Thank you for this video! I work in an Immunology Lab and am giving a presentation about coeliac disease to my team. This has given me a lot of help articulating it, so thank you 😊
Thank you so much. I am presenting Celiac Disease for a case study to the Colonel and pathologists in 2 weeks and this helped me better understand exactly what is happening in the lining of the small intestines on a microscopic level.
Seriously, amazing videos. I am a 6th year Medical Student and this videos still help me! You even inspired me to make a channel on my own! I make YT videos on medical topics. And today I posted a video about celiac disease as well. Thanks for all the knowledge bombs, and thanks for the inspiration. Keep it up, So will I!
thank you very much for your videos from Italy. i have a question for you and i hope you have time to answer me becuase this doubt stopped me to keep going studying. what happen to those who dont suffer coeliac disease, once the gliadin is inside the lamina propria of the gut? how do they break down gliadin to get its amminoacids? i mean gliadin goes intact into the lamina propria also for those who dont suffer coeliac disease, so they should have a way to digest it and get the AA. many foods have many allergen inside that cause immune response to those who actually havve food allergy for that specific allergen. but if i dont have allergy and i eat the food with allergen, and the allergen goes intact in the lamina propria without being digested by gut enzyme, how do i get its amminoacid anyway? my body wont waste them? thank you again
There is decreased absorption for those with celiac disease due to morphological changes including Villous blunting and decreased surface area. Some don’t have these morphological changes despite having positive antibodies on a blood test. These may not have issues with absorption.
So the things that get the Disease started is a genetic predisposition of HLA II molecules AND an overexpression of CXC3 cytokines. Is that how it starts? And what about LT that escaped tolerance? Oh is that all those mechanisms at once? Thanks a bunch for the video. Im grateful 😍
khan kase parhna ha gee yes, but there is not enough awareness for most scientists to research on the disease. its sucks but hopefully in the long run treatment is more effective.
Probably the best animatic about Celiac disease
Playback speed at 1.5 is about right.
I like 1.25
Thank you for this video! I work in an Immunology Lab and am giving a presentation about coeliac disease to my team. This has given me a lot of help articulating it, so thank you 😊
i appreciate the time you spent on making these animations
Amazing. I'm a student dietitian and this was presented more clearly than a recent lecture.
Thank you so much. I am presenting Celiac Disease for a case study to the Colonel and pathologists in 2 weeks and this helped me better understand exactly what is happening in the lining of the small intestines on a microscopic level.
Awesome video! The pathophysiology is explained on point. Thanks!
I'm a Nutrition and Biomedicine Master and wow, what an explanation! Really good job mate
Seriously, amazing videos. I am a 6th year Medical Student and this videos still help me!
You even inspired me to make a channel on my own! I make YT videos on medical topics.
And today I posted a video about celiac disease as well.
Thanks for all the knowledge bombs, and thanks for the inspiration.
Keep it up,
So will I!
Awesome 😎. Best of luck to you
You guys are the best, up there with Osmosis. Please, keep up the great work. I am fully supporting you.
Thats so kind of you - thanks for all your support and all the best!
Great explanations Thanks so much!
Thank you for such an amazing explanation♥️♥️
Thank You too much 4 this! You really saved my project!! Very Clear Explanation :D
BEAUTIFUL !
thank you ,it was awesome
رحم الله والديك
Thank you so much for this amazing explanation🙏🏽
You're so welcome!
Helps a lot!
really nice
thank you!
Just a quick question about AntiTTG, where do these come from? Are they due to mutations in B cell genes? Do people without celiac also have them?
It's amazing what us humans know about how the body works
It truly is amazing
Nope we know less than 1 percent and every now and then we know more new things about that 1 percent.
@@brightdz2403 That “1%” is a whole lot though lol
@@petersosa268 I said less than 1 😂😂😂😂
Laugh at neuroscience and genomics
That was great thanks!
Thanks glad it was helpful
thnk you sir
Way above me.
Thanks you
You’re very welcome Khawla- all the best to you. 😀
great one thank youuu:))
You’re welcome
Does secalin get deamidated by tissue transglutaminase?
thank you very much for your videos from Italy. i have a question for you and i hope you have time to answer me becuase this doubt stopped me to keep going studying.
what happen to those who dont suffer coeliac disease, once the gliadin is inside the lamina propria of the gut? how do they break down gliadin to get its amminoacids? i mean gliadin goes intact into the lamina propria also for those who dont suffer coeliac disease, so they should have a way to digest it and get the AA.
many foods have many allergen inside that cause immune response to those who actually havve food allergy for that specific allergen.
but if i dont have allergy and i eat the food with allergen, and the allergen goes intact in the lamina propria without being digested by gut enzyme, how do i get its amminoacid anyway? my body wont waste them? thank you again
There is decreased absorption for those with celiac disease due to morphological changes including Villous blunting and decreased surface area. Some don’t have these morphological changes despite having positive antibodies on a blood test. These may not have issues with absorption.
Great video. How did you illustrate this? What programs did you use?
Thanks a lot..😊😊
Most welcome 😊
Brilliant..plzz upload videos on bone pathology..ua awsome
Do you have a particular pathology of the bones in mind and Ill get started
PhysioPathoPharmaco it would b great if u upload video on detailed pathology of osteoarthritis n osteoporosis with complications..plzzz
how was all of this going on inside me for 19 years and I didn't even know it
also... really great video.
Thanks for the comment, hope you're feeling better after going gluten free
Alysa gluten free reverse able
Great video 👌 Isn't dermatitis herpetiformis also a manifestation of celiac disease owing to cross reaction of antibodies?
Yes it is
Helpful
Thank you Tahir
Can you give us the references you used? @PhysioPathoPharmaco
Much of that came from the Review article "The Role of Gluten in Celiac Disease and Type 1 Diabetes" published in the journal Nutrients.
@@physiopathopharmaco4190 tks
Sir can you please share the source of information..
Much of that came from the Review article "The Role of Gluten in Celiac Disease and Type 1 Diabetes" published in the journal Nutrients.
Is it true that your intestines FULLY heal after a glutenfree diet?
Yes but it can take up to at least a year.
Celiacs need to use hookworms. They put my celiac into full remission.
So the things that get the Disease started is a genetic predisposition of HLA II molecules AND an overexpression of CXC3 cytokines. Is that how it starts? And what about LT that escaped tolerance? Oh is that all those mechanisms at once?
Thanks a bunch for the video. Im grateful 😍
Yes several genetic factors can increase the risk - DQ2 and DQ8 and CXC3 cytokine expression
Could you speak a little bit slower next time?
Scientist should do something for this
khan kase parhna ha gee yes, but there is not enough awareness for most scientists to research on the disease. its sucks but hopefully in the long run treatment is more effective.
Celiac is also spreading v quickly in the world like corona
Sir i have celiac disease and suffering from lack of sleep is this normal?pls reply🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🏻