a really nice video, and set up very nicely! I have one question/correction: As I understood it from literature the Na/K pump is not as you indicated on the apical side of the cell pumping the Na into the tubule but on the basolateral side. Since we want to reabsorb Na, we pump out Na into the interstitium, and the concentration in the cell decreases. this leads to a passive inflow of Na into the cell from the tubular lumen, creating also the symport mechanism for glucose and amino acids. Am I right?
Hello I have a note📌 Na++ K+ ATPase pumps Na out of the proximal convoluted tubles cells, mean into the interstium not into tubules lumens. So Na concentration inside the cell become lower than in the lumen that is make the gradient. Thanks
Your videos have been so helpful towards my studies and makes my reading faster because I now understood better. Thank you so much. Love from The Philippines
ohhhh Great videos! I love the high definition image of the camera. I love how u set up the white board neatly and before starting the video. Great job!well done
Based on the comments.. 1) The Na+K+ pump is on the basolateral side of the of epithelial cells. The Na+ is pumped out and K+ pumped in, therefore the Na+ levels are kept low in the cell so that the symport/antiports can work as needed. The K+ can then passive diffuse out of the cell to the blood so K+ is reabsorbed. 2) The HCO3- is being reabsorbed. The H+ being secreted allows for pH regulation (low H+ in blood = higher pH to offset acidity [low pH] in blood)
confident almost daunting delivery of the lecture .. listening it after reading and jotting down Guyton's chapter on kidney. Thanks for helpful academic videos.
I have seen many videos of many lecturers regarding excretion but they have explained in very simplistic manner even not that much clear. After watching the these series of lecture I have clarified my doubt and concept..I want to give my sincere thanks to you for this informative video.
Sir, from the previous videos that i came across, you did mention that due to the presence of basement membrane and of its negatively charge character, it helps passage of positive solutes more and much more easier , where as the negatively charge solutes like chlorine gets repelled due to its negative charge. So, if you'd tell me from where are the chlorine molecules getting into the proximal tubule and in the latter parts in loop of henle. I'd be obliged by your answer. :)
I am very thankful for your amazing detailed explanations and your deep understanding for the physiology , never seen such precise knowledge in my professors, I love and depend on everything you say Doctor Andrey ❤.
Thank you Andrey for the excellent videos. However I have a question in mind. If Na reabsorption is a passive inflow secondary to the Na active secretion by the Na/K ATPase, how would we end up reabsorbing more Na than secreted?
the active transport is using ATP to transport materials from low concentration to higher concentration, and we know from nervous system that sodium is more outside the cell so the active transport must be from cell to the outside. i.e. 3Na+ outside cell. why is your arrow in the diagram pointing that 3 Na+ will be transported into the lumen of the cell?
when the level of aldosterone increases, na+ absorption increases, and as you said na+ helps in absorption of glucose and amino acids, so does it mean that increased levels of aldosterone indirectly increases the glucose level in blood?
Hi, one small comment please. The peritubular capillary is a branch of the efferent arteriole, not the afferent as indicated by your labeling. It had me a bit confused when I first saw it but other wise, great work!!!!!!
Imagine the Na+/K+-ATPase as a pump for sodium. The pump is in the basolateral membrane and pumps sodium from the cell into the interstitium. This not only makes the sodium more concentrated in the insterstitium but also less concentrated inside the cell. That creates a gradient that sucks sodium from the tubule into the cell (no active transport needed).
I have to agree with others that the ATPase pumps are on the basolateral side of the membrane. I am finding your other videos helpful though. But, I do want to learn things correctly and am kind of surprised there has been no correction posted.
REALLY GOOD ! but you know what helps to memorize the things better,if you would draw all the pictures live.because then its nicer for the brain to remember what you have drwn :)
Sorry, but you have a HUGE MISTAKE. The 3Na+/2K+ ATPase is on the Basolateral side, NOT the apical side, of the PTC cell. It is absolutely imperative that this pump is located on the basolateral side.
![Lp. Сердце Вселенной #60 РОЖДЕНИЕ ЛОЛОЛОШКИ [Финал] • Майнкрафт](http://i.ytimg.com/vi/YoR0pAV9FVQ/mqdefault.jpg)
Na-K pumps are located on the basolateral surface of the tubular epithelium and not the apical surface
a really nice video, and set up very nicely!
I have one question/correction: As I understood it from literature the Na/K pump is not as you indicated on the apical side of the cell pumping the Na into the tubule but on the basolateral side.
Since we want to reabsorb Na, we pump out Na into the interstitium, and the concentration in the cell decreases. this leads to a passive inflow of Na into the cell from the tubular lumen, creating also the symport mechanism for glucose and amino acids.
Am I right?
Johannes Steibl yes that’s totally true
Hello
I have a note📌
Na++ K+ ATPase pumps Na out of the proximal convoluted tubles cells, mean into the interstium not into tubules lumens. So Na concentration inside the cell become lower than in the lumen that is make the gradient.
Thanks
Your videos have been so helpful towards my studies and makes my reading faster because I now understood better. Thank you so much. Love from The Philippines
ohhhh Great videos! I love the high definition image of the camera. I love how u set up the white board neatly and before starting the video. Great job!well done
You're a life savior!!! Thank you so so so so so much dear Andrey!!!!
Based on the comments.. 1) The Na+K+ pump is on the basolateral side of the of epithelial cells. The Na+ is pumped out and K+ pumped in, therefore the Na+ levels are kept low in the cell so that the symport/antiports can work as needed. The K+ can then passive diffuse out of the cell to the blood so K+ is reabsorbed. 2) The HCO3- is being reabsorbed. The H+ being secreted allows for pH regulation (low H+ in blood = higher pH to offset acidity [low pH] in blood)
confident almost daunting delivery of the lecture .. listening it after reading and jotting down Guyton's chapter on kidney. Thanks for helpful academic videos.
Great videos! I love the high definition image of the camera. I love how u set up the white board neatly and before starting the video. Great job!
Thanks Sam! Appreciate your input and glad to see that you're enjoying the lectures :)
Very nice lectures, made me understand renal physiology.
sebagala umar Awesome! :)
I have seen many videos of many lecturers regarding excretion but they have explained in very simplistic manner even not that much clear. After watching the these series of lecture I have clarified my doubt and concept..I want to give my sincere thanks to you for this informative video.
Sir, from the previous videos that i came across, you did mention that due to the presence of basement membrane and of its negatively charge character, it helps passage of positive solutes more and much more easier , where as the negatively charge solutes like chlorine gets repelled due to its negative charge. So, if you'd tell me from where are the chlorine molecules getting into the proximal tubule and in the latter parts in loop of henle. I'd be obliged by your answer. :)
I am very thankful for your amazing detailed explanations and your deep understanding for the physiology , never seen such precise knowledge in my professors, I love and depend on everything you say Doctor Andrey ❤.
Shouldn't the Na/K Pump be located on the basolateral side? If the PCT is trying to reabsorb Na, why would it pump it back out to the tubular lumen?
I think there is a mistake here the N-K pump is not located as you indicated
god bless u ak, ur doing gods work
Shouldn't be the Na/K pump on the basolateral side? Are you sure that the hco3 must be secreted?
I enjoy your lectures and express my gratefulness.One correction: bicarbonate is not secreted in PCT,it is reabsorbed.Stay blessed.
love your videos...dont stop making videoes pleaseeeeee...
Thank you Andrey for the excellent videos.
However I have a question in mind. If Na reabsorption is a passive inflow secondary to the Na active secretion by the Na/K ATPase, how would we end up reabsorbing more Na than secreted?
the active transport is using ATP to transport materials from low concentration to higher concentration, and we know from nervous system that sodium is more outside the cell so the active transport must be from cell to the outside. i.e. 3Na+ outside cell. why is your arrow in the diagram pointing that 3 Na+ will be transported into the lumen of the cell?
Hey man, correct me if I'm wrong, but shouldn't the peritubular capillaries be coming off of the efferent arteriole?
Happy Teachers day, sir
when the level of aldosterone increases, na+ absorption increases, and as you said na+ helps in absorption of glucose and amino acids, so does it mean that increased levels of aldosterone indirectly increases the glucose level in blood?
Thank you for contributing .. liked
Hi, one small comment please. The peritubular capillary is a branch of the efferent arteriole, not the afferent as indicated by your labeling. It had me a bit confused when I first saw it but other wise, great work!!!!!!
Yes you're absolutely correct! Sorry for that misrepresentation! I added an annotation to clear that up.
thank u sir..your lecture helped me understand the thing well
Imagine the Na+/K+-ATPase as a pump for sodium. The pump is in the basolateral membrane and pumps sodium from the cell into the interstitium. This not only makes the sodium more concentrated in the insterstitium but also less concentrated inside the cell. That creates a gradient that sucks sodium from the tubule into the cell (no active transport needed).
I have to agree with others that the ATPase pumps are on the basolateral side of the membrane. I am finding your other videos helpful though. But, I do want to learn things correctly and am kind of surprised there has been no correction posted.
UA-cam removed the ability to annotate videos; hence I cannot really correct this existing video.
Nice tutr
your lecture helped me alot
great information . i really understood everything so thank you very much 😊.
VERY HELPFULLLL!!
The automatic subtitles are spot on :')
probably because the accent sounds so american
REALLY GOOD ! but you know what helps to memorize the things better,if you would draw all the pictures live.because then its nicer for the brain to remember what you have drwn :)
great work sir i really understand now.
Derny Mason awesome to hear :)
Is sodium ion comes from afferent arteriole
thank you
you made it easier
This guy kills me...like how can anyone forget wat he says...
nice notes thank you so much
I just like the tutorial
You are legend
Sorry, but you have a HUGE MISTAKE. The 3Na+/2K+ ATPase is on the Basolateral side, NOT the apical side, of the PTC cell. It is absolutely imperative that this pump is located on the basolateral side.
you are the fucking best!!! your vidios are highly underrrated!!
Listening alone does nt seem to help in full comprehension so i just pick up the note pad and am writing down key points from ur lecture.
Thank you_But, if possible, slow down to explain
❤️
why am in a high school thats already at uni level omg
❤️❤️❤️❤️
does this guy know everything???
definitely not!
Your speech is not well-paced. Let the importance of what you are teaching or discussing determine the rapidly of your stream of words.
Thank you_But, if possible, slow down to explain