I love this format, Sally! You're a skilled interviewer who does a great job of translating terminology for the viewer whilst keeping the pace of the conversation steady. It's also great to see a casual conversation with a scientist which not only clearly explains the science behind their work, but also provides an insight into their research methods and day-to-day life. A+ science communication! - Ross
+At-Bristol Science Centre Thanks Ross, those are really really lovely comments :) It was certainly a challenge including science, practical aspects and personal life!
It was nice to meet your biology partner in crime lol. Who ever did the drawings deserves some praise. I'm a visual learner haha and it made a notable difference :)
Do you have to go through some kind of dexterity training to be able to pick microscopic stuff up with that platinum wire? I can't imagine having the ability to do that with my shaky hands!
+James Allen You don't train per se but you definitely improve with practise. That said, some people are naturally better than others at fine motor skilled work like microscopy.
I do the same with PCB's repairing the components and copper traces. It just takes practice. Even if you do shake you learn to move within the shaking to do what you need to. Of course what I'm doing the targets aren't moving around but I'm working with a 500F iron or heat gun. Is it the same with moving objects under a scope?
This was really good.If you can then please make more videos where you talk with your friends about some of their recent research in their lab. Maybe follow this up with some questions and answers as I imagine there will be many good questions. :)
My friend just turned in his Masters Thesis today, and my job on it was to entertain him, through the long days and nights in the lab, while he was counting pieces of bugs and insects in sediment samples. So i kinda know how much you needed those Pretty Little Liars :) I was streaming me playing games, and we would chat during. Great video and info, on some much needed science. We can't you throw antibiotics at everything, and hope for the best.
I have trying to simulate a c-elegans worm's brain using machine learning since its neural connectivity has been mapped with amazing detail. This is SO AWESOME to see it being used for antibiotic research!
It's so strange to see someone with so many PhDs and who is obviously so intelligent watching Pretty Little Liars - not because it's low brow, but because it's normal. I sometimes forget that scientists and researchers are ordinary people with lives beyond labs and libraries. I never even considered it, but of course they have hobbies, loved ones and lives of their own. It's nice to be reminded that humanity is universal like that. And the research itself is pretty fascinating, too.
I'm jealous of Suzie's work. Was reading her other paper last weekend. If she wasn't so nice it would be easier to be envious of her cool model. If you get a chance you should see if Kayla is happy to talk, her work is awesome.
I see! I thought you meant someone else had covered this paper (which would have been impossible since it was only released this morning!). What an interesting story. People are already starting to use good bacteria to treat infections (faecal transplants, vaginal swabs after C sections) so it's interesting to hear another case of that. The research in the video is the first scientific evidence that one strain of bacteria will evolve a new strategy to become less harmful in the presence of another. People are certainly taking this seriously in the medical field - it's a rapidly growing area of research, particularly because of those exact medical applications he described.
I feel for Suzie, when I did my MSc, I read the entirety of the first game of thrones book, while I waited for a machine to ping every 15 minutes. Lab work sucks sometimes.
realy interesting topic :D but one question. you said that the worms were great models, is it only because you can test multiple generations very quickly or are they in some way similar to us aswell? Another question. wouldn''t relying on the good bacteria kinda be counter evolutionary, since you'd be relying on an other lifeform instead of evolving own immunity?
ricardo rodrigues C. elegans (the worm) is a good model because they reproduce very quickly and as a common model organism we know huge amounts about them already. E.g. We know how many neurons they have. 302 neurons if you are curious. Plus, they fit the needs and restrictions of the experiment. As for your second question, evolution works with what is already in the environment. Bacteria, like any competing species, evolve to get more resources than the other. Your body is no better off building a system that already exists in bacteria that are already in your gut. Plus, such a system would probably require a lot of mutations to operate properly, so it would have taken a significant number of generations, which is why bacteria are more likely to have it than humans, faster reproduction. Plus, humans already have a generalized system for dealing with germs, your immune system.
It's along similar lines that we often see MRSA and similar resistant bacteria reverting to their pre-resistance forms given a number of generations in the total absence of antibiotics. They give up certain advantages for the greater gain of surviving the chemical resistance. Sadly, we have, by our overuse of antibiotics and careless application of them where they are necessary, created monsters that aren't really the type of gribblies that we can just allow to revert on their own time :(
+mrsanity I actually had to cut our chat about antibiotic misuse and how killing everything indiscriminately leaves behind an empty space for another opportunistic disease to take over.
Recently i have heard a few things about an amazing microbe that could be used to recycle carbon in space and all these great things like producing different kinds of oils for basically all kinds of products that used refined oils, such as plastic, cosmetics etc., but i have also heard that this bacteria can reduce the amount of time it take to grow plants, and by that i mean from days, weeks, months to hours and i'm wondering if there is any truth to it. They were hydrogenrotrophs. the big thing here is the reducing the time to hours i find hard to believe, now i don't know how it would effect plants but cell division at that rate would be dangerous wouldn't it?
Also I can't imagine how mind numbing it would be to crush down microscopic worms, awesome job to Suzie for coming through with this break-through! (I like how the "good" bacteria kills and steals haha)
Oh to have friends that store poo bacteria in their freezer! :) How could we get you (both!) to our STEM festival next year? Do you have people our people can speak to? Maybe we need to get people first...
I love this format, Sally! You're a skilled interviewer who does a great job of translating terminology for the viewer whilst keeping the pace of the conversation steady. It's also great to see a casual conversation with a scientist which not only clearly explains the science behind their work, but also provides an insight into their research methods and day-to-day life. A+ science communication!
- Ross
+At-Bristol Science Centre Thanks Ross, those are really really lovely comments :) It was certainly a challenge including science, practical aspects and personal life!
It was nice to meet your biology partner in crime lol.
Who ever did the drawings deserves some praise. I'm a visual learner haha and it made a notable difference :)
+Allan Locke You're welcome, glad they helped!
"We're all smart. Distinguish yourself by being kind."
1) Be kind
2) Talk to each other
3) Take pride in our comments section
I would like to answer something deep and witty to underline your statement, but ... first.
Do you have to go through some kind of dexterity training to be able to pick microscopic stuff up with that platinum wire? I can't imagine having the ability to do that with my shaky hands!
+James Allen You don't train per se but you definitely improve with practise. That said, some people are naturally better than others at fine motor skilled work like microscopy.
I do the same with PCB's repairing the components and copper traces. It just takes practice. Even if you do shake you learn to move within the shaking to do what you need to. Of course what I'm doing the targets aren't moving around but I'm working with a 500F iron or heat gun. Is it the same with moving objects under a scope?
This was really good.If you can then please make more videos where you talk with your friends about some of their recent research in their lab. Maybe follow this up with some questions and answers as I imagine there will be many good questions. :)
True friendship is letting your friend wear the only lavalier mic XD
+Maxwell Shin XD
My friend just turned in his Masters Thesis today, and my job on it was to entertain him, through the long days and nights in the lab, while he was counting pieces of bugs and insects in sediment samples. So i kinda know how much you needed those Pretty Little Liars :) I was streaming me playing games, and we would chat during.
Great video and info, on some much needed science. We can't you throw antibiotics at everything, and hope for the best.
OBSESSED with your channel
Wow, you two have amazing chemistry. I'd love to see the two of you discuss biology more often!
I have trying to simulate a c-elegans worm's brain using machine learning since its neural connectivity has been mapped with amazing detail. This is SO AWESOME to see it being used for antibiotic research!
It's so strange to see someone with so many PhDs and who is obviously so intelligent watching Pretty Little Liars - not because it's low brow, but because it's normal. I sometimes forget that scientists and researchers are ordinary people with lives beyond labs and libraries. I never even considered it, but of course they have hobbies, loved ones and lives of their own. It's nice to be reminded that humanity is universal like that.
And the research itself is pretty fascinating, too.
+The Madhouse Thanks! I deliberately kept in the bits like that to do just that, so it's really nice to hear it made an impact :)
Sally Le Page Well, it certainly worked. I'd say "keep it up", but I'll leave you to decide how you carry out your videos.
I'm jealous of Suzie's work. Was reading her other paper last weekend. If she wasn't so nice it would be easier to be envious of her cool model. If you get a chance you should see if Kayla is happy to talk, her work is awesome.
+JimTheEvo Have the two of you never met? You'd get on really well :)
Nah, we've met a couple of times, she's great!
As a girl of physics (and one of the few in my class) it's great seeing girls in science!
+mia Bevilacqua Woop woop!
Thanks for the awesome video; it was really interesting.
+Uk Gamer You're welcome :)
Congrats on the publication!
StormCloudsGathering scooped you on this one, but it was great to hear more about the mechanisms involved. Cheers!
+B Will Can you send me a link? I literally published this video as soon as the embargo was lifted!!!
I see! I thought you meant someone else had covered this paper (which would have been impossible since it was only released this morning!). What an interesting story. People are already starting to use good bacteria to treat infections (faecal transplants, vaginal swabs after C sections) so it's interesting to hear another case of that. The research in the video is the first scientific evidence that one strain of bacteria will evolve a new strategy to become less harmful in the presence of another. People are certainly taking this seriously in the medical field - it's a rapidly growing area of research, particularly because of those exact medical applications he described.
Always interesting to hear about peoples research!
Excellent information, ty
"Wow, science is super glamorous" Dr.No-one, ever.
I feel for Suzie, when I did my MSc, I read the entirety of the first game of thrones book, while I waited for a machine to ping every 15 minutes. Lab work sucks sometimes.
+Remy LeBeau I listen to podcasts only when doing lab work and boy have I listened to a lot of podcasts!
Sally Le Page was that how you found Rooster Teeth?
+Remy LeBeau No, I had never heard of them! They were part of the promotional/publicity for my work with GE and then I kept in touch.
Sally Le Page Very lucky. And now you get to answer all the crazy questions Gavin and Chris can think of.
Laptop in a bio-lab?! My lecturers would be FURIOUS! But thanks, possibly my favourite video of yours so far!
+Clem "The Stamina" Carter They have a UV lamp in their lab to sterilise anything they take in, including laptops
Suzie it could be less virulent for nematodes but in human it could be homologous recombination but you did great job i have many question any contact
i studied genetics, and i love research! i loved the idea! make more videos like this, thanks :)
Oh my god the "whateverivore" edit.. SO GOOD! =D
realy interesting topic :D but one question. you said that the worms were great models, is it only because you can test multiple generations very quickly or are they in some way similar to us aswell? Another question. wouldn''t relying on the good bacteria kinda be counter evolutionary, since you'd be relying on an other lifeform instead of evolving own immunity?
ricardo rodrigues C. elegans (the worm) is a good model because they reproduce very quickly and as a common model organism we know huge amounts about them already. E.g. We know how many neurons they have. 302 neurons if you are curious. Plus, they fit the needs and restrictions of the experiment. As for your second question, evolution works with what is already in the environment. Bacteria, like any competing species, evolve to get more resources than the other. Your body is no better off building a system that already exists in bacteria that are already in your gut. Plus, such a system would probably require a lot of mutations to operate properly, so it would have taken a significant number of generations, which is why bacteria are more likely to have it than humans, faster reproduction. Plus, humans already have a generalized system for dealing with germs, your immune system.
Is this one reason antibacterials are probably not a good idea?
+James Tuvell YES! Antibiotics aren't specific - they kill everything. So you can be left with a vacuum in which an even worse disease can take hold.
finally a science video.
It's along similar lines that we often see MRSA and similar resistant bacteria reverting to their pre-resistance forms given a number of generations in the total absence of antibiotics. They give up certain advantages for the greater gain of surviving the chemical resistance. Sadly, we have, by our overuse of antibiotics and careless application of them where they are necessary, created monsters that aren't really the type of gribblies that we can just allow to revert on their own time :(
+mrsanity I actually had to cut our chat about antibiotic misuse and how killing everything indiscriminately leaves behind an empty space for another opportunistic disease to take over.
Really interesting! especially for aspiring biology students like myself :)
I KNEW microbes like candy too! I mean, who doesn't?
Recently i have heard a few things about an amazing microbe that could be used to recycle carbon in space and all these great things like producing different kinds of oils for basically all kinds of products that used refined oils, such as plastic, cosmetics etc., but i have also heard that this bacteria can reduce the amount of time it take to grow plants, and by that i mean from days, weeks, months to hours and i'm wondering if there is any truth to it. They were hydrogenrotrophs. the big thing here is the reducing the time to hours i find hard to believe, now i don't know how it would effect plants but cell division at that rate would be dangerous wouldn't it?
great video girls and really interesting.
Sally how have you got your name in the replies to be blue with white writing? looks really effective
Paul
Thanks! It's a new feature on UA-cam - the video creator's name is highlighted when they comment on their own videos.
So if I eat more yogurt I'll never get sick?
Yay science!!!
Also I can't imagine how mind numbing it would be to crush down microscopic worms, awesome job to Suzie for coming through with this break-through! (I like how the "good" bacteria kills and steals haha)
Hurray for C.elegans! :)
+Dr Mike Hip hip...
Hurray!!
You can retire now Neil DeGrasse Tyson. We have an upgraded model - Sally Le Page ;-)
Oh to have friends that store poo bacteria in their freezer! :) How could we get you (both!) to our STEM festival next year? Do you have people our people can speak to? Maybe we need to get people first...
"Shed science"? Nice "shed" you have there
Caimbridgshed
That sweet voice.
:)
I feel awful while watching your videos. What have I done with my life?