The Coagulation Cascade | Most COMPREHENSIVE Explanation
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- Опубліковано 8 чер 2024
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►👨🏫💊Antibiotics Lectures: www.medicosisperfectionalis.c... ... Check out my brand new "Electrolytes" course at www.medicosisperfectionalis.c... and use the PROMO code: ELECTROLYTES50 to get a 50% discount. The coagulation cascade is aka secondary hemostasis...Its main job is to convert fibrinogen into a strong fibrin meshwork that will trap the red blood cells and stop the bleeding.
These coagulation factors are beta globulins (vs immunoglobulins "aka antibodies" which are gamma globulins).
This secondary hemostasis comes after primary hemostasis (the temporary platelet plug)
Primary hemostasis is balanced on the dynamic harmonious antagonism between the smooth endothelium (that prefers laminar blood flow) and thrombocytes (which favor clotting and thrombosis).
Platelets are called thrombocytes "cells of thrombus".
The smooth endothelium is squamous epithelium that lines the blood and lymphatic vessels from the inside.
When platelets roll over the smooth endothelium, nothing happens.
But, once there is an injured endothelium, platelets adhere, activate and aggregate to form a temporary platelet plug (primary hemostasis).
Then, the coagulation factors are stimulated "thanks to subendothelial collagen, tissue thromboplastin and platelet factor 3), coagulation cascade ensues until fibrinogen is converted into fibrin fibers trapping the RBCs and forming a stronger thrombus (secondary hemostasis).
After that, fibrinolysis occur (thanks to tissue plasminogen activator or tPA) to destroy the clot and restore function and flow.
Hemostasis is defined as “cessation of blood bleeding”.
There are 2 types of hemostasis:
1. Primary hemostasis: formation of weak, temporary platelet plug (by platelets).
2. Secondary hemostasis: formation of stronger fibrin meshwork (by coagulation factors).
Get all of my notes and cases here: / medicosis
Check my full playlist on "bleeding and coagulation" here: goo.gl/Dt41Bg
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To be able to answer exam questions, Try to think of primary hemostasis and secondary hemostasis as two separate entities. 1ry hemostasis involves platelets and 2ry hemostasis involves the coagulation cascade. If you like my videos, please consider leaving a tip at www.paypal.me/perfectionalis/
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Trust me when I get into med school and finish my MD my salary is going for your patreaon account 🔥🔥🔥
Even when you explain it “like my professor” u explain it better looool
Wow 🤩
@@MedicosisPerfectionalis very true
What's your number
Someone pls give this man an oscar for best male actor for his 3:31 performance because it is exactly like my professors
Haha 😂
I couldn't agree more. I just saw a video from my instructor. Identical to 3:31. Medicosis is THE best!!!!
Ahahah -"blah blah blah go to hell" amazing
I've had so many "OHHHH so that's how it works" moments watching your videos it's crazy! Thank you for explaining the material so thoroughly yet easy to follow! Love your channel!
Thank you so much, Jackie!
Another mnemonic for PT & PTT for expression of extrensic Abd Intrinsic pathway is that
PT= Play Tennis >>outside door >>extrinsic pathway
PTT=Play Table Tennis >>inside >>Intrinsic pathway 🎾🎾🎾
Foe answer I think the entire of tube is like blood vessel wall
I like the mnemonic 👍
following on - could have PTT = play table tennis - indoors - intrinsic pathway!
Yup 👍
This is from Osmosis thanks for sharing
Med student here. Your way of sharing knowledge is the best for me! You must be a great doctor and teacher. Please upload more videos, they're literally saving me..😭
I am honored 😊
I never knew I could laugh while studying coagulation cascade , cheers to you sir !
Thank you 🙏
" Let me explain like your professor" --> # Sleeping mode on
😂😂😂
Oh god why is that so true 🤣🤣🤣🤣🤣🤣🤣🤣🤣🤣🤣🤣🤣🤣
Haha 😂
Lmfao i cant stop laughing on that part. 😂😂😂😂😂😂😂😂😂😂😂😂 i literally replay it to get a laugh. N i now know d cascade😂😂😂😂😂😂
I actually got that lol
"Let me explain it like your professor "
me : *having intense flashbacks"
Haha 😂
This is hilarious 🤣
👋 Hey! Did you like Messi being part of the coagulation cascade?!
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Warning ⚠️ : Some of these cases are really difficult...Not for the faint-hearted 😱
Plz answer my other questions also
Always thought of the cascade as something I could never learn and only cram it. You've solved my problem. Thank you.
You’re very welcome!
You definitely deserve a millions subscribers. I’ve tried to study the coag cascade so many times and never really could until I watched your videos. Thank you thank you thank you!!!
My pleasure 😇
Brilliant! Blood clots when it touches the glass tube and factor 12 is activated
Yes!
Your delivery is so efficient, precise and entertaining. A refreshing channel.
You're awesome! When you said, pause the video and try to repeat it yourself, I was surprised that I could do it without stoping at any point to memorize what you were saying. Thank you so much!
ive been trying to learn this but i really couldnt to the point that i lost motivation and stopped studying for weeks but you really made it look very easy and simple you are a life saver thank you !
Wow 🤩
Thank you 😊
I’ve been a Medtech for 10 years and I think this is the first time I remember every step of this damn cascade great job 👏🏽. Ive always heard it explained like your example of a professor. I’m pretty sure “go to hell”was said also.
Haha 😂
I think I will finally remember the coagulation pathway. Thank you so much. Every time this topic comes up I feel like I have to relearn it because it never sticks. You are a savior!!!
Thank you 🙏
In vitro factor XII is activated by substance such as glass kaolin and ellagic acid .
I am amazed by this explanation! Thank you so much! I admire people who understand the material so deeply and can explain it to anyone in such easy way! I am so grateful for you sharing knowledge with me!
great explanation. I could never remember the coag pathway and after spending 20 min watching this video I feel like I'm now an expert. thank you!
My pleasure 😇
No one could ever ever lighten the heaviness of such a crazy subject like you did. It was awesome thanks a lot
Thank you 😊
Struggling med student from Malaysia.. And you're the saviour 😭😭.. Thank you raised to infinity
My pleasure to the infinity and beyond (Toy Story) 😂
The amount of knowledge and concepts that I've gotten by watching this video is so much fun and amazing than my 1hour 35 min lecture.love your channel
Thank you so much ☺️
Medicosis never disappoints. Thanks!
You’re always grateful 😊
Thanks 🙏
That's was marvelous !!! ... you just wrote these in a stone.. I'll never forget it... thanks
Our cerebral cortex needs logic, our limbic system requires emotions...This video has both 😉...Sorry, I am exaggerating a little...Thanks a lot...You made my day!
I just finished our presentation today! I understood coagulation cascade through this
Your ability to effortlessly demystify complex medical concepts is truly remarkable! I am always left astounded at the level of dedication and hard work you put in every video
Your commitment shines through each lesson, making learning an absolute pleasure. Wishing you boundless success as you continue to illuminate and guide us through the intricacies of medicine!
this is incredible!! I totally understand it all now. You took something that seems so complicated and made it so simple!! Thank you!
Awesome as always!! And the humorous way u teach is fab..thanks for making our learning experience better...
Thank you so much ! What I couldn’t understand my whole medlife … you just made me not only understand but also remember this for life !! 🙌🏻
Thank you 😊
I've been stuck on this subject for a while, but this actually makes sense!!! Thank you!
My pleasure 😇
Thank you so much for watching!
SO SO SOOOO GLAD I CAME ACROSS YOUR VIDEOS BEFORE EXAM! Kept me interested in your videos since the second I started! Telling all my medschool friends to subscribe and benefit! 👌🏽👌🏽
Thank you so much 😊
I’ve been a Medtech for 10 years and I think this is the first time I remember every step of this damn cascade great job 👏🏽
Thank you so much!
I appreciate you!
Amazing!
Being trying to learn this for 30 years!
You finally cracked the case
Thanks 🙏
I am honored!
Can you please help me by sharing?
So grateful for your content. Please keep making them!!!!! You are a life saver
Thank you 😊
MEDICOSIS YOU ARE AMAZING!! Med student here, your videos have made me enjoy studying medicine!
I love the way you put all the information in order and give a complete picture about the topic ❤ genius ❤
Thank you so much!
Thank you so much. I use your channel for almost every concept I come across in school.
Awesome 👏
Thank you so much 😊
Can you please help me by sharing?
Really helpful! thanks
Answer: the intrinsic pathway can be activated when the blood is in contact with a surface different from the vascular endothelium.
If an injury occurs, the blood will be in contact with the SEC, but if it is placed in a test tube ( made of glass), the cascade can also be activated.
Excellent, but there are 2 additional reasons.
@@MedicosisPerfectionalis other than the contact activation system?
Yes!
What are 2 diff reasons?
Medicosis Perfectionalis what are those two reasons😔😔?
This will be great for my next semester! Thanks medicosis!!
My pleasure, dear 😊
I know now that I have been made to think I would never learn Haematology by my professors. You sounded just like them in that bit. Traumatic flashbacks ensued. Thanks for righting that wrong and congratulations on your outstanding teaching skills.
Thank you 😊
Your videos are fantastic! Really helped me get through medical lab tech school. Thank you for sharing your knowledge.
My pleasure 😇
actually I loved how you delivered the information to your watchers >>> u are amazing >>> keep going
You’re welcome >>> Thanks for watching 😊
The best vid I’ve ever seen on this topic. Well done ❤
If anyone has not understood coagulation by now - and that is thanks to Medicosis' playlists - there is no hope for them! 😁 I'm a post-graduate (MD) working in science and your videos are really great for revising, because when you specialize in certain fields, the brain begins to neglect others. But your sense of humor makes one remember the facts of even the most boring topics. Thank you for your time and your work. 😊
You’re very welcome 😊
Thank you so much for watching!
Good luck with your career!
@@MedicosisPerfectionalis Thank you very much and all the best to you, too!
You just earned my subscription, that was awesome! Very well explained
Thank you 🙏
This has to be the best youtube channel ever!
Thank you so much 😊
"Use your prefrontal cortex for heaven seck" I'm dying laughing
Haha 😂
Thank you so much this was extremely helpful!
My pleasure 😇...Happy to help :)
Simple illustration. Straight to the point. thank you very much for this great job.
My pleasure!
Awesome Thank you! Loving your videos!
This video is not boring. Telling stories while explaining is a wow!....
Thank you!
you made it verrrry easy!! thank you so much
My pleasure 😇
Luuved this soo much! Lifesaver ! Never understood it this well ! Thanks so much 🤓🤓🤓
How come you explain something so good? I dont know how many times I read this but this never stayed in my memory! Now I believe I will remember it for a long time!
THANKS
Thank you so much, dear :)
I am so honored 😊
So, are you a student?
@@MedicosisPerfectionalis Yes, I am! :)
Perfectly explained! Thank you!
My pleasure!
Thank you for your videos, they help me a lot. From Roumania to you sir, my respect!
😍😍
Thanks 🙏
Now I'm addicted to your videos ❤️ such a nice explanation.. can't believe that I could understand the cascade within the very first time 😃
Thank you so much!
Always come to the rescue! thank you. I take my NAVLE soon and the coagulation cascade was always "almost there", now i can draw it and remember what is going on at all steps, thank you!!!
You’re very welcome 😊
Good luck 🍀
Thank you sir for your amazing and clear explanation! Saved my life!
Thank you so much ☺️
god... i love this guy... hes so witty while being super informative. You really helped me use my prefrontal cortex today. LOL ... this is after two years your video was posted! and I love messi too!!
Thank you so much ☺️
I appreciate you!
Bless you, saving one med student at a time. Also, your humor is 🔥 !!!
Thank you so much, Alondra!
This is the best explanation ever
I can't believe that I finally understood the coagulation cascade 😂
Thank you so much you are our hero ❤
I am blushing ☺️
Thank you so much 😊
This is awesome! Love all your videos!
Thank you so much 😊
Whole blood is added to a test tube containing an activator called diatomaceous earth (celite) or kaolin. This activator augments the contact activation phase of coagulation, which stimulates the intrinsic coagulation pathway.
Amazing explanation! Thank you so much! Greetings from Ecuador 🇪🇨 👋🏼
Welcome Welcome Welcome ☺️😊😃👋
Great lecture. That was amazing! Thank you.
My pleasure!
Excellent explanation! You save another soul🥲
Thank you so much! Watched 10 videos before this and you made it really easier to understand!
My pleasure 😇
Thank you so much for watching!
@@MedicosisPerfectionalis so much sense when you said the after and before 10! So simple but so genius in memorizing the sequence.
Thank you 😊
thanks. I really love your videos!!
My pleasure 😇
I was cramming a presentation on andexanet alfa and dreaded revisiting the coagulation cascade. You just saved my life. Thank you.
Glad it helped!
I am honored!
And here we have, my friends, another perfect video about a complex subject made simple. Thank you, Egypt, for this son of you.
been waiting for thiiiis, thank youuu. Will you ever do a few videos on microbiology ?
Yeah! But not now!
You are amazing please keep up the great work I can't wait to start working to donate to your amazing work! Funny and informative
Awesome 👏
Thanks 🙏
You can mark your calendar for a year from now, and when you’re financially stable, you can support my channel at www.patreon.com/medicosis/ ...No pressure, of course...Thanks for your kindness 😊
@@MedicosisPerfectionalis definitely
يعطيك الف عافيه
Thank you. I learned so much
Glad it was helpful!
Thxx alot this helped alot in understanding this topic. U made it easy
I am honored, thanks 🙏
How can you make everything so smooth and easy? you're an angel Sir and you deserve the world
Thanks a ton!
Answer: the blood comes into contact with the SEC on it's way out through the needle into the tube. Since the pathway is slower it takes longer to coagulate but it was triggered initially during the blood draw and just continues in the tube.
I would disagree. The eye of the needle goes straight into the blood vessel, so there will be no contact between the blood and the SEC. I think the answer is that the factor XII gets activated by contact to the glass wall of the tube.
@@medicaluser5833 but how would contact with the glass wall activate , its not something from inside of the body.
@@mennaelhamy402 the test tube glass kaolin, Celite, silica helps to activate Xll
This is AMAZING!!!!!!!!! Thank you so much
My pleasure 😇
Omg! This the Best explanation ever!!! Thank you
You’re very welcome 😊
Many amazing videos on this chanel but this one is on another level 🔥
just came across your website,super dope! biomedical and lab science major.will definitely direct my friends..you are the best.
Thanks, bro 😊
I am honored!
Your videos are saviours. Thank you so much ❤️
My pleasure!
I just love the way you teach.❤️😍 I’m actually enjoying physiology and kind of addicted to your videos.. congrats..
Thank you 🙏
Thanks a lot for the spectacular videos !!
My pleasure 😇
So nice show.
I watched many videos but all of them were difficult. Now it's clear.
Very thankful to u.
From Sudan 🇸🇩
My pleasure 😇
Pathophysiology and pharmacology combined in one course are more toxic than ever! This is a heaven sent from above for me right now including sarcasm and jokes are the best and cracks me up everytime!🤣 Amazing youtube channel for health care professionals simplified like a pro! Kudos!!!👏🏼 Really worth sharing without a doubt!!!😉
Thank you so much, dear 😊😊
It’s my pleasure 😇 and honor to help!
Good luck 🍀
Please let me know if you have any questions!
You’re awesome! Thanks for the valuable presentation and knowledge.
My pleasure!
one of the greatest blessing in med school is finding this youtube channel fr
Thank you 🙏
Wow. I have never understood this better than now. Thank you medicosis
My pleasure 😇
this video made to easily understand coagulation cascade.. thank you I've understand coagulation cascade now
شكرا جزيلا، نفع الله بك وبارك لك في علمك
🙏
MLS studnt here...
Wow...amazing
Thnks a lotttt....never frgtable
Pls upload more & more all sub under heamatology
Thnk uuuuuu
Great explanation! You have talent 😊
Thank you so much 😊
Oh my god, do professors all over the world explain it the same way? I'm dying of LAUGHTER!! Best Actor is for you
Thank you 😊
You guys are amazing thank you so much for this explanation 👏🏻👏🏻👏🏻♥️
My pleasure 😇
It's just amazing channel, help me a lot and the explanation it's super easy and informative, THANK YOU SO MUCH.
Thank you 🙏
شكرا لك عن جد فديوهاتك ممتعة وجميلة وأنا كطال طب سوري بفتخر أنك انسان عربي ومصري مبدع .. ألى الأمام وتستاهل كل الخير :)
Thank you so much, bro
مصري؟ بجد؟
بجد
Great video... Absolutely fantastic explanation, I finally got it! Thanks so much, really appreciate it! Nobel price for you! You are genius!
Thank you so much, Martin!
I'm preparing for my biochemistry exam at medical school and coagulation was terrifying for me, but your videos are absolutely stunning. Thanks once again for saving me!❤️