TWiV 1152: Clinical update with Dr. Daniel Griffin
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- Опубліковано 30 вер 2024
- In his weekly clinical update, Dr. Griffin deep dives into the durability of the antibody response following mpox vaccination, vaccine security, global mpox circulation, the origins of SARS-CoV-2, including a list TWiV episodes and combatting scientific misinformation, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if remdesivir + dexamethasone lowers mortality of hospitalized COVID-19 patients and the finding of how SARS-CoV-2 infection impacts memory and cognition.
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I’m Vincent Racaniello, Earth’s Virology Professor, and I believe that education should be free.
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A smiling Daniel Griffin on the thumbnail for a change? This is gonna be a good one 😂
Thank you, gentlemen; another great episode. Much appreciated!
A search for lab leak versus crossover from animals is how I discovered TWIV all those years ago. Now clinical update is part of my Saturday routine.
Thanks as always.
This information needs a wider audience. They need someone to promote the great work they do. How s promoter.
I don't understand why there isn't more concern that there was "significant mental impairment" on all the test subjects who were infected
A beer and clinical update=perfect Friday
I'm denied beer but I have quite a good German 0% one
There was a coordinated censorship campaign to stifle discussion of Covid origins in 2020 and 2021 when it mattered most. Blame that for the mistrust.
Examples of who tried to censor it ? From the very beginning the genetics ( after the first few days had clearly suggested it was not lab created at least ) so they did try to tell people it’s not nice blaming specific people without reason specially when one is a real world super hero Dr Fauci .
What an amazing episode. Definitely saving the link. THANK YOU!!!
Excellent update covering several important topics (as always).
His updates plus TWiV make me the go-to person for information as I refer them to his updates! Love the viewer questions as well.
The fact that COVID caused cognitive impairment is scary as heck in that challenge test.
And people keep harassing those who wear a respirator to not spread this disease.
Only a low procent of SARS COV2 infection induce Covid19.
Why ?
Maybe at some Covid19 patients blood capillary flow is weakened ?by reversibile erytocite aggregation ?
@@wortelsorbeton respirator body and lung temperature decrease.
If ,, cold agglutinine,, occur, erytocite aggregation can also occur, but can be reversibile by increasing blood temperature and avoiding to decrease lung temperature.
There are other studies that show that the cognitive impairment is a risk with each infection and that the degree of the condition is cumulative.
So why aren't we making more of an effort to avoid spreading the virus?
Could someone please reach out to Lisa Catanese and Michelle Chan about the misinformation in the Paxlovid Rebound article?!
Bavarian Nordic stock jumped in Aug. You know what they say, if you listen to the obvious news, you will be the one holding the bag. ie. the general public are typically the last to know when these things happen.
Yeah, that would have worked too with ozempic.
Mpox cases in "Africa" means nothing. It is not under control also means little.
The continent is fucking huge, you can put the US three times into the same area.
Therefore it needs to be by country, and which country is able to control ot and which not.
At present the outbreak is mainly confined to a handful of central African countries, which should be targeted; however there are political issues that may make the distribution of the vaccines difficult.
@@christopherrobinson7541 yes, it is called the Eastern Kongo, the rest of East Africa, minus South Sudan should not have problems with distribution.
Aside from the Eastern Kongo, mpox is now in Kinshasa, a city of 14 million people, that is a nightmare.
What should also be mentioned, this means the chance of mpox mutating aka adapting to humans and becoming more contagious has increased. Luckily, it is a DNA virus and hence much more stable than COVID.
Anti bodies wane but memory B cells remain. I thought i heard Daniel last week indicate that T cells wane after 6 months and elsewhere (CIDRAP) recommended C19 boosters because of this waning. I'm trying to learn but sometimes it seems I'm getting contradictory messages!
I believe the issue is if the memory cells to the virus match the antigens of the virus trying to replicate. Yes antibodies and T cells wane. But memory cells remain. If you are younger, healthier, you have more of a buffer for those cells to replicate, adapt and protect you. A booster will immediately activate the memory cells, try to adapt to the vaccines new code if there is one, and boost levels of the cells. So that if you encounter the virus, more active immune cells would be present. Adapting to the newer genetic depends on immune imprinting of course. But T-cell epitotes are less likely to mutate I believe.
@@AlbertMark-nb9zo Thank you! I'm a complete layperson so trying to understand can be a long process! Blessings.
@@AlbertMark-nb9zodepends on the immune response.
There is a short lived b cell immune response to certain vaccines (primarily polysaccharide vaccines).
Hence there is a risk that a certain vaccine could just elicit that pathway.
@@AlbertMark-nb9zoalso the important epitopes are around the binding sites the virus uses to infect a cell. If the virus changed to use a different binding site then it would probably not be considered SARS-CoV-2. The bigger issue is if the virus mutated such that it could use either ACE2 or another binding site to infect a cell. Antibodies reduce naturally once a pathogen has cleared with a half life of 21 days. Also there are both memory T cells and B cells.
@@WillNewcombit may be worth your time to watch some immunology videos on UA-cam, particularly Brianne Barkers undergraduate course, the 2024 version is available now.
This show also calms my nerves.
It is hard to question the age of "children " around the world. Including the United States.
Are children having sex ? MPox may be from parents and close contact.. But they do have sex ,some at very young ages. Some countries are married at puberty .
Nao esqueça da pefofilia um dos demonios do mundo.😢😢😢😢😢
Yes of course kids are sexually active at much younger age in Africa and abused by adults. Kids having sex below 16 in the UK is common place. It would be more informative if any other STD’s was also detected in the children Mpox cases in Africa.
@@ritaazevedo5047 it’s the real pandemic and one that scientists can’t cure with a vaccine.
Thank you.💕
That was excellent. Thank you very much.
Dr Griffin doesn't make a problem of the 1100$ too expensive cost but has a problem with search for alternatives. Where is the focus? Helping patients or helping pharmaceutical companies?
He has expressed problem with the high cost in previous videos and what alternatives ? So many have been tried only a few Remdesivir and Japanese Paxlovid equivalent ? Molnupiravir what do we have ?
All science asks re a treatment is -1-Show me it's safe and 2- Show me it works . What else do we have aside from the stuff we all should be doing- sleep , light, diet etc.?
These two gentleman can't themselves influence the price of treatments, their job is to say what has been safe ands effective and read journals that most cannot understand (even most clinicians - I know this personally as a double Boarded physician). As mentioned before they have indeed expressed concern and sadness over the fact you raised. Keep listening ,you'll find they are the real deal and many clinicians look to them for guidance!
What a great episode! My favorite part was Dr. Racianello doubling down on his prediction that the winter wave might be attenuated by community immunity from all the covid that popped off in the last 6-8 weeks.
He could be wrong, everybody else has been, but he seems to know what he's about. 🤘
We're watching..
It'll give more information on if the waves are based more on waning immunity vs. shift in variant.
We're now at 8% of the sequenced US population with the recombinant XEC.
Do serial HIV and/or rabies exposures convert to infections yield community immunity?
If a person in North Carolina who is stage 4 cancer and near death catches covid and dies what is the cause of death listed on the death certificate ?
Primary, secondary or tertiary cause of death are usually listed. Could Covid hasten the death of someone with stage 4 cancer? Likely, but not always, since I know some one who has stage 4 and lived through Covid.
Retired Oncology nurse here. Many people live with stage four cancers for months or years. If their cancer condition is stable and they catch Covid and develop a severe illness and die then I would say that Covid killed them before their cancer did.
Medical doctor here. The cause of death should be labeled as covid and that would be the only honest and correct way. Contributing factors are also required which can include cancer but will first include complications of cancer for example renal failure etc .
Most also do not know that no body worth their Daly counts official PCR based numbers as total count as it has been proven to be severely underestimated in third world countries and mildly underestimated in the developed countries except 1 or two where it was slightly overcounted but than adjusted - USA was not one one of them.
Thank you
If ,, cold agglutinine,, occur after some viral infection at some patients,if blood temperature decrease, increase tendency of erytocite to aggregate (reversibile),damaging capillary circulation at some level.
If oxigenoterapy use cold oxigen mix,at lung capillary level blood temperature decrease
Rarely if ,,cold agglutinine,,, occur, or level of cryoglobuline IgM antibody increase must avoid to decrease body temperature.
When I used warmed oxigen mix at body temperature on ambulance (using warmed water in barbotor) oxigen saturation increased more and rapidly.
At this patients a drop of blood put on a glass surface,agglutinate before coagulate (at room temperature )
If glass surface was warmed at 36C -37C agglutination did not occur.
Mortality and distribution of MPox is minimal. It is a treatable disease and the focus should be on treatment and not vaccination. The only reason for the focus on vaccination seems to be economic and the WHO is being influenced by money it receives from big pharma.
Simple explanation for why children are 60% of the cases: the adults underreport, for stigma in Africa.
Cognitive impairment for a year in everyone: this is more support for the idea that covid causes a long lasting taurine deficiency somehow, since taurine is known to improve cognition.
A more relevant question is how did Sars cov2 spread out of the quarantine zone to the resorts and business hubs of the world. As I recall a certain world leader insisted their citizens not stay in the zone and wouldn't require quarantine if they didn't fly straight home.
Thank you, again, for doing this! I’m grateful.❤
The specifics about the Huanan market in China, only just released this month.
41:35 too bad remdesivir still not available in oral route yet, could be a good altnative to pax.
Thank you Vincent for your optimism! I needed that today.
Thank you gentlemen for another great broadcast!
Speaking of bacteria and water: I went to AI to find out if surgeons rinse with distilled water or tapwater. Apparently they use tapwater after washing their hands, but I assume there’s obviously different levels of contamination and tapwater is generally assumed to be safe enough.
Bacteria in tap water can be killed by a UV-C light treatment. How many of the remaining pathogens can migrate through two(?) surgical gloves?
Love you guys. But while YLE was wrong on the viewer question, there was an undeserved harshness in the response given what she has done during the pandemic to speak to the science. Everyone gets it wrong sometimes. Do better.
YLE has a large audience and has been problematic. I have no issue with them calling her out.
@54:34 Is the paper saying that multiple C-19 vaccinations can compromise immune systems?
***crickets***
No where did you get that ? How does “ those were older age and had multiple Covid vaccines” translate into immune compromise?
@@Sceince007 Are you trying to gaslight me by omission? "Compared with untreated persons...received more Covid vaccinations, AND MORE COMMONLY HAD IMMUNOSUPPRESSION."
@@cylon5741 no need to gaslight some me already very dumb .
Immunosuppression ( from different reasons than vaccine ) vaccines are not immunosuppressants they improve it . But also read that sentence ( you just posted ) carefully several times and you may finally understand it .
Katelyn Jetelina "Your Local Epidemiologist" has a large audience. If she has made a mistake in this instance, I am sure she would be keen to correct it. Perhaps you should make contact.
$1100 for Paxlovid. I thought you could still get it for free or minimal price!
That stopped in March. Fortunately my insurance covered it and ivv be only paid $25.
They don't consider today an emergency. Figures.
Isn't paxlovid made from two generic drugs ? Shouldn't the government step in control the price ? Didn't Pfizer already make a huge profit off paxlovid ?
You can through the Paxcess program.
People, stop eating animals
Sorry you are wrong with your test question. When rapid tests turn positive correlates strongly with a viral load.
@@zheuscher got a study for that?
@@brendanmay9585 'Antigen concentration correlated well with viral load when measured in the same specimen type but not across specimen types.'
Ref: Antigen concentration, viral load, and test performance for SARS-CoV-2 in multiple specimen types (PLoS One. 2023)
Do Dr. Griffin and his family members have concerns about the safety of mRNA vaccines?
Not from what I heard. Isn’t it more that Novavax is gentler with less harsh side effects? You can go back and listen but didn’t he say Novavax is less reactogenic meaning more mild side effects? Isn’t that right?
@@JW4REnvironment That would mean fewer safety concerns, right?
Fewer safety concerns with Novavax. If not, why would they be preferentially seeking it out when mRNA vaccines are readily available?
LOUDER please! Why did you change your setup or refuse to revert it back to the way it was? What good is an AUDIO podcast if no one can hear it but dogs?
Counterquestion, I can hear them fine.
You sure you dont experience some progressive hearing loss?
@@sciencefliestothemoon2305 Not talking about the video here but the podcast from the website. I would comment there but it hasn't been working for months.
Regarding Novavax JN. 1 availability in England… It’s still being evaluated by the MHRA. Very much want it myself.
Thanks! I would agree and plan to try Novavax here in the States!
I wish his instructor would come back Dickerson Des Pompeii these guys ain’t no good