Regulation of Gene Expression: Operons, Epigenetics, and Transcription Factors
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- Опубліковано 14 жов 2017
- We learned about gene expression in biochemistry, which is comprised of transcription and translation, and referred to as the "central dogma" of molecular biology. But how is this process regulated? How does a cell know which genes to express and when? Well it's pretty complicated, but let's just get our feet wet by looking at operons, epigenetics, and transcription factors!
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There should be a UA-cam university and all the best UA-cam Professors should teach there. You Sir would be one of them.
Agreed
agreed
disagreed, he didn't mention one protein/one gene
I'm sorry he did give example of genes but it hardly scratched the surface of different regulation of gene expression, where are all the lncRNA, miRNA, siRNA, different histone deacetylases and (de)methylases, cytosine methylases. No mentioning of tissue specific promotors, I don't know it just felt like a lot was missing
@@alexdeschipper it's an introduction to the topic.
This is truly amazing how complex notions can become so easy to understand when clearly explained. I’m grateful for your channel. Lots of love from France.
Je suis aussi français et je suis totalement d'accord ! (I'm French as well and I wholeheartedly agree!)
Parfaitement d’accord!!! C’est dommage que l’on est pas des aussi bonnes vidéos en français , il faudrait se mettre à la page
Pareil mdrr
Hey everyone, at 9:34 I drew a methyl group under the word acetylation and an acetyl group under the word methylation, sorry for this ridiculous error! Please correct in your minds. Oh also, I've been informed that at around 1:50, even though the labels have disappeared by that point, I previously marked the mRNA as 5' on the left and 3' on the right, and ribosomes read mRNA molecules 5' to 3', so technically the ribosome should have translated the mRNA left to right. Sorry for that small error as well!
thanks for the correction
no forgiveness 😤
you are too good.......I understood that mistake by see that. but you are too responsible.....I have no words to thank you!! GOd bless you!!!
ok daddy
I am too much pleased after hearing your lecture.Thanks sir.
I'm literally coming here from Khan Academy--thats how high calibre you are of an educator. To be fair, the KA video I didn't like was a one-off, as generally they are pretty good. If anyone is wondering--watch this video by Prof D instead of "Regulation of transcriptions" in the KA MCAT>Biomolecules>Gene Control.
You just helped me survive my O. Chem final.... now I'm discovering you cover my Genetics final too. Just... wow.
Thanks alot Professor Dave. Your teaching videos are not just clearing the concepts but arousing the curiosity to learn more about the topics.
Wow! I was not looking forward to even this 13 minute clip. But, WAS I WRONG. Your presentation is by far one of the best. Again, most of us are visual learners and the animation along with your teaching was spot on and kept me interested and rarely was I lost or confused. Thank you so very much!
Professor Dave! I have been watching your videos for at least a year now. You got me an A- in Gen Chem 2, are currently helping me ace Organic Chem 1, and microbiology! THANK YOU. YOU ARE THE BEST
You seriously CAN'T IMAGINE HOW MUCH I LOVE YOUR YT CHANEL. OMFG, SUCH A GOOD, "FRIENDLY" (easy to understand) AND YET ACADEMICLY SUFFICIENT CONTENT, WOW!
Im an instant new sub, keep up the excelent work!
Awesome video. Very clear and to the point. Ive been watching a lot of videos trying to wrap my head around this stuff -- this video made it stick.
I was interested in diet and people used to talk a lot about insulin metabolism at first, now I'm learning about genetics and gene expression because of research I did into the keto diet and its histone deacetylase inhibiting qualities, thank God for the internet and people like you Professor! I never really liked school but I do love learning with a passion.
Learning with passion is all you need!
YOU, prof Dave, are an AMAZING teacher. Thank you so much for your videos that I will be binging as a novice neuroscience major!!!!
This was very short and precise. I understand clearly all that he said more than how my professor taught it. Thank you professor 🙏🏽 🤗
Professor Dave out here saving my A Level Biology grade amen
Ugh so I took Gene expression this past fall and had to drop because I refuse to get a C in the course so I’m retaking it this spring. I so wish I found this video before because I honestly had no clue what was going on in the class, but this has helped me organize the concepts so much better! Thank you so much.
hands down this is the best video on youtube of this subject man
You explain so easily that even if i don't know english very well i can understand you AND the topic. Incredible thank you
bless this man and his plaid
yes
thank you so much professor dave, you made it in a very simple explanation!
This is one of THE BEST biology videos on UA-cam!
Thanks and Plz give this professor a nobel prize for making this vedio ❤️
thank you so much~~~
This video had a lot of the details I needed to review :)
this explanation was so great thank u professor
thanks professor Dave ! u made my nightly study session a lot more endurable
Thanks for the video. Much more direct and concise than KA. Exactly what I needed for quick review on operons for the MCAT.
What is MCAT ?
Sir u are brilliant and fabulous explainer of concepts .Thanks a lot May God bless you and keep making such videos. 😚😚
This is super helpful, but it would be even more helpful if you put in the corner which organisms these concepts apply to, since some of these only happen in bacteria and others in eukaryotes, and still others in both. This is something that confuses me all the time, so if you make more videos along these lines in the future, that would be very informative!
Another wonderful session, thanks a ton
professor Dave you are a best teacher for chemistry and biology thanks for your efforts
i enjoy your lessons alot as they have been so so helpful..keep it up
this is an absolutely wonderful video specifically, thank you so much. you have no idea
You’re an amazing teacher, thank You so much. 👌🏻🙏🏻🙌🏻
Your video is so great! Thank you so much!
Wow this cleared so much up. Thank you!
This guy and AK lectures have saved my from my profs reading slides and calling it teaching
Just found your channel and I absolutely love it! Very in depth videos for real science geeks! Subbed and liked!
Excellent explanation, thanks again.
Beautifully clear. Thanks
This is the first video I’ve watched in your channel and the opening credit had me in stitches 🤣😂🤣😂
I love biology and chemistry
A big fan of you sir !!
Your video tutorials helped me a loot
❤
This is an excellent review!
You're a great professor, your delivering techniques with clear expressional pictures makes it easier to understand things. But also suppose you're teaching someone who's being introduced to a topic the first time, you know, not to super summarize scientific concepts.
God bless you professor, thank you for your presentation.
Wow! wonderful teaching Prof. Dave! More than in a University.
Thank you very much for your brilliant explanation.
Thank you so much this video really helped!!
this video is extremely helpful, thank u very much
Awesome video! Only thing that it had acetylation with a methyl group and methylation with an acetyl group. Minute 9:38
THis is explained soo good omg
Bless ur soul professor dave
Thank you professor. You got subscribed
Very nice video....easy to learn
You are my secret weapon when it comes to study. :-D
Very helpful video!
Great video!
Very well explained!!!!
*I love it that this video is exactly whats in Campbell*
This is very helpful. Keep it up! You just got my sub :)
Best explanation.
you're awesome! thanks
Great work as always Dave ! A small mistake: at 1:50 translation is happening in the wrong direction, it should start at 5’
?
Yes, this is driving me nuts also. Translation starts from the 5' end with the methyl-G cap, then the mRNA feeds through the ribosome and finally the 3'-poly-A tail end comes out.
But shouldn't it go in the opposite direction. Because on the "parent" strand its 3-5 but building the opposite so thats 5-3
RNA is single stranded 🤨
Thank you for this!
excellent prof
Nice expleined, thanks.
Awesome video!
I've graduated HS and passed the need to study these (taking econ in college) but i still remain loyal to watching dave
thanks professor dave easy to learn 😃😃😃😃😃
thankyou for the explanation
this is help me a lot. amazing
Brilliant!! Thanks for this 🙏🏽🙏🏽🙏🏽
yeah
Why you explain it so much better than my textbook..
Really perfect explanation! I have a question, so only e.coli has operator to turn gene transcription on\off, is there also operator in human?
thanks so much..it was usefull for me
More of these please
Thanks Proff.
13 minutes beat 3 hours on the official AP course.
sorry sir i have a problem
In an operon, the location of the regulatory region occurs before, within or after the structural genes.?????
just loved it, such tough concepts explained cleanly ! bless professor Dave
Amazing sir..💖❤
I have a question professor.. If we can find and block transcription factors in some way which are activating proto oncogenes then its a possible way to supress tumours?
you're the best professor !
yeah
there is a minor error in this video: at 9:37, you color coded the three groups, but they are not properly matched below.
The methyl group should be green, and the acetyl group should be red
ah man what a dumb error! thanks for catching that.
Yeah it may be alot of work to re animate the video, but you could put an annotation with the correction
I’m literally an idiot and I understood this just fine omg dont forget your hat king 👑 😌😌
I think it is very important education providers like yourself be very honest, accurate and portray scientific findings exactly how they are presented in journals and not exaggerate or distort them in any way such as what has been mentioned here at 3:28
This is not what the literature is saying, there is on going debate in this area of research, how are you able to make a concluding statement like this with such confidence? when there is division between those currently researching in this area? You need to word this video more accurately to reflect the literature more honestly
Professor kindly you may help me how to identify TF of my gene sequences or TF of my genes motifs
Thank you so much
Is transcription a controlling factor in enzyme production for translation or transcription itself??
good one
i pay my college to teach me but i always ended up on youtube because of some or so many reasons
Well done
At 9:37 the func groups for acetylation and methylation are placed in wrong order please do notice
I have a question, when I saw the animation about the spliceosome, when the introns are removed, and only left exons, when the exons are combined, is it forming a cistron?
The alternative name of Gene os cistron . Today we don't use the term Cistron ..we now use Gene
thank for saving me
I am pretty sure I learned recently that methylation silences genes, esp with the formation of methyl bound domains and CpG islands from a khan academy video. So I don't know what that is about 9:40
Thank you
and why do boring class lectures where teachers just dictate notes still exist ? well majiority of learning happens in youtube anyways. Thanks to people like prof. Dave 🌻
Thanks
Very nice video. A little correction, if am not mistaken in 9:35, the acetyl group and the methyl groups are switched. It should be acetyl -CH3CO and methyl is -CH3
yes that was a dumb error on my part
nice Rembrandt lighting