Freeze drying or Lyophilization in depth

This video consists of information in detail about freeze drying, its parts, its steps and various applications.
#PharmacyInDepth
#SublimationDrying
#ColdDrying
#foodindustry
#pharmacy
#pharmaceutics
#formulation
#drying
#freezedryer

[@pharmacyindepth9715]

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[@bgeeta7195]

Finally I got very helpful channel for pharmacy nice explanation about freeze dryer...👍

[@2muchtalk173]

Great Video … thanks for making this

[@pharmacyindepth9715]

😊

[@msdl1035]

Very simple and clear explanation.
Thank you.

[@bhardwajV3847]

General introduction well explained in brief.

[@roadman5930]

Mate, you're an absolute god, thank you so much for this

[@aamnaashfaq8087]

I want to freeze dry a biomaterial for my research work. This video help me to know things about that.

[@hazariwalapoota]

समझाने का तरीका बिलकुल ही जीरो है
ऐसा तो किताबों में लिखा हुआ ही है

[@chetanmatale2001]

Excellent videos for pharma student

[@ashishpandya780]

Very nice explain sir

[@simranshah3478]

Awesome

[@lifejourneywitharadhya1314]

Thanks brother, you revise all things in a good way...

[@kate__attract9989]

You explained so well!
Will you please explain other drying methods as well... 🥺

[@sudhirpatil3434]

Appricated!👍

[@shimmisuja5404]

Thankuu so much sir for this great explanation ......
🙏🙏🙏🙏

[@NeeNeenu]

Nice presentation 👏 and well explained 😻

[@jessen00001]

Thank you very much good Sir.

[@ananthanayaginarayanan1562]

Nice 👍

[@shimmisuja5404]

Very helpful 😀😀😊

[@dahcari6548]

Hi Pharmacy in depth
I have question about Freeze Drying, by the way:
In 4:41, Freeze drying can maintain shape and form BUT conventional drying has shape and form shriveled. -> Could you explain it ?
I hope I would receive your answer soon.
Thanks Pharmacy in depth so much.

[@pharmacyindepth9715]

Thanks for the question dah Cari.
In conventional drying process, drying takes place as a result of evaporation from liquid to gas state which gives a shriveled appearance upon drying.
Whereas in freeze drying process, drying takes place as a result of sublimation from solid to gas state. So in solid state the degree of freedom of molecules is lower than in case of liquid state. Hence they remain fixed in a specific position and orientation in case of solid, giving a non-shriveled appearance upon drying.

[@dahcari6548]

​@@pharmacyindepth9715 "drying takes place as a result of evaporation from liquid to gas state which gives a shriveled appearance upon drying."
I guess the shriveled create because
+ When evaporation from liquid to gas, create empty space in materials and the force between material will be appearanced and create shriveled.
3/ Is this a right thought ?
I hope I would receive your answer soon.
Thanks Pharmacy in depth so much.

[@pharmacyindepth9715]

Yes right.

[@dahcari6548]

@@pharmacyindepth9715 thanks so much.

[@kasireddylakshminarasimha7090]

It made my concept clear. Thanks 👍

[@amanvikas4255]

Nice

[@pinoyvetacadz]

My thesis is about cryopreservation

[@ashishpandya780]

Kindly make and share trouble shooting video of freeze dryer machine

[@jirensama1622]

Sir are all sterile manufactured products only in the form of injectables??? like no cream and all?

[@pharmacyindepth9715]

Freeze drying is an expensive and complicated process. This increases additional price of the product. That’s why it is only done in case of rare medicines like in cancer treatment.

[@docbob5821]

I'm trying to lyophilize peptides I froze peptide at -50 for 12 hours then primary 24 hours my samples just stay as liquid 11grams mixed with 260mls of water

[@KinGamerBoy568]

You not a scientist are u

[@docbob5821]

@@KinGamerBoy568 no I'm learning to be a tech not scientist job why would you say that?

[@KinGamerBoy568]

Cause if you were you would know. But it makes sense now🙌🏼

[@estorilblu]

Could someone please help explain the Vacuum pressure required 50 mmHg? every gauge i find on Ebay goes from 0 to -30 Hg thanks.

[@jirensama1622]

does lyophilization only happen for aseptically manufactured products? or for terminal as well?

[@pharmacyindepth9715]

Both

[@curiousqueen2108]

Does all being freeze dryed result would be hard and powdery?

[@pharmacyindepth9715]

They would be powdery and fluffy.

[@jirensama1622]

secondary drying basically just serves the function of removing residual water?

[@pharmacyindepth9715]

Yes right.

[@ka.mol_s5922]

Will I get your reference about condition of lyophilization , please ?

[@pharmacyindepth9715]

Thanks for watching the video. I did not get your question clearly. Can you please repeat it?

[@NwoDispatcher]

How cold must a substance be @ -1 atm?

[@frostvisto9610]

You're thumbnail has the arrows from sublimation and deposition switched

[@user-cy5kd6kn2j]

hello sir,
I have started new freeze drying plant
I want some detailed advise from you regarding use of this process in the pharma industry
please tell me where to contact you.

[@pharmacyindepth9715]

Hi you can contact me at [e-mail]

[@user-np3fc1qr1r]

How to communicate with you

[@mitraarjunan49]

It's little faster

[@Madhumitha-jb7to]

Adjust the play back speed according to ur speed of understanding

[@descalf]

This would be great if it were in English.

[@pharmacyindepth9715]

This is English only, in Indian accent.

[@hitherewatsup127]

i turned it off , try to speak clearly

[@Sonex1542]

You really need to talk slower with such a very heavy accent. It's not English if it's not recognizing any words.