Don't want cancer? Be an elephant

One third of all adults will get cancer over their lifetime. Less than 5% of elephants ever get cancer. So what is the elephant's secret? Elephants have 20 times more p53 than humans do. p53 is a powerful tumor suppressor protein that causes cell death or apoptosis. When elephant cells are damaged they undergo cell death. In contrast, human cells stick around and accumulate cell damage that can result in cancer. I will draw for you how a sun burn damages DNA and how p53 reacts to cells damage by 1) cell cycle arrest or 2) cell death in a human versus an elephant.
Sources:
www.nationalgeographic.com/sc....
www.cell.com/cell-reports/ful...
jamanetwork.com/journals/jama...
pubmed.ncbi.nlm.nih.gov/26447...

[@BarkatAli-pp9gt]

A great Informative public service you are rendering dear Immunologist! I am truly admired by your instinct of creating awareness, in common people whatever you have learned.
You are like a great Teacher & Guide who always disseminates their knowledge, for the other's wellbeing! I am greatly touched by your kind nature! God always keep you Blessed, dear Immunologist!

[@friendlyneighborhoodimmuno7192]

Thank you so much! Your kind words mean a lot to me.

[@yelenak6153]

So, the million question is “WHY do elephant calls always choose cell death”? Can we, by taking quercetin and practicing intermittent fasting, help our cells do the same?

[@friendlyneighborhoodimmuno7192]

Ah very interesting points. It is entirely possible that intermittent fasting activates autophagy which does remove cell waste and promote healthy turnover. Not sure about quercetin pills. But eating foods high in flavaniods like kale and onions is certainly a good idea.

[@vipnetworker]

I have a crush on her now. You had me at, “How does Novavax work?”

[@Ironvan007]

Great I like the way you explain these complicated mechanism 👍🏼

[@chodeyscott7944]

Thank you, this was a great teaching

[@garliclovers1416]

Thanks Professor. Really interesting and educational. I learned a lot from your clear and straightforward presentation. Looking forward to working my way through your other videos.
Hi from Australia 😎😎

[@friendlyneighborhoodimmuno7192]

Thank so much! Australia must be a beautiful place to live.

[@satyabratadash1326]

Thanks a lot for the information..it's really amazing..keep it up....u r really doing a great job...best wishes & love from India...

[@friendlyneighborhoodimmuno7192]

Thank you so much! I really appreciate the best wishes! I have a crazy busy week at work, but I promise more videos next week! Take care

[@ogaana6753]

Thank you for being so sweet wholesome🥺 I learned so much + the way you speak is relaxing in a world full of hyperactive content made by content creators overdosing on coffee 😅👏

[@friendlyneighborhoodimmuno7192]

Thank you kindly! I couldn't be UA-cam fast even with a double espresso. 😂

[@Ironvan007]

Real great how you explain. But how I can become now an elephant 🐘? 😊. Anyhow may I ask you also explaining about the different methods in preparation to treat cancer by Immuntherapie? How work for instance CAR-T cells? Many thanks ☺️

[@sanjumhoudi9601]

amazing

[@topperharley9182]

Naked mole rats also rare to get cancer. Do they have similar amounts of p53 as elephants? Or different mechanism with them ?

[@max3334441]

Your explanations are very clear, are you a teacher or professor?

[@friendlyneighborhoodimmuno7192]

I’m a professor!

[@max3334441]

@@friendlyneighborhoodimmuno7192 Wow thanks for taking the time to make those videos!! I was not lucky enough to study medecine but I am curious on how our body works 😀

[@joeycan6801]

Would that explain why sharks rarely get cancer ?? More P53 ?

[@friendlyneighborhoodimmuno7192]

YES!!! I love sharks.

[@arjitsingh5989]

U r so beautifull

[@topperharley9182]

Naked mole rats also rare to get cancer. Do they have similar amounts of p53 as elephants? Or different mechanism with them ?

[@friendlyneighborhoodimmuno7192]

That’s a fantastic question. The answer is complicated. Naked mole rats don’t have more copies of p53, but they do have a version of p53 that seems to work better and longer than other rodents.