Listening to the comments about reducing BMI took me back to when I was treated for prostate cancer. At the time, there were suggestions that a low fat diet would be a good thing. It was good for my mental health to have something, anything, to do to combat the disease. I think a program of improving your health and reducing risk factors would be a great way to combat anxiety.
I really enjoyed this podcast. Dr. G and Dr. R covered so much ground. Answered a lot of my current questions. Love the academic references. Thank you for being two calm voices in a winter storm.
Valiant effort at explaining Guidance!! It just gets more confusing. I will continue to study the references and your commentary in hope of being able to be conversant on the subject to my patients. The bottom line for me is to take this information as far as I can and then Draw a Line.
We believed in this beautiful country of the USA. Today, subscribing to your UA-cam has given us hope for the future. It is absolutely outstanding that you have created this UA-cam channel!
Vincent, can you do something about the sound level of the outro music? It's really freaking loud and makes Mathea and I jump two feet in the air. Seems worse on the clinical update than on other TWIV epitopes.
Count me in Joe !! That "bumper music" Vince is using really is jolting, crass, and irritating even when played at lower volume levels. Surely, there must be an alternative musical product that would fit this otherwise EXCELLENT podcast.
As a prof musician (whose concert halls are cancelling week by week😞) I TOTALLY agree w you- it’s so loud and tinny. Just buckle your seat belts towards the end of each podcast
I was vaccinated with 2 doses of Moderna the end of January and February, 2021. On Sept 5, 2021 I tested positive for COVID, my main symptom being pain taking deep breaths. I received monoclonal antibodies. I am guessing I had delta. On Sept 16, 2021, I had a sudden coronary event complete with chest pain, STEMI EKG, elevated troponins, and angiogram. My coronary arteries were not clogged to the point of being a cause for an MI. The cause of my event was attributed to coronary artery spasm, and my EKG apparently resolved enough to be downgraded to a NSTEMI. I believe COVID was a factor in this “ special” experience. All of this for background. Sequel:
@@gferraro8353 “Acute coronary syndrome (ACS) refers to any constellation of clinical symptoms that are compatible with acute myocardial ischemia. ACS is divided into ST- elevated myocardial infarction (STEMI), non-ST elevated myocardial infarction (NSTEMI), and unstable angina (UA). STEMI results from complete and prolonged occlusion of an epicardial coronary blood vessel and is defined based on ECG criteria..NSTEMI usually results from severe coronary artery narrowing, transient occlusion, or microembolization of thrombus and/or atheromatous material. NSTEMI is defined by an elevation of cardiac biomarkers in the absence of ST elevation. “ - PubMed Daga LC, Kaul U, Mansoor A. Approach to STEMI and NSTEMI. J Assoc Physicians India. 2011 Dec;59 Suppl:19-25. PMID: 22624277.
Wow. My nephew is 16, in athletics, good health, and was in the hospital with a coronary event. He had to sit out sports for the rest of the year. Every doc in the hosp came to visit him bc they had never seen a heart patient so young. But they never got a positive covid test on him (and he didn't have the vaccine.) In the end they said it must have been caused by "some" virus.
So sorry to hear about your struggles. What you describe was likely a NSTEMI due to demand ischemia or Type 2 NSTEMI not caused by plaque rupture but rather oxygen supply/demand mismatch. In your case, this appears to have been triggered by coronary spasm as you indicated.
@@lisas4776 well my ST was definitely elevated on my first EKG. I saw it. I didn’t see the subsequent EKGs. My original point in setting up my scenario was to ask advice about whether or not my monoclonal antibodies could have prevented my body from developing its own natural immunity. I was glad to get rid of the infection, but as of Jan 2, 2022, I again tested positive for COVID. I am coming out of it now. However, I am concerned about developing micro clots, if anybody has any info/ suggestions. 🌹🌹🌹☘️☘️☘️☘️❄️❄️
These updates are great! _But_ I think it would be a good idea to *normalize the volume of the intro and outro music* with the rest of the video. Right now the show, at a reasonable volume, ends and the outro music comes _blasting_ on.
Dr. Griffin, regarding your patient that almost died this morning (the unvaccinated one coughing up thick stuff)... is it possible that he is in the 10% of infected people that do not have the omicron variant? Did they sequence a sample from him yet?
The other day on Q & A with A & V , I heard that Dr. Griffin feels we are testing too much. Yet in this update he recites the venerable mantra "Never miss an opportunity to test" . Can you please clarify ?
18:18 Unfortunately here, Vincent is assuming that the antibody response in a vaccinated person results in substantial production of IgA, and there is very little evidence to show that there is robust IgA response, which would be necessary to neutralize infectious viral particles in the upper respiratory tract.
I’m confused by the discussion of vaccine effectiveness and the potential over emphasis on infection prevention. The MMWR paper linked from the show notes says “Among those who acquired COVID-19 after primary vaccination, 1.6% (36) died,” Isn’t that about the same case fatality rate as in the unvaccinated? Wouldn’t that support the focus on infection avoidance? What am I missing?
FLCCC uses much higher doses of methylprednisolone! Says 10 mg is peeing in the ocean especially during the later stage of this awful disease when cytokines are wreaking havoc Please give your take on this...and what about fluvoxamine and cyproheptadine for the serotonin toxicity in that second stage, what do you say about this??
It is great to hear a study that seems to show risk of death does not go up after 6 months. But there have been so many observations before, showing that hospitalizations went up, and the risk of death did increase after 4-6 months post 2nd vaccine shot - as seen and confirmed in multiple countries (hence the importance of boosters especially for age >60). This does not agree at all with these observations. When a new study comes up that completely disagrees with multiple previous studies, I think it is important to put it in context and not just present it as the newest study that must be true now. And try to explain the discrepancy. I think that would be very important.
@@lucid118 Actually, I looked it up in the publication: the paper itself said: no significant difference for time since vaccination (and not "increase of protection after 6 months"). The Odds Ratio (OR) for a severe outcome might show slightly lower OR for time >120 days in the table, but that was not statistically significant, hence it is not correct to say it was lower. But still, interesting to see that there was no difference, although there can be so many confounding factors here, including that they didn't differentiate between delta and non-delta, as well as no differentiation by age, which is the critical factor. Also no differentiation by vaccine, so it is a big average of many factors. So, just because they didn't find waning here, doesn't mean much in my mind, also because this study wasn't really designed to look for that...
Thanks for another informative update. Saddened to hear again that omicron is not shaping out to be a more mild version in the US like it was in South Africa. Daniel, have you heard anything more about fluvoxamine? It sounded promising a while back but i have not heard anything more about it.
Dr Stallings here... What type of Dr is Dr griffin? You didn't mention that, is he a intensive care doctor, pulmonologist? I would guess he is either a researcher or has been in the past. I realize he's probably been on other podcasts of yours but I haven't seen them. You'll be useful if you introduced him with his credentials. None of this should be taken as a criticism because he was extremely knowledgeable and I learned a lot, thanks for the work you do
Here's what I found... "Dr. Daniel Griffin is an instructor in Clinical Medicine and an associate research scientist in the Department of Biochemistry and Molecular Biophysics at Columbia University. Dr. Griffin attended New York University School of Medicine and then did his 3-year categorical internal medicine residency at the University of Utah. After a decade in private practice, he returned to academia and earned a Ph.D. in Molecular Medicine at the Elmezzi Graduate School of Molecular
Somehow the thought of a phage on my pillow does not seem like any way to get to sleep. But then I loop TWIV and news and Medcram all night anyway so maybe I should try out some kind of microbe pillow...sometime...
In Los Angeles 66% of the infected are 18-30 year olds. This makes sense since they are congregating, going to movies, going out, hanging out in malls. They just do not seem concerned at all for getting this.
It's probably because more older people are vaccinated so they become asymptomatic and or very mild to not warrant a test. Over here in densly packed NYC, we hear of droves of boosted people testing positive. One person gets sick (positive) and thus triggers a bunch of other "close contacts" to test and turn up positive. And since we're so packed, you really get the real life experience of vaccinated people arround you testing positive and presumably spreading it to eachother. I don't see any difference in transmission though. It's like when we got the Wuhan variant. I can stand at my trian station and point in every direction and diagonal and talk about a ground zero death within a couple of blocks. And I only know store people arround here. Tons of scattered asymptomatic and milds as well, but most of those never tested but assumed "loss of taste and smell", etc. was a hint. Most in hindsight as well considering that symptom wasn't on the list back then.
@@TheMrSuge Eventually, you're going to encounter it so accept it. No one measures the flu (and common cold...like perhaps old coronaviruses), but I bet some of those spread arround a lot but you just don't know it. We're all breath the same air.
The Q&A with AnV it's said we're testing too much. Here we're told to test, what's the deal? Per the qna we don't know enough about vaccinated people spreading disease. This is conflicting info. Thanks for what you do
Amy and Vincent are virologist, Daniel is a pediatric physician. They have different perspectives. Maybe if Vincent had a grandchild, too young to be vaccinated, he'd have a different perspective.
IMO, Amy was way off on that event. I put in the chat that testing is for the unvaxxed (and they echoed it!) as we want to be sure we aren’t spreading it to them.
Healthcare should be between a doctor and his patient. Why could US not donate more vaccines to third world countries? Boosters would be better than nothing. My spouse and I both took Pfizer vaccines. Its cool to see the incubator here, Vincent. I like those shelves with books etc behind you. I watch to support Vincent's work. I am not paying $50 for two tests. Cheers! 🍷
Fear, anxiety and many of the daily impositions used to control the spread have evidently caused a decline in mental health. Stress related issues such as prolonged anxiety/depression negatively impact a person's physical health. Could the immunosuppressive aspects of excess stress hormones, over a long period, cause an individual to be more likely to contract a virus and/or develop severe disease?
Can you talk please about natural and proactive ways to keep our immune systems strong including the importance of not scaring everyone into a frenzy? Maybe you can't find any studies about that? Also, I would like to see previous infections included in the discussions. Don't worry we had it and both vaccines. Where does the majority of your funding come from?
This is the 96th clinical update with Dr. Daniel Griffin, and TWiV has covered COVID19 extensively since roughly episode 602 to present, in addition to the Q&A with A&V. Each episode of TWiV covers two papers, with links in the show notes to studies they discuss. I'm sure you can find something in the roughly 600+ hours of Covid coverage Vincent and crew have done if you bother looking. Most episodes clock well over 2 hours and drop twice a week (3 if you count the Q&A). They also take emails.
Paxlovid is not readily available is it? I don’t think there’s enough yet so I’m not sure why it was presented as if it is? I live near Glen Cove and it’s not like if I were to get Covid I can go to the Dr. and ask for Paxlovid. This information is not accurate. Really frustrating and when information is not accurately represented, it calls in to question other information in the video. I would appreciate it if you would be more aware of this because I think there is important information in all the videos.
IMO Dr. Griffin was speaking mostly to clinicians about what medications to choose. They know, and we know, that supplies of the antivirals will be extremely limited for months until production ramps up.
Do you have a suppressed immune system? A transplant or undergoing some other such treatment ? If so, your doctor might very well be able to get some of that limited supply of Paxlovid. If not, you’re going to be trying to get one of the other therapies mentioned. The first line of defense is vaccines, I’m assuming you’ve had those.
@@bobedgar6647 yes. I was objecting to the way Paxlovid was presented. People need to understand that they can’t just go to the doctor and say “I need Paxlovid now” because there simply isn’t enough supply at this time. If you know some general practitioners, ask them how many calls they get from patients demanding it now. They get a lot of these calls. Just one more thing doctors don’t need to deal with right now.
@@UtahOwl do you know any practitioners and have you heard about how many calls they are getting from people demanding Paxlovid? It’s a lot, and it should not be encouraged.
@@jenibarra385 agreed that expectations far exceed the supply (currently, I don’t know what production planning looks like). The part where I’d like to disagree is that the audience here isn’t (largely) the general public but rather a good few clinicians looking for guidance. To that end I believe the information presented was useful to that audience. As I perhaps to brusquely responded in my last post: for those in critical need I believe there is access to the very limited supplies available, as well as the alternatives to be considered based upon individual patient requirements. e.g. the also extremely limited monoclonals. Let us all hope production can rapidly be expanded, for the entire world is anxiously waiting for this new drug. Let’s also hope that resistance doesn’t rapidly develop too, as all too often observed with HIV-AIDS drugs.
I wish that you would address why you’re not masked for the show. If rapid antigen tests are not as accurate now for omicron, how can you be confident you’re ok to meet without masks?
Apparently, his stance has changed from the past since he mentioned in a previous TWIV that he is not afraid of mild illness ensured by the vaccine and is no longer trying to "protect the unvaccinated" since they had ample chance. It's actually kind of relieving as I thought that stance is long overdue for everyone. I mean, it was evident from early on it's gonna be like the flu. You get your shot if you want and don't worry about it and live on. We never wore masks even when we HAD the flu so what's so different about COVID?
Strangely Omicron in UK is pretty mild while it seems to be very much more severe in US. Maybe it's AstraZeneca (UK) handling Omicron much better than Pfizer (US). About time Pfizer get back to their drawing board and come up with a more effective strain rather than forcing people to get even more doses of the same apparently not too effective jabs.
I understand what you are trying to say, but there is little data in your conclusion. We have more than just Pfizer. We had different times between doses. So many more factors
Yesterday my friend wanted to test due to feeling ill. I have tests at home, so I had him spit in a cup. I tested his spit and it went positive almost immediately.
In 2020 drop of blood from some hypoxic Covid19 patients agglutinate before coagulate on glass lamela. At microscop I see tendency of erytocite to agregate ( at room temperature) but not if glass lamela was warmed at body temperature. At this patients use of warmed oxigen mix at body temperature increased more rapidly oxigen saturation.
I don't mean to be that guy, but shouldn't you guys be masked or further apart? I hope the room you are in is well-ventilated, right? If my response is an over-reaction please let me know -- these are exactly the sort of unmasked meeting room interactions I have been staunch about avoiding, of late...
Is the change in age and sex incidence of Omicron in SA and also in Australia due to better immune memory from AZ vaccine, rather than mRNA vaccines used in younger populations and women?
Obesity, human factor -- we're still congregating in US in AC/ heat cubes where culture isn't about opening windows but pushing forced air, older population vs South African population while people like to cite HIV as unhealthy popn... it's only 18-20ish%, their protective factors are younger population, leaner, healthier diet esp African traditional food...obvs there's fast food but overall, windows get opened on average - air gets cleaned .
Exactly! They always say that „vaccination seems to protect from long-covid“, but rarely with good data, maybe because most of the data so far shows a maximal reduction of risk for long covid of ~50%, 30%, or close to 0%, depending on the study. But even halved isn‘t good enough in my eyes when now suddenly it looks like everybody is supposed to get their omicron „boost“ this winter. So I‘m hoping to avoid infection with the help of my booster & N95/ FFP2 masks. 🤞🤞🤞
I follow your interview with Amy and this dr and today I feel very confused are ye all talking about covid very difrent opinions so wath are we ment to beleave can u explain this please
Yes, because with Amy, V&A completely disregard the potential overwhelming of the hospitals that can easily happen with so many infections going on, so the „who cares about infections“ attitude with potential contribution to the rising case numbers doesn‘t do well in the presence of a medical Dr. who knows how the situation in the hospitals is.
The only way you are getting a test in my area of Southern California, is if you are in the ER or being admitted. There are simply no tests available unless you book them 1 to 2 weeks in the future, then wait another week for the results. No need to try. You are already in the hospital or recovering by then. This includes PCR and RAG. People are dropping like flies but not testing.
It is a serious fallacy, and basically intellectually dishonest, to keep arguing that "vaccination is not so great" by citing individual cases in which a vaccinated person has died due to COVID. Vaccination, just like practically every drug, procedure, operation, potion, lotion, ointment, powder, or poultice we use in healthcare acts PROBABILISTICALLY -- we cannot sense the value/non-value of vaccination except by looking at comparative outcome data from GROUPS of patients who have, and have not, received the vaccine. Please!
@@jamesleem.d.7442 Comon on, man. Are you really this dense? IT WAS A FREAKIN' JOKE!!!! Vincent said "severe death", which I found funny, since there is no mild form of death. I even put a laughing emoji at the end... For the record: I am not a stupid antivaxxer. I am fully vaccinated and boosted. Do you really think that someone who listens to TWiV could be an antivaxxer?!?
Today I got my 13 year old boosted - 8 months after her 2nd dose (I feel they forgot about the 12-15 year old kids for too long). She goes to a school that has zero mitigation. I wonder if I should keep her home for a week just to build back some immunity?
Was confused that a comment I posted with a link to a BMJ article wasn’t posted, but now I understand. The BMJ article was designated as misinformation by a Facebook fact checker, Dean Miller from Lead Stories. Many thx to Mr. Miller for protecting everyone from the dangerous ideas in the BMJ.
I can't be the only one who is having a difficult time forming an opinion about Omicron. Are we worried? Are we not worried? During the height of the last surge in January of 2021 here in Los Angeles County we hit 20,000 positive cases per day. Today we hit 43,712 positive cases. Are we going to start treating Omicron liked the common cold?
I feel the same way. I'm also in LA and it seems as if the county is not even sure of what they are doing. On one hand, they now want employers to provide high grade masks and on the other hand they seem to be messaging that the economy is somehow more important. I think that the unvaccinated should be really worried and the vaccinated should proceed with the basic masking and distancing caution. I honestly think that we should be worried on a system level. The hospitals will be filled with unvaccinated covid patients that will take away beds from people needing other emergency care services. It's a weird situation. As an individual (vaccinated) I should not be too worried, but as a member of a society I don't want the hospitals to be full and am very worried.
I don't know how anyone can really "know what they're doing," when even the brightest experts can't agree on some of the basics. As for me I'm not worried. I'm not setting policy and don't need to have an opinion on everything. The virus probably won't get me, but before long something else surely will. Enjoy this precious life!
@@mehg8407 Indeed, an elderly neighbor has had his hip replacement surgery put on hold as there are no hospital beds available. No indication of when he will be able to have the surgery.
@@mehg8407 trying to protect those workers from infection is trying to keep them working. If they were to become infected, they would not be working for the time they were in isolation. If one of their co-workers is infected then both of them will be missing work, the first recovering, the second in isolation so as to avoid infecting anyone should they themselves be infected. That’s the thing about modern economies, we’re pretty much all essential workers.
If I remember correctly, the USA was strict with the time period between doses, and Moderna went with 4 weeks separation vs 3 weeks of Pfizer, so that might explain why they had better immunity in the long term - ie: they antibodies didn't fade out until 6 months vs the 5 months of the Pfizer. In Canada I had 9 weeks between the 2 Pfizer doses because we had a shortage of vaccines.
Why are there so many differences between USA and e.g. Europe/South-Africa/Japan reg. Omicron? In these places cases are going up, hospitalizations & deaths are going down, hospitalizations in November and December consisted of 60-70% fully vaccinated…. Seems a completely different picture than the one painted here for the USA… why is that?
I sure appreciate hearing details and substantial info around what a clinical response to more serious presenting disease looks like. I am vaccinated and support that, but I also think we need to know much more about what can help those in risk of great health catastrophe, and also we need to understand what is the MOST EFFECTIVE so that our hospitals can continue to provide capacity as we go forward. I too am doing my best to lose weight and tell everyone I know to try supplemental vitamin D, because it is solidly known to aid the body in fighting back. Not everyone is aware of this supplement or of the way it works other than for bones and teeth.
And don’t forget having your MD test your D3 blood levels to vary your dosage. Even supplementation is frequently too low in northern regions and for all in the northern hemisphere winter months
@@bobedgar6647 Well, far too many Dr. are utterly oblivious to D. At best, they suggest 400 or a 'whopping' 800 iu per day as a 'healthy supplement.' Unfortunately, these dose are grossly insufficient if you are aiming for 'likely optimal' 25-D blood levels around ~50+ng.
@@geonerd yes, that was the intent of my comment. Blind supplementation is insufficient and potentially dangerous if using very high doses for extended periods. Having blood levels tested let’s both the patient and doctor know where they are 😉
I realise that the unvaccinated make an easy subject to pillory but here's a report out of Australia from the last day or so: "Devastated family and friends have reacted with shock to the death of a 23-year-old Australian man who had Covid-19, remembering him as a talented science graduate and sportsman. James Kondilios, who was double vaccinated and had no significant underlying health conditions, died at St Vincent’s Hospital in Sydney this week. "
"Double vaccinated" means he had ~35% protection against serious Covid illness. A third or booster dose would have put him back up in the ~75% protection level increasing his chances of surviving the illness, but that is not 100%. No one fully vaccinated has 100% protection against Covid. Whereas, the unvaccinated deserve all the "pillory" society can bestow upon them. They're making this pandemic far worse, using limited resources and back-breaking healthcare institutions everywhere.
Even if something is 95% effective in preventing death, that means five out of a hundred will still die. One death does not mean the vaccines don't work.
@@deborahfreedman333 I was really only looking at the number of people getting really sick. Just seems too many with all the vaccinated people plus I feel there will be unknown side effects down the road ( from the vaccinations). Just the worrying, wondering opinion of someone who is definitely not anti vaccine!!
@@donnamcmillan6950 No evidence covid shots ruining the immune system. The shots are nothing more than a "message" forewarning the immune system of something dangerous to come. Bottom line: vaccines save lives.
What is the “vaccine vortex”? Did I miss this definition? (Rewound, rewatched for about 4 minutes unsuccessfully, but don’t have time to listen to entire video 2nd time now).
Son vaccinated in March. Caught Covid between shots. Just had Covid now but very mild symptoms for two days. Can’t that 2nd infection act as a booster? On board with vaccine but he is 20 and very healthy. Just not sure for this age group booster is necessary esp after recent infection. Paul Offit recommended, as did majority of advisory Board, against boosters for everyone.
They think boosters will reduce the chance of variant infection in the short term. I dunno, all evidence I've come accross seem to indicate the reduction chance they come up with doesn't really matter in real world situations, tbh. Maybe big pharma is convincing governments to do it for extra money? But if you're high risk vulnerable, I guess it's like flu shot for over 65's (or other reasons I suppose).
So why don't we have different protocols with respect to isolation of vaccinated Vs unvaccinated people? I'm triple vaccinated but got COVID with symptoms in Thailand - pretty severe for a few days. But we're expected to isolate for 10 days and not allowed to wash clothes. It's too much, no?
I'm quite surprised by your answer to one of the last questions and frankly very disappointed. While I love virtually all of the information provided, in the 56th minute there is a very specific question about pregnant women receiving a booster that is flat out dodged. It's this type of dodging and misleading answers to questions that galvanises vaccine hesitancy. An "I don't know" is far better than the straw man's argument provided. If there is an answer provided, then it's a flat out miss. To break it down: The question is for women who received 2 doses of an MRNA vaccine: should they be boosted in pregnancy? The question is NOT!- is there a benefit to pregnant women being vaccinated? (which is the question you answered). No person of sound argument would argue against this point, hence the "straw man" claim. There were potential specifics that were missed, such as maybe vaccination during pregnancy is superior to vaccination prior to pregnancy as greater acquired immunity is passed on, but after your answer I am unfortunately none the wiser as you never discuss the complications of the obvious question THAT IS... There is a diminishing benefit to receiving boosters as you have already received the improvement in fetal and maternal survival during covid and now have the potential for increased and unforeseen risk due to the additional intervention. Maybe more questions are better than one broad question. What benefits does BOOSTING provide given understanding of the obvious benefit of initial vaccination? What additional known and unknown risks are ensured through boosting, aside from the known low risk of initial vaccination? Given the narrowed risk-reward analysis, how would you interpret and recommend prospective mothers considering a booster? Please know, I am no troll. In fact I'm a huge fan. My first introduction to your content was on a superb MedCram video...for which I never thanked you. For context, my question originated from a group of individuals using this specific "dodge" as an example of experts hiding the truth. I believe this to be far from the case. Please, Please respond.
I assumed he did not directly answer the question because it is not his patient and it would not be appropriate for him to make assumptions about her health history, risk factors, etc. Also, he is not an OBGYN and might not have enough data to make a blanket recommendation about boosters in pregnant women. Instead, he pointed to data that is clearly known and peer reviewed regarding the benefits of vaccination during pregnancy. I would say that the biggest benefit to getting a booster for a pregnant woman who is near term is that it would generate circulating antibodies that would be passed directly to the baby, as well as through breast milk after birth. If it has been more than 4 months since her last vaccine dose, those antibodies are likely not present in large quantities and I don't believe the newborn baby would have the same level of protection.
Hes just an instructor in Clinical Medicine and an associate research scientist in the Department of Biochemistry and Molecular Biophysics at Columbia. I'm sure he just made it up out of thin air
Well, I am assuming he wouldn’t come on here and pull it out of thin air. I am genuinely curious. That type of data would actually make me more concerned about omicron and I would like to check it out.
Hi Kyle. If you click on "show more" in the info section, you will find a link for the show notes. That link has all the links for where they get their data from.
@@chip9372 ... apologies, not sure if the 2000 figure specifically is in the first CDC link, but I assume you could find it there with enough sleuthing.
@@ethicsmatter2851 - he’s an anti-vaxxer and advocates the use of Ivermectin to treat COVID-19. In addition, he has spread many forms of misinformation.
India is right. molnupirovir is mutagenic as heck, that’s it’s mechanism of action. The data presented to the FDA was a scandal, and I don’t think it should have been approved. But desperate people are easy marks.
Sir - can you plz through light on - 1- how many antibody assays are made by any of the vaccine - 2- how many of them R actually neutralizing 3- against which variant 4- details of the claimed high antibody titer the companies claim visavis which of the assays. 5 - what exact form of spike is formed by any of these mrna or adeno vaccine - i hope the companies and any virologist can model - and then correlate with the antibody assay actually formed and reverse model the spike or AB Most IMP - how many anti-ace2 antibodies are made in the process by these vaccines - refer to Dr Peter Daszaks statement - there can be 'no anitbody' against the china virus.
I wish people would listen to you guys instead of all the tools on the Joe Rogan Embarrassment. Sagan was surely right about the lowest common denominator taking over the public consciousness. Keep up the good work guys!
Thanks a lot for the update! It was useful. About the new O-variant of SARS-Cov-2 raised in South Africa: can it be because a lot of vaccinated persons also are immunocompromised due to HIV? And the virus is trying to avoid an immune response? Thank you
May be If ,,low temperature agglutinine occur,,at some patients ,avoiding hypothermia and using warmed oxigen at this specific patients, will be avoided micro erytrocyte agregation at low temperature at capillary level? This presumption can explain some paradoxal effects of SARS COV2 infection.
I find it funny that people like Fauchi and CNN now say let’s not focus on cases when a lot of people were saying this two years ago. So who are the experts?
Realistically we didn’t have vaccines or effective drugs figured out 2 years ago, so any cases were important back then, and now more just serious disease
But if doubling 2-3 days just by the meteoric rise more ppl will die than ever before, more people will get long covid, they will overwhelm heath systems by sheer consequence of meteoric rise in cases.
@@skepticalbadger yes there is. ICU admission rates and death rates from the UK and South Africa. In the UK there has been a DOWNWARD trend in ventilation numbers for the last month. 7 day average of 891 a month ago v 7 day average of 875 now. Deaths in the UK have seen a slight increase, but only a slight increase going from a 7 day average of 112.1 to a 7 day average of 131. In South Africa there was a small increase in deaths but that has now subsided. Nowhere near the level of deaths from previous waves and vastly more cases. So yes it CAN be said this is less virulent.
Listening to the comments about reducing BMI took me back to when I was treated for prostate cancer. At the time, there were suggestions that a low fat diet would be a good thing. It was good for my mental health to have something, anything, to do to combat the disease. I think a program of improving your health and reducing risk factors would be a great way to combat anxiety.
,,,
Is it possible to share screen of what Dr Griffin is discussing? Many people are visual people.
Just a suggestion.
Great content
I really enjoyed this podcast. Dr. G and Dr. R covered so much ground. Answered a lot of my current questions. Love the academic references. Thank you for being two calm voices in a winter storm.
Yeah but the endtro music is so ridiculously loud. I'm often not at my computer so I can turn it down like I do for the intro.
@@gottagowork Yes, and my husband always laughs when it starts. He loves it.
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I love you guys! You are a huge wealth of fact based information. Thank-you so much for your service to the public.
Valiant effort at explaining Guidance!! It just gets more confusing. I will continue to study the references and your commentary in hope of being able to be conversant on the subject to my patients. The bottom line for me is to take this information as far as I can and then Draw a Line.
We believed in this beautiful country of the USA. Today, subscribing to your UA-cam has given us hope for the future. It is absolutely outstanding that you have created this UA-cam channel!
Thank you for all the good work you guys do.
Vincent, can you do something about the sound level of the outro music? It's really freaking loud and makes Mathea and I jump two feet in the air. Seems worse on the clinical update than on other TWIV epitopes.
Count me in Joe !! That "bumper music" Vince is using really is jolting, crass, and irritating even when played at lower volume levels. Surely, there must be an alternative musical product that would fit this otherwise EXCELLENT podcast.
I always fast forward past the TWIV intro music to avoid the audio volume assault, I also exit the video before it plays at the end of the podcast.
As a prof musician (whose concert halls are cancelling week by week😞) I TOTALLY agree w you- it’s so loud and tinny. Just buckle your seat belts towards the end of each podcast
I was vaccinated with 2 doses of Moderna the end of January and February, 2021. On Sept 5, 2021 I tested positive for COVID, my main symptom being pain taking deep breaths. I received monoclonal antibodies. I am guessing I had delta.
On Sept 16, 2021, I had a sudden coronary event complete with chest pain, STEMI EKG, elevated troponins, and angiogram. My coronary arteries were not clogged to the point of being a cause for an MI. The cause of my event was attributed to coronary artery spasm, and my EKG apparently resolved enough to be downgraded to a NSTEMI. I believe COVID was a factor in this “ special” experience.
All of this for background.
Sequel:
@@gferraro8353
“Acute coronary syndrome (ACS) refers to any constellation of clinical symptoms that are compatible with acute myocardial ischemia. ACS is divided into ST- elevated myocardial infarction (STEMI), non-ST elevated myocardial infarction (NSTEMI), and unstable angina (UA). STEMI results from complete and prolonged occlusion of an epicardial coronary blood vessel and is defined based on ECG criteria..NSTEMI usually results from severe coronary artery narrowing, transient occlusion, or microembolization of thrombus and/or atheromatous material. NSTEMI is defined by an elevation of cardiac biomarkers in the absence of ST elevation. “ - PubMed
Daga LC, Kaul U, Mansoor A. Approach to STEMI and NSTEMI. J Assoc Physicians India. 2011 Dec;59 Suppl:19-25. PMID: 22624277.
Wow. My nephew is 16, in athletics, good health, and was in the hospital with a coronary event. He had to sit out sports for the rest of the year. Every doc in the hosp came to visit him bc they had never seen a heart patient so young. But they never got a positive covid test on him (and he didn't have the vaccine.)
In the end they said it must have been caused by "some" virus.
@@gferraro8353 😀👍
So sorry to hear about your struggles. What you describe was likely a NSTEMI due to demand ischemia or Type 2 NSTEMI not caused by plaque rupture but rather oxygen supply/demand mismatch. In your case, this appears to have been triggered by coronary spasm as you indicated.
@@lisas4776 well my ST was definitely elevated on my first EKG. I saw it. I didn’t see the subsequent EKGs.
My original point in setting up my scenario was to ask advice about whether or not my monoclonal antibodies could have prevented my body from developing its own natural immunity. I was glad to get rid of the infection, but as of Jan 2, 2022, I again tested positive for COVID. I am coming out of it now. However, I am concerned about developing micro clots, if anybody has any info/ suggestions. 🌹🌹🌹☘️☘️☘️☘️❄️❄️
These updates are great! _But_ I think it would be a good idea to *normalize the volume of the intro and outro music* with the rest of the video. Right now the show, at a reasonable volume, ends and the outro music comes _blasting_ on.
THANK YOU! Extremely useful, especially the remarks at the end about immune-compromised transplant patients.
I think the doctor is mixing up the numbers. Can you post the link to the paper? Thanks!
Dr. Griffin, regarding your patient that almost died this morning (the unvaccinated one coughing up thick stuff)... is it possible that he is in the 10% of infected people that do not have the omicron variant? Did they sequence a sample from him yet?
The other day on Q & A with A & V , I heard that Dr. Griffin feels we are testing too much. Yet in this update he recites the venerable mantra "Never miss an opportunity to test" . Can you please clarify ?
Great point. I was confused by Amy’s stance.
Very helpful information as always. Thank you.
18:18 Unfortunately here, Vincent is assuming that the antibody response in a vaccinated person results in substantial production of IgA, and there is very little evidence to show that there is robust IgA response, which would be necessary to neutralize infectious viral particles in the upper respiratory tract.
I’m confused by the discussion of vaccine effectiveness and the potential over emphasis on infection prevention.
The MMWR paper linked from the show notes says “Among those who acquired COVID-19 after primary vaccination, 1.6% (36) died,”
Isn’t that about the same case fatality rate as in the unvaccinated? Wouldn’t that support the focus on infection avoidance? What am I missing?
FLCCC uses much higher doses of methylprednisolone! Says 10 mg is peeing in the ocean especially during the later stage of this awful disease when cytokines are wreaking havoc Please give your take on this...and what about fluvoxamine and cyproheptadine for the serotonin toxicity in that second stage, what do you say about this??
Thanks! Extremely informative.
It is great to hear a study that seems to show risk of death does not go up after 6 months. But there have been so many observations before, showing that hospitalizations went up, and the risk of death did increase after 4-6 months post 2nd vaccine shot - as seen and confirmed in multiple countries (hence the importance of boosters especially for age >60). This does not agree at all with these observations. When a new study comes up that completely disagrees with multiple previous studies, I think it is important to put it in context and not just present it as the newest study that must be true now. And try to explain the discrepancy. I think that would be very important.
I’ve been curious about that too.
@@lucid118 Actually, I looked it up in the publication: the paper itself said: no significant difference for time since vaccination (and not "increase of protection after 6 months"). The Odds Ratio (OR) for a severe outcome might show slightly lower OR for time >120 days in the table, but that was not statistically significant, hence it is not correct to say it was lower. But still, interesting to see that there was no difference, although there can be so many confounding factors here, including that they didn't differentiate between delta and non-delta, as well as no differentiation by age, which is the critical factor. Also no differentiation by vaccine, so it is a big average of many factors. So, just because they didn't find waning here, doesn't mean much in my mind, also because this study wasn't really designed to look for that...
Thanks for another informative update. Saddened to hear again that omicron is not shaping out to be a more mild version in the US like it was in South Africa. Daniel, have you heard anything more about fluvoxamine? It sounded promising a while back but i have not heard anything more about it.
Ontario does not have paxlovid yet. So fluvoxamine is now used. Johns Hopkins too..
@@jamesdoak2153 Good to hear. Thanks for the reply. I hope they are having success with it. Every tool helps!
Dr Stallings here... What type of Dr is Dr griffin? You didn't mention that, is he a intensive care doctor, pulmonologist? I would guess he is either a researcher or has been in the past. I realize he's probably been on other podcasts of yours but I haven't seen them. You'll be useful if you introduced him with his credentials. None of this should be taken as a criticism because he was extremely knowledgeable and I learned a lot, thanks for the work you do
Here's what I found... "Dr. Daniel Griffin is an instructor in Clinical Medicine and an associate research scientist in the Department of Biochemistry and Molecular Biophysics at Columbia University. Dr. Griffin attended New York University School of Medicine and then did his 3-year categorical internal medicine residency at the University of Utah. After a decade in private practice, he returned to academia and earned a Ph.D. in Molecular Medicine at the Elmezzi Graduate School of Molecular
Vincent you should get a mic 🎙 that has that viral head (like that image behind you)
Somehow the thought of a phage on my pillow does not seem like any way to get to sleep. But then I loop TWIV and news and Medcram all night anyway so maybe I should try out some kind of microbe pillow...sometime...
I had a huntsman spider this week.. bit my hand for brushing it off
Not that it hurts but a phage pillow would be better for sleep purposes
In Los Angeles 66% of the infected are 18-30 year olds. This makes sense since they are congregating, going to movies, going out, hanging out in malls. They just do not seem concerned at all for getting this.
Their percentage of being vaccinated is lower as well
It's probably because more older people are vaccinated so they become asymptomatic and or very mild to not warrant a test. Over here in densly packed NYC, we hear of droves of boosted people testing positive. One person gets sick (positive) and thus triggers a bunch of other "close contacts" to test and turn up positive. And since we're so packed, you really get the real life experience of vaccinated people arround you testing positive and presumably spreading it to eachother.
I don't see any difference in transmission though. It's like when we got the Wuhan variant. I can stand at my trian station and point in every direction and diagonal and talk about a ground zero death within a couple of blocks. And I only know store people arround here. Tons of scattered asymptomatic and milds as well, but most of those never tested but assumed "loss of taste and smell", etc. was a hint. Most in hindsight as well considering that symptom wasn't on the list back then.
why should they be? there chance of these getting severely ill is next to zero
@@whbgegs5571
To stop the spread to others
@@TheMrSuge Eventually, you're going to encounter it so accept it. No one measures the flu (and common cold...like perhaps old coronaviruses), but I bet some of those spread arround a lot but you just don't know it. We're all breath the same air.
The Q&A with AnV it's said we're testing too much. Here we're told to test, what's the deal? Per the qna we don't know enough about vaccinated people spreading disease.
This is conflicting info.
Thanks for what you do
Amy and Vincent are virologist, Daniel is a pediatric physician. They have different perspectives. Maybe if Vincent had a grandchild, too young to be vaccinated, he'd have a different perspective.
IMO, Amy was way off on that event. I put in the chat that testing is for the unvaxxed (and they echoed it!) as we want to be sure we aren’t spreading it to them.
Dr. Griffin's arithmetic is a bit fuzzy on the point of 120 days being 6 months. I'd be more inclined to call that 4 months, just saying.😃
What was the mortality rate in that pediatric COVID outcomes analysis?
Healthcare should be between a doctor and his patient. Why could US not donate more vaccines to third world countries? Boosters would be better than nothing. My spouse and I both took Pfizer vaccines. Its cool to see the incubator here, Vincent. I like those shelves with books etc behind you. I watch to support Vincent's work. I am not paying $50 for two tests. Cheers! 🍷
Fear, anxiety and many of the daily impositions used to control the spread have evidently caused a decline in mental health. Stress related issues such as prolonged anxiety/depression negatively impact a person's physical health.
Could the immunosuppressive aspects of excess stress hormones, over a long period, cause an individual to be more likely to contract a virus and/or develop severe disease?
I was still struggling at day 18,
Dr. Griffin: how long is an N95 mask effective? Is there any information on how often we need to change masks? What do you do?
Can you talk please about natural and proactive ways to keep our immune systems strong including the importance of not scaring everyone into a frenzy? Maybe you can't find any studies about that? Also, I would like to see previous infections included in the discussions. Don't worry we had it and both vaccines. Where does the majority of your funding come from?
This is the 96th clinical update with Dr. Daniel Griffin, and TWiV has covered COVID19 extensively since roughly episode 602 to present, in addition to the Q&A with A&V. Each episode of TWiV covers two papers, with links in the show notes to studies they discuss. I'm sure you can find something in the roughly 600+ hours of Covid coverage Vincent and crew have done if you bother looking. Most episodes clock well over 2 hours and drop twice a week (3 if you count the Q&A). They also take emails.
I appreciate your calm humerus informative updates.
Paxlovid is not readily available is it? I don’t think there’s enough yet so I’m not sure why it was presented as if it is? I live near Glen Cove and it’s not like if I were to get Covid I can go to the Dr. and ask for Paxlovid. This information is not accurate. Really frustrating and when information is not accurately represented, it calls in to question other information in the video. I would appreciate it if you would be more aware of this because I think there is important information in all the videos.
IMO Dr. Griffin was speaking mostly to clinicians about what medications to choose. They know, and we know, that supplies of the antivirals will be extremely limited for months until production ramps up.
Do you have a suppressed immune system? A transplant or undergoing some other such treatment ? If so, your doctor might very well be able to get some of that limited supply of Paxlovid. If not, you’re going to be trying to get one of the other therapies mentioned. The first line of defense is vaccines, I’m assuming you’ve had those.
@@bobedgar6647 yes. I was objecting to the way Paxlovid was presented. People need to understand that they can’t just go to the doctor and say “I need Paxlovid now” because there simply isn’t enough supply at this time. If you know some general practitioners, ask them how many calls they get from patients demanding it now. They get a lot of these calls. Just one more thing doctors don’t need to deal with right now.
@@UtahOwl do you know any practitioners and have you heard about how many calls they are getting from people demanding Paxlovid? It’s a lot, and it should not be encouraged.
@@jenibarra385 agreed that expectations far exceed the supply (currently, I don’t know what production planning looks like). The part where I’d like to disagree is that the audience here isn’t (largely) the general public but rather a good few clinicians looking for guidance. To that end I believe the information presented was useful to that audience. As I perhaps to brusquely responded in my last post: for those in critical need I believe there is access to the very limited supplies available, as well as the alternatives to be considered based upon individual patient requirements. e.g. the also extremely limited monoclonals.
Let us all hope production can rapidly be expanded, for the entire world is anxiously waiting for this new drug. Let’s also hope that resistance doesn’t rapidly develop too, as all too often observed with HIV-AIDS drugs.
I wish that you would address why you’re not masked for the show. If rapid antigen tests are not as accurate now for omicron, how can you be confident you’re ok to meet without masks?
Apparently, his stance has changed from the past since he mentioned in a previous TWIV that he is not afraid of mild illness ensured by the vaccine and is no longer trying to "protect the unvaccinated" since they had ample chance.
It's actually kind of relieving as I thought that stance is long overdue for everyone. I mean, it was evident from early on it's gonna be like the flu. You get your shot if you want and don't worry about it and live on. We never wore masks even when we HAD the flu so what's so different about COVID?
Curious about what the impact of proper Vitamin D levels is on outcome results.
Having less vitamin d than normal increases your risk, but taking more vitamin d than normal doesn't decrease your risk
US residents must be different to SA or UK -- very little death or hospitalisation in those areas
Maybe more risk factors in the US? Obesity? Age? Co-morbidities? Would have to compare each country for the risk factors?
@@janpat7373 yes - i agree -- most people in the USA have their own postcode.. Most die from a stroke after a quota of 10,000 burgers in a month ..
@@martinhughes2549 how many in hospitals have been vaccinated ? percentages
@@martinhughes2549 A big increase yes, but not proportionate to the case rate and still no rise in ICU.
@@skepticalbadger as always, simply a matter if time, unfortunately.
Thank you both for the information
Strangely Omicron in UK is pretty mild while it seems to be very much more severe in US. Maybe it's AstraZeneca (UK) handling Omicron much better than Pfizer (US). About time Pfizer get back to their drawing board and come up with a more effective strain rather than forcing people to get even more doses of the same apparently not too effective jabs.
You can't say that when there is a 5X population difference between the two countries.
I understand what you are trying to say, but there is little data in your conclusion. We have more than just Pfizer. We had different times between doses. So many more factors
USA has a higher obesity rate.
Yesterday my friend wanted to test due to feeling ill. I have tests at home, so I had him spit in a cup. I tested his spit and it went positive almost immediately.
So, now what ???
@@jamesleem.d.7442 just confirming that saliva worked for omicron testing in my friends case.
In 2020 drop of blood from some hypoxic Covid19 patients agglutinate before coagulate on glass lamela.
At microscop I see tendency of erytocite to agregate ( at room temperature) but not if glass lamela was warmed at body temperature.
At this patients use of warmed oxigen mix at body temperature increased more rapidly oxigen saturation.
Thank you! 🍪
I don't mean to be that guy, but shouldn't you guys be masked or further apart? I hope the room you are in is well-ventilated, right? If my response is an over-reaction please let me know -- these are exactly the sort of unmasked meeting room interactions I have been staunch about avoiding, of late...
😂
Agreed.
Over reaction imo
Both vaxxed and boosted. They should be fine.
Maybe hazmat suits as well
I enjoy listening to Dr Daniel tremendously.
Is the change in age and sex incidence of Omicron in SA and also in Australia due to better immune memory from AZ vaccine, rather than mRNA vaccines used in younger populations and women?
Obesity, human factor -- we're still congregating in US in AC/ heat cubes where culture isn't about opening windows but pushing forced air, older population vs South African population while people like to cite HIV as unhealthy popn... it's only 18-20ish%, their protective factors are younger population, leaner, healthier diet esp African traditional food...obvs there's fast food but overall, windows get opened on average - air gets cleaned .
I'd really really like to know the chance of long covid if vaxxed.
Exactly! They always say that „vaccination seems to protect from long-covid“, but rarely with good data, maybe because most of the data so far shows a maximal reduction of risk for long covid of ~50%, 30%, or close to 0%, depending on the study. But even halved isn‘t good enough in my eyes when now suddenly it looks like everybody is supposed to get their omicron „boost“ this winter. So I‘m hoping to avoid infection with the help of my booster & N95/ FFP2 masks. 🤞🤞🤞
I think they believe vaccine's don't change the chance of long COVID. Whether it shortens it remains to be seen I guess.
I follow your interview with Amy and this dr and today I feel very confused are ye all talking about covid very difrent opinions so wath are we ment to beleave can u explain this please
Yes, because with Amy, V&A completely disregard the potential overwhelming of the hospitals that can easily happen with so many infections going on, so the „who cares about infections“ attitude with potential contribution to the rising case numbers doesn‘t do well in the presence of a medical Dr. who knows how the situation in the hospitals is.
The only way you are getting a test in my area of Southern California, is if you are in the ER or being admitted. There are simply no tests available unless you book them 1 to 2 weeks in the future, then wait another week for the results. No need to try. You are already in the hospital or recovering by then. This includes PCR and RAG. People are dropping like flies but not testing.
Thanks so much gentlemen.
Very enjoyable video.
Thank you.
Vincent at 40:26 "You're still protected against severe death and disease"
So I guess the protection against mild death is not so great... 🤣
It is a serious fallacy, and basically intellectually dishonest, to keep arguing that "vaccination is not so great" by citing individual cases in which a vaccinated person has died due to COVID. Vaccination, just like practically every drug, procedure, operation, potion, lotion, ointment, powder, or poultice we use in healthcare acts PROBABILISTICALLY -- we cannot sense the value/non-value of vaccination except by looking at comparative outcome data from GROUPS of patients who have, and have not, received the vaccine. Please!
@@jamesleem.d.7442 Comon on, man. Are you really this dense? IT WAS A FREAKIN' JOKE!!!! Vincent said "severe death", which I found funny, since there is no mild form of death. I even put a laughing emoji at the end...
For the record: I am not a stupid antivaxxer. I am fully vaccinated and boosted. Do you really think that someone who listens to TWiV could be an antivaxxer?!?
Thanks for the weekly update 🇿🇦🇿🇦🇿🇦
Enjoyed this one a lot, especially minute starting 35:20… to sleep better when fully vaccinated!
Today I got my 13 year old boosted - 8 months after her 2nd dose (I feel they forgot about the 12-15 year old kids for too long). She goes to a school that has zero mitigation. I wonder if I should keep her home for a week just to build back some immunity?
The volume is too low
Thank you
Was confused that a comment I posted with a link to a BMJ article wasn’t posted, but now I understand. The BMJ article was designated as misinformation by a Facebook fact checker, Dean Miller from Lead Stories. Many thx to Mr. Miller for protecting everyone from the dangerous ideas in the BMJ.
I can't be the only one who is having a difficult time forming an opinion about Omicron. Are we worried? Are we not worried? During the height of the last surge in January of 2021 here in Los Angeles County we hit 20,000 positive cases per day. Today we hit 43,712 positive cases. Are we going to start treating Omicron liked the common cold?
I feel the same way. I'm also in LA and it seems as if the county is not even sure of what they are doing. On one hand, they now want employers to provide high grade masks and on the other hand they seem to be messaging that the economy is somehow more important. I think that the unvaccinated should be really worried and the vaccinated should proceed with the basic masking and distancing caution. I honestly think that we should be worried on a system level. The hospitals will be filled with unvaccinated covid patients that will take away beds from people needing other emergency care services. It's a weird situation. As an individual (vaccinated) I should not be too worried, but as a member of a society I don't want the hospitals to be full and am very worried.
I don't know how anyone can really "know what they're doing," when even the brightest experts can't agree on some of the basics. As for me I'm not worried. I'm not setting policy and don't need to have an opinion on everything. The virus probably won't get me, but before long something else surely will. Enjoy this precious life!
@@mehg8407 Indeed, an elderly neighbor has had his hip replacement surgery put on hold as there are no hospital beds available. No indication of when he will be able to have the surgery.
@@mehg8407 trying to protect those workers from infection is trying to keep them working. If they were to become infected, they would not be working for the time they were in isolation. If one of their co-workers is infected then both of them will be missing work, the first recovering, the second in isolation so as to avoid infecting anyone should they themselves be infected.
That’s the thing about modern economies, we’re pretty much all essential workers.
Hi Vincent, there is no episode 848 on your website
It's just out of order. Use the Playlists to see the videos grouped.
If I remember correctly, the USA was strict with the time period between doses, and Moderna went with 4 weeks separation vs 3 weeks of Pfizer, so that might explain why they had better immunity in the long term - ie: they antibodies didn't fade out until 6 months vs the 5 months of the Pfizer. In Canada I had 9 weeks between the 2 Pfizer doses because we had a shortage of vaccines.
More likely because Moderna has a higher concentration in their doses.
@@imgonnawin555 Both elements may play a part. I sought out Moderna for the reasons mentioned by many posters such as you.
Why are there so many differences between USA and e.g. Europe/South-Africa/Japan reg. Omicron? In these places cases are going up, hospitalizations & deaths are going down, hospitalizations in November and December consisted of 60-70% fully vaccinated…. Seems a completely different picture than the one painted here for the USA… why is that?
Perhaps the age groups that it is circulating in are very different?
After Mycoplasma pneumoiae infection,, cold agglutinine,,can occur.
If ,,cold agglutinine,, occur maybe must avoid to decrease lung temperature ?
Sometimes radiologic aspect of Covid19 and Mycoplasma pneumoiae infection are the same
In Mycoplasma pneumoiae infection macrolid antibiotics was effective
I sure appreciate hearing details and substantial info around what a clinical response to more serious presenting disease looks like. I am vaccinated and support that, but I also think we need to know much more about what can help those in risk of great health catastrophe, and also we need to understand what is the MOST EFFECTIVE so that our hospitals can continue to provide capacity as we go forward. I too am doing my best to lose weight and tell everyone I know to try supplemental vitamin D, because it is solidly known to aid the body in fighting back. Not everyone is aware of this supplement or of the way it works other than for bones and teeth.
And don’t forget having your MD test your D3 blood levels to vary your dosage. Even supplementation is frequently too low in northern regions and for all in the northern hemisphere winter months
@@bobedgar6647 Well, far too many Dr. are utterly oblivious to D. At best, they suggest 400 or a 'whopping' 800 iu per day as a 'healthy supplement.' Unfortunately, these dose are grossly insufficient if you are aiming for 'likely optimal' 25-D blood levels around ~50+ng.
@@geonerd yes, that was the intent of my comment. Blind supplementation is insufficient and potentially dangerous if using very high doses for extended periods. Having blood levels tested let’s both the patient and doctor know where they are 😉
I realise that the unvaccinated make an easy subject to pillory but here's a report out of Australia from the last day or so: "Devastated family and friends have reacted with shock to the death of a 23-year-old Australian man who had Covid-19, remembering him as a talented science graduate and sportsman.
James Kondilios, who was double vaccinated and had no significant underlying health conditions, died at St Vincent’s Hospital in Sydney this week. "
"Double vaccinated" means he had ~35% protection against serious Covid illness. A third or booster dose would have put him back up in the ~75% protection level increasing his chances of surviving the illness, but that is not 100%. No one fully vaccinated has 100% protection against Covid. Whereas, the unvaccinated deserve all the "pillory" society can bestow upon them. They're making this pandemic far worse, using limited resources and back-breaking healthcare institutions everywhere.
Maybe all the shots ruined his own healthy immune system? Just wondering?? Sad for this young man!!
Even if something is 95% effective in preventing death, that means five out of a hundred will still die. One death does not mean the vaccines don't work.
@@deborahfreedman333 I was really only looking at the number of people getting really sick. Just seems too many with all the vaccinated people plus I feel there will be unknown side effects down the road ( from the vaccinations). Just the worrying, wondering opinion of someone who is definitely not anti vaccine!!
@@donnamcmillan6950 No evidence covid shots ruining the immune system. The shots are nothing more than a "message" forewarning the immune system of something dangerous to come. Bottom line: vaccines save lives.
👍👍👍👍👍Another great podcast!! Thank you Professor and Dr Griffin!❤❤❤❤❤❤ (I really want to make some viral confections now! 😘)
What is the “vaccine vortex”? Did I miss this definition? (Rewound, rewatched for about 4 minutes unsuccessfully, but don’t have time to listen to entire video 2nd time now).
A vaccine emulsion prepared using the vortex technique is less viscous, and may have immunological consequences.
Can a link to the MMWR article referenced at 35 min mark, be posted here? I’ve cruised around the website and I’m not seeing it. Thank you so much
It's up now.
Search: Risk Factors for Severe COVID-19 Outcomes Among Persons Aged ≥18 Years Who Completed a Primary COVID-19 Vaccination Series
It's referenced on the TWiV website.
@@gribbler1695 found it! Thank you
Son vaccinated in March. Caught Covid between shots. Just had Covid now but very mild symptoms for two days. Can’t that 2nd infection act as a booster? On board with vaccine but he is 20 and very healthy. Just not sure for this age group booster is necessary esp after recent infection. Paul Offit recommended, as did majority of advisory Board, against boosters for everyone.
They think boosters will reduce the chance of variant infection in the short term. I dunno, all evidence I've come accross seem to indicate the reduction chance they come up with doesn't really matter in real world situations, tbh. Maybe big pharma is convincing governments to do it for extra money?
But if you're high risk vulnerable, I guess it's like flu shot for over 65's (or other reasons I suppose).
So why don't we have different protocols with respect to isolation of vaccinated Vs unvaccinated people? I'm triple vaccinated but got COVID with symptoms in Thailand - pretty severe for a few days. But we're expected to isolate for 10 days and not allowed to wash clothes. It's too much, no?
Not wash clothes ?
Why ?
@@laurier3348 Shared laundry facilities. The (evidence-free) fear is that SARS-CoV-2 will transmit via clothes.
@@davidcann8788 - use bleach
I'm quite surprised by your answer to one of the last questions and frankly very disappointed. While I love virtually all of the information provided, in the 56th minute there is a very specific question about pregnant women receiving a booster that is flat out dodged. It's this type of dodging and misleading answers to questions that galvanises vaccine hesitancy. An "I don't know" is far better than the straw man's argument provided. If there is an answer provided, then it's a flat out miss. To break it down: The question is for women who received 2 doses of an MRNA vaccine: should they be boosted in pregnancy? The question is NOT!- is there a benefit to pregnant women being vaccinated? (which is the question you answered). No person of sound argument would argue against this point, hence the "straw man" claim. There were potential specifics that were missed, such as maybe vaccination during pregnancy is superior to vaccination prior to pregnancy as greater acquired immunity is passed on, but after your answer I am unfortunately none the wiser as you never discuss the complications of the obvious question THAT IS... There is a diminishing benefit to receiving boosters as you have already received the improvement in fetal and maternal survival during covid and now have the potential for increased and unforeseen risk due to the additional intervention. Maybe more questions are better than one broad question. What benefits does BOOSTING provide given understanding of the obvious benefit of initial vaccination? What additional known and unknown risks are ensured through boosting, aside from the known low risk of initial vaccination? Given the narrowed risk-reward analysis, how would you interpret and recommend prospective mothers considering a booster?
Please know, I am no troll. In fact I'm a huge fan. My first introduction to your content was on a superb MedCram video...for which I never thanked you. For context, my question originated from a group of individuals using this specific "dodge" as an example of experts hiding the truth. I believe this to be far from the case. Please, Please respond.
I assumed he did not directly answer the question because it is not his patient and it would not be appropriate for him to make assumptions about her health history, risk factors, etc. Also, he is not an OBGYN and might not have enough data to make a blanket recommendation about boosters in pregnant women. Instead, he pointed to data that is clearly known and peer reviewed regarding the benefits of vaccination during pregnancy. I would say that the biggest benefit to getting a booster for a pregnant woman who is near term is that it would generate circulating antibodies that would be passed directly to the baby, as well as through breast milk after birth. If it has been more than 4 months since her last vaccine dose, those antibodies are likely not present in large quantities and I don't believe the newborn baby would have the same level of protection.
“People are dying of omicron, 2000 people some days.” Where is that data?
Hes just an instructor in Clinical Medicine and an associate research scientist in the Department of Biochemistry and Molecular Biophysics at Columbia. I'm sure he just made it up out of thin air
Well, I am assuming he wouldn’t come on here and pull it out of thin air. I am genuinely curious. That type of data would actually make me more concerned about omicron and I would like to check it out.
Hi Kyle. If you click on "show more" in the info section, you will find a link for the show notes. That link has all the links for where they get their data from.
@@chip9372 ... apologies, not sure if the 2000 figure specifically is in the first CDC link, but I assume you could find it there with enough sleuthing.
Have you ever heard of CDC data
Ethically would you be willing to have dr Robert Malone on your show
Malone is not a credible source.
@@christopherrobinson7541 why is he not credible? Oh no, is he a trumper.😔, thanks for your interest.
@@ethicsmatter2851 - he’s an anti-vaxxer and advocates the use of Ivermectin to treat COVID-19. In addition, he has spread many forms of misinformation.
@@Patrick_Ross thanks good to know
India rejected molnupirovir : teratogenic, mutagenic, also saying that men who desire to impregnate their wives should also avoid this EUA drug??
India is right. molnupirovir is mutagenic as heck, that’s it’s mechanism of action. The data presented to the FDA was a scandal, and I don’t think it should have been approved. But desperate people are easy marks.
@@UtahOwl both of you should dig a bit deeper and read some of the less controversial but more scientific explanation of how the drug works.
I’m tired of hearing it’s so mild, just like a common cold. I heard that someone I knew some years ago died of covid. It was a shock to everyone
Another good one. Thank you!
Sir - can you plz through light on -
1- how many antibody assays are made by any of the vaccine -
2- how many of them R actually neutralizing
3- against which variant
4- details of the claimed high antibody titer the companies claim visavis which of the assays.
5 - what exact form of spike is formed by any of these mrna or adeno vaccine - i hope the companies and any virologist can model - and then correlate with the antibody assay actually formed and reverse model the spike or AB
Most IMP - how many anti-ace2 antibodies are made in the process by these vaccines - refer to Dr Peter Daszaks statement - there can be 'no anitbody' against the china virus.
I wish people would listen to you guys instead of all the tools on the Joe Rogan Embarrassment. Sagan was surely right about the lowest common denominator taking over the public consciousness. Keep up the good work guys!
Thanks a lot for the update! It was useful. About the new O-variant of SARS-Cov-2 raised in South Africa: can it be because a lot of vaccinated persons also are immunocompromised due to HIV? And the virus is trying to avoid an immune response? Thank you
no
May be If ,,low temperature agglutinine occur,,at some patients ,avoiding hypothermia and using warmed oxigen at this specific patients, will be avoided micro erytrocyte agregation at low temperature at capillary level?
This presumption can explain some paradoxal effects of SARS COV2 infection.
They warned us about masking and mucking with science.
I find it funny that people like Fauchi and CNN now say let’s not focus on cases when a lot of people were saying this two years ago. So who are the experts?
Realistically we didn’t have vaccines or effective drugs figured out 2 years ago, so any cases were important back then, and now more just serious disease
Delta almost replaced by omicron talk about risk in omicron
"More transmissible less virulent"
But if doubling 2-3 days just by the meteoric rise more ppl will die than ever before, more people will get long covid, they will overwhelm heath systems by sheer consequence of meteoric rise in cases.
There's no hard evidence that it's less virulent.
@@skepticalbadger yes there is. ICU admission rates and death rates from the UK and South Africa. In the UK there has been a DOWNWARD trend in ventilation numbers for the last month. 7 day average of 891 a month ago v 7 day average of 875 now. Deaths in the UK have seen a slight increase, but only a slight increase going from a 7 day average of 112.1 to a 7 day average of 131.
In South Africa there was a small increase in deaths but that has now subsided. Nowhere near the level of deaths from previous waves and vastly more cases.
So yes it CAN be said this is less virulent.
Thank you