Thank you for this video. I watch several different UA-camrs all with different opinions on diet for insulin resistance. Each one says their way is the only way!!! I found that a combination of each works best for me. You are the only one who says different people have different results. Thank you!!!
@@nicknorwitzPhD I express it a little differently in the courses I teach, by using the phrase "NOKAFS," which is an acronym for "No One Knows Anything For Sure."
'Biology isn’t about balance, it’s about cycles' this one is good one. Especially, when taking into consideration that at the heart of ATP production in mitochondria is Krebs cycle (tricarboxylic acid cycle).
Hit it out of the park! I work with languages, and my mantra is always, "Context is everything!" Being reminded that it takes time and that "host context matters" really rang a bell with me - that is so very well put. The Curiosity Catalyst is at it again! Thanks, Nick.
Great points, though you saved the best for last, at 10:59. I hate when people use science as a noun instead of an adjective. I want to hear about the scientific method, scientific evidence, scientific hypotheses, and scientific theories, not "The Science."
Wow!! This video should be streamed to the general warring public as a precursor to engaging in health/diet pursuits!!! Just awesome, succinct presentation.
Much needed education for these discussions, thank you. Keep in mind that age especially before and after the rise and fall in gonadal steroids dramatically effects all these variables and that's what I see in my rheumatology practice and my own 60+ year old body every day. My metabolism is changing more relative to time like it was before age 20. Those middle ages between 20 and 45 are deceptively stable. Keep up the good work 💪.
When I see comments from people saying that a commenter is doing their diet the wrong way, I sometimes add my 2 cents worth and say that we each have to find what works for us.
Thank you! This was such a refreshing video. I only wish more people took the logical approach when it comes to various diets or ways of eating. I also appreciate you pointing out that keto isn't classified as staying under a set number of carbs. I don't think people often realize this. I also think people tend to look at one lab number in isolation and this isn't very useful. I'd love to learn more about metabolism and I hope you create more videos on the topic.
'Dr. Nick' You are good as usual '7 Under-Appreciated Truth About Metabolism, Medicine, and Diet' was right on point; we really need to think before we speak, and observe the 'progress'. !
Excellent Video! Why do some people have a propensity toward cancer and then others get diabetes? Could it be due to the same factor: Higher Insulin and Glucose? Maybe ketosis is optimal for all people but there are different dietary means to accomplish it.
I realize that this is a somewhat truncated presentation, not in depth, but your sections on gut microbiome and then insulin resistance seem almost to imply that different reactions based on the state of those are static. Whereas we know that insulin resistance can change fairly dramatically, particularly with loss of visceral fat. And microbiome is also malleable - some would say that inflammation with fiber consumption is a mark of gut microbiome dysfunction, which may be changed with treatment. But I like the mention of the need for adequate time to be given to affect change.
Thanks Nick. Great content. Individual responses vary, individual goals vary, individual histories/backgrounds vary and even this can continue to change over time! Life is not static, and it is very hard to isolate any one thing separate and apart from everything else. This reminds me of the classic commercial disclaimer--"individual results may vary." This is true most of the time but saying that won't lead to more sales!
Great stuff, Nick. Would really like to hear to talk more about the thyroid. For example, a 3 year carnivore tests with normal range TSH, high RT3, and T3 at the lowest end of the reference range. Takes levothyroxin (T4). If she takes levothyroxin, wouldn't that raise her RT3 at the same time raising her T3??? If that is the case, wouldn't a different drug that only raised T3 be a better choice? In decades, her last test was the first test that showed RT3. That alone may change the reason for the doc putting her on Levothyroxin????
Hi Nick, I love what you do and following your channel from the beginning but I find it hard to understand you since you are using so many terms I don't know and phrases that I didn't hear, like for example "facilitate communication", English is not my native language so please consider to speak more "not so smart" for our dumbasses :) Thank you for everything you do. Cheers!
Re: point 1, it's not just "cutoffs", which are obviously arbitrary. Essentially EVERY category humans use/invent is fake, and reality doesn't respect it. Example: "Dogs", "people", "hurricanes", "toilets", "birthdays" are all completely false constructs without clear definitions. Reality has no respect for these categories, because what they are, at the root level, is a definition that's basically, "I know it when I see it". To expose the arbitrariness further, that's really, "things that activate my neural network (brain) to a sufficient degree of dog-ness, people-ness, hurricane-ness, etc".
@@aurapopescu1875 Yes, but that's meaningless. The point is that the platonic ideals that we map to words are categories, which are excitations of our neural networks, which reality doesn't respect.
@@weksauce nonsense, b/c you can’t formulate your thesis without presupposing a reality, without presupposing there’s such a thing as words and meaning and “arbitrariness” and convention, and even things like neurons and causation. You’d get a C- in an intro to philosophy class. Much progress has been made on meaning and language since Plato. Perhaps start with Aristotle and then work your way to Wittgenstein, Austin, Kripke, McDowell, etc. Ultimately, you take a misguided conception of language to its logically absurd conclusion and instead of rejecting the conclusion, you embrace it and think you’ve stumbled onto an insight. The only insight is that you never should’ve embraced the misunderstanding of language and reality to begin with.
@@nicknorwitzPhDno, because according to this guy, corgis don’t exist, they are just a convention. But then, conventions don’t exist either, because they are conventions. And existence doesn’t exist, because it’s a convention. So nothing can either exist or not exist, because everything is a convention, which don’t exist. Huh huh. This is what happens when kids get YT accounts.
Aren’t our microbiomes different as a result of the different things people eat? I’m struggling with your assertion that, “therefore we’re each different”, based on that. IOW… If we all ate the same species-specific, meat-based diet, our microbiomes would all be the same. It’s how some choose to eat that creates differences across the species. Along the same lines, sure, people will respond differently to fiber also based on their diet. Do that same study with a meat-only diet group and see if any of them respond differently. That whole part of the argument sounds a bit disingenuous to me.
Physiology does not care about cut points! Even the definition of a human with skin boundaries and the environment being outside of us is a cut point. It's not just the organism but the organism/environment meta structure that affects the outcome of the organisms. If the tree grows poorly you don't blame the tree you check the sun/soil/air/rainfall etc. Understanding the environment that led to the outcomes matters leads to better results than blame.
At least you're learning when you're young. Many of us didn't get the proper information until our 50's or 60's. If you eat real food, prioritize protein, fuel with fat, and cut carbs, your chances of thriving will be maximized.
And remember, whatever your diet, these problem slowly accumulate over time and fasting is the quickest way to reverse them! Fasting also regenerates your white blood cells and reduces autoimmune reactions and reprograms the immune system not to have such issues in the future! The people having issues with the current thing going around are those with bad metabolic health, especially with age, which leads to bad immune function!
Metabolic adaptation takes patience, but epigenetic adaptation takes much less time than many consider. For instance, a group of humans arrive to an island, and in less than 5 generations they totally adapted to most or all local foods. It doesn't take thousands of years to adapt to a new dietary pattern.
@@nicknorwitzPhD Not comparable scenarios. When someone spoiled for choice changes diet for whatever effect has nothing to do with primitive humans getting to a new place, and surviving on whatever the new place offers.
I appreciate this, thank you. To points 4 and 7, I daily adjust macro-nutrients relative to lifting, aerobic and rest days. Being flexible with what my body needs.
Something else cool: you can measure how well a system responds to a signal by measuring the signal strength and the system's output. Whether that's insulin and non-esterified fatty acids, or whether it's LH and testosterone, the same principle holds true.
@@hollyhopalong7405 yeah, but if you want to be respected as a content creator and scientist, and not just some kid in his mom’s basement, then it’s best to be professional and look professional.
Adaptation takes times mainly, when you jump from extreme to another extreme, you can see it mainly in digestion. For example when long term carnivore adds a vegetables (fibre) into the diet, of course they will have problems and feel bad.
OK, though it doesn't seem helpful to say I'm not eating a keto diet just because the test strip says there's no ketones in my blood. I eat mostly meat, eggs and cheese plus salad and some Brazil nuts. What do I call that?
I am confused about your definition of a ketogenic diet. When my carb intake is too high my glucose raises and ketones drop. Listening to Dr. Bickman it is my understanding that if insulin is high your body produces low ketones as the body's priority is to lower the glucose amount in your blood. That seems to be true for me. The lower my glucose the higher my ketones. Yesterday when I measured my glucose it was high because I ate too many carbs and it went up to 122 while my ketones measured 0.5. After cutting out carbs and walking my glucose dropped to 73 and my ketones went up to 3.2 putting me back into a high level of ketosis. What am I missing?
He is meaning that standard is to say that eat less than 20g of carbs (cut point) is ketogenic diet but we are all different with different starting points.
I did not say carbs won't kick you out of nutritional ketosis. I said a specific universal carb threshold doesn't define a ketogenic diet, which is better defined as a metabolic state based on ketone levels (or better yet, flux; although that's difficult to measure)
@@nicknorwitzPhD you know what might make for a great video? I am always amazed that “scientists” routinely put out marginal or poor studies as fact leaving people like you to have to educate the masses to clear up misrepresentations. What if you were to produce a video that describes the most optimal one or two or three ways to design studies, and even the challenges that the best design studies can still produce? Also, the costs involved and the reasons they are not always done, perhaps. I don’t know, do you think that would be useful on this channel?
The biggest mistake in nutrition and medicine too, is the belief that a diet that keeps a healthy person healthy, makes an unhealthy person healthy again. You can say this a 100 times (I probably have) and yet it gets completely ignored. I hope now that Nick gives this more attention, it will get some more attention everywhere. But I suspect it will be mostly: "Yeah, that's true,... you're so smart,... " and then everyone forgets about it again. I guess it's not sexy enough.
" "Yeah, that's true,... you're so smart,... " and then everyone forgets about it again. I guess it's not sexy enough." -- Off to Victoria's ... stay tuned for my next video 🤣
Just a comment on 4, best human diet or species appropriate diet. We do have this. Just look at our body as a whole, what our body is designed to eat. Don’t look at the individual markers like inflammatory markers. We don’t digest fiber at all, we are designed to digest meats. Some might not do well on some meats, but definitely some will be good. We do have this solid patten. If you mean optimization, true, but that’s just your standard your opinion, it’s not what our body designed to do. As Dr Chaffee said, we humans are apex predators, though we are losing this trait after 10k+ years of farming and trying the very best to eat some plants. We do need to see this from the designer perspective. There are a lot more to say, but I guess it’s enough for a UA-cam comment.
@@nicknorwitzPhD Please don’t pick on things with such extreme technicality. Our body has mechanisms to digest meats, but no mechanisms to digest fiber the most abundant part of plants. Bacteria digest fiber and spit out fatty acids, true, but clearly not what we are designed to digest because it’s such a small percentage and your whole digestive tract does nothing to fiber except at the end using bacteria, and we can literally eliminate fiber from our foods without any negative consequences. Our body is not designed to process fiber, but like everything in the world, some level of tolerance exists, let alone we humans WERE herbivores. Don’t use tolerance as the basis of your argument, it’s part of the design so that you don’t accidentally eating some fiber and get killed. It’s designed in this way by evolution. Human already adapted the carnivore diet over millions of years eating animal fresh, with our body tuned to eat the carnivore diet, of course not all animals. Some plants don’t hurt much and some can tolerate them for life, but it doesn’t mean they are beneficial or belong to our proper diet, and in fact you can see the degradation of the body of vegans such as Michael Greger, hands got so skinny like sticks, and a giant stomach. Why do you think meats, especially ruminant meats have such a good ratio of fats and protein to humans but not plants? Because we humans adapted to eat meats, tuned to eat meats. The optimization standard is just your opinion. Eating the proper diet is the optimization. We humans lived in the harsh environment of nature as apex predators, hard to say we are now, but the design within our genes via evolution over millions of years hasn’t changed much as a whole. Exceptions of course exist like everything in the universe, but it’s just how life adapts and evolves.
Nick, I love your content. Help me understand why a fasting-adapted and zone 2 cardio as well as resistance trained middle aged person who after a 20 hour fast and workout has zero ketonuria despite a fasting insulin of 5 (quest diag. units, can’t remember sorry!) or less? Thanks. My question is why zero ketonuria under these metabolic conditions.
I hope he answers your question…. Is it because you are fat adaptive? Your liver is producing more glucose? Your body has less insulin sensitivity? Too much cortisol?
@@dr.julia-heyakarcic8862 Please remember, a fasting insulin gives you a measurement in one instant of time (fasted). To truly learn how sensitive or functional your insulin is, it's ideal to measure it intermittently over time (e.g. 2 hours) to see how it is working after eating something. There are tests to do this (e.g. the Kraft test). The problem with that test is they give you a bolus of glucose (e.g. 75 grams) to consume before starting the test and then they can track how your glucose and insulin react over time. If you are low carb or carnivore and your body is no longer used to being struck with a "sugar shock," so to speak, the results of a Kraft test might be invalid. I feel a Kraft type of test (for low-carbers) should be done after you have eaten a typical meal, say bacon and eggs. Then see what happens over a two-hour period. The trouble with doing that is there is no set standard to begin the test with. So, for now we can at least check fasting insulin. It's certainly better than nothing. But in people doing a classic Kraft test it's possible that a person starting with a fasting insulin of 20 could have a better 2-hour function of insulin than a person starting with a fasting insulin of 5. And then Ben Bikman talks about things like 1st phase and 2nd phase insulin. In other words, you eat some sugary/carby junk and your insulin reacts a bit, to bring your blood sugar down, then after some period of time your glucose continues to go up so your pancreas squirts out a 2nd hit of insulin. It doesn't always happen every time or with every person or every meal, but it can. Well, that's how I understand it but to be sure go ahead and watch some Ben Bikman videos yourself.
“Stay humble” that’s what real scientist do, not just “I’m right you’re wrong” . Your content is amazing bro
Thanks 🙏🏻 🐺
Yeah way too much of the "I'm right, you're wrong" crowd in science. Way too much corporate money in it too.
completely agree with you
Glad to hear it
yes, ebb & flow.
Like no single, continuous ideal body weight
comp>kg ;)
Depending on your good and bad lectin load
I could hardly watch with that stain on your shirt. 😂😂😂
Just watching the comment #. Thanks data point ;)
So good. If everyone would just apply these truths to every system, not just the body's use of chemical energy, the world would be so much better off.
Thanks "wek sauce" ... weak sauce? ... or does the name have other meaning?
@@nicknorwitzPhD wek sauce. the word weak is weak. wek is strong
@@nicknorwitzPhD You're gonna comment on this guy's username but not mine, Nick? Really?
Thank you for this video. I watch several different UA-camrs all with different opinions on diet for insulin resistance. Each one says their way is the only way!!! I found that a combination of each works best for me. You are the only one who says different people have different results. Thank you!!!
"You are the only one who says different people have different results" -- well that's kinda' sad. Lol
@@nicknorwitzPhD I express it a little differently in the courses I teach, by using the phrase "NOKAFS," which is an acronym for "No One Knows Anything For Sure."
This is so true. More people need to hear it. There is no "one size fits all" with diet and it's surprisingly controversial to say it.
'Biology isn’t about balance, it’s about cycles' this one is good one. Especially, when taking into consideration that at the heart of ATP production in mitochondria is Krebs cycle (tricarboxylic acid cycle).
Spin and Spin and Spin ... then die. Then you're "balanced"
Hit it out of the park! I work with languages, and my mantra is always, "Context is everything!" Being reminded that it takes time and that "host context matters" really rang a bell with me - that is so very well put. The Curiosity Catalyst is at it again! Thanks, Nick.
Very welcome!
Great points, though you saved the best for last, at 10:59. I hate when people use science as a noun instead of an adjective. I want to hear about the scientific method, scientific evidence, scientific hypotheses, and scientific theories, not "The Science."
Cheers! I agree 100%
Unfortunately we have a society that wants instant results. This "things take time" is foreign to most of us.
😂😂😂😂 probs why views are what they are
The best video you ever did!
Awe! Thanks!
Our minds are clearly on the same wavelength. I love that you called these out, Nick! 👏
Welcome!
Everyone has to see and share this video! Thanks 🙏 a lot! Life is so beautiful let be humble to each others
Thank you Mr Bilartur !
Wow!! This video should be streamed to the general warring public as a precursor to engaging in health/diet pursuits!!! Just awesome, succinct presentation.
Thank you Cynthia!
here! here!
Much needed education for these discussions, thank you.
Keep in mind that age especially before and after the rise and fall in gonadal steroids dramatically effects all these variables and that's what I see in my rheumatology practice and my own 60+ year old body every day. My metabolism is changing more relative to time like it was before age 20. Those middle ages between 20 and 45 are deceptively stable. Keep up the good work 💪.
Can't say I have the life experience for what happens to metabolism north of 30... but will keep up the good work :)
"Stay Humble" needs to be a new shirt option!!
👏
I think the optics of selling a shirt saying stay humble is... iffy
@@nicknorwitzPhD What?! 😮
humility is one of my greatest qualities.
Too many religious connotations.
You have knack for providing clarity to complex concepts that promotes understanding. Thank you.
Very welcome!
Excellent points. Thank you.
Welcome!
When I see comments from people saying that a commenter is doing their diet the wrong way, I sometimes add my 2 cents worth and say that we each have to find what works for us.
💪🙏🏻
Thank you! This was such a refreshing video. I only wish more people took the logical approach when it comes to various diets or ways of eating. I also appreciate you pointing out that keto isn't classified as staying under a set number of carbs. I don't think people often realize this. I also think people tend to look at one lab number in isolation and this isn't very useful. I'd love to learn more about metabolism and I hope you create more videos on the topic.
You're so welcome! And stick around… I’m a metabolism firehose 😅
'Dr. Nick' You are good as usual '7 Under-Appreciated Truth About Metabolism, Medicine, and Diet' was right on point; we really need to think before we speak, and observe the 'progress'. !
Awesome! Find what works for me, and take with a grain of salt, the wide world of "you should", "you can't", "don't to this, do that"!
Excellent Video! Why do some people have a propensity toward cancer and then others get diabetes? Could it be due to the same factor: Higher Insulin and Glucose? Maybe ketosis is optimal for all people but there are different dietary means to accomplish it.
I loved this! Thank you so much! Watched this twice. I think I need to order one of those mugs too
You should! Link below video ;).
Love the nuance. Great points, especially the human-microbiome meta organism framing and viewing science as a process.
I realize that this is a somewhat truncated presentation, not in depth, but your sections on gut microbiome and then insulin resistance seem almost to imply that different reactions based on the state of those are static. Whereas we know that insulin resistance can change fairly dramatically, particularly with loss of visceral fat. And microbiome is also malleable - some would say that inflammation with fiber consumption is a mark of gut microbiome dysfunction, which may be changed with treatment. But I like the mention of the need for adequate time to be given to affect change.
wouldn't it be amazing if actual MD's and GP spoke like this with this level of acuity and understanding.....WOW!
😍🙏🏻😍
Well this might be one of the most important videos you have ever produced because of its foundational importance.
Than you Scott Jones! So kind!
I agree. This was clear and concise and a topic that needs to be clearly heard. Thank you.
Every change in you life takes time before you will see the real differences ... exactly!
Thanks Nick. Great content. Individual responses vary, individual goals vary, individual histories/backgrounds vary and even this can continue to change over time! Life is not static, and it is very hard to isolate any one thing separate and apart from everything else. This reminds me of the classic commercial disclaimer--"individual results may vary." This is true most of the time but saying that won't lead to more sales!
Well said!
This is a really good video Dr Norwitz. Cheers. Andre
Glad it was helpful!
This should be a required video for anybody to watch before getting into the nutrition world and being exposed to the cults
Glad you found it valuable
Very good video, and the best of this video is that in only 11 minutes you get a lot of intelligent points, thank you
You're very welcome!
GREAT video! EVERYONE needs to watch this!
Thank you Michael!
Excellent thoughts! Thank you!!
You are so welcome!
Great stuff, Nick. Would really like to hear to talk more about the thyroid.
For example, a 3 year carnivore tests with normal range TSH, high RT3, and T3 at the lowest end of the reference range. Takes levothyroxin (T4).
If she takes levothyroxin, wouldn't that raise her RT3 at the same time raising her T3??? If that is the case, wouldn't a different drug that only raised T3 be a better choice? In decades, her last test was the first test that showed RT3. That alone may change the reason for the doc putting her on Levothyroxin????
Hi Nick, I love what you do and following your channel from the beginning but I find it hard to understand you since you are using so many terms I don't know and phrases that I didn't hear, like for example "facilitate communication", English is not my native language so please consider to speak more "not so smart" for our dumbasses :) Thank you for everything you do. Cheers!
Such fabulous information, thanks. Just for the colour-blind can you please stay away from red fonts on green background? thanks :)
Re: point 1, it's not just "cutoffs", which are obviously arbitrary. Essentially EVERY category humans use/invent is fake, and reality doesn't respect it. Example: "Dogs", "people", "hurricanes", "toilets", "birthdays" are all completely false constructs without clear definitions. Reality has no respect for these categories, because what they are, at the root level, is a definition that's basically, "I know it when I see it". To expose the arbitrariness further, that's really, "things that activate my neural network (brain) to a sufficient degree of dog-ness, people-ness, hurricane-ness, etc".
Every word is a convention 🤷♀️
@@aurapopescu1875 Yes, but that's meaningless. The point is that the platonic ideals that we map to words are categories, which are excitations of our neural networks, which reality doesn't respect.
@@weksauce nonsense, b/c you can’t formulate your thesis without presupposing a reality, without presupposing there’s such a thing as words and meaning and “arbitrariness” and convention, and even things like neurons and causation. You’d get a C- in an intro to philosophy class. Much progress has been made on meaning and language since Plato. Perhaps start with Aristotle and then work your way to Wittgenstein, Austin, Kripke, McDowell, etc. Ultimately, you take a misguided conception of language to its logically absurd conclusion and instead of rejecting the conclusion, you embrace it and think you’ve stumbled onto an insight. The only insight is that you never should’ve embraced the misunderstanding of language and reality to begin with.
Does this mean I can be a Corgi! Dream come true!
@@nicknorwitzPhDno, because according to this guy, corgis don’t exist, they are just a convention. But then, conventions don’t exist either, because they are conventions. And existence doesn’t exist, because it’s a convention. So nothing can either exist or not exist, because everything is a convention, which don’t exist. Huh huh. This is what happens when kids get YT accounts.
Aren’t our microbiomes different as a result of the different things people eat? I’m struggling with your assertion that, “therefore we’re each different”, based on that. IOW… If we all ate the same species-specific, meat-based diet, our microbiomes would all be the same. It’s how some choose to eat that creates differences across the species. Along the same lines, sure, people will respond differently to fiber also based on their diet. Do that same study with a meat-only diet group and see if any of them respond differently. That whole part of the argument sounds a bit disingenuous to me.
A complex subject but a very simple explanation of what may drive metabolism and hormone production is the perceived energy state of targeted cells?
Physiology does not care about cut points! Even the definition of a human with skin boundaries and the environment being outside of us is a cut point. It's not just the organism but the organism/environment meta structure that affects the outcome of the organisms. If the tree grows poorly you don't blame the tree you check the sun/soil/air/rainfall etc.
Understanding the environment that led to the outcomes matters leads to better results than blame.
You give me hope, I’m 23 and hoping to the universe that in my 20-22 years I didn’t build up too much from carbs in my arteries lol. Keep going!!
At least you're learning when you're young. Many of us didn't get the proper information until our 50's or 60's. If you eat real food, prioritize protein, fuel with fat, and cut carbs, your chances of thriving will be maximized.
It's never too late to start learning more, experiment, track your biomarkers and see how you can optimize, improve or enhance.
@@vss963 indeed, it’s awesome to be benefiting from the truth about things metabolic for the past 3 years.
And remember, whatever your diet, these problem slowly accumulate over time and fasting is the quickest way to reverse them! Fasting also regenerates your white blood cells and reduces autoimmune reactions and reprograms the immune system not to have such issues in the future! The people having issues with the current thing going around are those with bad metabolic health, especially with age, which leads to bad immune function!
seems like you like to not eat ;) ... at least for a while ...
Hope there will be a research on GKI and effects of different levels of GKI on reversing metabolic diseases
Congrats on the 40k
Only just beginning 😉
Remember Austin Powers? 'Mole, mooole, moooooooole' Me watching this video: 'Stain, staaaain, staaaaaaain'
Could be sweat!
LOLOLOL! You get points for the Austin reference... I want my baby back ribs! (not what the stain is from though)
Yea, what Nick said.
Ha. Cheers
Could anyone simply write out the 7 truths?
As a carnivore, I also have fat stains on all my t-shirts...
Nick "Nuance" Norwitz
I take a shot of beef tallow every time he says “nuance”.
New Ants!
@@RC-qf3mp Someone has to live off the fat of the land. Lucky are those who do.
@@petermadany2779Blessed be the high fat dieters, for the kingdom of ketosis shall be theirs.
yes Giant Monkey!🦍
My big question is how I find a solution to Lipid problem with all variables, what is good for the you are not always good for me.
Don’t you love it when there aren’t simple answers
love this video. I do not believe in the "proper human diet" There are way too many variables. Thank you!
Isn't that cool though?!
You spilled something on ur shirt i cant belive you did that why did u spill something on ur shirt...
Whoops 😬
appreciate you
appreciate you back!
Biology is about homeostasis.
Algorithm support!!
Metabolic adaptation takes patience, but epigenetic adaptation takes much less time than many consider. For instance, a group of humans arrive to an island, and in less than 5 generations they totally adapted to most or all local foods. It doesn't take thousands of years to adapt to a new dietary pattern.
5 generations is longer than 2 week dietary intervention in a metabolic ward...
@@nicknorwitzPhD Not comparable scenarios. When someone spoiled for choice changes diet for whatever effect has nothing to do with primitive humans getting to a new place, and surviving on whatever the new place offers.
Important content to remember to help filter thru the crap out there!
Cheers :)
You just put into words and then proved with data a lot of suspicions I've had about nutrition, medicine, and the human body. Big ups to you, Nick.
Tyvm!!
I appreciate this, thank you. To points 4 and 7, I daily adjust macro-nutrients relative to lifting, aerobic and rest days. Being flexible with what my body needs.
Something else cool: you can measure how well a system responds to a signal by measuring the signal strength and the system's output. Whether that's insulin and non-esterified fatty acids, or whether it's LH and testosterone, the same principle holds true.
❤❤❤ do you think you could come to canada and have a quiet little chat with our doctors?
Oh, it’s tricksy! ❤
😍
You have a food stain on your shirt.
I have stains on my very soul and nobody ever bothers to point it out
@@BBWahoo On the contrary, you just pointed it out. 😄Hopefully, you have access to the grace that will wash away those stains.
As do I.
@@hollyhopalong7405 yeah, but if you want to be respected as a content creator and scientist, and not just some kid in his mom’s basement, then it’s best to be professional and look professional.
@@RC-qf3mpyou are not respected as a non serious “person”
Adaptation takes times mainly, when you jump from extreme to another extreme, you can see it mainly in digestion.
For example when long term carnivore adds a vegetables (fibre) into the diet, of course they will have problems and feel bad.
It's called the cauliflower combustion effect
Thanks Nick I learn something from every video
Glad to hear it!
OK, though it doesn't seem helpful to say I'm not eating a keto diet just because the test strip says there's no ketones in my blood. I eat mostly meat, eggs and cheese plus salad and some Brazil nuts. What do I call that?
I'd be surprised if you're eating a very low carb diet and BHB measuring
Great video. Thank you for sharing.
You’re welcome Nick
I am confused about your definition of a ketogenic diet. When my carb intake is too high my glucose raises and ketones drop. Listening to Dr. Bickman it is my understanding that if insulin is high your body produces low ketones as the body's priority is to lower the glucose amount in your blood. That seems to be true for me. The lower my glucose the higher my ketones. Yesterday when I measured my glucose it was high because I ate too many carbs and it went up to 122 while my ketones measured 0.5. After cutting out carbs and walking my glucose dropped to 73 and my ketones went up to 3.2 putting me back into a high level of ketosis. What am I missing?
He is meaning that standard is to say that eat less than 20g of carbs (cut point) is ketogenic diet but we are all different with different starting points.
I did not say carbs won't kick you out of nutritional ketosis. I said a specific universal carb threshold doesn't define a ketogenic diet, which is better defined as a metabolic state based on ketone levels (or better yet, flux; although that's difficult to measure)
@@nicknorwitzPhD Thank you. I should have listened to your video a second time.
Nice job on trying to educate about the all important “nuance” (in most things)!
Thank you very much :)
@@nicknorwitzPhD you know what might make for a great video? I am always amazed that “scientists” routinely put out marginal or poor studies as fact leaving people like you to have to educate the masses to clear up misrepresentations. What if you were to produce a video that describes the most optimal one or two or three ways to design studies, and even the challenges that the best design studies can still produce? Also, the costs involved and the reasons they are not always done, perhaps. I don’t know, do you think that would be useful on this channel?
@@kevy1yt Based on your questions, I think you would like following Zoe Harcombe. Look her up.
Stay curious!
Yes!
Thanks Doc.
Very welcome
The biggest mistake in nutrition and medicine too, is the belief that a diet that keeps a healthy person healthy, makes an unhealthy person healthy again.
You can say this a 100 times (I probably have) and yet it gets completely ignored. I hope now that Nick gives this more attention, it will get some more attention everywhere.
But I suspect it will be mostly: "Yeah, that's true,... you're so smart,... " and then everyone forgets about it again. I guess it's not sexy enough.
" "Yeah, that's true,... you're so smart,... " and then everyone forgets about it again. I guess it's not sexy enough." -- Off to Victoria's ... stay tuned for my next video 🤣
@@nicknorwitzPhD Looking forward to it!
But can a diet that makes an unhealthy person healthy, be healthy for a healthy person?
@@defeqel6537 Yep. That's actually the best diet you can eat.
Just a comment on 4, best human diet or species appropriate diet. We do have this. Just look at our body as a whole, what our body is designed to eat. Don’t look at the individual markers like inflammatory markers. We don’t digest fiber at all, we are designed to digest meats. Some might not do well on some meats, but definitely some will be good. We do have this solid patten. If you mean optimization, true, but that’s just your standard your opinion, it’s not what our body designed to do. As Dr Chaffee said, we humans are apex predators, though we are losing this trait after 10k+ years of farming and trying the very best to eat some plants. We do need to see this from the designer perspective. There are a lot more to say, but I guess it’s enough for a UA-cam comment.
"We don’t digest fiber at all" ... umm ... are you a germ free human?
@@nicknorwitzPhD Please don’t pick on things with such extreme technicality. Our body has mechanisms to digest meats, but no mechanisms to digest fiber the most abundant part of plants. Bacteria digest fiber and spit out fatty acids, true, but clearly not what we are designed to digest because it’s such a small percentage and your whole digestive tract does nothing to fiber except at the end using bacteria, and we can literally eliminate fiber from our foods without any negative consequences.
Our body is not designed to process fiber, but like everything in the world, some level of tolerance exists, let alone we humans WERE herbivores. Don’t use tolerance as the basis of your argument, it’s part of the design so that you don’t accidentally eating some fiber and get killed. It’s designed in this way by evolution. Human already adapted the carnivore diet over millions of years eating animal fresh, with our body tuned to eat the carnivore diet, of course not all animals. Some plants don’t hurt much and some can tolerate them for life, but it doesn’t mean they are beneficial or belong to our proper diet, and in fact you can see the degradation of the body of vegans such as Michael Greger, hands got so skinny like sticks, and a giant stomach.
Why do you think meats, especially ruminant meats have such a good ratio of fats and protein to humans but not plants? Because we humans adapted to eat meats, tuned to eat meats. The optimization standard is just your opinion. Eating the proper diet is the optimization. We humans lived in the harsh environment of nature as apex predators, hard to say we are now, but the design within our genes via evolution over millions of years hasn’t changed much as a whole. Exceptions of course exist like everything in the universe, but it’s just how life adapts and evolves.
@@LittleRadicalThinker lol.
@@chuckleezodiac24 hahahaha
Nick, I love your content. Help me understand why a fasting-adapted and zone 2 cardio as well as resistance trained middle aged person who after a 20 hour fast and workout has zero ketonuria despite a fasting insulin of 5 (quest diag. units, can’t remember sorry!) or less? Thanks. My question is why zero ketonuria under these metabolic conditions.
Fasting insulin in the U.S. is typically reported in units of uIU/mL, i.e. "micro International Units per milliliter."
My question is why zero ketonuria under these metabolic conditions not what the units of fasting insulin is.
I hope he answers your question…. Is it because you are fat adaptive? Your liver is producing more glucose? Your body has less insulin sensitivity? Too much cortisol?
A fasting insulin of 5 is a very insulin- sensitive metabolism.
@@dr.julia-heyakarcic8862 Please remember, a fasting insulin gives you a measurement in one instant of time (fasted). To truly learn how sensitive or functional your insulin is, it's ideal to measure it intermittently over time (e.g. 2 hours) to see how it is working after eating something. There are tests to do this (e.g. the Kraft test). The problem with that test is they give you a bolus of glucose (e.g. 75 grams) to consume before starting the test and then they can track how your glucose and insulin react over time. If you are low carb or carnivore and your body is no longer used to being struck with a "sugar shock," so to speak, the results of a Kraft test might be invalid. I feel a Kraft type of test (for low-carbers) should be done after you have eaten a typical meal, say bacon and eggs. Then see what happens over a two-hour period. The trouble with doing that is there is no set standard to begin the test with. So, for now we can at least check fasting insulin. It's certainly better than nothing. But in people doing a classic Kraft test it's possible that a person starting with a fasting insulin of 20 could have a better 2-hour function of insulin than a person starting with a fasting insulin of 5. And then Ben Bikman talks about things like 1st phase and 2nd phase insulin. In other words, you eat some sugary/carby junk and your insulin reacts a bit, to bring your blood sugar down, then after some period of time your glucose continues to go up so your pancreas squirts out a 2nd hit of insulin. It doesn't always happen every time or with every person or every meal, but it can. Well, that's how I understand it but to be sure go ahead and watch some Ben Bikman videos yourself.
"Stay humble" ... brilliant😛
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Nic, have you looked at glucolipotoxicity or lipotoxicity? If so, I'd be interested to hear your thoughts.
Broad topics. As with anything "in excess," the excessiveness will depend on metabolic context