliant! Having animations and a voiceover is so much easier to understand than static diagrams and walls of text.
Thank you!
You're very welcome!
I just gave my cell signaling final exam yesterday and struggled with an essay question about insulin signaling. Today I discovered this helpful video. You can imagine my frustration.
this helped me alot, thanks JJ medicine!!
this video literally helped me understand a whole subtopic of my biochem project. thank you so much!!
Aleida M what project did you make?
@@hrishabhupadhyay751 it was about insulin but i didnt really understood how the signaling cascade was explained in my coursework and this vid really helped
Thanks for the simplistic explanation
Thanks a lot, I love your explainations.
One of my favorite channels⚘️.
This tremendously helped me to understand insulin resistance pathogenesis. Many thanks, that’s a gold content!!
through what mechanism if you don't mind me asking?
Very good explaining and fully understanding
I did my master's with your videos ❤
This video is amazing. Very informative and clear explanations. Thank you so much!
The best ever teaching style soo good!
Excellent presentation. Could you please tell the book you followed to make this presentation ? It would be very very helpful for me.
This has been very helpful. Can u please share your reference?
(P.S I wish I can cite your video but I need a book or a paper for an educational project). thank you
You just saved my life!
REQUEST: could you please continue this video with an explanation of how insulin resistance occurs. Thanks.
Anthony Mak, I second this request. Specifically how Diacylglycerol could interrupt this signaling cascade?
Please how is insulina resistan ocurrs
I like your videos you explanation is quite simple and easy to remember thank you so much for such a great work
Very good explanation!
I love your videos and how you make sense of all the detailed information in the end! I also love the tool you use to draw your very comprehensive pathways, if you don't mind telling us what software you are using, i would like to use it for my own pathways. Thank you very much!
This is PERFECT
Thank you very much. Extremely well-done explanations.
Thank you for very clear presentation.
Thank you!! Very clearly explained. I now understand what GLUT4 translocation means. :)
Thank you so much for this video!
Thank you so much. You made this topic easier!
Thank you so much ..really it is so helpful
Isn't the PI3K present inside IRS ?
Plz clear it out.
looove your videos !
Great video. Helped tremendously!
Helpful video many thanks sir
What about the pathway that activates protein phosphatase 1 tho? I was waiting for you to comment on this very enzyme : (.
prior to phosphorylation, don't they need to dimerize? I thought that was the conformational change that occurs as a result of insulin binding
mTOR tore my brain
please continue with Claire de lune ♡♡ we miss youu
Very helpful, thank you!
@8:00 is he saying "REB" proteins?
you just saved my master's degree
very clear and good one
So how is this affected by insulin resistance?
Exactly How does increased pip3 recruit and activate pdk1/AKT?
very helpful 😍thank you.
Please can you give me the source of this information ?
great video!
Great Video! What program did you use to make this?
probably powerpoint
Most likely powerpoint, but any drawing software can do the same. Just create shapes and colour them. Then group them together and drag them around.
Sorry, could you explain me the pathway of PKB?
So understanding insulin resistance, I've been trying to find research on this, insulin is just don't trigger the cascade at the insulin receptor site? or it triggers but connects and doesn't trigger the AKT to inhibit the AS16 so GLUT 4 is unable to open the channel for glucose uptake. Is it autoimmune, is the body creating antibodies that latch onto the insulin to make is less effective?
It was really helpful ,thank you sir
What happens when a lectin sticks to the insulin receptor?
during 7.25 hesaid that AKT is inhibiting the inhibitor means you activate the glycogen synthesis. so it means AKT has two roles which are inhibiting and phosphorylates the GSK3 ? is it???
No, AKT is inhibiting GSK3, which results in GS being turned on. AKT (serine/threonine-specific protein kinase) phosphorylates GSK3 at the inhibitory residue at serine-9 in GSK-3β & serine-21 in GSK-3α and thus makes it more difficult for GS3K to bind it's substrate and therefore reduces catalytic activity. So, AKT (Which is a serine phosphatase), phosphorylates these residues and decreases GSK3 activity. Glycogen Synthase (GS) is directly regulated by GSK3. GSK3 phosphorylates GS at inhibitory residues and therefore inactivate GS and turn off glycogen synthesis. Because GSK3 is inhibited, and not there to turn off GS, GS becomes activated as a result. I know it’s really easy to think about phosphorylation as only being “on” but a lot of inhibitory sites are also activated. The easiest way I remember it is ON-OFF-ON for AKT-GSK3-GS. Its an on sandwich.
@@samanthal9114 wow, cool. Thankss !!
Once IRS1/2 is activated, you better have your taxes ready.
Thank you so much for this
Brilliant and very helpful. Could have been a bit more smooth but wonderful explanation nonetheless.
What app do u use to make this video ?
Great video!
You should have mentioned that P110 is the catalytic part of PI3K while p85 is the regulatory one of it
You are the best
Anyone could explain me the IRS4 signaling cascade?
Wowwww thanks!!!
Your description of the islets is true for mice, but not for humans. Humans there is a more even distribution of alpha and beta cells throughout the islet
Thank you so much 👏🏻
Akt inactivate AS160???
Thank you!
Wonderful!
I SUBSCRIBED!
GOOD JOB Thank you
Thanks
great, thanks!
thank you !!
thank you
Wow. So molecular
thank u
despite all these molecules the whole picture still is unknown how Insulin affect other cellular structures and cells. More discoveries are needed to understand it
wait a minute so the protein as160 actually anhibits the transportation og GLUT4? i dont get it? i thought it was the opposite. plz can someone esplain me?
0:25
3:14
3:45
4:30
7:42
Insulin is much more than just controlling glucose. This is just ridiculous. What about MAPK pathway? What about de novo lipogenesis and fat storage?
you did not mention the role of PKB.
AKT is PKB
PKB actually IS Akt. I found that out too from my own question.
Great video. Just one thing, if you could please try to talk somewhat a tiny bit more clearly, it would make everything perfect. :)
Hi JJ, do you have a mail adress?? Thanks
way to badly planned, very hard to follow along when you jump back and forth
Thank you 🌸🌸
Thank you