I forgot to mention something on mitochondrial movement: There is also some evidence that excess sugars in the cells can cause a block on the trafficking of mitochondria from one area of the cell to another through a process known as glycosylation. This does not translate to 'carbs are bad', but it could mean that people with diabetes or some other condition could be affected.
Hi Nicolas, Txs again. We as a community start to understand how the proces of fusion, fission and transportation works. How about growth and shrinking? And as you said pretty nifty, really freaking cool to see the kinesin and denin proteins walk the mitochondria through the cell. How about the philosophical problem of the homunculus. For the fusion and fission it can be explained in the existence or absence of amino-acids etc. But not for the transportation. This needs several steps like creating the highway, and "someone' deciding that Mitochondria needs to be transported along that temporary highway. As if there is a 'someone' who decides on this walking around. Somebody is saying: we need more energy there, lets transport. Waiting for some scientific updates on authopagy.
Growth and shrinking are also mediated by fusion and fission, respectively. The movement aspect is really incredible, I completely agree. I'll do the autophagy one this week, likely. Thanks, Martjin!
7:19 thanks for the insight in how some researchers elevate their work. Found your channel after watching a few water fast videos. Looking to see how water fasting affects people with metabolic diseases like diabetes. Anyway, about to watch the rest of the video. Just want to say thanks for keeping it real.
Dr Gundry has really embraced the uncoupling mechanism and run with it in his latest book, Unlocking the keto code. I would be interested in your analysis. Also thought you might want to have a look at Nick Lane's Transformer. Really enjoying your diligent approach!
Somewhat familiar (i.e. that I'm aware) that mitochondria undergo fission and fusion but not at the level of the protein hooks involved. That walking of the mitochondria down a path blew my mind when I first heard about. Brad Marshall often mentions cell fission/fusion in his blog about the ROS theory regarding fat loss/gain. Thanks for the detailed overview. What about the role of the endoplasmic reticulum? Gary Taubes when asked about why some can't lose fat back to previous healthy levels talked about it may be a damaged endoplasmic reticulum. This was a long time ago (more than a decade) when a private forum I was in was able to ask him some questions regarding his book Good Calories Bad Calories.
A damaged endoplasmic reticulum would lead to cell death. That's nonsense. There is something in endoplasmic reticulum stress shown as elevated ERAD, but if the endoplasmic reticulum can't process fats, you will soon see cell death. It wouldn't be in my top 5 reasons why a person can't lose body fat. As for Marshall's theory on ROS - no doubt ROS plays a factor in fission and fusion, but I'd need to look into his reasoning for its relationship to fat loss and fat gain.
It is said that pqq increases mitochondrial density, is there any truth to that? If so can eating a few kiwis on a regular basis help with that or can we only reach required levels through supplementation?
Would love to see your thoughts on DNP and it’s potential to be the cure for obesity and it’s risk/reward ratio. People have died but there’s also a lot of people on UA-cam that use it for bodybuilding.
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I forgot to mention something on mitochondrial movement:
There is also some evidence that excess sugars in the cells can cause a block on the trafficking of mitochondria from one area of the cell to another through a process known as glycosylation. This does not translate to 'carbs are bad', but it could mean that people with diabetes or some other condition could be affected.
Hi Nicolas, Txs again. We as a community start to understand how the proces of fusion, fission and transportation works. How about growth and shrinking? And as you said pretty nifty, really freaking cool to see the kinesin and denin proteins walk the mitochondria through the cell. How about the philosophical problem of the homunculus. For the fusion and fission it can be explained in the existence or absence of amino-acids etc. But not for the transportation. This needs several steps like creating the highway, and "someone' deciding that Mitochondria needs to be transported along that temporary highway. As if there is a 'someone' who decides on this walking around. Somebody is saying: we need more energy there, lets transport. Waiting for some scientific updates on authopagy.
Growth and shrinking are also mediated by fusion and fission, respectively. The movement aspect is really incredible, I completely agree. I'll do the autophagy one this week, likely. Thanks, Martjin!
7:19 thanks for the insight in how some researchers elevate their work.
Found your channel after watching a few water fast videos. Looking to see how water fasting affects people with metabolic diseases like diabetes. Anyway, about to watch the rest of the video. Just want to say thanks for keeping it real.
Thank you, Nanette. I really appreciate it. I have much more content around this area coming out, soon.
@@Physionic subbed! Can't wait to see it
Dr Gundry has really embraced the uncoupling mechanism and run with it in his latest book, Unlocking the keto code. I would be interested in your analysis. Also thought you might want to have a look at Nick Lane's Transformer. Really enjoying your diligent approach!
Looking forward to autophagy
Somewhat familiar (i.e. that I'm aware) that mitochondria undergo fission and fusion but not at the level of the protein hooks involved. That walking of the mitochondria down a path blew my mind when I first heard about. Brad Marshall often mentions cell fission/fusion in his blog about the ROS theory regarding fat loss/gain. Thanks for the detailed overview. What about the role of the endoplasmic reticulum? Gary Taubes when asked about why some can't lose fat back to previous healthy levels talked about it may be a damaged endoplasmic reticulum. This was a long time ago (more than a decade) when a private forum I was in was able to ask him some questions regarding his book Good Calories Bad Calories.
A damaged endoplasmic reticulum would lead to cell death. That's nonsense. There is something in endoplasmic reticulum stress shown as elevated ERAD, but if the endoplasmic reticulum can't process fats, you will soon see cell death. It wouldn't be in my top 5 reasons why a person can't lose body fat. As for Marshall's theory on ROS - no doubt ROS plays a factor in fission and fusion, but I'd need to look into his reasoning for its relationship to fat loss and fat gain.
It is said that pqq increases mitochondrial density, is there any truth to that? If so can eating a few kiwis on a regular basis help with that or can we only reach required levels through supplementation?
I haven't looked into it, so I can't say.
Would love to see your thoughts on DNP and it’s potential to be the cure for obesity and it’s risk/reward ratio. People have died but there’s also a lot of people on UA-cam that use it for bodybuilding.
I’m working on a video on the topic. :)