Dmitry Korkin: Evolution of Proteins, Viruses, Life, and AI | Lex Fridman Podcast
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- Опубліковано 30 тра 2024
- Dmitry Korkin is a professor of bioinformatics and computational biology at WPI. Please support this podcast by checking out our sponsors:
- Brave: brave.com/lex
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- Magic Spoon: magicspoon.com/lex and use code LEX to get $5 off
- Eight Sleep: www.eightsleep.com/lex and use code LEX to get special savings
EPISODE LINKS:
Dmitry's Website: korkinlab.org/
Dmitry's Twitter: / dmkorkin
PODCAST INFO:
Podcast website: lexfridman.com/podcast
Apple Podcasts: apple.co/2lwqZIr
Spotify: spoti.fi/2nEwCF8
RSS: lexfridman.com/feed/podcast/
Full episodes playlist: • Lex Fridman Podcast
Clips playlist: • Lex Fridman Podcast Clips
OUTLINE:
0:00 - Introduction
1:57 - Proteins and the building blocks of life
9:00 - Spike protein
15:48 - Coronavirus biological structure explained
20:45 - Virus mutations
27:16 - Evolution of proteins
37:02 - Self-replicating computer programs
44:38 - Origin of life
52:11 - Extraterrestrial life in our solar system
54:08 - Joshua Lederberg
1:00:07 - Dendral
1:03:01 - Why did expert systems fail?
1:05:12 - AlphaFold 2
1:26:50 - Will AI revolutionize art and music?
1:33:49 - Multi-protein folding
1:38:16 - Will AlphaFold 2 result in a Nobel Prize?
1:40:47 - Will AI be used to engineer deadly viruses?
1:55:54 - Book recommendations
2:05:37 - Family
2:08:15 - A poem in Russian
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Here are the timestamps. Please check out our sponsors to support this podcast.
0:00 - Introduction & sponsor mentions:
- Brave: brave.com/lex
- NetSuite: netsuite.com/lex to get free product tour
- Magic Spoon: magicspoon.com/lex and use code LEX to get $5 off
- Eight Sleep: www.eightsleep.com/lex and use code LEX to get special savings
1:57 - Proteins and the building blocks of life
9:00 - Spike protein
15:48 - Coronavirus biological structure explained
20:45 - Virus mutations
27:16 - Evolution of proteins
37:02 - Self-replicating computer programs
44:38 - Origin of life
52:11 - Extraterrestrial life in our solar system
54:08 - Joshua Lederberg
1:00:07 - Dendral
1:03:01 - Why did expert systems fail?
1:05:12 - AlphaFold 2
1:26:50 - Will AI revolutionize art and music?
1:33:49 - Multi-protein folding
1:38:16 - Will AlphaFold 2 result in a Nobel Prize?
1:40:47 - Will AI be used to engineer deadly viruses?
1:55:54 - Book recommendations
2:05:37 - Family
2:08:15 - A poem in Russian
Thanks Lex really enjoy your show.
hey lex, would i be able to make captions for your videos?
Hello Gorgeous.
Hey lex can you ask joe if he thinks his show sucks ass after moving to Spotify. Because we the people do.
24:5 the reason people get a flu shot every year is because we dont know which flu its gnna be this year, not because of mutations. There are hundreds of flu strains. They are shooting in the dark. So to speak
Lexei, I think it would be great if we could have a ‘book club’ episode, say, once a month.
I like that
Thats such a simple yet beautiful way to cultivate some community around these podcasts while also allowing interaction with Lex in a controlled environment that he could easily take advantage of and earn quite a bit of loyalty to the "brand" or to himself in a proper, or deserved imo, kind of way.
Great Idea...perhaps quarterly. Linked to Amazon or not so he can source some funds. The Lex Fund.
Lex, Robert Sapolsky pleeeeeeease!!!!
THIS!!!!!!!
YESYESYESYESYESYESYESYESYESYESYESYESYESYESYESYESYESYESYESYESYESYESYES
+1
Sapolsky's most recent book Behave had quite a lot of ghosts of the replication crisis in it though. I haven't seen him publicly address this yet, and I doubt Lex would be the kind of interviewer to press him on something like that.
@@lokitekone Fascinating. I don't disbelieve you but to which ghosts are you referring? (p.s. I haven't read it yet).
The weird feeling to be a Russian listening to two Russians speaking English to each other. :)
They should seriously just skip the trouble of translating in their heads from Russian to English
Haha
@@pvmcorpWhen someone knows a language at a high level, they don't translate in their head. They simply understand the language as it is. You know that you are at that level when you start thinking and dreaming in that language.
That's our future 😉
@@singularonaut ;)
The content you have been putting out lately has been amazing!
Just like Joe always defaults to DMT, Lex defaults to talking about alien life :-D
Thank God
Lex, I hope you understand the good you do for the world. You've opened the door to a part of society that rarely get heard outside of specific circles, and that means a lot to us. Life changing for some. So thank you.
Awesome! George just did a live stream looking into bio stuffs. Look forward to you talking to him again in the future too!
I would watch this on UA-cam, Lex.. but,
it's already downloaded in my Pod caster.. so, I'll go there.
Lex love your podcasts! They make me feel smarter than I really am. 🙏🏻🙏🏻
Lex "Linger on that" Fridman back at it again.
beautifully put
Are you Andrew "Fan of Joe Rogan's comment section" Gardiner?
Lex: For AI & music creation you should check out and interview David Cope (EMI: Experiments in Musical Intelligence)
Amazing book by Bulgakov, among my favorites, and masterfully written, too. Characters rock!
It breaks my heart when sponsors won't deliver to the UK - great interview though. Lex you are the best!
Like the comments and replys to your podcast Lex. Great job on the technical conversational interview. My grandfather spoke Russian, I never had that opportunity.
Hey Lex! Great episode! Would love for you to speak to Pavel Tsatsouline! What is his meaning of life and how could AI play a role in strength training in the future? Thanks!
Loving this one. We want more computational biologists in the podcast
56:35 Lex's "What's a forum" joke flew right over his head lol
i didnmt get it
1:51:18
"Transparency is more beneficial than secrecy."
And encryption is not antagonistic to transparency. Au contraire, it ensures fidelity of information.
Thank you, Lex!
From Brazil - Santa Catarina, Florianópolis.
@Lex Fridman, when will you upload your content to @t?
I'm only 30 mins in, but I am tempted to say this talk requires a primer in structural biology to begin to understand.
You are right. I paid attention in bio fundamentals in college and I am not able to follow the details.
While I agree, to the extent of understanding to where maybe you could intelligently form questions in their own language and truly participate in the furthering of the ideas being presented...but as an uneducated amateur with an imaginative mind and a high enough IQ, to quickly form ideas and opinions and kind of learn on the fly, I think you can listen along closely and come out with a better understanding on the biological structure and functions of the coronavirus and certain building blocks of life in general.
I took 2 semesters of biochemistry (med track) and I understood 90+% of this. Not super complicated. You only really need to understand central dogma and that proteins have 4 levels of structure (primary to quarternary) to get most of it.
@@6ixpool520 not trivial or intuitive though, right?
@@nappykins-AND-lotion Not at all, no. It isn't *that* complicated though. You only really need central dogma and protein folding as prerequisite knowledge to understand, but if you don't know then good luck keeping up :)
Thanks i knew about Michael Hill! He was my professor in Oxford and told us FBC fund!
Nice video! What about FBC fund and their algorithm review?
I’m Easter European Slovak and Jew. I love the Russian culture and your podcast
Scam not lex
I'm interested to hear about what alphafold could potentially do for various forms of cancer. Seems like something worth some serious airtime
so what you want to do is block the ACE ll receptor - normally Zinc should do this if it has the transporter to bring it into the cell. Zinc deficiency is a problem - and what about Ivermectin + Doxicycline combination?
Good stuff like always, makes me think of how crystals form as well. They always follow the same structural pattern depending on the crystal its different but ultimately you get a crystal.
I just discovered your channel. You're so fascinating, my friend.
@@user-fb9it6vr3w talk with my higher self
Wow Lex, you've been churning out these podcast episodes like you're trying to win a race or something.
Don't compromise your work or private life for this and make sure you get enough sleep every night and stay healthy my friend!
Agreed. Lex is the goat. #ProtectLex
There is a Lockdown going on. None og these "celebs" does anything other thank tend their mansions, and fearing not to be trending on so-me
Maybe this show is helping him to further understand his path in life. Keep it going Lex!
cringe
@@hugoheyman1306 cringe or not cringe. there is no try
Bioinformatics is an extremely fun field for the computer scientist today, very much looking forward to listening to this episode
Great work handling the complex terminology and get clarifications! I find the description of the virus proteins fascinating, I had no idea how much has been learned
Man I could listen to this dude talk all day.
It's been long time without Manolis Lex. We all know round 5 is coming becouse we all fell in love with this beautiful human being.
Yes
Definitely my favorite guest 100%
Yes I want his brain uploaded to the cloud for us to enjoy like an amusement park.
Much love Lex. You are appreciated!
Although most of this discussion was outside the scope of my true understanding, I found it very interesting and would like to hear more about these topics. (I have no idea how anyone could "thumb down" this interview. Yes, it was very technical. But how can you "down vote" facts?) It was like finding out about a whole new reality, a new world that I had not idea existed. My favorite part was when he mentioned his favorite protein. His face lit up :) That shows true passion for his work. Now I must find more about this Post Synaptic Density 95.... Thanks!
EDIT: Ok, I take it back. My OTHER favorite part is the book recommendation segment. ♥
There are two types of people in the world
-------------------------------------------------------------------
1. Those who can extrapolate from incomplete data
This needs more likes!
@@moomoocowsly Interpolate, is adding something unfamiliar into something else. 2. ...those who can't... 😆
Deep focus and pure listening is required to listen to this podcast...understanding protein and their variants is a key,I believe to understanding mutations in other functions, like viruses. A dna " like" structure in its function, as a ladder of evolution.
Love code golf!
Call Donald Hoffman to the show, please!
Yes!
Oh yes pleaaseeeee
Who’s that
Great guest! And that poem was the one John Kleese quoted in a fish called Wanda 😂 . My mother is from Poland, but I played with a Russian girl as a child and she taught me a Russian children’s song that I can still to this day remember. I don’t know how to spell the name, but I think it’s about a little bear that drinks out of a fountain, but it’s vodka, and he gets dizzy and falls down, lol.
lol
I'm not on facebook or instagram or any of those things. Could you please start a mailing list or at least collect e-mails encase you need to start one in the future due to censorship..?..
Next minute Roman calling in for bowling
Constantly learning more about bioinformatics for my PhD, so stoked for this one! More biology focussed episodes please 😁
I am blown away by how complex the protein molecule is! Some of those membrane proteins sound like they would make fun building blocks for kids.
I am a curious person but not an expert in the protein folding domain.
Q1: It seems the DNA sequence combined with physics rules can create a copy of a living organism. Would it be possible to look at the early stage of the living organism reproduction and figure out how they produce different proteins?
Q2: Can we put many building blocks for different proteins in a container and watch how they interact? If we have powerful imaging technology, this could create a huge database. These images might not be useful for humans, but they could be of great value for a machine learning algorithm. Pushing this idea one step further, a machine learning-based algorithm like MuZero could control the container's content by adding different building blocks and getting images (in different resolutions and of different parts of the container). People should invest in imaging technology that enables the computer to interact with the environment and directly see the results.
Love Russian poetry! Can't understand the words(my fault) but it sounds great!
21:20 a conversation about mutagens in 2021... thank you!
Except he fails to state that the vast majority of mutations are bad and reduces efficiency. This guy is a con man
need to figure out how to cut the linkers chemically...joining the domains
I just want to know what his t-shirt says.
There are two types of people in the world:
1) Those who can extrapolate from incomplete data
@@lonelyquark 😂 😂
1:08:22 saving my spot for later
I feel way too proud of myself for understanding Korkin's t-shirt
I wonder what are your perspectives, about the potential of AI in making progress in virus evolution, functionality, vaccination and treatment, in the near future. Particularly related to the corona virus and in general.
Mind blowing
Awesome podcast episode! Biology is fascinating, with literally endless possibilities.
Yep. "Change is always scary."
This man is the most frightening rambler. Knowing more than you can describe in words is the border line between a calm, functioning member of society and a raving lunatic who can't get across the profundity which is much simpler than needed and can be described in words. Lexei, the patient translator sits quietly anticipating the waves of abstraction.
Lex “this is crazy but I get it” Fridman 🤯
Lex please talk to Will Wright if you can
Any plans to talk to Mr. Dorsey again?
this whole talk sheds light on proteomics and mapping out all the associated proteins with various genes and genomes - it is going to take a vast amount of computation and it is going to result in unfathomable amounts of data - it is all good - hopefully more ai and quantum and optical computers will help us solve some of these gigantic mathematical puzzles
Lex gets it. 1:50:20
ACE-2 Receptor. This is why inhaled Vasoactive Intestinal Peptide (VIP) is needed for treatment of COVID-19.
great information!
The delight into intro sold me to it, I have to watch this on one sitting.
Good discussion on the whole. The section on protein folding was too long and technical and not very interesting.
Invite Richard Wolff, please, pozhaluista :)
Love his Russian accent and that poem. Russian does have a way.
My American ass had a hard time with his accent..but I stuck it out..so worth it..verry interesting!!!!!!:) btw..always enjoy all the Russian poetry I hear here..;) even though I dont understand..its still beautiful!!
Life on Earth may have started more than once
Also you will probably never read this with so many people reaching out and chances are ill never be in your podcast but i believe the meaning of life is to connect the dots with ones knowledge to further increase the knowledge of the community. Even if the information is never published or exposed i believe when the thought is made it becomes available and can be picked up by others.
Last time I was this early , a varus was making its way out from a lab in far east.
you mean to a lab in the far east from the west...then out from the eastern lab
shouldnt be EDM an easy step for music AI?
1st comment. BTW big fan of yours bro. I love your videos. They're very much intellectual and brilliant.
Is the Hedgehog a representation of Isaiah Berlin's essay, 'The Hedgehog and the Fox'.
Dmitry looks like a modern day William Shakespeare.
We do not know how Shakespeare looked though...
Interview Vladimir Megre author of The book series, The Ringing Cedars of Russia....
Can we put the audio through Autotune?
Interesting conversation kamaraty! Only the guest is not in focus
Back when they came out with the Tupac hologram, I was wondering what if they could make some kind of AI to write the music, then your pop star is basically an avatar for an algorithm and you'd essentially have immortal pop stars. They've basically got the shell of it with Hatsune Miku in Japan, however it's human written music for the most part.
Can MRNA vaccines increase the likelihood of prion disease?
Lex: he is russian...
Me: okay i can understand russian accents
Dmitry: Thy proyttyin dyomyains
Makes me wanna play Metro 2033
Thanks for the subtitles Lex!!
Hi Lex, love the videos! Is there still an invite link to your discord out there somewhere? all the ones I've found are dead.
@Lex Fridman lol nice try, wrong podcast 😂
Lex knows about izotope rx 🤩🤩🤩 no wonder the podcast sound this good
I get the feeling that these scientists are so enamoured with their field that they don't realise they are taking us deeper and deeper into a tail-biting bio-maelstrom of complexity that will soon implode on itself taking us down with it.
Hey Lex, the last few months I have been following someone who I think could be very interesting as a guest on your show. He's Daniel Naroditsky, a russian-american chess grandmaster and stanford graduate in history. I've heard him talking about his views a few times and he had some interesting points about division in the US which sort of fit with your open minded perspective. I don't know that much more about him except he's a great chess teacher and often quotes soviet chess players, but I could imagine you having an interesting conversation and I'm really curious about what he's like in a long form discussion. He lives in Charlotte South Carolina AFAIK.
Anyway if you read this thanks for your great podcast, your guests and you have given me many insights and helped me through some darker times. Greetings from Germany!
Wow that was so interesting. Thank you very much for that mate.. 😎👌
According to Dmitry, there is still much to understand about the spike protein, and yet, we have vaccines designed for it specifically. Did researchers rush their findings to create a vaccine? is it safe to produce a vaccine without all the information?
Does anyone have an answer for this question?
David Deutsch, please.
is there really still a person who does not know about the existence of FBC fund and their algorithm?
scam
We know about what life is from Theoria Apophasis
just google FBC fund and don't worry
SLAVOJ ZIZEK WHEN LEX
Hi Lex... If w look around. We can see that there are patterns that occur over and over again. All kinds of patterns. Like that things goes in cirkles (recycling i nature and more) and also what I know there isn´t a single thing known to humanity that is existing in only one copy (that is not manmade). If you look around you there is not only one tree, one human, one planet, one stone, one star, one galaxy, one electron, one photon or one of anything. So why would that be different with with life in the Universe. Why would there be only one place with life if anything else is not one? Also why would there be only one Universe and one multiverse? What feels most natural is that everything is infinite and eternal and just goes in circles over and over again. An never ending circle of life/energy in an eternal space. Only the human mind may think that anything starts and stoppes. Like death and life is only words of humans to describe the world. We are just part of it all that always change form and attributes. So noone ever dies or are born what we call to be born is just a part of the eternal ongoing infinite/eternal chainreaction that goes around in all of "it" (space). So why would we think that we should be the exception to all signs and patterns out there?
We are one world, one family and one people (DNA and genomics now can prove) with same origin and same ancestors (if we only go enough generations back in time). Nomatter how different we are (outside/looks or inside/personality).
ed.ted.com/best_of_web/qRqRiz5q#digdeeper
Good morning, Lex ❤
Why are you watching this!? Read about the FBC fund and their algorithm!
Very inspirational and eye opening podcast, thank you for sharing!
Why watch all these forecasts!? Read about FBC fund and their unique algorithm