This youtube channel is doing the Lord's work, I'm a medical student and this is like the 10th video that I've had complete 'AH HA! OHHHHHHHHHH' light bulb moments. Amazing
Hi, thank you for speaking up about this protein related to Angelman Syndrome. This is a debilitating but curable disease that affects children. So vital to support research to eliminate it!
Many thanks, Prof. Deshaies, for the video. As a synthetic/medicinal chemist and pharmacist, I would like to work in development of PROTAC molecules, for cancer and neurodegenerative diseases. I have been reading a lot about... Many thanks for sharing your knowledge.
28:53 oxygen sensing / hypoxia response ; prolyl hydroxylase uses molecular oxygen to hydroxylate a proline on HIF; the hydroxylated proline acts as a direct ligand for VHL ubiquitin ligase, HIF is ubiquitinated and destroyed by 26S proteasome
Great video! Just one remark... On min. 11:13 concerning the human diseases, don't you mean Angelman syndrome (instead if Angleman) and isn't it a neurodevelopmental disorder (and not neurodegenerative)?!
My son has Angelman Syndrome and you are correct. It is Angel-man not angleman. Many of us met Harry Angelman who confirmed it's pronounciation. And it is a neurodevelopmental disorder (and not neurodegenerative).
This is a really great presentation and very helpful, thank you. The point about certain proteins needing to be unstable to enable rapid changes of steady state in certain areas of cell biology to be possible, is very interesting.
Hi John, i have some questions for you about a comment you wrote about a year ago on the occasion of Asthma. Do you have an email l can contact you on or do you have facebook? It would be a huge help for me Best regards Mathias :-)
This youtube channel is doing the Lord's work, I'm a medical student and this is like the 10th video that I've had complete 'AH HA! OHHHHHHHHHH' light bulb moments. Amazing
Hi, thank you for speaking up about this protein related to Angelman Syndrome. This is a debilitating but curable disease that affects children. So vital to support research to eliminate it!
Brilliant lecture! Thank you. Again I am amazed at the level of complexity that random mutations can achieve over billions of years.
This is one of those lectures you go "WOW!". Evolution is fucking incredible for coming up with such complex system.
Many thanks, Prof. Deshaies, for the video. As a synthetic/medicinal chemist and pharmacist, I would like to work in development of PROTAC molecules, for cancer and neurodegenerative diseases. I have been reading a lot about... Many thanks for sharing your knowledge.
this is fascinating... thanks for producing it
The content and slides were clear and well explained. Thank you!
28:53 oxygen sensing / hypoxia response ; prolyl hydroxylase uses molecular oxygen to hydroxylate a proline on HIF; the hydroxylated proline acts as a direct ligand for VHL ubiquitin ligase, HIF is ubiquitinated and destroyed by 26S proteasome
Great video! Just one remark... On min. 11:13 concerning the human diseases, don't you mean Angelman syndrome (instead if Angleman) and isn't it a neurodevelopmental disorder (and not neurodegenerative)?!
My son has Angelman Syndrome and you are correct. It is Angel-man not angleman. Many of us met Harry Angelman who confirmed it's pronounciation. And it is a neurodevelopmental disorder (and not neurodegenerative).
Thank you professor. Your lecture is so much useful.
This is a really great presentation and very helpful, thank you. The point about certain proteins needing to be unstable to enable rapid changes of steady state in certain areas of cell biology to be possible, is very interesting.
Hi John, i have some questions for you about a comment you wrote about a year ago on the occasion of Asthma. Do you have an email l can contact you on or do you have facebook? It would be a huge help for me Best regards Mathias :-)
Very well-explained. A really helpful revision video 👍
Thank you ❤
Very helpful, thanks
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(On Wednesday of April 19, 2023)....Heil!