The Complement System

The complement system is part of the immune system. Its main function is to guide phagocytic cells and clear microbes and damaged cells from an organism. In this video, we introduce the role of C3 protein and how the protein can kill bacteria with/without the help from the other parts of the immune system. The video ends with an illustration of how those powerful tiny bombs (proteins) contribute to the progression of Alzheimer’s disease.
This video was made by McMaster students Jiawen Deng, Jiawei Sun, Simran Saini, Gurratan Gill in collaboration with the McMaster Demystifying Medicine Program.
Copyright McMaster University 2020
References:
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[@bradleybell9581]

I LOVE this video! It's extremely well made and I really appreciate you showing the specific names of all of the complement components as they are moving in and out of the video! Seriously, amazing work!

[@nicoles6965]

Hi, There are some significant errors in this video. For instance, C3 convertase is composed of C4bC2b (formerly C4bC2a) and its role is to cleave C3 into C3a/C3b. Most importantly, cells in the brain (neurons, microglia, and astrocytes) produce complement proteins themselves during normal development and in neurodegeneration. I suggest consulting with a complement expert and editing this video (which was brought to my attention by a student that found it very informative and entertaining--although it is wrong). I am happy to give additional information if requested.

[@faizmohammadshee6618]

Beautiful Video. Excellent narration

[@puneet1173]

beautiful video

[@alemier8422]

What piece is playing at the beginning of this video? So beautiful

[@Fatima-ih8ru]

I really love the music