Acute Lymphoblastic Leukemia (ALL) - Symptoms, Pathogenesis, Diagnosis - Down Syndrome - Hematology

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  • Опубліковано 7 жов 2024

КОМЕНТАРІ • 393

  • @MedicosisPerfectionalis
    @MedicosisPerfectionalis  3 роки тому +4

    ♥️ Cardiac Pharmacology: www.medicosisperfectionalis.com/
    📝 Download Notes: www.medicosisperfectionalis.com/

  • @mariasaliba2672
    @mariasaliba2672 5 років тому +282

    I've reached a new level where I watch your videos for fun.

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  5 років тому +66

      😁😁😁
      It says a lot about you.
      You are a great person who is passionate about knowledge and education...I am honored...Thank you 😊

    • @jamieong600
      @jamieong600 4 роки тому +13

      SAME HERE I LOVE YOUR COMMENTARIES 😂

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  4 роки тому +8

      Thanks a million!

    • @rahmahl5762
      @rahmahl5762 4 роки тому +1

      YES YES I was about to comment the Same thanks a lot MEDICOSIS

    • @mrsamandabernier
      @mrsamandabernier 3 роки тому

      Me too!

  • @silvertix2996
    @silvertix2996 7 місяців тому +20

    How are you not a doctor???

  • @reemsaleem7805
    @reemsaleem7805 2 роки тому +29

    I’m starting to like this hematology thing because of you, thank you for making it so fun to listen to 😂💖

  • @jillianbaptiste1214
    @jillianbaptiste1214 3 роки тому +10

    I wish you were my lecturer for all my courses. Very simple, and trust me it takes a lot for me to understand something.

  • @vijaybylla9541
    @vijaybylla9541 4 роки тому +25

    Best teacher ever seen😍
    U r far more magnificient than anyone else
    Genius u are 👍👍
    Stay safe keep going😇

  • @yasminese5487
    @yasminese5487 3 роки тому +26

    You are brilliant, funny, a helper, and a doctor. What else to wish?
    Thank you for your contribution !

  • @rak1994
    @rak1994 5 років тому +14

    You are absolutely brilliant and really have a gift when it comes to teaching! I have told everyone about your channel and wish you all the success! Thank you so much for your top quality work ❤

  • @Goodmorningbonn
    @Goodmorningbonn 3 роки тому +3

    You deserve more views! I honestly forget that I am studying when watching your videos. Thanks!

  • @spencerh8882
    @spencerh8882 3 роки тому +4

    Wow I'm so surprised that you're not a doctor. Your lesson and video are so much better than what I've learn from hospital. Thanks for sharing the knowledge.

  • @hannahrosa5485
    @hannahrosa5485 3 роки тому +19

    Thank you once again. A doctor who once doctored my husband passed away from ALL in January, 2021 after one year of treatments. He was 48. So incredibly sad.

    • @Toyeditx_.
      @Toyeditx_. Місяць тому +1

      Excuse me, why does he passed away? Is he allergic to the chemotherapy or else or other reasons? I also have ALL.

  • @taniabiswas3305
    @taniabiswas3305 3 роки тому +7

    How do you manage to teach these topics sooooo well when you're not a doc?!!!!!😭😭

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  3 роки тому +4

      I just love ❤️ medicine!

    • @taniabiswas3305
      @taniabiswas3305 3 роки тому

      @@MedicosisPerfectionalis you're a genius ❤️❤️❤️ thank you for making these topics so easy for us ❤️

  • @shrutibora5339
    @shrutibora5339 2 роки тому +3

    Amazing! Have one month left for my MD Pediatrics exam..your videos have helped me a lot.Thank you so much.

  • @k.a.gchannel3591
    @k.a.gchannel3591 4 роки тому +4

    ALL level 3 survivor here. Nice explanation.

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  4 роки тому

      Thank you so much!
      How is your health now?

    • @k.a.gchannel3591
      @k.a.gchannel3591 4 роки тому +2

      @@MedicosisPerfectionalis I got cured in 2005 and I am very much healthy and fit now.

  • @yousafrivaz9935
    @yousafrivaz9935 Рік тому +1

    Great video, so recently my nephew of 5 years of age was diagnosed with PRE-B ALL which was a terrible news for us, we fought through it, his first biopsy showed more than 95% blast cells in his bone marrow, however they didnt make it to his blood stream, and his other test was fine as well some cpf or cpr some spine test to see if the brain is fine or not I dont really know I'm not a doctor,
    Anyway, we started off his treatment and immediately even through in his first few weeks of chemotherapy he started showing good improvements like no more bone pains and could start to walk again and do some normal children chores again, we started seeing hope and him being an amazing warrior started battling hard, he started eating a lot which is quite common since his medical team told us because they started giving him steroids and we were happy that our son is doing well diet wise, he has started to gain weight.
    Long story short it has only been a bit more than a month into his treatment and his last major biopsy, I call it major because it was supposed to show the percentage of the blast cells in his bone marrow because in that biopsy they also took a tiny bit of his bone as well. The doctors said that the could not calculate the percentage of the blast cells because there number was very less so the machine couldn't calculate it.
    There are a few things that I'd like to add here, I'm a bit concerned about how chemo can have effects on reproduction, and also his gene panel showed ETV6-RUNX1 fusion. Anyone that can help me understand a bit would be much appreciated.
    Anyway, what my concerns are that is he doing really fine? I mean we can see the improvements in his health but I'm not a doctor so I cannot know for sure, if please you could share some insights. Thanks
    One thing that I would like to add here for everyone is Do not lose hope if you are given this horrible disease. Always be hopeful and there is light for sure at the end of the tunnel. Peace

  • @dennispaulson6954
    @dennispaulson6954 Рік тому +3

    You have no idea how nice it is to be taught by someone who has a sense of humour and has a genuine interest in the topic. Thank you Mr Perfectionalis 🫡

  • @collectingstars1
    @collectingstars1 4 роки тому +6

    I LOVE LOVE LOVE THE WAY YOU EXPLAIN THINGS.

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  4 роки тому

      Thank you so much 😊

    • @collectingstars1
      @collectingstars1 4 роки тому

      Medicosis Perfectionalis Btw Im studying Medicine in Alexandria,Egypt. Your home country! May I know where did you study medicine? :)

  • @EiliyaLavasani
    @EiliyaLavasani 4 місяці тому +1

    Your channel is a blessing, thank you Doctor Medicosis

  • @mariapazsarmiento3826
    @mariapazsarmiento3826 Рік тому

    I can't believe you're not a doctor, you know so much that you're basically a doctor. It's a shame you don't treat patients, you would be the best.

  • @safesoundequine8511
    @safesoundequine8511 2 роки тому +1

    You are literally a lifesaver, I support you on patreon and owe you so much more

  • @Ss-cn8rr
    @Ss-cn8rr 5 років тому +21

    Awesome!!!! Dude where was ur channel all these years.

  • @dr.hannibal8338
    @dr.hannibal8338 Рік тому +1

    Best medical channel I have ever seen.

  • @allaboutmovies4821
    @allaboutmovies4821 4 роки тому +2

    I love you man, you compare and contrast and that's exactly what we need in medicine so much to know so confusing. Philadelphia has always gotten me before but never anymore.

  • @MuhammadAli-ml9bt
    @MuhammadAli-ml9bt 6 років тому +2

    very nice lecture simplified easy for internal exam and board exam , you will not concentration for a moment.Thanks alot

  • @Asif_Iqbal_Jonty
    @Asif_Iqbal_Jonty 4 роки тому +3

    Incredible way of teaching.. You're a lifesaver bruh♥️

  • @halharinfigar6039
    @halharinfigar6039 5 років тому +5

    OMG! I just stumbled into your channel and thank God I did! Your videos are really helpful for my board exam preparations. Good work bro 😄

  • @rukiee.b.ovwigho5709
    @rukiee.b.ovwigho5709 2 роки тому +1

    Amazing. Thanks a lot for simplifying ALL. Your hematology videos are 💯💯🔥🔥👏

  • @chaosheng9400
    @chaosheng9400 4 роки тому +3

    Love your videos, extremely helpful and fun to listen to. You’re awesome!

  • @hadeel425
    @hadeel425 3 роки тому +1

    you’re my superman .. thank you so much forever

  • @MedicosisPerfectionalis
    @MedicosisPerfectionalis  5 років тому +8

    💊 👨‍🏫 Antibiotics Lectures: www.medicosisperfectionalis.com/products/courses/antibiotics/
    💉 📜 My Notes, cases and courses www.medicosisperfectionalis.com/
    😍🖼Animated Mnemonics (Picmonic): www.picmonic.com/viphookup/medicosis
    📗 Get my notes in pdf files at www.medicosisperfectionalis.com/
    If you like my videos, please consider leaving a tip at www.paypal.me/perfectionalis/

    • @kz6188
      @kz6188 4 роки тому +2

      Why it's ALL ..it's can be AML also ..please explain..?

    • @abhikhalder7351
      @abhikhalder7351 4 роки тому

      Incorporating Ethics was cool :)

  • @dr.jasimmohammed313
    @dr.jasimmohammed313 4 роки тому +3

    You are so great ! Excellent presentation and very simple😍❤️

  • @rohu2223
    @rohu2223 3 роки тому +1

    I really appreciate ur channel existence on UA-cam 🥺❤️ Thank u alot

  • @rayayalmaz9403
    @rayayalmaz9403 3 роки тому +17

    Oh my Allah... i can't stop laughing each time i watch your videos:
    Dr medicosis: ok! If you didn't watch my previous videos, your chance to understand this topic i ZERO! 😂😂😂

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  3 роки тому +3

      Haha 😂
      Thank you so much for watching!

    • @SylviaAputazie
      @SylviaAputazie 3 роки тому +1

      @@MedicosisPerfectionalis how do we know the previous videos. There's no outline .please can you direct me. Thanks

    • @childemperor7475
      @childemperor7475 3 роки тому

      @@SylviaAputazie the heme onc playlist fam!

  • @hassinayazid9286
    @hassinayazid9286 6 років тому +3

    you are doing a good job. God bless you

  • @saraespejo7614
    @saraespejo7614 4 роки тому +1

    This channel is just wonderful. Thank you so much.

  • @juanitezjezreelbon7571
    @juanitezjezreelbon7571 3 роки тому

    Thanks ! Was watching this for my review!

  • @muhammadasadrazajatoi959
    @muhammadasadrazajatoi959 5 років тому +2

    U man just nailed All special pathology Every lecture is awesome...i luv u yrr

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  5 років тому +1

      ❤️❤️

    • @muhammadasadrazajatoi959
      @muhammadasadrazajatoi959 5 років тому

      @@MedicosisPerfectionalis U should make page on fb about ur new comming video series..most of people dont know u...Ur channel and method is excellent soon u will be in top ranked...

  • @ananyam4978
    @ananyam4978 3 роки тому +1

    You are a lifesaver🥺

  • @josephakalonu1052
    @josephakalonu1052 3 роки тому

    I like how you incorporated Hme/Onc with Ethics. Good job!

  • @mertarican5456
    @mertarican5456 9 місяців тому

    how is he not a doctor he is smarter then my profs

  • @allikaypark
    @allikaypark 4 роки тому

    I have been referred to a hematologist for my CBC. I had it taken and had a low WBC count (2.8). I waited 2 weeks for another CBC, and it raised to 3.3 (still low). I looked at the CBC, and it indicates that my Neutrophils are quite low and my Lymphocytes are quite high. I’ve had many viral infections (lasting 3+ months), UTIs, and I’ve started to bruise easily. The bruises sometimes take months to go away, despite them being from minor bumps. I also get frequent mouth ulcers. I’m more fatigued than usual, and my bones and joints ache. I felt like my hair was falling out more than usual, so I got a very short haircut out of frustration. I had very long hair and donated it for cancer patients. I noticed my gums bleeding a bit more frequently as well when brushing. I haven’t met with my hematologist yet, but I keep watching videos like these that talk about the levels and their possible meaning. I truly hope I just have an infection and will bounce back. I’m still waiting for a call to make an appointment. I’m getting a little antsy.

  • @030bhumikadas5
    @030bhumikadas5 4 роки тому +2

    Awesome..best of its kind! Make more videos please!

  • @snehayujju8336
    @snehayujju8336 Місяць тому +1

    Thankyou 😊

  • @charlieandreese4046
    @charlieandreese4046 2 роки тому +1

    I went here to understand, why it's hard to get cured of this disease. My family is heartbroken because my older sister's nephew died the other day because of this type of leukemia. I just hope that scientists may find other treatments that have promising results especially when chemo drugs stop working.

  • @shalinisingh4943
    @shalinisingh4943 3 роки тому

    Well explained topics.Ater watchings these, I can easily remember difficult concepts. Thanks for uploading these videos.😊

  • @Besho320
    @Besho320 5 років тому +4

    The questions at the end😍😍😍. Thank u sooo much

  • @mpage7169
    @mpage7169 5 років тому +1

    Thank you! Your videos are so helpful!

  • @haifad3372
    @haifad3372 4 роки тому

    Just who dares to dislike these videos !?😤

  • @kainatkhawaja8844
    @kainatkhawaja8844 Рік тому

    A 46-year-old female patient presented with nose bleeding, she had pallor but no icterus or cyanosis, spleen was enlarged 1 cm below the right costal margin and there was mild hepatomegaly. CBC: WBC - 124,2 х 109/L, Band Neutrophils - 5 %, Segmented Neutrophils - 15 %, Monocytes - 10 %, Eosinophils - 0 %, Basophils - 0 %, Lymphocytes - 5 %, Blasts 65 %.
    Since they don't mention what kind of blasts there are, what other ways are there to differentiate between ALL and AML?

  • @memealamri8519
    @memealamri8519 2 роки тому +1

    Thank you for the effort and time you spent to give us this knowledge ❤️

  • @meryemlahbara2834
    @meryemlahbara2834 7 місяців тому +1

    Thank you. Thank you, Thank you .... ❤❤

  • @balajipeddisetty598
    @balajipeddisetty598 6 місяців тому

    Thank you...for nice explanation....

  • @deepwithin6517
    @deepwithin6517 Рік тому +1

    Thank you so much very amazing.

  • @d8457
    @d8457 4 роки тому

    Love to watch your videos ! Great job !

  • @johurulhasan4688
    @johurulhasan4688 Рік тому +1

    Thank you so much

  • @indiabiologyexplains5013
    @indiabiologyexplains5013 Рік тому

    Thank you for posting this video, it was so helpful!!
    But it is TdT not tDt

  • @dikshitabajracharya
    @dikshitabajracharya 5 місяців тому +1

    amazing video as always ❤

  • @nooralebarhim8965
    @nooralebarhim8965 5 років тому +4

    thank you sooooo much medicos. god bless you

  • @Kookie-gb3fq
    @Kookie-gb3fq 3 роки тому +1

    Leukemia 💯 well understood because of you🔥

  • @melisgurcagan6288
    @melisgurcagan6288 4 роки тому +1

    thank you so much your videos ate amazing

  • @martinezbiz
    @martinezbiz 3 роки тому +1

    My wife and I lost our just turned 2 year old son 7 months ago to Aml. He had MLL gene rearrangement or subtype KMT2A or 11q23. He had a translocation between chromosomes 6 and 11, t(6;11). He received cytarabine, daunorubicin, etoposide, gemtuzumab ozagamicin then mitoxNtrone and cytarabine. He relapsed after the second chemo which signified refractory Aml which had a poor prognosis. Decitabine with mylotarg was then used. He died shortly after from within 4 months of treatment. Some side effects he had were bloody nausea and diahrea. Horrible bloody mouth sores. He was in pain all over. His right eye was covered by a leukemia pool that ended up bleeding.He had a lot of liquid in his lungs which they thought was pnemonia. He ultimately died from a brain bleed within 24 hours caused we think by the chemo.

  • @arturozapata8407
    @arturozapata8407 4 роки тому

    ALL is the most common cancer in pediatrics, but in Down syndrome patients AML M7 is most frequent.

  • @nawalabutouq2080
    @nawalabutouq2080 5 років тому +3

    you are just perfect!

  • @susanmateo515
    @susanmateo515 Рік тому +3

    I am creating a nursing case study question set for RN's preparing for NCLEX-RN and loved your RDW videa as well as the ALL video (also, I am mom to a person with Down syndrome). Can you share a common value of RDW% for a T21 patient with ALL RDW%? I cannot find an actual example value online anywhere for my made up lab report

  • @ahmedaliisak1657
    @ahmedaliisak1657 3 роки тому

    Thank you very much sir.
    my teacher ileen😂 watches your video's .No more headaches.
    Var caught

  • @MedicosisPerfectionalis
    @MedicosisPerfectionalis  5 років тому +2

    50 hematology 💉 *cases*: www.medicosisperfectionalis.com/

  • @robertkaranja6056
    @robertkaranja6056 6 днів тому

    What if you first do counselling??

  • @DaminionC
    @DaminionC 2 роки тому

    I went through 4 years of treatment when I turned 18

  • @SA-gr9gc
    @SA-gr9gc 4 роки тому +2

    Wowwww! Love from India! :)

  • @samaaelmeghallawy2708
    @samaaelmeghallawy2708 5 років тому +1

    thank you so much youre the best

  • @shkokurda2098
    @shkokurda2098 5 років тому +1

    Thank you very much Dude.

  • @rowenadelrosario4209
    @rowenadelrosario4209 2 роки тому +5

    Thank you so much for your videos. You made most of your discussions seem like a walk to the park compared to the books that I've been reading for hours and made me feel like I'm being punished in hell lol

  • @aishikdasgupta5051
    @aishikdasgupta5051 2 роки тому +1

    Great video!

  • @cosmicdelusions_re
    @cosmicdelusions_re 3 роки тому

    Wait... you're not a doctor?! Wow yet your medical knowledge is so amazing!! May I ask what is your profession?

  • @tejasris.s2934
    @tejasris.s2934 3 роки тому

    Amazing job very useful keep it up

  • @iuw3ug
    @iuw3ug 4 місяці тому +1

    Thanksssss❤

  • @tharinduuggalla6366
    @tharinduuggalla6366 6 років тому +2

    iv been through the whole set of videos and now have a great understanding of hematology. Thanks alot for the great videos.
    could you pls explain what u mean by WBC being 100,000. But the question in the video says 50,000?

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  6 років тому +1

      Hey! Thanks a lot for watching...I think you misunderstood the WBC count point...I did NOT say, that WBCs will be either < 10,000 or > 100,000...I said that the WBC count can range from less than 10,000 up to >100,000...So leukemia can have WBC count of 8,000 , 20,000 , 50,000, 100,000 or 130,000,...etc...The WBC count can be anything....Hope it helps :)

    • @tharinduuggalla6366
      @tharinduuggalla6366 6 років тому +1

      oh! i get it now. Thanks alot for getting back so soon. :)

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  6 років тому

      Of course...Good luck!

  • @agunghari_w
    @agunghari_w 4 роки тому

    Thanks...

  • @themirroroflife848
    @themirroroflife848 Рік тому +1

    Very nice

  • @SylviaAputazie
    @SylviaAputazie 3 роки тому +3

    How do I watch the videos in sequence. How can I get that outline so I follow them topic after topic

  • @archanabudhathoki8222
    @archanabudhathoki8222 4 роки тому +1

    Thank you so much ❣️lots of love from nepa

  • @muru1234567890
    @muru1234567890 5 років тому +1

    Nice explanation

  • @amnak5002
    @amnak5002 4 місяці тому +1

    video is kinda lacking...(med student)

  • @amitsaklani1207
    @amitsaklani1207 4 роки тому +1

    Thank you so much. I got residency in oncology ,so brushing up the basics.
    Your videos are very good.
    Btw ,u said that u are not a doctor. Then ,how come you know all these concepts so well?

  • @Daniel-iy1ed
    @Daniel-iy1ed 2 роки тому

    You are the best 💖

  • @samyan_saleem4252
    @samyan_saleem4252 3 роки тому

    Thnx alot

  • @afshahkhanagha8947
    @afshahkhanagha8947 4 роки тому +1

    or Mirror, Minor & milder :) & thnx for the videos.
    /DR Mahmood Ramazan :)

  • @RedsJourneyTV
    @RedsJourneyTV 4 роки тому

    My son is battling leukemia at this very moment, it is shown in our channel

  • @jebin2
    @jebin2 3 роки тому +1

    Acute...the patient is younger ? does not count for acute myeloid leukemia. Acute means rapid in this context. But still, remarkable video and abo is on !

  • @rlsister9631
    @rlsister9631 5 років тому +2

    Can you add coagulation cascade? I can't find anything yet. thank you! By the way I love your videos, they are amazing.

  • @ulfatgul868
    @ulfatgul868 3 роки тому

    Thank u so much

  • @sujith2074
    @sujith2074 5 років тому +1

    Awesome work👍

  • @ajeethrehman7811
    @ajeethrehman7811 6 років тому +2

    Hello..why there are less than 10 or 15 videos in other systems such as cardio,etc etc..if you make other systems also in a series like hematology it will be very useful..you are doing a great job in hematology..thank you..

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  6 років тому +3

      I am going to do all of them, but I am trying to focus on one at a time...Thanks a million:)

    • @ajeethrehman7811
      @ajeethrehman7811 6 років тому +1

      Medicosis Perfectionalis thats good..but many students are depending on your lectures as this is really great..so it will be good if you make little faster than now..

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  6 років тому

      Thanks a lot...Do you mean speak faster, or upload more videos faster?

    • @ajeethrehman7811
      @ajeethrehman7811 6 років тому +1

      Medicosis Perfectionalis upload the videos faster.. The huge plus point of your videos are the slowness of words..DON’T EVER increase the speed of saying.. my request is to upload the other system’s videos faster..

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  6 років тому

      Got it...I will do my best to upload more...thanks!

  • @swathis198
    @swathis198 4 роки тому +1

    Thank u so much sir..i can understand clearly each n every point😊but i have 1 doubt sir..u told ALL occurs in less than 14yrs..but in the last question 21yr old male had ALL...i am little bit confused sir

  • @thepalettewhispererasmr1227
    @thepalettewhispererasmr1227 Рік тому +1

    Wait a minute...who drew that picture?! I’m cracking up over here 😂 you’re messed up in a perfect way

  • @isabellav.cabaleiro5431
    @isabellav.cabaleiro5431 4 роки тому +1

    OKAY SO, I have a presentation on this and I wanted to confirm a piece of information with you. So there is the type of classification which divides ALL according to morphology, immunology and genetics (which I want to assume is the same as cytogenetic, correct me if I am wrong). And then there is the classification depending on which lymphocyte precursor is being affected, whether that be the T or B lymphocyte. Anyways, I was planning on using the classification based on morphology etc and briefly (in the introduction) speak about the genetics regarding ALL; however, I was planning on mostly speaking about the gene translocation on chromosome t(9:22) and t(12:21) and rather just presenting the other types of mutations. Anyways, could you please tell me if I have understood correctly all this info? And do you agree that I should talk more in depth about the classification I told you about. Bear with me, I know it is a long post but hopefully I have expressed myself correctly (english is not my first language).

  • @jacksparrow-wq1pb
    @jacksparrow-wq1pb 6 місяців тому

    ❤ medicosis perfectionalis ❤

  • @riko2965
    @riko2965 4 роки тому +1

    you are a hero. thank you :)

  • @Dr.Shivachev
    @Dr.Shivachev Рік тому

    Hello so your not a doctor as I understand?The videos are great!

  • @elenacapoccia6752
    @elenacapoccia6752 3 роки тому

    At the minute 7:00 I think CD20 positive in pre-B ALL is a mistake, since CD20 is a B mature cell marker. Could you let me know if it is so?
    Loving your videos, greetings from Rome.